44results about How to "Resolve irritation" patented technology

The invention relates to capparis spinosa fruit gel ointment, a production method thereof, and application thereof to antirheumatic medicaments. The capparis spinosa fruit gel ointment comprises a backing layer, a medicament-containing ointment body and a covering layer protective film, wherein the medicament-containing ointment body is prepared from the following raw materials: a medicinal part of the capparis spinosa and a medicinal excipient; a covering material of the covering layer protective film is one of release paper, a plastic film, a polyester, an aluminum foil-polyethylene composite film and hard gauze; and a backing material of the backing layer is one of cotton cloth, non-woven fabric and chemical fiber cloth. The apparis spinosa fruit gel ointment provided by the invention substitutes the apparis spinosa fruit serving as a medicament for the traditional root bark, so the contradiction between the resource utilization of the apparis spinosa medicinal plants and ecological protection is solved. More importantly, the apparis spinosa fruit gel ointment provided by the invention solves the problems of irritability and hypersensitivity caused by the clinical application of the traditional formulation and administration way of the apparis spinosa, and has the characteristics of long action time, high moisture retention, high air permeability, avoidance of the first pass effect of livers, using comfortableness and high compliance of patients.

The invention discloses a prescription of a ketorolac tromethamine injection and a preparation method. The injection provided by the invention can not only effectively solve the problem that the existing ketorolac tromethamine injection containing ethanol causes irritation while being injected and improve the safety of the drugs and the compliance of the drugs, but also completely avoid the white points caused by the traditional technology after sterilization treatment, and thus the ketorolac tromethamine injection is good in stability, high in safety, reliable in quality and significant in efficacy.

A composite vegetative liquid extract for preventing fowls' influenza is prepared from 10 plants including honeysuckle flower, wild chrysanthemum flower, albizia flower, pueraria flower, etc through extracting, concentrating and packing.

The invention belongs to the technical field of skin medicines, and particularly relates to acne-removing ointment and a preparation method thereof. The acne-removing ointment is prepared from the following components in percentage by weight: 5 to 20 percent of azelaic acid, 0.1 to 1 percent of menthol, 15 to 25 percent of fatty alcohol, 50 to 70 percent of polyhydric alcohol, 2 to 10 percent of emulsifier and 0.1 to 2 percent of polydimethylsiloxane. According to the acne-removing ointment disclosed by the invention, azelaic acid can exist in a formula in a dissolved state, and effective components can permeate into skin more easily, so that the treatment effect of acne is improved; meanwhile, the emulsifier and the fatty alcohol are added, so that azelaic acid dissolved by the polyhydricalcohol is slowly released, greasy feeling and adverse reaction caused by high-content polyhydric alcohol are relieved, and the low-temperature stability of the ointment is improved.

The invention discloses doxycycline hydrochloride oil turbid liquor, a preparation method and application thereof. The doxycycline hydrochloride oil turbid liquor of the invention is obtained through preparing 50 to 300g of doxycycline hydrochloride raw medicine, 1 to 50g of suspending aids, 1 to 30g of surface active agents, 0.1 to 2g of oxidation inhibitors and a proper amount of oil into the oil turbid liquor with the volume amount of 1L. The doxycycline hydrochloride oil turbid liquor of the invention is prepared by a dispersing method, has the advantages of high stability, prolonged absorption time, delayed peak reaching time, prolonged elimination half life and good biocompatibility, and can be used as long-effect injection preparations for animals.

The invention relates to the field of biological pharmacy, in particular to a pichia pastoris fermenting method for improving precursor expression of insulin and analogue thereof. The fermenting culture comprises the following stages of an initial growth phase, a glycerin supplementing phase and a methanol inducing phase. The method has the advantages that by controlling a formula of an initial culture medium, and the nitrogen source type and carbon source supplementing type, and continuously or semi-continuously supplementing a small amount of microorganisms or plant-source organic nitrogen sources in the middle and later period of fermenting, the fermenting cycle is extended; while the quality of the target product is guaranteed, the output is increased by not less than 30%.

