121results about How to "Improve imaging depth" patented technology

An image processing unit comprises a first processing unit (101) which generates a depth indication map for an image. The depth indication map may be, for example, an image object separation mask or a predetermined depth profile or background depth map. A second processing unit (103) generates a modified depth indication map by filtering the depth indication map in response to image characteristics of the image. The image adaptive filtering may, for example, provide a more accurate separation mask and / or may modify the predetermined depth profile to reflect the specific image. A third processing unit (105) generates an image depth map for the image in response to the modified depth indication map. The image depth map comprises data representing a depth of at least one image region of the image. The invention leads to the generation of an improved depth map for an image.

The invention relates to an electronic display that combines the optical function of the display and part of the electronic function of the display into an array of individual fibers. The individual fibers contain a lens or optical function and at least one set of electrodes. Containing the lens function and the address electrode in the same fiber assures alignment of each pixel with its representative lens system and allows for the fabrication of very large three-dimensional, direct view displays. The electronic part of the displays can function as a plasma display (PDP), plasma addressed liquid crystal (PALC) display, field emission display (FED), cathode ray tube (CRT), electroluminescent (EL) display or any similar type of display.

The invention discloses a spectrum OCT (optical coherent tomography) image method and relative system based on optical scanning delay line, wherein it arranges an optical scanning delay line in a reference arm of a spectrum OCT system, to realize scatter-free phase shift of reference light and system scatter compensation. And when guides in optical scanning delay line based on double gratings, the invention can generate group speed scatter and third-order scatter formed by any marks in large change range, to accurately match the scatters of reference arm and sample arm in spectrum OCT system. The scatter-free phase shift and scatter compensation can assure the axial resolution ratio of spectrum OCT system, eliminate coherent noise, and expand the image depth for one time. The invention is significant for dual-spectrum OCT system with ultra-high resolution ratio.

The invention discloses an up-conversion-nanocrystal-based stimulated depletion super-resolution optical microscopic method and an up-conversion-nanocrystal-based stimulated depletion super-resolution optical microscopic system. An up-conversion nanocrystal and the stimulated emission depletion super-resolution fluorescence micro-imaging technique are combined, a super-resolution multiphoton fluorescence signal generated by stimulated emission depletion of an up-conversion luminescent nanometer material labeled sample is detected, a continuous low-power steady-state stimulated depletion process of multiphotons excited by a laser is realized and the simple and effective three-dimensional super-resolution imaging effect having low cost, low complexity and high resolution can be achieved. The stimulated emission depletion super-resolution optical micro-imaging system composed of a depletion light generating module, an exciting light generating module, a plurality of dichroscopes, a multiphoton micro-scanning module and a photoelectric detection module is built based on the method, and a simple and effective real-time dynamic three-dimensional image having low cost, low complexity and high resolution can be acquired.

An image processing unit comprises a first processing unit (101) which generates a depth indication map for an image. The depth indication map may be, for example, an image object separation mask or a predetermined depth profile or background depth map. A second processing unit (103) generates a modified depth indication map by filtering the depth indication map in response to image characteristics of the image. The image adaptive filtering may, for example, provide a more accurate separation mask and / or may modify the predetermined depth profile to reflect the specific image. A third processing unit (105) generates an image depth map for the image in response to the modified depth indication map. The image depth map comprises data representing a depth of at least one image region of the image. The invention leads to the generation of an improved depth map for an image.

The invention discloses a sweep frequency laser light source based on a hyperfine tuned filter. An annular laser oscillation cavity is formed by a semiconductor light amplifier, two polarization controllers, a dispersion control delay line, a circulator, the hyperfine tuned filter and an optical fiber coupler. The hyperfine tuned filter mainly consists of a double-grating combined dispersion system of expanded beam grating-auto-collimation beam grating based on a Littman-Littrow structure and a rotary polygonalmirror. The double-grating layout based on the Littman-Littrow structure utilizes the dispersion and beam expanding ability of the expanded beam grating to improve the caliber of the incident light of the auto-collimation beam grating, form different deviations to the auto-collimation condition of the auto-collimation grating by different coloured lights and improve the angle dispersion ability of the double-grating combined dispersion system. In addition, reasonable matching of grating parameters, incident angles and diffraction efficiency can be easily realized. The tuned filter based on the double-grating and the rotary polygonalmirror can simultaneously ensure the hyperfiness of tuning and high transmissivity of the whole tuning range.

