31results about How to "Reduce steric hindrance" patented technology

The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.

Disclosed are: an adsorbent which enables highly efficient and excellently selective solid phase extraction of a solute with a wide range of chromatography polarity, including high-polarity solute molecules, while suppressing adsorption of impurities; and a solid phase extraction method. Specifically disclosed is a heterocyclic ring-containing copolymer adsorbent which is characterized by being composed of a copolymer that is formed from a multifunctional heterocyclic ring-containing monomer, which has a heterocyclic ring that contains at least two heteroatoms in the ring structure, and a monomer that is copolymerizable with the multifunctional heterocyclic ring-containing monomer. The heterocyclic ring-containing copolymer adsorbent is also characterized in that the main chain structure of the adsorbent is configured of the multifunctional heterocyclic ring. Also specifically disclosed is a solid phase extraction method which comprises a step wherein a solution, which contains low-polarity solute molecules, medium-polarity solute molecules or high-polarity solute molecules as a solute, is brought into contact with the heterocyclic ring-containing copolymer adsorbent so that one or more kinds of solutes are selectively adsorbed and held by the adsorbent.

A platinum complex, an OLED and an apparatus for providing visible emission or near-infrared (NIR) emission using the same are described. The platinum complex has a structure represented by formula (I):wherein A1 to A4 each independently represent a 5-membered or 6-membered unsaturated ring, a first chelating ligand including A1 and A4 fragments has a minus one formal charge, and a second chelating ligand including A2 and A3 fragments has a minus one formal charge.

A device, system and method for molecular computing which not only includes a suitable, renewable power source, but actually is able to receive power through the performance of the computations themselves. The molecular computing machine of the present invention actually employs the free-energy difference between its input and output to accomplish a computation, preferably by using its input DNA molecule as a partial source of energy, or alternatively by using the input DNA molecule as the sole source of energy. This molecular finite automaton preferably transforms an input DNA molecule into an output DNA molecule by digesting the input as it computes.

The invention relates to a fluorescence analysis method based on hydrogel-based HCR and cation exchange reaction. The C-C double bond is modified on the surface of the substrate through the silanization reaction, and the radical polymerization reaction induced by ultraviolet light is used on the substrate with the help of a photomask. On-chip construction of PEG hydrogel arrays. The target molecule opens the hairpin structure of the capture probe modified on the hydrogel, triggers the hybridization chain reaction between biotinylated hairpins H1 and H2, and forms a long string of double-stranded DNA at the sensing site. Biotinylated quantum dots CdS were immobilized to the sensing sites through a biotin-streptavidin-specific binding reaction. by Ag + Initiate CdS to undergo cation exchange reaction, Cd 2+ The fluorescence of Rhod‑5N is greatly enhanced. The fluorescence of array spots is quantified by a gene chip scanner, so as to achieve highly sensitive and specific analysis of target molecules. The method of the invention has the advantages of simple operation, low cost, high sensitivity, good specificity and high universality.

The invention relates to a multi-mode targeted probe for early hepatic fibrosis diagnosis and a preparation method thereof. The multi-mode targeted probe for the early hepatic fibrosis diagnosis is characterized by comprising a vector, and the vector is connected with a fluorescence group and a magnetic resonance imaging group and can be connected with a targeted compound group, which can be combined with a receptor on the surface of a hepatic stellate cell in hepatic fibrosis / cirrhosis, through a bridging group. The preparation method comprises the steps of: connecting the targeted compound group, which can be combined with the receptor on the surface of the hepatic stellate cell in the hepatic fibrosis / cirrhosis, with the bridging group, and sequentially connecting the targeted compoundgroup, the fluorescence group and the magnetic resonance imaging group on the vector. The targeted probe has higher sensitivity when being used for diagnosing and evaluating the fibrosis diagnosis.

The invention provides a compound initiating agent for polymerization reaction. The initiating agent comprises the following components in percent by weight: 20-35 percent of cobalt acetate, 40-60 percent of benzoyl peroxide and 15-25 percent of azobisisoheptonitrile. The initiating agent can not only reduce spatial barrel effect of macromolecule materials (like fullerene) and improve the polymerization efficiency, but also play a role of initiating double bond oxidation reaction, broadening the ultraviolet ray light wave absorption range of obtained polymerization products and improving the absorption effect consequently. By utilizing the initiating agent, the fullerene can be smoothly mixed into a carbon chain of an acrylic polymer, and a nano-fullerene modified acrylic polymer with an average blocking rate reaching above 80 percent on the ultraviolet ray with wavelength ranging from 250 nm to 400 nm can be acquired.