The invention discloses a self-cleaning water-based UV ultraviolet curing varnish. The varnish comprises the following components in parts by weight: 60-85 parts of a dispersion, 0.3-0.7 part of a defoaming agent, 0.2-0.5 part of a wetting agent, 0.1-0.7 part of a flatting agent, 0.1-3 parts of a nano assistant, 2-3 parts of a water-based photoinitiator, 0.2-1 part of a thickening agent, 2-4 partsof a film-forming agent and 1-30 parts of water, wherein the dispersion is a water-based fluorine modified polyurethane dispersion or acrylic dispersion which needs ultraviolet light curing, and thenano assistant is nano titanium dioxide. The varnish provided by the invention has the advantages of high curing hardness, good toughness, good abrasive resistance, easy cleaning, capability of purifying the surrounding environment, greenness, environment friendliness, energy conservation and the like, can be applied to coating of decorative glass, solid wood furniture, plate furniture and indoorwood floors, and has an excellent application effect.

The present invention relates to organic salt of pyritinol as shown for treating cerebral concussion, brain trauma, encephalitis, meningitis sequelae and senile dementia. The organic salt exists in hydrate and is named as 3, 3-(dithio methylene) bis(5-hydroxy-6-methyl-pyridyl methane) organic salt chemically. The organic salt is salt of nicotinic acid, lactobionic acid, malic acid, etc. Experiments show that the organic acid and pyritinol have synergistic effect of protecting cardiac muscle, and the nicotinate of pyritinol is especially hopeful in developing pyritinol medicine.

The invention relates to a supramolecular preparation of retinol and derivatives thereof and a preparation method of the supramolecular preparation. The supramolecular preparation is characterized byconsisting of the following components in percentage by mass of 3.00-25.0 percent of retinol and derivatives thereof, 36.5-91.0 percent of hydroxypropyl-gamma-cyclodextrin, 4.00-32.0 percent of hydroxypropyl methylcellulose stearoyl ether and 2.00-8.0 percent of PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, wherein the mass ratio of the PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin to the hydroxypropylmethylcellulose stearoyl ether is 1:(2-4). The obtained supramolecular preparation of the retinol and the derivatives thereof has the advantages of good stability, high solubility, low irritation, good anti-wrinkle effect and the like.

The invention relates to the field of biological pharmacy, in particular to a pichia pastoris fermenting method for improving precursor expression of insulin and analogue thereof. The fermenting culture comprises the following stages of an initial growth phase, a glycerin supplementing phase and a methanol inducing phase. The method has the advantages that by controlling a formula of an initial culture medium, and the nitrogen source type and carbon source supplementing type, and continuously or semi-continuously supplementing a small amount of microorganisms or plant-source organic nitrogen sources in the middle and later period of fermenting, the fermenting cycle is extended; while the quality of the target product is guaranteed, the output is increased by not less than 30%.

The invention relates to a decumbent corydalis tuber eye drop and a preparation method thereof. According to the decumbent corydalis tuber eye drop, the pH value is 4.6 to 6.5, and the permeation pressure is between 0.24 and 0.360 smol / kg; each 1,000 milliliters of decumbent corydalis tuber eye drop is prepared from the following substances: a decumbent corydalis tuber extract containing 0.32 to 0.43 gram of protopine, 0.0036 to 0.0048 mol of diluted phosphoric acid solution, and 0.1 to 3.0 grams of sodium dihydrogen phosphate, 3 to 8 grams of solubilizer, 0.2 to 0.8 gram of disodium edentate, 0.1 to 0.8 gram of bacteriostatic agent, 0 to 2.0 grams of thickening agent, 0 to 4 grams of medicinal ethanol solution of freshener, disodium hydrogen phosphate and glycerol which serve as auxiliary materials and the balance of water for injection, wherein the concentration of the diluted phosphoric acid solution is less than or equal to 0.5 mol / L, and a mass ratio of the freshener to medicinalethanol is 1:(1-15); the amount of the disodium hydrogen phosphate is used for regulating the pH value of the decumbent corydalis tuber eye drop; and the amount of the glycerol is used for regulatingthe permeation pressure of the decumbent corydalis tuber eye drop. The decumbent corydalis tuber eye drop has a mild effect, and the compliance of patients is improved greatly, so the decumbent corydalis tuber eye drop is an eye drop which is small in irritation and high in stability.