The invention discloses a three-dimensional high-definition mammary gland imager in the biological medical imaging domain, which is characterized by the following: judging pathologic position and degree of mammary gland tissue according to optical parameter according to grey, tissue structure and size semi-quantitatively or qualitatively; adopting infrared (600-900nm) as light source; modulating space of irradiated light through coded aperture without harmful detecting; forming digital infrared optical scanning hologram; utilizing digital decoded technique to extract the information of galactophore tissue; displaying three-dimensional high-definition image.

The invention discloses an extra-large imaging depth three-dimensional display method based on an optical 4f system, belongs to the technical field of helmet-based three-dimensional display and mainly solves the problems that the three-dimensional display image has small depth and cannot be displayed in a monocular helmet in a three-dimensional mode and people are easily fatigue after watching the image for a long time. The method comprises the following steps: segmenting a three-dimensional image to be displayed into a series of two-dimensional images with different imaging depths, respectively modulating the two-dimensional images with different imaging depths by employing stripe images in different directions to acquire a coded image; putting the coded image on an input panel of the optical 4f system, putting a phase template on the spectrum surface, wherein the phase template is formed by splicing a series of lenses with different focal distances, redisplaying the coded two-dimensional images at the imaging positions of different corresponding depths on the output panel of the optical 4f system, and realizing extra-large imaging depth three-dimensional display.

The invention provides a tissue optical clearing agent and an application thereof. The tissue optical clearing agent comprises 30-70 wt% of fructose, 2-10 wt% of octyl phenoxy poly ethoxy, 5-25 wt% of N,N,N',N'-tetra (2-hydroxypropyl) ethylene diamine and the balance of water. The tissue optical clearing agent does not damage the spatial structure of collagen in tissue, a secondary harmonic signal diagram or a fluorescent signal diagram of collagen of the tissue can be obtained, and the tissue optical clearing agent can greatly increase an imaging depth.

The invention relates to a microwave thermoacoustic early hepatoma detection device and method. The device comprises a microwave trigger, a microwave generator, a transmitting antenna, an ultrasonic transducer, a data acquisition card and a computer connected successively. The microwave generator transmits pulsed microwaves to the liver of the detected human body through the transmitting antenna under the triggering of the microwave trigger, and ultrasonic signals are generated by utilizing thermoacoustic effects; and the ultrasonic transducer converts the ultrasonic signals into electric signals, transmits the electric signals to the data acquisition card and finally inputs into the computer for image reconstruction by using a filter back projection algorithm and an ultrasonic processingtechnology. The detection device adopts a non-destructive detection technology and has the advantages of high contrast, high resolution, large visual field, easy adjustment and the like.

The invention discloses a gold nanorod multifunctional probe-based nuclide-cerenkov luminescence-CT multi-mode imaging method, which applies a <68>Ga-AuNRs-RGD multifunctional molecular probe to the field of multi-mode molecular imaging. The caudal vein of a tumor-bearing mouse is injected with the <68>Ga-AuNRs-RGD multifunctional molecular probe, nuclide-CT imaging is performed by a PET / CT imaging system, cerenkov luminescence-CT imaging is performed by a CLI / CT (cerenkov luminescence imaging / computed tomography) system, and a PET / CT image serving as a source image and a CLI / CT image serving as a target image are fused by means of grey rectification to obtain a nuclide-cerenkov luminescence-CT multi-mode imaging display image based on the <68>Ga-AuNRs-RGD multifunctional molecular probe. According to the method, the <68>Ga-AuNRs-RGD multifunctional molecular probe is applied to multi-mode molecular imaging, has the advantages of increasing optical signal intensity, improving imaging resolution, improving imaging depth and the like, and has the characteristics of excellent dispersion, low toxicity, high living cell membrane permeability and the like.

