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Doxycycline hydrochloride oil turbid liquor, preparation method and application thereof

The technology of doxycycline hydrochloride and oil suspension is applied in the field of oil suspension of doxycycline hydrochloride and its preparation, which can solve the uneven administration of tablets and powder injections, animal toxicity and side effects, and reduce the therapeutic effect. and other problems, to achieve the effect of solving irritating problems, good animal compliance, and good biocompatibility

Active Publication Date: 2012-02-29
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the administration of tablets and powder injections is uneven, and they are easily affected by the contents of the gastrointestinal tract, which reduces the therapeutic effect
Ordinary doxycycline aqueous injections have low drug content and often need to be administered repeatedly. Generally, they need to be administered once a day, which is likely to cause animal stress, and the blood drug concentration curve is generally wavy, with obvious peaks and peaks in the blood drug concentration. trough, which can also have some toxic side effects on animals

Method used

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  • Doxycycline hydrochloride oil turbid liquor, preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: 20% doxycycline hydrochloride oil suspension

[0024] Prepare each component according to the following ratios, and all components are conventional medicinal raw materials (commercially available):

[0025] Doxycycline hydrochloride API: 200g;

[0026] Aluminum monostearate: 5g;

[0027] Span 80: 2g;

[0028] Propyl gallate: 0.5g;

[0029] Camellia oil: Add to 1000mL.

[0030] The preparation method is to weigh doxycycline hydrochloride bulk drug, aluminum monostearate, Span 80, propyl gallate and camellia oil according to the above ratio, and mix them uniformly through a colloid mill under aseptic conditions to obtain polyhydrochloride hydrochloride. Cyclocycline in oil suspension. There are no special requirements for the colloid mill, as long as it meets the requirements of uniform mixing.

Embodiment 2

[0031] Embodiment 2: 10% doxycycline hydrochloride oil suspension

[0032] Prepare each component according to the following proportions, and all components are conventional medicinal materials:

[0033] Doxycycline hydrochloride raw material: 100g;

[0034] Aluminum monostearate: 5g;

[0035] Hydrogenated castor oil: 5g;

[0036] Soy lecithin: 1g;

[0037] Span 80: 2g;

[0038] BHA: 0.1g;

[0039] BHT: 0.1g;

[0040] Peanut oil: 300g;

[0041] Add tea oil to 1000mL.

[0042] The preparation method is to weigh doxycycline hydrochloride bulk drug, aluminum monostearate, hydrogenated castor oil, soybean lecithin, Span 80, BHA, BHT, peanut oil and camellia oil according to the above proportions, and under aseptic conditions, pass colloidal Grind and mix evenly to obtain the oil suspension of doxycycline hydrochloride.

Embodiment 3

[0043] Embodiment 3: 5% doxycycline hydrochloride oil suspension

[0044] Prepare each component according to the following proportions, and all components are conventional pharmaceutical raw materials:

[0045] Doxycycline hydrochloride raw material: 50g;

[0046] Polyvinylpyrrolidone: 10g;

[0047] Soy lecithin: 2g;

[0048] Ascorbyl palmitate: 0.2g;

[0049] Corn oil: add to 1000mL.

[0050] The preparation method is to weigh doxycycline hydrochloride bulk drug, polyvinylpyrrolidone, soybean lecithin, ascorbyl palmitate and corn oil according to the above ratio, and mix them uniformly through a colloid mill under sterile conditions to obtain doxycycline hydrochloride oil suspension.

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Abstract

The invention discloses doxycycline hydrochloride oil turbid liquor, a preparation method and application thereof. The doxycycline hydrochloride oil turbid liquor of the invention is obtained through preparing 50 to 300g of doxycycline hydrochloride raw medicine, 1 to 50g of suspending aids, 1 to 30g of surface active agents, 0.1 to 2g of oxidation inhibitors and a proper amount of oil into the oil turbid liquor with the volume amount of 1L. The doxycycline hydrochloride oil turbid liquor of the invention is prepared by a dispersing method, has the advantages of high stability, prolonged absorption time, delayed peak reaching time, prolonged elimination half life and good biocompatibility, and can be used as long-effect injection preparations for animals.

Description

technical field [0001] The invention belongs to the technical field of veterinary antibiotic medicine, and in particular relates to an oil suspension of doxycycline hydrochloride and a preparation method and application thereof. Background technique [0002] Doxycycline hydrochloride, also known as deoxyoxytetracycline hydrochloride and doxycycline hydrochloride, belongs to tetracycline drugs, and is used in veterinary medicine to treat gram-positive bacteria, negative bacteria and some chlamydia, mycoplasma and rickettsia , Diseases caused by spirochetes. [0003] At present, the commonly used dosage forms of doxycycline in clinical veterinary medicine mainly include powder injection, tablet, water injection and so on. However, the administration of tablets and powder injections is uneven, and they are easily affected by the contents of the gastrointestinal tract, which reduces the therapeutic effect. Ordinary doxycycline aqueous injections contain low drug content and of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K31/65A61K47/44A61P31/00
Inventor 曾振灵黄显会刘辉旺魏海涛
Owner SOUTH CHINA AGRI UNIV
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