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44results about How to "Good antiviral activity" patented technology
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Gene segments for coding alpha, beta or gamma interferons of pigs and application thereof
ActiveCN101818154AGood immune regulationBroad prospects for promotion and applicationMicroorganism based processesFermentationInterferonYeast
The invention relates to gene segments for coding alpha, beta or gamma interferons of pigs and an application thereof. According to the preference of codons of a Pichia stipitis expression system, high-expression codons are selected to renewedly design and synthesize new mature peptide nucleotide sequences of the alpha, beta and gamma interferon of the pigs, and recombinant yeast expression plasmids of pPICZalphaC-IFN-alpha, pPICZalphaC-IFN-beta and pPICZaplhaC-IFN-gamma are successfully constructed, which not only correctly expresses the alpha, beta and gamma interferons of the pigs in Pichia stipitis, but also enables the alpha, beta and gamma interferons of the pigs to be easier to express in the Pichia stipitis with higher expression level, and lays a foundation for the large-scale production and fermentation of the gene engineering.
Owner:SOUTH CHINA AGRI UNIV +1
Porcine alpha interferon and interleukin 2 chimeric gene, construction method and protein purification method thereof
InactiveCN101570757AGuaranteed dual activityGood antiviral activityMicroorganism based processesAntiviralsAdditive ingredientInterferon alpha
The invention belongs to the technical field of biological genetic engineering, and discloses technology for constructing and expressing porcine alpha interferon (PoIFN-alpha) and interleukin 2 (PoIL-2) chimeric gene and quickly renaturing and purifying expression protein. The technology constructs mature peptide genes of PoIFN-alpha and PoIL-2 into PoIFN-alpha-linker-PoIL-2 chimeric gene through a genetic flexible linker (linker) (G4S)3 and clones the chimeric gene into a pGEM-T Easy vector by adopting an overlap extension PCR method, and subclones the chimeric gene into a pQE-30 expression vector for prokaryotic expression. The recombinant fusion protein (rPoIFN-alpha-linker-PoIL-2) can be quickly renatured and purified through urea modification, renaturation by low concentration protein renaturing solution, PBS solution dialysis and other steps. The purified rPoIFN-alpha-linker-PoIL-2 fusion protein has proliferation activity for inhibiting vesicular stomatitis virus (VSV) on a cell, is used for prevention and treatment of porcine virosis as a main ingredient of an antivirus preparation, and has high efficiency, broad spectrum, safety and low price.
Owner:HENAN CENT FOR ANIMAL DISEASE CONTROL & PREVENTION
Sulphation modification method of codonopsis pilosula polysaccharide
InactiveCN101781372AEstablishing a Sulfation Modification MethodOptimizing Sulfation Modification ConditionsSulfationCodonopsis pilosula
The invention relates to a sulphation modification method of codonopsis pilosula polysaccharide, belonging to the traditional Chinese medicine polysaccharide structure modification technical field. Codonopsis pilosula polysaccharide is extracted and purified, chlorosulfonic acid-pyridine method is used for carrying out sulphation modification, throughput and substitution ratio are taken as indexes, L9(34) orthogonal experiment method is used for optimization on three factors of reagent matching ratio, reaction temperature and reaction time, and the optimal modification conditions that mass ratio of chlorosulfonic acid and pyridine is 1:6, reaction temperature is 80 DEG C and reaction time is three hours are determined, and the obtained sulphated codonopsis pilosula polysaccharide is high in throughput and substitution ratio and strong in activity. The invention can obviously improve antiviral activity of codonopsis pilosula polysaccharide.