The invention discloses a high-speed linear frequency-sweeping laser source. The high-speed linear frequency-sweeping laser source comprises a tunable laser, a first optical switch, a polarization controller and a frequency shift ring, wherein the frequency shift ring is formed by sealing a first input port and a first output port of an optical fiber coupler; an optical isolator, a frequency shifting device, an optical amplifier, a second optical switch, a band-pass filter and the polarization controller are successively connected in series in the frequency shift ring through an optical fiber; then pulsed laser enters the optical fiber coupler; the laser is split in the optical fiber coupler; part of optical signals are directly output by a second output port of the optical fiber coupler; the other part of the optical signals are subjected to frequency shift again in the frequency shifting ring through the first output port of the optical fiber coupler; the optical signals subjected to frequency shift are split again by the optical fiber coupler. The process is recycle repeatedly; the frequency shift of laser is achieved in each cycle; the laser is output at different time, so that the high-speed, single-direction and K-space linear output of the frequency-sweeping laser with discrete wavelength, tunable wavelength interval and extremely narrow instant line width is achieved.

The invention discloses a rapid K-space linear frequency sweep laser source. The laser source comprises a semiconductor optical amplifier, two polarization controllers, a dispersion control delay line, a circulator, a tuned filter and an output optical fiber coupler, wherein radiation light emitted from the semiconductor optical amplifier is transmitted to the dispersion control delay line through a polarization controller I; the middle port of the circulator is connected to the tuned filer through a first port of the circulator; returned signals are connected to the optical fiber coupler after passing through a third port of the circulator; one path of the optical fiber coupler outputs frequency sweep laser through a 60% port, and the other path of the optical fiber coupler is connected to the polarization controller II and then returns to a ring laser oscillation cavity; the tuned filter mainly comprises two dispersion elements, namely a grating and a prism, and a rotary polygonal mirror; and the linearity of a wave number space is achieved through combination of linear dispersion of the grating and non-linear dispersion of the prism as well as selection on the angles and directions of the prism. The rapid K-space linear frequency sweep laser source can be used for outputting the rapid K-space linear frequency sweep laser, and can obtain the signals of the linearity of the wave number space directly without calibration when being applied to an OCT (Optical Coherence Tomography) imaging system.

The invention discloses a speckle blood flow imaging method and device based on component analysis. The method comprises the steps of performing component analysis on an original blood flow speckle signal, separating out a blood flow light intensity signal and a tissue light intensity signal, calculating out an imaging parameter, utilizing the imaging parameter as a gray value of a two-dimensional blood flow distribution diagram and establishing a two-dimensional blood flow distribution diagram of a sample. The method has the advantages of no invasion, no contrast medium injection, no damage and the like; the method can be applied to living small animal samples like blood flow imaging of mice, fish embryo and the like; the method has great application prospect in pathology diagnosis and analysis of a part of blood flow diseases. The device has the advantages of low cost, no damage to samples, ability in quickly achieving blood flow imaging, high imaging accuracy and application to blood flow monitoring; a transmission type imaging system is utilized, so that a deeper imaging depth is obtained; a long-focus telecentric lens is introduced into, so that blood flow at a deep position is in a focus depth range, a camera can collect clear images, and a higher spatial resolution is obtained.

The invention discloses a footpad skin tissue optical clearing agent, which includes fructose, ethanol, water, and at least three of the following substances: polyethylene glycol-400, sorbitol, glucose, propylene glycol, glycerol, sodium dodecyl benzene sulfonate, dimethyl sulfoxide, butylbenisothiazolene, azone, peppermint oil and petroleum jelly, wherein the mass percentage of fructose in the footpad skin tissue optical clearing agent is 20%-75%, the mass percentage of ethanol in the footpad skin tissue optical clearing agent is 0.8%-1.5%, the mass percentage of water in the footpad skin tissue optical clearing agent is 7%-30%, and the balance of other substances. The present invention acts on the footpad skin tissue, so that the refractive index in the tissue can be quickly uniform, the scattering in the tissue is reduced, the tissue becomes transparent to light, imaging depth is improved, and a new method is provided to obtain information of skin blood vessels and blood flows.

The invention discloses a super-resolution imaging system comprising a femtosecond laser, a picosecond laser, a first data acquisition card, a second data acquisition card and a spatial light modulator. The dissipation light generated by the femtosecond laser and the exciting light generated by the picosecond laser are emitted to a sample and then a fluorescence signal is generated. The second data acquisition card converts the fluorescence signal into voltage information. The voltage information acts as the fitness value of a genetic algorithm. The voltage information is calculated accordingto the genetic algorithm and a maximum voltage absolute value is obtained, and a phase diagram corresponding to the maximum voltage absolute value acts as a phase compensation diagram. The phase compensation diagram is superposed on the dissipation light to perform aberration correction on the dissipation light so that the aberration introduced in the STED imaging process can be overcome, the imaging depth and the spatial resolution of the STED super-resolution imaging system can be enhanced and thus the super-resolution imaging system can be widely applied in physical medicine and other fields.

