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Anti-alcohol liver-protecting health-care product and preparation method thereof

A technology for hangover and liver protection and health care products, applied in the fields of antitoxin, digestive system, food science, etc., can solve the problems of no hangover, liver protection effect, separation and removal of acetic acid bacteria cellulose, etc., and achieve large-scale industrial production Value, big marketing value, increase detoxification effect

Pending Publication Date: 2019-05-21
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no reports on using acetic acid bacteria cellulose to improve the anti-alcohol and liver-protecting effects of acetic acid bacteria or its enzyme preparations. The main reason is that the existing technology generally performs a filtration process after fermentation, resulting in the separation and removal of acetic acid bacteria cellulose

Method used

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  • Anti-alcohol liver-protecting health-care product and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] (1) Preparation of anti-alcoholic and liver-protecting health products

[0031] The hangover mechanism provided by the present invention adopts the hangover formula with alcohol dehydrogenase and acetaldehyde dehydrogenase as the main active ingredients, and takes orally the alcoholic acid bacteria cell and its metabolite acetate bacteria cellulose containing high activity Acetobacter extract of alcohol dehydrogenase and acetaldehyde dehydrogenase, which makes ethanol decomposed into acetic acid in the gastrointestinal tract. For acetic acid bacteria, the production pathway of acetic acid is basically the same as the metabolic pathway of ethanol in the human body. Ethanol is decomposed into acetic acid through first-pass metabolism, and acetic acid has little toxic effect on the human body, so it can effectively reduce the absorption of ethanol , to achieve the effect of hangover and anti-drunk.

[0032] The preparation process of the anti-alcohol and liver-protecting ...

example 1

[0043] Take the preparation of 1000 capsules as an example:

[0044] Gluconacetobacter xylinum (CGMCC 3917, references: Dehui Lin, Patricia Lopez-Sanchez, RuiLi, Zhixi Li*. Production of bacterialcellulose by GluconacetobacterhanseniiCGMCC 3917using only waste beer yeast asnutrient source, BioresourceTechnology, 2014, 151C: 113-119) Inoculate in liquid medium (medium composition: glucose 20g, yeast extract 5g, dipotassium hydrogen phosphate 1g, magnesium sulfate 15g, distilled water 1L, absolute ethanol 20mL), culture at 30°C, shaking cycle 150rpm, after 72 hours of culture, add 10 times the amount of 0.05M phosphate buffer solution with pH=6.5, homogenized at 12000rpm for 5 minutes in a high-speed homogenizer, added an enzyme stabilizer (such as ferric sulfate, final concentration 0.1mM) and freeze-dried (freeze-drying conditions: cell lysate Thickness: 6mm, pre-freezing at -20°C for 10h, drying at -50°C under 30Pa for 24h), to obtain dry powder of acetic acid bacteria extrac...

example 2

[0048] Take the preparation of 1000 capsules as an example:

[0049] Gluconacetobacter xylinum in Example 1 was inoculated in liquid medium (medium composition: glucose 20g, yeast extract 5g, dipotassium hydrogen phosphate 1g, magnesium sulfate 15g, distilled water 1L, absolute ethanol 20mL), cultured at 30°C, shaken Cycle 150rpm, after culturing for 72 hours, add 10 times the amount of 0.05M phosphate buffer with pH=6.5, homogenize at 12000rpm for 5 minutes in a high-speed homogenizer, add enzyme stabilizer (such as ferric sulfate, final concentration 0.1mM) and freeze-dry (Freeze-drying conditions: cell lysate with a thickness of 6mm, pre-frozen at -20°C for 10h, and dried at -50°C under 30Pa for 24h), to obtain dry powder of acetic acid bacteria extract in the form of white powder.

[0050] The obtained extract dry powder and auxiliary materials are fully mixed according to the following ratio:

[0051] Acetic acid bacteria extract dry powder (main ingredient) 30g

[0052...

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Abstract

The invention discloses an anti-alcohol liver-protecting health-care product and a preparation method thereof. Acetic acid bacteria which contain high-activity ethanol dehydrogenase, acetaldehyde dehydrogenase and metabolite acetic acid bacterium cellulose serve as the main material and are prepared into granules, tablets or capsules. The product has good alcohol dispelling and intoxication preventing effects, alcohol can be quickly metabolized into acetic acid in gastrointestinal tracts to be absorbed or excreted after a drinker eat the product before drinking, harm of excessive alcohol to human body can be reduced, and the effects of dispelling the alcohol effects and protecting the liver are achieved. The product is natural, safe, convenient to eat, easy to store and carry and relatively high in industrial production value.

Description

technical field [0001] The invention relates to an anti-alcoholic product, in particular to a anti-alcoholic liver-protecting health product and a preparation method thereof. Background technique [0002] Long-term heavy drinking can lead to a variety of acute and chronic liver diseases. Studies have shown that after ethanol enters the liver cells, it is oxidized to acetaldehyde through three pathways: alcohol dehydrogenase, hydrogen peroxide decomposing enzyme and liver microsomal alcohol oxidase. Excessive drinking causes a large amount of acetaldehyde to accumulate in the liver, which has obvious toxic effects on liver cells and directly and indirectly causes liver damage. Long-term heavy drinking and excessive drinking will not only lead to alcoholism, but also lead to alcoholic liver disease, including: alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis, alcoholic cirrhosis and mild alcoholic liver disease. A series of problems such as long-term alco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23L33/105A61K35/74A61P1/16A61P39/02
Inventor 杨兴斌林德慧姜欣欣刘哲
Owner SHAANXI NORMAL UNIV
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