Owner:NANJING AGRICULTURAL UNIVERSITY
Composite porcine alpha-IFN gene and recombinant vector thereof
InactiveCN101845441AConducive to commercial productionStrong antiviral activityMicroorganism based processesFermentationPichia pastorisBiotechnology
The invention relates to a composite porcine alpha-IFN gene and a recombinant vector thereof, and belongs to the technical field of genetic engineering biological products. The newly designed gene sequences of composite porcine alpha-IFN are recombined to pPICZ alpha-A vectors, and the vectors are electronically transformed into yeast competent cells; and the positive identification, and the screening and the induced expression of high copy yeast strains are carried out. A pichia pastoris expression system is used for expressing foreign genes so as to be favorable for the commercial production of porcine IFN. Compared with the natural IFN which is expressed by yeast, the expression level of the protein which is expressed by genome increases by 3.17 times. The fluorescent quantitative PCR result shows that the level of PRVmRNA after PK-15 cells treated by 10-6mg / ml of the composite porcine alpha-IFN are re-infected with PRV is obviously lower than the level of PRVmRNA after the PK-15 cells which are not treated by the composite porcine alpha-IFN are infected with the PRV, and the level of PRVmRNA decreases by 37 times.
Owner:NANJING AGRICULTURAL UNIVERSITY
Complex duck interferon-alpha gene, and recombinant vector and application thereof
The invention discloses a complex duck interferon-alpha gene, and a recombinant vector and application thereof. The nucleotide sequence of the complex duck interferon-alpha gene is disclosed as SEQ ID NO:1. The optimized complex duck interferon-alpha gene can be expressed in Pichia yeast gene engineering bacteria to produce complex duck interferon-alpha. The obtained complex duck interferon-alpha has the following advantages: high purity: the thin-layer chromatography scanning on the yeast-expressed duck interferon-alpha SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis) result indicates that the target ribbons of the recombinant yeast duck interferon-alpha account for more than 80% of the total expression proteins; and high antivirus action: compared with the yeast-expressed natural duck interferon-alpha, the protein expressed by the novel genome has higher antivirus activity, and the action of resisting 100TCID50VSV virus infection on duck embryo fibroblasts is enhanced by 40 times. The complex duck interferon-alpha gene can be used for preparing drugs for treating poultry virus diseases.
Owner:广东省农业科学院兽医研究所
Bicyclol-carnosine conjugate, and preparation method and application thereof
InactiveCN104610240ASignificantly protects the liver and lowers enzymesStrong anti-virus abilityOrganic active ingredientsOrganic chemistryLiver functionStructural formula
The invention discloses a bicyclol-carnosine conjugate, and a preparation method and an application thereof. The structural formula of the compound is shown in the specification. By adoption of the bicyclol-carnosine conjugate, the problem of poor oral bioavailability of bicyclol is solved. The preparation method comprises the following steps of: bonding hydroxyl groups of bicyclol and carboxyl groups of carnosine by ester bonds or bonding protected histidine and beta-alanine to the bicyclol in sequence, and then removing protecting groups to obtain the bicyclol-carnosine conjugate. The bicyclol-carnosine conjugate and pharmeceutically-accepted salts thereof can be used for treating the liver injury and improving the liver function.
Owner:NANJING UNIV OF TECH
Method for sulfonating pectin
InactiveCN102585034AImprove anticoagulationGood antitumor activityAntiviralsAntineoplastic agentsAnti virusPectic polysaccharide
The invention discloses a method for sulfonating pectin, which comprises the step of sulfonating pectin or triethylamine pectin salt by using sulfur trioxide-pyridine complex in a dimethylsulfoxide (DMSO) environment so as to obtain sulfonated pectin polysaccharide. The method adopts the following two systems: a trioxide-pyridine complex-DMSO system, and a TBA-trioxide-pyridine complex-DMSO system. The method disclosed by the invention is simple in operation and good in sulfonating effect. The sulfonated pectin polysaccharide prepared by the method is small in degradation in the reaction process, small in side reaction, has good anticoagulation, anti-tumor and anti-virus actives and a wide application range.
Owner:ZHEJIANG UNIV
Novel compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing same, and pharmaceutical composition for prevention or treatment of viral diseases containing same as active ingredient
ActiveCN105121433ALow cytotoxicityGood antiviral activityOrganic active ingredientsSenses disorderDisease causeHepatitis A
The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.
