A kind of medicine for preventing and treating cervical spondylotic myelopathy and use thereof
A technology for cervical spondylotic myelopathy and use, applied in the field of drugs for the prevention and treatment of cervical spondylotic myelopathy, can solve problems such as dyspnea, slow limb function of patients, and limb paralysis
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[0021] After the rats were anesthetized with pentobarbital sodium, the skin was cut to expose the C5 and C6 lamina, and the polyvinyl alcohol-polyacrylamide interpenetrating network hydrogel was placed under the C5-C6 lamina to prepare chronic compression of the cervical spinal cord SD rat model. They were randomly divided into model group and muscone group. From day 1 after operation, 5 mg / kg muscone was injected intraperitoneally, and the model group was injected with the same amount of normal saline for 4 consecutive weeks. The rats were subjected to behavioral tests such as BBB and inclined plate test at different time points after operation. On day 28 after operation, the rats in each group were anesthetized with pentobarbital sodium, and the cervical spinal cord was collected after cardiac perfusion. Gradient sucrose solution was used to dehydrate, and frozen sections were prepared for pathological tissue staining.
[0022] Muscone (1, 5, 10 uM) pretreated microglial c...
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