The invention belongs to the technical field of ultrasonic imaging in the medical treatment, and particularly relates to an ultrasonic modulation imaging system and method. The ultrasonic modulation imaging system comprises an ultrasonic processing unit, an ultrasonic transducer and a display device, wherein the ultrasonic processing unit comprises a programmable logic gate array, the programmable logic gate array is used for controlling an ultrasonic modulation exciting signal and demodulating an ultrasonic signal, the ultrasonic transducer is used for generating the ultrasonic signal into a measured tissue through the exciting signal, converting the ultrasonic signal reflected by the tissue into an electric echo signal and transmitting the electric echo signal to the ultrasonic processing unit to be demodulated, and the display device is used for displaying and processing ultrasonic image data. The ultrasonic modulation imaging system and method disclosed by the embodiment of the invention have the advantages of finishing control over the exciting signal and processing of the ultrasonic signal by adopting the programmable logic gate array and a power amplifier, improving the flexibility and the imaging quality of the ultrasonic modulation imaging system and being lower in cost and high in system integration.

The invention discloses a multi-mode cholangiopancreatography system which comprises an image processing system, a first optical imaging system, an ultrasonic imaging system, an endoscope probe, a photoelectric slip ring component, a first optical fiber, a second optical fiber, a first electric signal line and a second electric signal line. The endoscope probe is provided with an optical probe component and an ultrasonic transducer, the photoelectric slip ring component drives the endoscope probe to rotate and comprises a rotary photoelectric coupling unit and a rotation driving device for driving the rotary photoelectric coupling unit to rotate, a photoelectric slip ring is arranged in the rotary photoelectric coupling unit, the first optical imaging system is connected with one end of the photoelectric slip ring through the first optical fiber, the other end of the photoelectric slip ring is connected with the optical probe component through the second optical fiber, the ultrasonic imaging system is connected with one end of the photoelectric slip ring through the first electric signal line, and the other end of the photoelectric slip ring is connected with the optical probe component through the second electric signal line. According to the multi-mode cholangiopancreatography system, by the aid of multi-mode (optical and ultrasonic) cooperative imaging, imaging resolution ratio and imaging depth are increased, and the system is applicable to cholangiopancreatography.

The invention discloses a photoacoustic imaging system which comprises an optical frequency comb module, a beam combining and splitting module, a balance detection module, a chopping module, a photoacoustic sample cell, an ultrasonic detection module, a control scanning module, a data acquisition module and a signal processing and imaging module; the optical frequency comb module generates two laser signals with different repetition frequencies; the beam combining and splitting module performs beam combining and splitting on the laser signals to form a detection laser signal and a reference laser signal; the balance detection module performs balance detection on the reference laser signal to obtain a first electric signal; the chopping module extracts an interference signal in the detection laser signal as an excitation pulse signal and emits the excitation pulse signal into the photoacoustic sample cell to generate a photoacoustic signal; the ultrasonic detection module performs transduction of the photoacoustic signal to obtain a second electric signal; and the data acquisition processing module acquires the first electric signal and the second electric signal and transmits the signals to the signal and imaging processing module for imaging a to-be-detected object. By combining the double-optical-comb spectrum technology and the photoacoustic imaging technology, the imaging speed and efficiency are high, and the cost is low.

The present invention discloses an axial super-resolution double-photon fluorescence microscopic device and method, relates to the field of laser spot scanning microscopy, and realizes double-photon axial super-resolution imaging of a sample. The method emits an ultrashort pulse laser through a femtosecond laser to achieve two-photon excitation of the fluorescent sample; and performs phase modulation to the excitation light through a spatial light modulator, sequentially scans the sample with an axial solid spot and an axial hollow spot, and performs weight difference to two scanned two-photonimages obtained to finally obtain an axial super-resolution image. Compared with other two-photon axial super-resolution imaging microscopes, the device has a simple structure and a large imaging depth, and provides a good research method for life science and nanotechnology.