The invention provides a retinol nano-emulsion with low irritation and high stability for cosmetics, which comprises the following components in percentage by mass: 5-15% of retinol, 4.1-7.1% of salt-sensitive surfactant composition, 13.4-30% of caprylic / capric triglyceride, 10-22% of glycerol, 2-4% of antioxidant composition and the balance of deionized water. The retinol nano-emulsion disclosed by the invention has the advantages of low skin irritation, good stability, convenience in use and the like.

The invention relates to timolol maleate cubic liquid crystal nanoparticle eye drops and a preparation method thereof. The imolol maleate cubic liquid crystal nanoparticle eye drops are mainly prepared from, by weight, 0.4-1.0 part of timolol maleate, 1.0-18.0 parts of liquid crystal material, 0.2-3.0 parts of surface active agent and 100 parts of water. The liquid crystal material is glycerol monoolein. The surface active agent is poloxamer. According to the timolol maleate cubic liquid crystal nanoparticle eye drops, the cornea infiltration capacity of timolol maleate can be remarkably improved, intra-ocular pressure can be remarkably and stably reduced, the retention time of a drug in the eyes can be prolonged, no preservative is added, and the problems that in the prior art, the retention time of timolol maleate eye drops in the eyes is short and irritation is caused by long-time use can be effectively solved.

The invention discloses a traditional Chinese medicine bath agent for treating duck / goose feather lice and a preparation method. The traditional Chinese medicine bath agent is prepared from the following raw materials in parts by weight: 10-30 parts of Chinese pulsatilla leaves, 10-20 parts of chrysanthemum indicum leaves, 20-40 parts of radix stemonae, 10-20 parts of pseudolarix amabilis., 5-10 parts of Carpesium abrotanoides, 20-30 parts of polygonum flaccidum and a proper volume of edible white vinegar. According to the traditional Chinese medicine bath agent for treating the duck / goose feather lice, disclosed by the invention, through a traditional Chinese medicine compound combination, the control efficiency is good, the traditional Chinese medicine bath agent plays relatively good roles in killing and eliminating ova, naiads and adults of the duck / goose feather lice and is non-toxic and nonirritant, drug residual cannot be generated, and the problem that hazards such as toxicity, irritability and environmental pollution are caused due to the fact that chemical insecticides are adopted to control the duck / goose feather lice currently is solved.

The present invention provides a water-in-oil nanoemulsion comprising an oil phase, an aqueous phase, and an emulsifier wherein the aqueous phase comprises a hyaluronic acid composition. The hyaluronic acid composition is added into a water-in-oil nano-emulsion formula to serve as an inner phase of the nano-emulsion, a depot effect can be achieved on a corium layer, storage of active ingredients in skin is enhanced, the active ingredients can be conveyed to a deep skin layer with better hydrophilicity by combining the characteristics that the nano-emulsion is small in particle size and easy to permeate, and therefore the skin can be effectively protected. The transdermal absorption effect is synergistically enhanced; meanwhile, the water-in-oil nano-emulsion can wrap water-soluble active ingredients with poor stability, so that the stability is enhanced, and the problem of irritation is solved.

The invention discloses a traditional Chinese medicine shampoo and a preparation method thereof. The traditional Chinese medicine shampoo comprises the following raw materials in parts by weight: 1-4parts of Chinese honeylocust fruit, 1-4 parts of Chinese soapberry fruit, 1-2 parts of moutan bark, 1-2 parts of platycladus orientalis leaves, 1-2 parts of radix ligustici sinensis and 1-2 parts of radix angelicae. The traditional Chinese medicine shampoo also comprises a thickening agent, a surfactant and a humectant, wherein the thickening agent, the surfactant and the humectant respectively account for 4-6%, 10-20% and 0.1-0.5% of the total weight of the shampoo. The invention also provides a preparation method of the traditional Chinese medicine shampoo. The shampoo mainly comprises the Chinese herbal medicine components, is only added with a few necessary chemical components, and greatly reduces irritation to scalp. The shampoo is prepared by adopting a water extraction method, so that effects of the Chinese herbal medicine components are fully exerted, and problems of irritation to the scalp, poor use effect, environmental pollution and the like are effectively solved.

