52results about How to "Restore nerve function" patented technology

The invention discloses a hand five-finger rehabilitation training and correction device and relates to the technical field of rehabilitation devices. An upper box body and a lower box body are connected in a matched mode, a containing cavity is formed in the inside, a hand training mechanism is fixed to the upper box body, prime mover mechanisms are arranged in the containing cavity and transfer power to the hand training mechanism through a transmission mechanism, the hands are driven to perform rehabilitation training. The hand five-finger rehabilitation training and correction device is provided with two different prime mover mechanisms, adopts hand-cranking and motor hybrid drive and provides active, passive and cooperated training modes, the designed hand-cranking drive is used for healthy limb training and promoting rehabilitation of a hand nerve function and a double-side cooperated function, a more simplified parallel six-rod mechanism is adopted, and the actual holding rule of the hands is greatly recovered. Quick and convenient dismounting of a drive rod and adjustment of a drive rod installing position are achieved through exercise and limiting of a secondary slide block, thus the exercise angles of knuckles are adjusted in a certain range, and the hand five-finger rehabilitation training and correction device achieves the purposes of meeting different rehabilitation training demands and achieving personalized training.

The invention discloses a biomimic massage couch which belongs to the technical field of medical instruments. The biomimic massage couch comprises a couch body, wherein the couch body is provided with a cervical traction mechanism, a bone setting and massaging mechanism, a thermal therapy device, a lower limb traction mechanism and a control unit; the cervical traction mechanism, the bone setting and massaging mechanism, the thermal therapy device and the lower limb traction mechanism are driven to work through circuits and a motor; and the control unit is used for controlling the circuits and driving the motor to control and coordinate the works among the parts. The biomimic massage couch has simple operation and easy control of traction, bone setting and messaging positions and force, and is suitable for clinically treating the acantha and surrounding soft tissues.

The invention discloses a preparation method of a medicament-carrying biological membrane, which comprises the following steps: preparing type I collagen into a porous and degradable collagen spongy carrier by a freeze-drying process by temperature cross-linking; according to the pharmacokinetics of the selected medicaments, adding medicaments with a certain concentration, such as antibiotics, antiepileptic medicaments, nerve growth factors, NMDA (N-methyl-D-aspartic acid) receptor stimulants, NMDA receptor antagonists and the like, into the liquid medicine slowly in the preparation process of slurry, or soaking a biological membrane into the liquid medicine with a certain concentration; adsorbing the medicaments for a period of time; freeze-drying; packaging; and sterilizing in a proper sterilizing mode (gamma rays or epoxy ethane) according to the properties of the medicaments to form a medicament-carrying preparation with a slow-release effect. The invention has wide application prospects in the technical fields of infection prevention, nerve growth promotion, NMDA metabolism, epileptic prevention and the like.

The invention discloses a medicinal composition for treating dizziness, headache, neural headache and migraine caused by cerebral thrombosis, hypertension, cerebral arteriosclerosis, cervical spondylosis and the like and a preparation method thereof. The medicinal composition is prepared from the following raw materials in part by mass: 20 to 180 parts of kudzuvine root, 10 to 70 parts of Szechuan lovage rhizome, 10 to 50 parts of gambir plant and 10 to 70 parts of root of red-rooted salvia. The method for the medicinal composition comprises the following steps of: decocting the raw materials for preparing the medicinal composition by adding water, extracting the decoction, collecting filtrate, concentrating the filtrate to obtain thin paste, adding 60 to 90 percent ethanol into the thin paste so that the ethanol content reaches 30 to 60 percent, standing the mixture, taking supernate and reclaiming all ethanol to obtain thick paste, drying the thick paste, crushing the dried thick paste to obtain powder, and preparing the powder into capsules or tablets and the like. Clinical experiments show that the medicinal composition has the effects of activating blood, dissolving stasis and dredging the channel, and is used for treating dizziness, headache, neural headache and migraine caused by cerebral thrombosis, hypertension, cerebral arteriosclerosis, cervical spondylosis and the like. The medicinal composition can improve cerebral ischemia and cerebral blood supply insufficiency, is favorable for recovery of neural function, enhances the memory, and can improve the blood circulation of the lower limb and enhance the activity of the lower limb.