The invention relates to design synthesis and application of a near-infrared two-window fluorescence probe based on Aza-BODIPY, and belongs to the field of organic fluorescence probes. A near-infraredtwo-area dyestuff (NIR-II, 1000-1700nm) has a long emission wavelength and less light scattering and tissue autofluorescence interference so as to obtain better resolution ratio and imaging depth inbioimaging. An Aza-BODIPY fluorescent dye has a longer absorption emission wavelength, a narrower peak width at half height and a larger molar extinction coefficient, and is widely applied to the fields such as photodynamic therapy. The structural formula of the near-infrared two-window fluorescence probe designed and synthesized by the invention is as shown in the figure (I). According to the probe, electron-donating group julolidine is introduced onto the classic Aza-BODIPY structure, and the molecular rigidity is improved. The probe has excellent light stability and a capacity of resistingdisturbance. The probe successfully realizes near-infrared two-window imaging during the mice imaging experiment.

The invention discloses a multi-photon exited near-infrared II fluorescence lifetime micro-imaging system. In the invention, a 1220 nm femtosecond laser is introduced into an Olympus upright scanningmicroscope, and focused on a sample through a near-infrared anti-reflection objective lens; a near-infrared II fluorescence signal is collected by a large-diameter fiber collimator and coupled into anear-infrared anti-reflection large-diameter optical fiber, and finally detected and converted into an electrical signal by a photomultiplier tube responded by near-infrared II; the electrical signalis amplified and converted into an electrical counting signal by a signal amplifier and input to a TCSPC (time-correlated single photon counting) board, and at the same time the TCSPC counting board receives a synchronous pulse signal, as a timing stopping signal, from a laser for calculate time information of received photons; and after processing by a computer, a near-infrared II two-photon fluorescence lifetime image and a near-infrared II two-photon fluorescence intensity image are achieved. The invention is simple, practical, stable and flexible.

System for producing a simulated 3D image from a 2D image having a fresnel lens with two planes of curvature transverse to each other so as to create a substantially convex. The fresnel lens may be flexible and positioned within a mount configured with adjustable tensioning members so as to tune the optical characteristics of the fresnel lens so as to optimise production of the simulated 3D image.

The invention discloses a microscopical hyperspectral chromatography three-dimensional imaging device, which comprises a light source unit, a three-dimensional scanning platform, a front microscopical light path unit, a beam-splitting imaging unit, a signal pretreatment unit, a signal acquisition unit and a control unit. The device integrates a hyperspectral imaging technology, a microtechnique, a fluorescence molecular tomography and a three-dimensional imaging technology. The device can obtain the two-dimensional hyperspectral chromatography images under conditions of multiple wavelengths and angles of an object and can obtain the light spectrum under wavelength corresponding to each pixel; meanwhile, based on a three-dimensional image reconstruction technology, the device can obtain the three-dimensional microscopical hyperspectral image of the object; and combining with the microtechnique, the device can obtain the micro three-dimensional hyperspectral chromatography images of the surface and internal structures of micro objects. Compared with other spectrographs, the device has the advantages of more information, higher precision, more powerful functions and higher stability. The device is suitable for biomedical test, food safety test and ecological environment monitoring.

The invention provides an optical coherence tomography method. The method comprises the following steps: transversely scanning a sample point by point by using a converged object light beam, synchronously recording an interference signal after interference between wide-field backscattered light of each scanning point on the sample and reference light through an imaging device to form a spectral interference image of each scanning point, performing fast Fourier transform on the spectral interference image of each scanning point to obtain optical field complex amplitude distribution corresponding to each scanning point, combining the optical field complex amplitude distribution corresponding to the scanning points in a scanning order into a back transmission matrix of the scattering medium,carrying out singular value decomposition on the back transmission matrix, extracting principal component signals from matrix signals, removing multiple scattering noise signals and calculating a three-dimensional tomographic image at the object focal plane according to the extracted principal component signal. According to the method, tissue deep imaging can be realized and the imaging depth andthe imaging speed are improved.

