Indolone-containing 4-thiazolidone derivatives and application thereof

Abstract

The invention relates to indolone-containing 4-thiazolidone derivatives shown in a general formula I as well as geometrical isomers and pharmaceutically acceptable salts of the indolone-containing 4-thiazolidone derivatives. In the formula I, substituted groups namely Ar, R2, R3, R4 and n are defined in the specification. The invention also relates to application of compounds of the general formula I in preparation of a medicine for treating and / or preventing cancer.

Description

technical field The invention belongs to the technical field of medicine, and relates to new 4-thiazolidinone derivatives containing indolinone and pharmaceutically acceptable salts thereof, including their preparation methods and pharmaceutical compositions containing the compounds. The present invention also relates to the use of the derivative in the preparation of medicines for treating and / or preventing cancer. Background technique Compounds containing 4-thiazolidinone structure have a wide range of biological activities, such as antibacterial, antifungal, antiviral, anti-inflammatory, hypoglycemic, cardiotonic, and antitumor effects. J.K.Choi et al. reported 5-substituted phenylmethine rhodanine derivatives with PRL-3 inhibitory effect, and the compound IC with the best in vitro activity of this series of compounds 50 0.9 μM. N.S.Cutshall et al. reported a class of N-substituted phenyl-5-substituted phenylmethine rhodanine derivatives, which have inhibitory effect on...

AI Technical Summary

Problems solved by technology

The 4-thiazolidinone derivatives containing indolinone belong to a new class of compounds, and there is no such compound and related activity reports in the prior art