The present invention provides a composition for treating ischemic diseases or neurogenic inflammation. PSA-NCAM-positive neural progenitor cells used in the present invention promote angiogenesis in injected tissue and inhibit an inflammatory response. The PSA-NCAM-positive neural progenitor cells can be simply isolated by using an anti-PSA-NCAM-antibody, and exhibit excellent angiogenic and anti-inflammatory activities compared with mesenchymal stem cells, and thus can be useful as a composition for effectively treating ischemic diseases caused by a vascular injury and nerve damage diseases caused by inflammation. In addition, a secretome of the neural progenitor cells of the present invention reduces the ischemic injury site and allows a neurological function to recover, and thus can be used as an agent for treating ischemic diseases and degenerative nervous system disorders such as nerve damage diseases caused by inflammation.

The invention discloses a Chinese medicinal composition for treating cerebral hemorrhage, which relates to the technical field of Chinese medicine. The composition consists of the following components in parts by weight: 8-16 parts of leech, 6-18 parts of giant knotweed, 8-16 parts of astragalus, 6-14 parts of safflower, 10-20 parts of pseudo-ginseng root, 10-20 parts of common selfheal fruit-spike, 10-20 parts of red paeony root, 6-16 parts of chaff flower root, 6-12 parts of ginkgo leaf and 6-18 parts of liquoric root. The Chinese medicinal composition for treating cerebral hemorrhage has the advantages of reasonable composition, short treatment course, high curing rate, no sequelae, safety, reliability and low price. The invention further provides a preparation method for the Chinese medicinal composition for treating cerebral hemorrhage; and the method has a simple process, and is suitable for industrial mass production.

The present invention provides a composition for treating ischemic diseases or neurogenic inflammatory disorders, containing a secretome of neural progenitor cells (NPCs) as an active ingredient. Thesecretome of NPCs, of the present invention, reduces an ischemic injury site and enables neurological functions to recover by means of roles such as anti-inflammation, neovascularization regeneration,and activation and proliferation of inherent stem cells, thereby being usable as a therapeutic agent for ischemic diseases and degenerative nervous system disorders such as nerve damage diseases caused by inflammation. Particularly, the secretome of NPCs, of the present invention, has an excellent behavior improvement effect when administered multiple times.

The invention discloses a pharmaceutical composition for treating bowel dysfunction after an abdominal surgery in order to solve the treatment problem of the bowel dysfunction after the abdominal surgery. The navel-applied agent is characterized by comprising raw materials including, by weight, aspongopus chinensis dallas, alyxia, timonius arboreus, jasminum grandiflorum, caryopteris terniflora maxim, allium victorialis, gastrodia elata bl, spatholobus suberectus dunn, securinega suffruticosa, azurite, cinnamomum cassia presl and setaria italica beauv. Clinical trials prove that the pharmaceutical composition has the advantages of good curative effect on bowel dysfunction, high security, and being worthy of clinical application and promotion.

The present invention relates to a phenylquinolinone-based and flavone-based derivative and a preparation method thereof, wherein the derivative is a histamine H3 receptor antagonist, can protect andrestore the normal function of central nervous system, especially can be used in neurodegenerative diseases and ischemic brain injury, and has great clinical application value.

The invention belongs to the technical field of biomedicine, and relates to new medical application of interleukin-4 (IL-4) in the field of neuroscience, in particular to application of interleukin-4 in preparation of medicine for promoting neural functional recovery after acute cerebral injuries. The experimental result proves that IL-4 has an obvious neuroprotective effect on white matter lesion related nerve dysfunction caused by the acute cerebral injuries, IL-4 can promote oligodendrocyte differentiation and maturation after white matter lesion by promoting polarization of M2-type gitter cells, restoration after white matter lesion is enhanced, the neurological function is improved, the sensorimotor function is improved, and the learning dysfunction is relieved. IL-4 can be prepared into a solid or liquid pharmaceutical preparation, and the prepared pharmaceutical preparation has an obvious neuroprotective effect, and can be used for treating white matter lesion related neurologic impairment related diseases caused by the acute cerebral injuries.