The invention discloses a high-flame-retardant antimony trioxide master batch. The high-flame-retardant antimony trioxide master batch comprises antimony trioxide, a flame-retardant synergist and a base material. By preparing the high-content antimony trioxide master batch, the irritation problem of antimony trioxide dust during rear-end feeding is solved, the flame-retardant synergist is a multi-halogen-group macromolecular polymer, and on the basis that the overall flame-retardant effect of the antimony trioxide master batch is improved, the compatibility of the high-content antimony trioxide and the base material is improved, so that the flame-retardant effect is better facilitated.

The invention discloses a composition with sterilization and disinfection effects. The composition is prepared from herba euonymi, fiveleaf gynostemma herb, inula herb, bunge corydalis herb, herba hyperici perforati, rhizoma rodgersiae aesculifoliae, patrinia heterophylla bunge root, rhizoma et radix patriniae, herba lysimachiae capillipe, rosemary herb, flos caryophylli, sugarcane juice, EM (effective microorganisms) original liquid, and the like, wherein the herba euonymi, fiveleaf gynostemma herb have the functions of promoting Qi circulation and activating blood circulation, clearing heat, supplementing deficiency and detoxifying, adjusting immunity, and resisting oxidizing, are human body strengthening products with clearing and tonifying effects, and are used for strengthening physique to prevent the invasion of bacteria virus; the inula herb, the bunge corydalis herb, the rhizoma rodgersiae aesculifoliae, dark plum, and the patrinia heterophylla bunge root have the functions of clearing heat, detoxifying, cooling blood and stopping bleeding, eliminating swelling and relieving pain, treating cough, inhibiting multiple types of bacteria viruses, resisting inflammation, easing pain, protecting liver, and promoting immunity. The composition has the advantages that the compounding of Chinese herbal medicines is scientific and reasonable, the broad-spectrum sterilization and disinfection effects are strong, the sterilizing capability is strong and quick, the pests and foreign odor are expelled, the air is refreshed, and the effects of killing insects, relieving itching, stopping bleeding, eliminating swelling, retracting muscles, and the like on skin of a human body are realized.

The invention provides an anti-inflammatory pain-relieving ointment and a preparation method thereof. The anti-inflammatory pain-relieving ointment comprises the following raw materials in parts by weight: 190-210 parts of extractum belladonnae liquidum, 70-90 parts of camphor, 50-65 parts of methyl salicylate, 98-105 parts of borneol, 275-285 parts of menthol, 60-70 parts of thymol crystals, 10-20 parts of diphenhydramine hydrochloride, 900-980 parts of zinc oxide, 580-620 parts of rosin, 95-110 parts of wool fat, 50-70 parts of perilla nankinensis and 35-50 parts of eucalyptus oil. According to the modern parmacology of traditional Chinese medicines, the anti-inflammatory pain-relieving ointment is formed by trial and errors through several years of clinical experiences, has a good curative effect, is free from peculiar smell, and has antianaphylaxis and antibacterial property. The raw materials are improved, the preparation process is simple, the production efficiency is high, and enterprise benefits are good.

The invention discloses a 377 whitening cream comprising glycerinum, Multilayer nanospheres, plant extracts, whitening fermentation product filtrate, hydrolyzed conchiolin, a whitening agent, cetostearyl alcohol, cetostearyl glucoside, ethylhexyl isopalmitate, tridecyl trimellitate, tocopherol, panthenol, dipotassium glycyrrhizinate, polyacrylate cross-linked polymer-6, 1, 2-hexanediol, p-hydroxyacetophenone, titanium dioxide and water. In addition, the invention also provides a preparation method of the 377 whitening cream. The whitening cream product disclosed by the invention has the characteristics of small irritation, mildness, stability, small influence of temperature and illumination and the like.

The invention relates to a method for treating tobacco stems and shreds by ozone. In stem and shred treatment in the prior art, the quality of tobacco stems can be effectively improved after an ozone treatment step is added, woodiness gas and irritation of stems and shreds during ignition and smoking can be avoided excellently, the smoking quality of the stems and the shreds is greatly improved, after ozone treatment, chemical components of the stems and the shreds and harmful ingredients in smoke of the stems and the shreds are obviously reduced, and harmfulness of cigarettes is effectively reduced.

