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Supramolecular preparation of retinol and derivatives thereof and preparation method of supramolecular preparation

A technology of derivatives and retinol, applied in the field of supramolecular preparations of retinol and its derivatives and its preparation, can solve the problems of delamination, limited retinol loading, and insufficient protective effect of cyclodextrin and other problems, to achieve the effect of alleviating irritation, stable structure and properties

Active Publication Date: 2021-02-02
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many studies on cyclodextrin supramolecules, and there are products of cyclodextrin inclusion complexes of retinol on the market, but there are still some shortcomings in the supramolecularization of retinol with cyclodextrin as the material. , if it can only be dispersed in water to form a suspension, stratification will occur after about 1 week of storage, and the load of retinol is limited. In the case of high load, cyclodextrin alone cannot provide sufficient protection. Long-term exposure to light , thermal stability problems

Method used

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  • Supramolecular preparation of retinol and derivatives thereof and preparation method of supramolecular preparation
  • Supramolecular preparation of retinol and derivatives thereof and preparation method of supramolecular preparation
  • Supramolecular preparation of retinol and derivatives thereof and preparation method of supramolecular preparation

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Embodiment 1

[0056] Embodiment 1: a supramolecular preparation of retinol and derivatives thereof and preparation method thereof, is characterized in that, adopts following steps:

[0057] A. Weigh 10.0% retinol, 70.0% hydroxypropyl γ-cyclodextrin, 15.0% hydroxypropyl methylcellulose stearyl ether, 5.00% PEG / PPG / polytetramethylene glycol according to the following mass percentages -8 / 5 / 3 glycerin;

[0058] B. Weigh an appropriate amount of deionized water, mix the hydroxypropyl γ-cyclodextrin and deionized water at a mass ratio of 1:3, and stir with a stirrer at a speed of 500-800rpm until completely dissolved to obtain hydroxypropyl γ-cyclodextrin γ-cyclodextrin aqueous solution;

[0059] C. Weigh an appropriate amount of ethanol, dissolve the retinol and its derivatives in ethanol at a mass ratio of 1:2-10, mix well, and drop into the hydroxypropyl γ obtained in step B at a rate of 5-20ml per minute - in the cyclodextrin aqueous solution, while keeping stirring the hydroxypropyl gamma-...

Embodiment 2

[0062] Embodiment 2: a supramolecular preparation of retinol and derivatives thereof and preparation method thereof, is characterized in that, adopts following steps:

[0063] A. Weigh 8.50% retinol, 15.00% retinyl palmitate, 36.5% hydroxypropyl γ-cyclodextrin, 32.00% hydroxypropyl methylcellulose stearyl ether, 8.00% by mass percentage % PEG / PPG / polytetramethylene glycol-8 / 5 / 3 glycerol;

[0064] B. Weigh an appropriate amount of deionized water, mix the hydroxypropyl γ-cyclodextrin and deionized water at a mass ratio of 1:3, and stir with a stirrer at a speed of 500-800rpm until completely dissolved to obtain hydroxypropyl γ-cyclodextrin γ-cyclodextrin aqueous solution;

[0065] C. Weigh an appropriate amount of ethanol, dissolve the retinol and its derivatives in ethanol at a mass ratio of 1:2-10, mix well, and drop into the hydroxypropyl γ obtained in step B at a rate of 5-20ml per minute - in the cyclodextrin aqueous solution, while keeping stirring the hydroxypropyl gam...

Embodiment 3

[0068] Embodiment 3: a supramolecular preparation of retinol and derivatives thereof and preparation method thereof, is characterized in that, adopts following steps:

[0069] A. Weigh 2.00% retinyl palmitate, 1.00% retinal, 91.0% hydroxypropyl γ-cyclodextrin, 4.00% hydroxypropyl methylcellulose stearyl ether, 2.00% by mass percentage % PEG / PPG / polytetramethylene glycol-8 / 5 / 3 glycerol;

[0070] B. Weigh an appropriate amount of deionized water, mix the hydroxypropyl γ-cyclodextrin and deionized water at a mass ratio of 1:3, and stir with a stirrer at a speed of 500-800rpm until completely dissolved to obtain hydroxypropyl γ-cyclodextrin γ-cyclodextrin aqueous solution;

[0071] C. Weigh an appropriate amount of ethanol, dissolve the retinol and its derivatives in ethanol at a mass ratio of 1:2-10, mix well, and drop into the hydroxypropyl γ obtained in step B at a rate of 5-20ml per minute - in the cyclodextrin aqueous solution, while keeping stirring the hydroxypropyl gamma...

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Abstract

The invention relates to a supramolecular preparation of retinol and derivatives thereof and a preparation method of the supramolecular preparation. The supramolecular preparation is characterized byconsisting of the following components in percentage by mass of 3.00-25.0 percent of retinol and derivatives thereof, 36.5-91.0 percent of hydroxypropyl-gamma-cyclodextrin, 4.00-32.0 percent of hydroxypropyl methylcellulose stearoyl ether and 2.00-8.0 percent of PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, wherein the mass ratio of the PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin to the hydroxypropylmethylcellulose stearoyl ether is 1:(2-4). The obtained supramolecular preparation of the retinol and the derivatives thereof has the advantages of good stability, high solubility, low irritation, good anti-wrinkle effect and the like.

Description

technical field [0001] The invention relates to the technical field of preparation of skin care products, in particular to a supramolecular preparation of retinol and its derivatives and a preparation method thereof. Background technique [0002] Retinol has a long history of being used in the treatment of rough skin and keratinization. In recent years, it has been favored by consumers as a proven effective skin anti-aging ingredient. However, the special physical and chemical properties of retinol limit its application: it is easily inactivated under light, heat, and oxygen conditions, its molecular weight is small, and its permeability is high. Improper use can cause irritation problems such as skin redness, swelling, heat, and pain. Obtaining retinol derivatives through chemical structure modification can improve stability and reduce irritation to a certain extent, but the corresponding efficacy will be weakened to varying degrees. In addition, the methods used to solve ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/86A61K8/73A61K8/67A61Q19/00A61Q19/08
CPCA61K8/671A61K8/738A61K8/731A61K8/86A61Q19/00A61Q19/08A61K2800/72A61K8/39A61K8/345A61K2800/594A61K2800/805
Inventor 王晗宁蒋丽刚毕永贤黄洁芳
Owner PROYA COSMETICS
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