The invention discloses a traditional Chinese medicinal composition for treating blood group incompatibility haemolytic disease, and belongs to the field of traditional Chinese medicines. Regarding the existing technical defects of high hepatotoxicity and poor curative effect of a current chemical treatment medicament for treating blood group incompatibility haemolytic disease, the invention provides the traditional Chinese medicinal composition for treating or preventing blood group incompatibility haemolytic disease, which comprises the following raw materials in parts by weight: 10 to 50 parts of burdock, 10 to 20 parts of oriental wormwood, 5 to 20 parts of Chinese angelica, 5 to 15 parts of common yam rhizome, 5 to 10 parts of cape jasmine, 5 to 15 parts poria, 5 to 15 parts of radix pseudostellariae, 1 to 10 parts of ginseng, 5 to 15 parts of medlar, 9 to 15 parts of astragalus, 9 to 15 parts of golden thread, 5 to 15 parts of rhizoma alismatis, 1.5 to 9 parts of radix ophiopogonis, 5.5 to 15 parts of white peony root, 6 to 9 parts of motherwort, and 10 to 15 parts of liquorice. The traditional Chinese medicinal composition has a good treatment effect in the field of treating or preventing blood group incompatibility haemolytic disease, is low in side effect, and has a remarkable clinical popularization value.