The invention relates to a decumbent corydalis tuber eye drop and a preparation method thereof. According to the decumbent corydalis tuber eye drop, the pH value is 4.6 to 6.5, and the permeation pressure is between 0.24 and 0.360 smol / kg; each 1,000 milliliters of decumbent corydalis tuber eye drop is prepared from the following substances: a decumbent corydalis tuber extract containing 0.32 to 0.43 gram of protopine, 0.0036 to 0.0048 mol of diluted phosphoric acid solution, and 0.1 to 3.0 grams of sodium dihydrogen phosphate, 3 to 8 grams of solubilizer, 0.2 to 0.8 gram of disodium edentate, 0.1 to 0.8 gram of bacteriostatic agent, 0 to 2.0 grams of thickening agent, 0 to 4 grams of medicinal ethanol solution of freshener, disodium hydrogen phosphate and glycerol which serve as auxiliary materials and the balance of water for injection, wherein the concentration of the diluted phosphoric acid solution is less than or equal to 0.5 mol / L, and a mass ratio of the freshener to medicinalethanol is 1:(1-15); the amount of the disodium hydrogen phosphate is used for regulating the pH value of the decumbent corydalis tuber eye drop; and the amount of the glycerol is used for regulatingthe permeation pressure of the decumbent corydalis tuber eye drop. The decumbent corydalis tuber eye drop has a mild effect, and the compliance of patients is improved greatly, so the decumbent corydalis tuber eye drop is an eye drop which is small in irritation and high in stability.

The invention provides an external clindamycin phosphate preparation composition. The composition comprises components as follows: every 20 ml of external clindamycin phosphate solution contains 0.1-0.3 g of clindamycin phosphate, 0.2-0.5 g of ethanol, 6-12 g of isopropyl alcohol, 0.5-2.0 g of propylene glycol, 0.002-0.008 g of menthol, 0.05-0.2 g of sulfobutyl-beta-cyclodextrin and 0.005-0.015 gof disodium hydrogen phosphate. The invention further provides a preparation method of the external clindamycin phosphate preparation composition. The components of the external clindamycin phosphatesolution have synergistic effects, and the finally prepared external clindamycin phosphate solution has higher stability and safety.

The invention provides a tea compound essential oil with a slimming effect, and its raw material ratio is calculated in parts by weight: 20-30 parts of tea tree essential oil, 10-16 parts of fennel essential oil, 9-15 parts of Angelica dahurica essential oil, and 7-15 parts of jojoba oil 5-10 parts of sea buckthorn oil, 5-15 parts of forsythia essential oil, 6-16 parts of petitgrain essential oil, 8-15 parts of Chuanxiong essential oil, 10-18 parts of Houttuynia cordata essential oil, 7-15 parts of cassia twig oil, 30‑40 parts of base oil. The invention adopts 10 kinds of Chinese herbal medicine essential oils, and mixes the components at low temperature to achieve a synergistic effect. It not only has the effect of losing weight, but also has the effects of beautifying the skin and improving immunity, and has no toxic and side effects, and is safe to use.

The invention discloses high-stability ultraviolet-light cured water-based ink for glass. The high-stability ultraviolet-light cured water-based ink consists of the following raw materials in parts by weight: 20-30 parts of unsaturated polyester, 10-15 parts of polyurethane acrylate, 20-30 parts of acrylated polypropylene ester, 10-15 parts of polyether acrylate, 10-15 parts of epoxy acrylate, 5-10 parts of water-based epoxy acrylate, 5-10 parts of water-based polyurethane acrylate, hydroxyethyl methacrylate, 5-10 parts of 1,6-hexalene glycol diacrylate, 20-30 parts of pentaerythritol tetraacrylate, 20-30 parts of alkoxylated neopentyl glycol biacrylic ester, 10-15 parts of ethoxylated trimethylolpropane triacrylate, 5-10 parts of ditrimethylolpropane tetraacrylate, 5-10 parts of ethyoxyl phenolic acrylate, 10-15 parts of propoxylated glyceryl triacrylate, 5-10 parts of neopentyl glycol diacrylate, 20-30 parts of dipropylene glycol diacrylate, 3-5 parts of photoinitiator and 2-4 parts of a surfactant. By adopting the high-stability ultraviolet-light cured water-based ink, the problems of VOCs, toxicity and irritation can be solved, the energy can be saved, the environment can be protected, the process can be simplified, and the product quality can be improved.

