59results about How to "Growth inhibitory activity" patented technology

The invention relates to a quinoline shown in the formula I, a cinnoline derivant, and pharmaceutically acceptable salt, hydrate, solvate and prodrug thereof, wherein substituent groups Ar, R1, R2, R3, X, Y, P, Z and n have the meanings given in the specification. The invention also relates to a compound shown in the formula I, which plays a strong role of restraining c-Met kinase, and the usages of the compound and the pharmaceutically acceptable salt and hydrate thereof in preparing drugs for treating diseases caused by c-Met kinase overexpression, particularly in preparing drugs for treating and / or preventing cancer.

The invention relates to artemisinin derivatives shown as a general formula I, and optical isomers and pharmaceutically acceptable salts thereof, wherein substituents Z, Ar, R and n are defined in the specification. The invention also relates to application of the compounds with the general formula I in preparing medicaments for treating and / or preventing cancers.

The invention provides a method for extracting and separating Ganoderma lucidum triterpenoid extract by using subcritical technology: subjecting Ganoderma lucidum to subcritical water extraction technology, using different pressure and temperature conditions, and sequentially extracting the active components in Ganoderma lucidum: the acidic part of Ganoderma lucidum triterpene and the Ganoderma lucidum triterpenoid neutral parts were extracted and isolated from Ganoderma lucidum fruiting bodies. The invention utilizes subcritical water extraction technology to obtain different active extracts in Ganoderma lucidum efficiently and economically. The antioxidant activity of Ganoderma lucidum triterpenoid acid site DPPH clearance rate in the obtained active extract can reach 88.38%, and the half-inhibition rate IC of Ganoderma lucidum triterpenoid neutral site on human large cell lung cancer cell H460 50 95.0μg / ml, the half-inhibition rate IC of human hepatoma cell HepG2 50 was 77.7 μg / ml.

This invention relates to Ailinofen bi lactone and its medical used salt or solvate. This invention also relates its preparation method and its medical combination and medical application. The compound in this invention can in vitro prevent six kinds of human body tumor cells activity as human original medullary cell leukemia cell(HL-60), nasopharyngeal carcinoma cell(CNE), oral epithelium cancer cell(KB), human lung cancer cell(549), human hepatic carcinoma cell(BEL-7404) and human uterus neck cancer cell(Hela). It can be developed as anti tumor medicine application.

The invention relates to a benzimidazole zinc complex and a preparation method thereof. A chemical name of the benzimidazole zinc complex is dichloro-2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole zinc complex. The preparation method includes following steps: mixing 2-(carboxymethyl)benzoic acid with o-phenylenediamine, placing the mixture in phosphoric acid, performing a heating process at 180 DEG C for 3 hours to obtain a purple-green reactant, cooling the reactant to room temperature, adding distilled water, performing a neutralization reaction to obtain a yellow-green solid, performing a washing process through distilled water for three times, carrying out a filtering process, carrying out a recrystallization process through alcohol to obtain a yellow-green solid 2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole, namely a ligand, dissolving ZnCl2 and the ligand 2-(2-(1H-benzimidazole-2-)benzyl)-1H-benzimidazole in a proper amount of a DMF solvent to obtain a mixture, stirring the mixture uniformly at room temperature, performing a volatilization process for seven days to obtain a slight yellow-green block-shaped complex monocrystal. The complex employs biological non-toxic element zinc as a metal ion, can be used for preparing antitumor drugs, can inhibit generation of esophagus cancer cells, and is free from remaining in human body and causing poisoning in human body due to metal accumulation. The complex is simple in the preparation method, is high in yield, is low in cost and is suitable for an industrial production.