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Application of traditional Chinese medicine composition to preparation of drugs for treating diarrhea caused by cancer chemotherapy

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve problems such as difficulty in periodic chemotherapy, serum electrolyte disturbance, acid-base balance disturbance, etc., and achieve the effects of enhancing drug treatment effect, reducing adverse reactions and side effects, and comprehensively acting

Inactive Publication Date: 2014-02-19
崔新明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, Xeloda, etc., the incidence of chemotherapy-related diarrhea has increased year by year. Treatment can easily lead to dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc., which not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Effective treatment has become an important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no antidiarrheal and synergistic drug against cancer chemotherapy

Method used

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  • Application of traditional Chinese medicine composition to preparation of drugs for treating diarrhea caused by cancer chemotherapy
  • Application of traditional Chinese medicine composition to preparation of drugs for treating diarrhea caused by cancer chemotherapy

Examples

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Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Chinese medicine composition of the present invention and preparation technology

[0021] The parts by weight of Chinese medicine components: 10 parts of hawthorn, 5 parts of red yeast rice, 6 parts of radish seed, 3 parts of coptis, 10 parts of Jiaogulan, 10 parts of mango leaf, 3 parts of sweet-scented osmanthus, 3 parts of Panax notoginseng, 10 parts of salvia miltiorrhiza, 8 parts of Atractylodes macrocephala , 6 parts of amomum, 10 parts of black cortex root, 10 parts of flying fairy vine, 10 parts of Codonopsis pilosula, 12 parts of rose root, and 9 parts of chestnut leaves.

[0022] Preparation method: take the prescription amount of the above-mentioned Chinese herbal medicines and crush them into coarse powder, add 40% to 95% ethanol solution according to the total weight of the coarse powder, reflux and extract three times, the reflux time is 2 to 5 hours, and filter , reclaim ethanol from the filtrate, cool and filter, wash with water, and dry t...

Embodiment 2

[0023] Embodiment 2 Chinese medicine composition of the present invention and preparation technology

[0024] Parts by weight of Chinese medicine components: 12 parts of hawthorn, 8 parts of red yeast rice, 9 parts of radish seed, 5 parts of coptis, 12 parts of Jiaogulan, 12 parts of mango leaf, 5 parts of sweet-scented osmanthus, 5 parts of Panax notoginseng, 12 parts of salvia miltiorrhiza, 10 parts of Atractylodes macrocephala , 9 parts of amomum, 12 parts of black cortex root, 12 parts of flying fairy vine, 12 parts of Codonopsis pilosula, 15 parts of rose root, and 12 parts of chestnut leaves.

[0025] The preparation method is the same as in Example 1.

Embodiment 3

[0026] Embodiment 3 Chinese medicine composition of the present invention and preparation technology

[0027] The parts by weight of traditional Chinese medicine components: 11 parts of hawthorn, 7 parts of red yeast rice, 7 parts of radish seed, 4 parts of coptis, 11 parts of Jiaogulan, 11 parts of mango leaf, 4 parts of sweet-scented osmanthus, 4 parts of Panax notoginseng, 11 parts of salvia miltiorrhiza, 9 parts of Atractylodes macrocephala , 8 parts of amomum, 11 parts of black cortex root, 11 parts of flying fairy vine, 11 parts of Codonopsis pilosula, 13 parts of rose root, and 10 parts of chestnut leaves.

[0028] The preparation method is the same as in Example 1.

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Abstract

The invention belongs to the technical field of medicine, relates to a novel medical application of traditional Chinese medicine composition, particularly to an application of the traditional Chinese medicine composition to preparation of drugs for treating diarrhea caused by cancer chemotherapy, and aims to relieve a constipation symptom in a cancer chemotherapy process and relieve the pain of cancer patients. The traditional Chinese medicine composition is matched with cancer chemotherapy for use and disclosed by China patent application CN103330900A. If the traditional Chinese medicine composition is combined with cancer chemotherapy drugs for use, not only can therapeutic effects of the cancer chemotherapy drugs be enhanced, but also the constipation symptom in the cancer chemotherapy process can be relieved. The traditional Chinese medicine composition has medical values and is worth popularizing.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a new medical application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition in preparing a medicine for treating diarrhea caused by cancer chemotherapy. Background technique [0002] Cancer has become a major killer facing human beings, and its mortality rate is second only to cardiovascular diseases, and it is increasing year by year. There are 1.8 million malignant tumor patients in my country every year, and 2 / 3 of them receive chemotherapy. Although there is a certain curative effect, most patients will experience side effects to varying degrees after chemotherapy. Chemotherapy drugs used alone or in combination can cause diarrhea in patients Toxicity and side effects, diarrhea after tumor chemotherapy is also called chemotherapy-associated diarrhea. In recent years, with the advent and popularization of...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61K36/9068A61P35/00A61P1/12
Inventor 刘学键
Owner 崔新明
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