The invention relates to a traditional Chinese medicine for curing spleen and kidney deficiency type ischemic post-stroke depression, which solves the problems of untoward reactions, such as dizziness, hypodynamia, drowsiness, thirsty mouth, constipation and intoxication, and side effects, such as hypopiesia, epilepsia, and respiratory and cardiac arrest, caused by other medication. The traditional Chinese medicine comprises 15 to 25 g of pilose asiabell root, 15 to 25 g of bighead atractylodes rhizome, 7 to 13 g of indian bread, 7 to 13 g of root of herbaceous peony, 15 to 25 g of rehmannia root, 9 to 15 g of dogwood fruit, 7 to 13 g of Indianmulberry, 7 to 13 g of kudzuvine root, 7 to 13 g of fruit of barbary wolf berry, 9 to 15 g of aucklandia root, 7 to 13 g of cyperirhizome, 23 to 37 g of fossil fragment, 23 to 37 g of oyster and 5 to 7 g of licorice root; and the material is prepared into medicinal broth through conventional soaking, boiling and filtering; or the traditional Chinese medicine is directly formed by blending commercially available single Chinese herb formula granule. The traditional Chinese medicine has obvious curative effect, improves the life quality of patients, and has safe and reliable efficacy and little side effects.

The invention relates to a pelvic floor vibration massage device, which comprises a chair body, a vibration massage device and a remote controller, wherein the vibration massage device comprises a bottom plate, a casing, a tailbone vibration body, a pars analis vibration head, an overriding body, a Huiyin point massage head, a pubis part vibration sheet and a support body; the pars analis vibration head and the perineum point massage head are positioned on the overriding body; a Changqiang point massage head is arranged on the pubis part vibration sheet; a vibration motor, a controller, a dataprocessing unit and a wireless communication module are arranged in the casing. The pelvic floor vibration massage device has the advantages that the operation is convenient; noninvasive and painlesseffects are achieved; the multi-dimensional massage can be realized; by using the vibration massage training mode, the aspects of pelvic floor muscle sensitivity, pressure intensity and traditional Chinese medicine acupuncture point are combined for massage vibration, the effects of relieving chronic pain syndromes and promoting restoration of injured muscle and nerve functions can be achieved; meanwhile, the pelvic floor nerves and muscles can be woken up; pleasant sensation and orgasm can be realized.

The invention relates to a traditional Chinese medicine composition for treating sequelae of cerebral apoplexy, and belongs to the field of medicines. The traditional Chinese medicine composition is prepared from radix astragali, honeysuckle flowers, cortex phellodendri, rhizoma atractylodis, radix scrophulariae, angelica sinensis, radix paeoniae alba, coix seeds and other raw medicinal materials.Pharmacodynamic test tables and clinical tests show that the composition disclosed by the invention has remarkable improvement and treatment effects on sequelae of cerebral apoplexy, and has a wide market prospect.

The invention relates to the technical field of rehabilitation apparatuses, aims to solve the problems that in the prior art, the function is single, recovery of nerves, muscle strength and hearing cannot be promoted more quickly, the operation method is traditional, and the artificial intelligence degree is low, and provides a multifunctional rehabilitation apparatus. The rehabilitation apparatus comprises a ball body. The ball body is provided with an outer shell and an inner cavity, a vibrator is arranged in the inner cavity, and one side of the vibrator is fixedly connected to the inner side of the outer shell; a control chip is arranged in the inner cavity and is connected with the vibrator; the inner cavity is internally provided with a power supply device for providing power, the power supply device is connected with the control chip, the outer wall of the outer shell is provided with a charging interface, and the charging interface is connected with the power supply device; and the outer shell is made of a polyurethane material. The rehabilitation apparatus has the beneficial effects that the rehabilitation apparatus has various functions, recovery of nerves, muscle strength and hearing can be promoted more quickly, the operation method is advanced, and the degree of artificial intelligence is high.

