50results about How to "High industrial production value" patented technology

The invention discloses a preparation method of high-purity topiramate. The topiramate is obtained by using 2,3,4,5-bis-O-(1-methylethylene)-beta-D-pyran fructose chlorosulfonate as a raw material and tetrahydrofuran and acetonitrile as solvents, adding ammonia-source ammonium acetate and performing amination under a heating condition, wherein the purity of the topiramate is not lower than 99.5%. The preparation method is low in cost, easy and convenient to operate, safe and efficient, and is suitable for large-scale industrial production.

The invention relates to the technical field of pharmaceutical chemical synthesis, in particular to a triazole derivative capable of affecting calcium ion channels of tumor cells, a preparation method and application thereof. The present invention uses dolutegravir as a lead compound, utilizes the principle of drug splicing, and through a click reaction, changes the benzyl group in the dolutegravir structure into a 1,2,3-triazole structure to obtain a new compound, It can inhibit the growth of tumor cells by affecting calcium ion channels in tumor cells, and has significant application value.

The invention discloses a method for synthesizing a 6, 7-methylene steroid compound, comprising the following steps that: in a solvent, a steroid compound having a 6, 7-double bond structure as shown in a formula I is in contact with dibromomethane by taking iodine as an initiator under the catalysis of Zn-Cu reagent, cyclopropyl is introduced at the 6, 7-position, then the 6, 7-methylene steroidcompound as shown in a formula II is gathered from reaction products. The method is simple in operation, the applied methylating agent, namely dibromomethane, only has a unit consumption of 7 to 10kg / kg in the step of reaction, and the price of dibromomethane is relatively low, so the method has low production costs and rather high industrialized production value.

The invention discloses a process for synthesizing sex pheromone of pine caterpillar, which employs 2-hexyne-1-alcohol as an initial raw material, three-bond positional transference is carried out under the effect of lithium and propane diamine to obtain 5-hexyne-1-alcohol; under acidic condition, 5-hexyne-1-alcohol is reacted with dihydropyran to obtain 1-THP-5-hexyne-1-alcohol protected by THP on hydroxyl, Under co-catalysis of metal palladium and cuprous iodide, 1-THP-5-hexyne-1-alcohol and trans-dichloroethylene are subjected to coupling reaction to generate conjugate enyne(7E)-1-THP-8-chlorine-5-alkyne-7-alkene-1-octanol; under the catalysis of metallic iron, (7E)-1-THP-8-chlorine-5-alkyne-7-alkene-1-octanol and a n-Butyl bromide grignard reagent are further subjected to coupling reaction to obtain (7E)-1-THP-5-alkyne-7-alkene-1-dodecanol, under the catalytic reduction of metal zinc, (5Z, 7E)-1-THP-dodecanol dienol; under the camphor sulfonic acid condition, (5Z, 7E)-1-THP-dodecanol dienol removes the THP protective group to obtain the final target product (5Z, 7E)-dodecanol dienol. The method of the invention has the advantages of easily available synthesis raw materials, low cost, mild reaction condition, easy operation, high yield and good stereoselectivity.

A preparation method of 2-amino-4,6-dimethoxypyrimidine, using malononitrile and methanol as raw materials, using one of toluene, xylene, chlorobenzene, and dichloroethane as a solvent, through hydrogen chloride The aeration reaction generates 1,3-dimethoxypropanediimine dihydrochloride without filtration and other post-treatment operations. Add a water-insoluble organic base dropwise to the reaction system to adjust the pH of the reaction system to 6-8, and then add The solid reaction of cyanamide generates 3-amino-3-methoxy-N-nitrile-2-propionamidine, and then the heating reaction generates 2-amino-4,6-dimethoxypyrimidine product. The invention utilizes a one-pot method to prepare 2-amino-4,6-dimethoxypyrimidine, the reaction conditions are mild, safe and environmentally friendly, the process operation is simplified, the amount of three wastes is small, and the total synthesis yield of the four-step reaction can reach 80%. Above, the product content can reach more than 99%, which is suitable for green industrial production.

The invention discloses a synthetic method of 3, 5-dichloro-2, 4-difluoroaniline. The synthetic method takes distillation residues which are generated in the manufacturing technology that 2,6-dichlor fluorbenzene is nitrified to prepare 2, 4-dichloro-3-fluoronitrobenzene as raw material, and the distillation residues are chlorinated through chlorine gas and fluorated through potassium fluoride so as to prepare 3, 5-dichloro-2, 4-difluoro nitrobenzene; and finally, 3, 5-dichloro-2, 4-difluoro nitrobenzene is reduced to obtain 3, 5-dichloro-2, 4-difluoroaniline. The synthetic method adopts by-products that are generated in the conventional manufacturing technology line as raw material, is directly used for synthesizing 3, 5-dichloro-2, 4-difluoroaniline without any treatment, is characterized by low price of raw material, full resource utilization, mild reaction conditions, high yield coefficient of products, low manufacturing cost and the like compared with a conventional method for preparing 3,5-dichloro-2,4-difluoroaniline, is easy to get raw material, and is very suitable for industrialized production.

The invention discloses a three-dimensional porous nanocarbon composite lithium manganate spherical positive electrode material and a preparation method thereof. The preparation method comprises the following steps of adsorbing Mn<2+> ions onto a carbonyl (-COH-) group in a microgel three-dimensional macromolecular network by adopting poly(acrylamide, acrylic acid) microgel spheres as a template; increasing the pH value of the poly(acrylamide, acrylic acid) microgel spheres so as to in-situ hydrolyze the Mn<2+> ions to generate Mn(OH)2 crystal nucleus, depositing the Mn(OH)2 crystal nucleus into a space formed by the three-dimensional macromolecular network to form nano composite polymer microspheres; placing the obtained nano composite polymer microspheres into a tubular furnace to be calcined at a high temperature in an inert gas atmosphere to prepare the three-dimensional porous nanocarbon composite lithium manganate spherical positive electrode material. The positive electrode material has the advantages of excellent high-temperature cycling performance, large multiplying power charging-discharging performance and the like, and can be widely applied to the production of a lithium battery.

The invention provides a sphingomonas with a preservation number of CGMCC No.12394; a method for cultivating a carotenoid-producing strain, its application in the production of carotenoids, and its use in the industrial production of astaxanthin in the application. In the sphingomonas producing nodoc xanthin of the present invention, the content of nodoc xanthin can reach 3.98±0.5 mg / g, accounting for 90% or more of the total pigment. The colorless phytoene-producing bacteria SP-Phy, the red lycopene-producing bacteria SP-Lyc, and the yellow zeaxanthin-producing bacteria SP-Zea selected and bred by the present invention are successively passed on for more than 5 generations respectively. The yields of lycopene, lycopene and zeaxanthin are stable, and the content can reach 3.7±0.5mg / g, 3.9±0.5mg / g, 4.0±0.5mg / g respectively, accounting for 90% and above of the total pigment; The produced zeaxanthin-producing strain SP-Zea introduced the ketolase gene and transformed it into an astaxanthin-producing strain SPZ-AST, with an astaxanthin content of 4.1±0.5 mg / g, accounting for 90% or more of the total pigment.