The invention relates to capparis spinosa fruit gel ointment, a production method thereof, and application thereof to antirheumatic medicaments. The capparis spinosa fruit gel ointment comprises a backing layer, a medicament-containing ointment body and a covering layer protective film, wherein the medicament-containing ointment body is prepared from the following raw materials: a medicinal part of the capparis spinosa and a medicinal excipient; a covering material of the covering layer protective film is one of release paper, a plastic film, a polyester, an aluminum foil-polyethylene composite film and hard gauze; and a backing material of the backing layer is one of cotton cloth, non-woven fabric and chemical fiber cloth. The apparis spinosa fruit gel ointment provided by the invention substitutes the apparis spinosa fruit serving as a medicament for the traditional root bark, so the contradiction between the resource utilization of the apparis spinosa medicinal plants and ecological protection is solved. More importantly, the apparis spinosa fruit gel ointment provided by the invention solves the problems of irritability and hypersensitivity caused by the clinical application of the traditional formulation and administration way of the apparis spinosa, and has the characteristics of long action time, high moisture retention, high air permeability, avoidance of the first pass effect of livers, using comfortableness and high compliance of patients.

The invention is suitable for the technical field of medicines, and provides an aspirin composition as well as a preparation method and application thereof. The aspirin composition comprises aspirin,an enteric coating layer, a first isolation coating layer, a gastric-soluble coating layer and a second isolation coating layer, wherein the enteric coating layer comprises an enteric material which dissolves in intestinal juice and does not dissolve in the stomach; the first isolation coating layer is arranged between the aspirin and the enteric coating layer; the gastric-soluble coating layer comprises a gastric-soluble material which dissolves in the stomach and cannot dissolve in water and intestinal juice; the second isolation coating layer is used for isolating the gastric-soluble coating layer from the enteric coating layer; and the second isolation coating layer comprises an adhesive. According to the aspirin composition provided by the invention, the aspirin is sequentially coatedwith the first isolation coating layer, the enteric coating layer, the second isolation coating layer and the gastric-soluble coating layer, so that medicines cannot dissolve under the conditions ofan oral cavity and gastric juice, and can quickly dissolve under the condition of intestinal tracts; and therefore, an oral formulation suitable for children is prepared, and the problem that the aspirin irritates the stomach is solved.

The invention discloses a multiple emulsion containing hyaluronic acid as well as a preparation method and application thereof. The multiple emulsion comprises an oil phase, a W / O type emulsifier, an O / W type emulsifier and a hyaluronic acid composition. The hyaluronic acid composition is added into the multiple emulsion to serve as an outer water phase of the W / O / W type emulsion, the stability of the multiple emulsion can be improved by adding the hyaluronic acid composition, and absorption of active ingredients in the multiple emulsion is promoted; the irritant active ingredients can be wrapped in the inner phase of the multiple emulsions, and the problem of irritation of cosmetics can be effectively solved by adding the hyaluronic acid composition.

The invention discloses a pharmaceutical composition for wound treatment and repair. The pharmaceutical composition is composed of the following components in percentages by weight: 1%-10% of iodo-oligochitosan, 1%-5% of carbomer, 1%-3% of triethanolamine, 1%-5% of Tween 80, 5%-10% of glycerol, 1%-2% of menthol, and 65%-90% of distilled water. Results of antibacterial experiments of the composition provided by the invention show that the composition has strong antibacterial ability against staphylococcus aureus, escherichia coli and candida albicans; and animal experiments and clinical experiments prove that the pharmaceutical composition provided by the invention has a remarkable effect on repairing wounds, so that the composition can be used for wound treatment and repair. The preparation method provided by the invention is simple, and suitable for industrial production, and has great clinical application value and social benefits.