The invention discloses a multi-photon exited near-infrared II fluorescence scanning micro-imaging system. In the invention, a 1220 nm femtosecond laser in the invention is introduced into an Olympusupright scanning microscope, and focused on a sample through a near-infrared anti-reflection objective lens; a near-infrared II fluorescence signal is collected by a large-diameter fiber collimator and coupled into a near-infrared anti-reflection large-diameter optical fiber, and finally detected and converted into an electrical signal by a photomultiplier tube responded by near-infrared II; and the electrical signal is amplified by a signal amplifier and input to a high speed data acquisition card for acquisition, and processed by a computer to obtain a near-infrared II fluorescence intensityimage of the sample. The invention has the characteristics of simplicity and practicality, good stability, tunable excitation wavelength and flexible use mode.

The invention discloses a two-photon fluorescence microscopy device based on photon recombination. The device comprises a femtosecond laser device, an optical parameter oscillator, a first half wave plate, a polarization beam splitter, a second half wave plate, a first quarter wave plate, an objective lens, an array detector and a computer, wherein the femtosecond laser device is used for sending ultra-short pulse laser to perform two-photon excitation on samples; the first half wave plate is used for regulating the proportion of light s and light p of emergent light of the optical parameter oscillator; the polarization beam splitter is used for regulating the light intensity; the second half wave plate is used for regulating the polarization direction of the line polarization; the first quarter wave plate is used for converting the line polarization light into round polarization light; the objective lens is used for focusing the round polarization light into solid round spots for illuminating a sample and exciting the fluorescence; the array detector consists of a plurality of detector units, and is used for collecting fluorescence signals; the computer processes the fluorescence signals obtained by each detector unit to obtain an image corresponding to one object point. The invention also discloses a two-photon fluorescence microscopy method based on photon recombination. The detector array is used for replacing the original single needle hole detector, so that the obtained image has a higher signal-to-noise ratio.

The invention provides a super-continuum spectrum light source based multicolor fluorescence imaging system. The system comprises a super-continuum spectrum laser generating device, a laser wavelength selecting device and an imaging device which are coupled in turn, wherein the super-continuum spectrum laser generating device is used for emitting super-continuum spectrum laser beams to the laser wavelength selecting device; the laser wavelength selecting device is used for successively selecting the single-wavelength laser beams in different wavelengths from the acquired super-continuum spectrum laser beams according to a preset rule; and the imaging device is used for acquiring a plurality of monochrome fluorescent light emitted by a to-be-detected object after being motivated by a plurality of single-wavelength laser beams in turn, generating a plurality of monochrome fluorescent images according to the acquired monochrome fluorescent light and stacking the monochrome fluorescent images, thereby acquiring a multicolor fluorescent image of the to-be-detected object. The irradiated frequency and time of different fluorogens in the to-be-detected object can be reduced and photo-thermal damage and light bleaching can be effectively reduced.

The invention provides a compressed sensing multi-photon body imaging device and method and an optical system. The optical system comprises a photomultiplier, a first convergent lens, a filter, a first beam expander, a dichroscope, a second beam expander, an objective lens, a first galvanometer, a first collimating lens, a second galvanometer, a second convergent lens, a second collimating lens, athird convergent lens and a femtosecond laser. An exciting light path in the light path comprises the third convergent lens, the second collimating lens, the second convergent lens, the second galvanometer, the first collimating lens, the first galvanometer, the second beam expander, the second dichroscope and the objective lens which sequentially pass through the femtosecond laser to reach a sample; a detection light path in the light path sequentially passes through the objective lens, the second dichroscope, the first beam expander, the filter and the first convergent lens from the sampleto the photomultiplier.

The invention discloses an optical coherence tomography system with a reference arm capable of synchronously scanning three-view imaging. The system comprises an OCT core component, a sample arm and the reference arm, optical fibers of the sample end of the OCT core component are connected with a first optical fiber collimator in the sample arm, and optical fibers of the reference end of the OCT core component are connected with a second optical fiber collimator in the reference arm; a first beam scanning galvanometer, a first focusing lens, a first focal length offset wave plate and a sample are arranged in the sample arm in sequence from top to bottom. According to the optical coherence tomography system with the reference arm capable of synchronously scanning three-view imaging, the number of imaging views of the optical coherence tomography system aiming at a tubular structure is effectively increased, and imaging is conducted on the sample in upper, left and right directions, so that the imaging depth of the system is improved through an image mosaic mode, and a good technical solving scheme is provided for comprehensive clear imaging of tubular structures like blood vessels.