The invention provides a traditional Chinese medicine for promoting blood circulation of the affected limbs of a patient with cerebral stroke and a preparation method. The traditional Chinese medicine includes herba piperis tonkinensis, callicarpa longissima (Hemsl.)Merr., fibrous roots of fistular onion, a diversifolious pimpinella herb, a three-leaf loosestrife herb, ficus esquiroliana, roots of rustyhair raspberry, giant knotweeds, radix maclurae, anthriscus sylvestris, schoch craspedolobium roots, cirald daphne barks, roots of blue cohosh, Chinese tupistra rhizomes, perny false fairybells rhizomes, lycopus lucidus turcz, radix achyranthis bidentatae, a big rattlesnake plantain herb, stachys sieboldi, radix salviae miltiorrhizae, echeveria peacockii, trichosanthes cucumeroides, a sibirica walking fern herb, roots of common lamiophlomis, radix paeoniae rubra, diphylleia sinensis and pubescent holly roots. The traditional Chinese medicine has the advantages that the traditional Chinese medicine can enhance the elasticity of blood vessels and blood supply, speed up blood flowing and promote blood circulation and recovery of a neurological function, a preparing process is simple and convenient, no toxic and side effect is produced, and the cost and price are low.

The invention relates to an ammonia borane / silicon sphere / mesoporous silica nano-composite particle, and a preparation method and application thereof. The chemical formula of the nano-composite particle is AB / SiO2@mSiO2, the nano-composite particle takes a silicon dioxide sphere as a substrate and the mesoporous silica as a shell, and a gas prodrug capable of generating hydrogen in an acidic microenvironment is loaded. The nano composite particle is used as a drug carrier, is used for imaging diagnosis, gas therapy and inflammation resistance, synergistically enhances neurological function recovery, reduces fibrosis scar formation, and promotes nerve regeneration by inhibiting an oxidative stress response. Compared with the prior art, the AB / SiO2 (at) mSiO2 nano-composite particle has a novel structure, has a broad application prospect on the aspects of gas prodrug loading, gas controllable release, ultrasonic imaging and spinal cord injury diagnosis and treatment, can transmit gas prodrugs to injured lesion sites and performs diagnosis and real-time observation of treatment conditions through imaging, and can effectively and visually treat the spinal cord injury by comprehensively adjusting oxidation and inflammation imbalance in the microenvironment.

The invention provides a traditional Chinese medicine preparation for treating axillary nerve injury. The preparation is prepared from radix astragali, ramulus cinnamomi, radix paeoniae alba, fructuschaenomelis, rhizoma chuanxiong, radix salviae miltiorrhizae, caulis spatholobi, dried tangerine peel, herba epimedii, ramulus mori, rhizoma gastrodiae, scorpio, ginger, Chinese dates, radix angelicaesinensis, herb of tuberculate speranskia, herba lycopodii, peach kernels, safflower, rhizoma corydalis, earthworms, honey-fried licorice roots and the like through a conventional traditional Chinesemedicine preparation process. Accordingly, the score of the nerve function obtained after nerve injury can be effectively increased, the pathological injury is alleviated, and neural functional recovery is promoted; traditional Chinese medicine believes that the axillary nerve injury is a series of pathologic changes produced due to the fact that meridian blocking and qi and blood stasis are caused by local injury, and the internal organs cannot be moistened and nourished due to the fact that qi and blood circulation is not smooth.

The invention discloses an application of knocking down ARID1A in inhibition of retinal ganglion cell apoptosis after injury. The invention finds that the ARID1A gene knockout can inhibit the RGC apoptosis of optic nerve injury animals, and the survival rate of the RGC after the ARID1A gene knockout is obviously increased compared with that of the RGC without the ARID1A gene knockout, so that the ARID1A gene knockout substance can be used as a protective agent of retinal ganglion cells to treat optic nerve injury. The invention provides a new gene intervention target spot to effectively inhibit the apoptosis of the retinal ganglion cells after optic nerve injury, and provides a strategy for repairing optic nerve injury, searching a treatment method for optic nerve injury to relieve the pain of a patient and restore the neurological function.

