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Medicine for preventing and treating spinal cord type cervical spondylosis and application thereof

A technology of cervical spondylotic myelopathy and medicine, which is applied in the field of medicine for the prevention and treatment of cervical spondylotic myelopathy, and can solve the problems of patients with slow limb function, spinal cord injury, and step-wise decline

Active Publication Date: 2019-06-11
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If cervical spondylotic myelopathy is not timely and effectively intervened, most patients will experience slow or step-wise decline in limb function, and even serious complications such as spinal cord injury, dyspnea, and limb paralysis, which will bring heavy burdens to individuals, families, and society. burden

Method used

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  • Medicine for preventing and treating spinal cord type cervical spondylosis and application thereof
  • Medicine for preventing and treating spinal cord type cervical spondylosis and application thereof
  • Medicine for preventing and treating spinal cord type cervical spondylosis and application thereof

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Experimental program
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Effect test

experiment example

[0021] After the rats were anesthetized with pentobarbital sodium, the skin was cut to expose the C5 and C6 lamina, and the polyvinyl alcohol-polyacrylamide interpenetrating network hydrogel was placed under the C5-C6 lamina to prepare chronic compression of the cervical spinal cord SD rat model. They were randomly divided into model group and muscone group. From day 1 after operation, 5 mg / kg muscone was injected intraperitoneally, and the model group was injected with the same amount of normal saline for 4 consecutive weeks. The rats were subjected to behavioral tests such as BBB and inclined plate test at different time points after operation. On day 28 after operation, the rats in each group were anesthetized with pentobarbital sodium, and the cervical spinal cord was collected after cardiac perfusion. Gradient sucrose solution was used to dehydrate, and frozen sections were prepared for pathological tissue staining.

[0022] Muscone (1, 5, 10 uM) pretreated microglial c...

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PUM

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Abstract

The invention discloses a medicine for preventing and treating spinal cord type cervical spondylosis. An effective component of the medicine is muscone, the in-vivo effective administration dosage is1-10mg / kg, and the effective concentration is 1-10mu M. The muscone can be mixed with various pharmaceutical adjuvants to form powder, paste, powder, injection, water aqua, enteric sustained-release preparations or injections and the like. Animal experiments prove that the muscone can relieve neuroinflammation of a lesion site of a cervical spinal chronic compression rat, inhibit neuronal apoptosis and improve neurological function deficiency symptoms. The invention also discloses an application of the muscone in preparation of a medicine or a health care product for preventing and treating spinal cord type cervical spondylosis.

Description

technical field [0001] The invention relates to a medicine for preventing and treating cervical spondylotic myelopathy. In addition, the invention also relates to various preparation forms of the medicine and its application in preparing medicine or health food for preventing and treating cervical spondylotic myelopathy. Background technique [0002] Cervical spondylotic myelopathy is a common degenerative disease of the cervical spine in spinal surgery, and it is also one of the most common causes of spinal cord dysfunction, and it often occurs in middle-aged and elderly patients. In recent years, with the accelerated pace of society and changes in lifestyles, the incidence of cervical spondylotic myelopathy has increased year by year, showing a trend of younger age. According to epidemiological surveys, in the United States, between 1993 and 2002, the number of patients admitted to hospital due to cervical spondylotic myelopathy doubled, while the number of patients underg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P19/08A23L33/00
Inventor 王拥军施杞崔学军周龙云梁倩倩孙悦礼姚敏田子睿刘书芬赵永见
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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