The invention discloses an application of glutamate transporter-1 (GLT-1) gene transfected glial cells in an aspect of treating traumatic brain injury (TBI). The application is characterized in that through in-vivo animal experiments, the influence of glutamate transporter-1 gene transfected glial cells on rat nerve cell apoptosis and learning and memory functions can be detected under the condition of using glutamate transporter-1 gene transfected glial cells. The invention further discloses application of the glutamate transporter-1 gene transfected glial cells in preparation of prognostic drugs for traumatic brain injury, the glutamate transporter-1 gene transfected glial cells are applied to treating TBI, the adverse effect of excitatory toxicity of glutamic acid on nerve cells after TBI is reduced, thereby restoring neurological function in TBI patients; and a new direction is provided for treatment of the traumatic brain injury, and meanwhile, a research basis is provided for preparing prognostic drugs for treatment of the traumatic brain injury.

The invention discloses herbal composition and an application thereof. The herbal composition is prepared from raw materials in parts by weight as follows: 250-400 parts of mugwort floss, 200-300 parts of Arabian jasmine flower, 120-200 parts of radix angelicae sinensis, 120-200 parts of tea leaf, 10-50 parts of semen cassiae, 10-50 parts of flos chrysanthemi indici, 10-50 parts of spica prunellae, 10-50 parts of cortex moutan, 10-50 parts of radix salviae miltiorrhizae, 10-50 parts of cortex phellodendri, 10-50 parts of rhizoma chuanxiong, 10-50 parts of climbing groundsel herb, 110-120 partsof poria cocos, 110-120 parts of caulis polygoni multiflori, 10-50 parts of flos magnoliae and 2-5 parts of menthol. The herbal composition is prepared from various natural herbaceous plants as the raw materials, is safe, reliable and easily absorbed by a human body, and can improve cell metabolism and microcirculation, realize vasoconstriction around eyes, help periorbital skin in detumescence,inhibit hyperemia and improve symptoms such as dark eye circles and crow's feet due to rich pharmacological actions of the natural medicinal materials; medicine efficacy can directly get through bloodoxygen channels in the ciliary muscle and the crystalline lens, metabolism of eye tissue is promoted, blood circulation in eyes is improved, eye acupoints are pressed in a dotting manner, anteroposterior diameter of eyeballs is corrected, nutrition is supplemented rapidly, and neurological functions are recovered.

The invention discloses liquefied tissue regenerating and skin healing paste which is preferably composed of rapeseed oil and the following raw materials based on the weight of the rapeseed oil: 3% ofherbacamptosorisibirici, 4% of hirudoseuwhitmania, 3% of rhizomabletillaestriatae, 3% of radix notoginseng, 3% of folium persicae, 5% of folium callicarpaeformosanae, 4% of gallachinensis, 3% of pyrolusite powder, 3% of pulvis catechu, 0.1%-0.6% of margarita radix, 0.1%-0.2% of bromelain, 10%-25% of beeswax and 3%of Vaseline. The preparation method comprises the following steps: adding herbacamptosorisibirici and other traditional Chinese medicine components into the rapeseed oil for soaking, then decocting with soft fire to obtain yellow oil, and sequentially adding beeswax and Vaseline as well as pulvis catechu, margarita radix and bromelain while the yellow oil is hot. The liquefied tissue regenerating and skin healing paste is applicable to skin sores caused by bacterial infection, old sodden legs, diabeticdecayed feet, vasculitis, decubitus, burns and scalds, postoperative bad healing and all wounds with ulcers, carrions not exfoliated, no new flesh or inability to heal for longtime, and has functions of inhibiting bacteria and killing viruses, protecting and repairing damaged cortices, promoting blood circulation, infiltrating surface wounds for deep absorption, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, promoting self-liquefaction and exfoliation of deep decayed tissues, discharging pus and carrions and the like.

The invention discloses a medicine for preventing and treating spinal cord type cervical spondylosis. An effective component of the medicine is muscone, the in-vivo effective administration dosage is1-10mg / kg, and the effective concentration is 1-10mu M. The muscone can be mixed with various pharmaceutical adjuvants to form powder, paste, powder, injection, water aqua, enteric sustained-release preparations or injections and the like. Animal experiments prove that the muscone can relieve neuroinflammation of a lesion site of a cervical spinal chronic compression rat, inhibit neuronal apoptosis and improve neurological function deficiency symptoms. The invention also discloses an application of the muscone in preparation of a medicine or a health care product for preventing and treating spinal cord type cervical spondylosis.

The invention provides applications of a receptor antagonist in treating focal cerebral ischemia injuries, and belongs to the technical field of biological medicine. In rat focal cerebral ischemia models, HAMI 3379 intracerebroventricular administration possesses protection effects on acute injuries of the rat focal cerebral ischemia models; HAMI 3379 intraperitoneal injection administration possesses protection effects on accurate and subacute injuries, and at the same time, inflammatory reaction is reduced, and especially microglial cell activation is inhibited; and HAMI 3379 intraperitoneal injection administration possesses protection effects on cerebral ischemia chronic injuries, and neurological function recovery can be promoted.

The present invention relates to a method for producing glycolipides substance using ganglioside as main component, sand method includes the following steps: pulverizing animal brain tissue, adding 20-100% alcohol solvent to make extraction, in which the ratio of dose of alcohol and weight of brain tissue is 1-10:1, filtering or centrifugalizing, concentrating filtrate, the concentrate and its freeze-dried powder can be diluted with water or mixed with edible auxiliary material, and can be made into the oral brain health-care product with various forms.

The present invention relates to a 5-HT7 receptor antagonist for use in preventing or treating a tauopathy. Further, the present invention also relates to a pharmaceutical composition for use in preventing or treating a tauopathy comprising the 5-HT7 receptor antagonist as mentioned above.

The invention provides application of a compound in the preparation of nerve protection and / or nerve repair related products, and provides application of the compound (I) in the preparation of neurophic growth factor enhancers and trophic nerve drugs. Through a drug screening model, the compound has a neuroprotective effect, and experiments indicate that endogenic stem cell expressed NGF and BDNFtrophic factors are important mechanisms of the compound for curing cerebral ischemia-reperfusion injury, so that drugs for preventing or curing nervous system related diseases such as cerebral ischemia-reperfusion injury are prepared.

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating diabetic peripheral neuropathy. Raw materials of the traditional Chinese medicine composition consist of the following components in parts by weight: 13-18 parts of cortex eucommiae, 18-23 parts of herba taxilli, 18-23 parts of radix cyathulae, 4-8 parts of cassia twig, 2-5 parts of herba asari, 18-23 parts of radix rehmanniae recen, 18-23 parts of radix astragali, 10-15 parts of radix angelicae sinensis, 7-12 parts of radix paeoniaerubra, 4-8 parts of roasted ephedra, 23-27 parts of lumbricus, 5-8 parts of radix glycyrrhizae and 8-12 parts of centipede. The traditional Chinese medicine composition is guided by theory of traditional Chinese medicine, optimized through a combination of prescriptions. According to the traditional Chinese medicine composition, and can obviously improve curative effect, effectively improve bloodrunning condition of patients, and promote recovery of nerve function through adding medicines for tonifying the kidney and dredging collaterals on the basis of Danggui Sini Decoction. In the traditional Chinese medicine composition, the cortex eucommiae, herba taxilli, and radix cyathulae can reinforce the liver and kidney, and strengthen muscles and bones; the cassia twig, herba asari, and ephedra can warm channel and expel cold, and dredge meridians; the radix rehmanniae recen can nourish Yin and cool blood, and restrict dryness of the cassia twig and the herba asari; the radix astragali, radix angelicae sinensis, and radix paeoniae rubra can nourish qi and activate blood; the radix glycyrrhizae can harmonize various medicines; and the medicines are used together to achieve effects of tonifying qi, tonifying the kidney, removing blood stasis and dredging collaterals.