Owner:KOREA RES INST OF CHEM TECH +1
Culture technology of mammalian cells capable of efficiently expressing recombinant cat interferon [omega]2
InactiveCN113355286AIncrease productionLow costGenetically modified cellsFermentationBiotechnologyProtein target
The invention provides a suspension culture technology of mammal cells capable of efficiently expressing recombinant cat interferon-[omega]2 (rFeIFN-[omega]2). The suspension culture technology is carried out in a bioreactor and comprises the following steps of: (1) setting the initial culture temperature to be 36.5 DEG C, the dissolved oxygen to be 40% and the pH to be 6.8 + / -0.5, and lowering the temperature to 33 DEG C on the sixth day of culture; and (2) supplementing 5%, 5%, 5%, 5% and 3% serum-free feed-batch culture medium on the third, sixth, eighth, tenth and twelfth days of culturing, maintaining the dissolved oxygen to be 40% and the pH to be 6.8 + / -0.5, and finishing culturing on the sixteenth day. The suspension culture technology has the advantages of a simple culture technological process, and long motility keeping time of cells under a condition of high-density growth, target protein expression can be 2g / L or above, antiviral activity is good, production cost is low, and the suspension culture technology is suitable for large-scale industrial application.
![Culture technology of mammalian cells capable of efficiently expressing recombinant cat interferon [omega]2](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/063b5ed5-e086-45d0-962d-fb5f14b7aa85/HDA0002396922470000011.png "Culture technology of mammalian cells capable of efficiently expressing recombinant cat interferon [omega]2")
![Culture technology of mammalian cells capable of efficiently expressing recombinant cat interferon [omega]2](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/063b5ed5-e086-45d0-962d-fb5f14b7aa85/HDA0002396922470000012.png "Culture technology of mammalian cells capable of efficiently expressing recombinant cat interferon [omega]2")
![Culture technology of mammalian cells capable of efficiently expressing recombinant cat interferon [omega]2](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/063b5ed5-e086-45d0-962d-fb5f14b7aa85/HDA0002396922470000021.png "Culture technology of mammalian cells capable of efficiently expressing recombinant cat interferon [omega]2")
Owner:成都彤琦恩生物科技有限公司
Natural anti- virus and composition comprising thereof
ActiveCN1997378AExcellent antimicrobial activityAntimicrobial activity safe and effectiveBiocideViral/bacteriophage medical ingredientsMicroorganismLactobacillus
Disclosed herein are a natural antiviral agent having high inhibitory activity against a broad spectrum of viruses without adverse side effects, obtainable using lactic acid bacteria isolated from kimchi, and a composition comprising the natural antiviral agent. The natural antiviral agent is safe to the body and can be applied to compositions, such as fodder, beverages, food, medicine, and cosmetics, imparting antimicrobial activity thereto.
Owner:COTDE +1
Rice black-streaked dwarf virus RNAi multivalent target gene sequence and application
InactiveCN103820442AGood antiviral activityVector-based foreign material introductionAngiosperms/flowering plantsSpecial designCoding region
The invention relates to a preferred rice black-streaked dwarf virus RNAi multivalent target gene sequence which sequentially comprises 206 bp segment in a rice black-streaked dwarf virus S8 code region, 205 pb in an S10 code region, 203 pb in an S4 code region, wherein a BamH1 restriction enzyme cutting site and three CCG protective bases are added at the 5'end of the S8; an XhoI restriction enzyme cutting site and three ACA protective bases are added at the 3'end of S4. According to the rice black-streaked dwarf virus RNAi multivalent target gene sequence and application, based on a special design and optimization and specific to common 614 bp of RANi target sequence of three genes, namely RBSDV S8, S10, and S4, the specific rice black-streaked dwarf virus RNAi multivalent target gene sequence is acquired, cloned and structured into an RNAi carrier pBDL03 to obtain an RNA silent carrier pBDL03-S8+S10+S4; then RNA silent carrier pBDL03-S8+S10+S4 is transferred to a rice variety Taigeng 394 through an agrobacterium transformation method. T1 generation positive plants have favorable resistance on RBSDV.
Owner:INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
Thiazole heterocyclic ring-containing steroid derivative as well as preparation method and application thereof
ActiveCN108218947AGood antiviral activityEasy to prepareOrganic active ingredientsAntiviralsThiazoleAntiviral drug
The invention discloses a thiazole heterocyclic ring-containing steroid derivative as well as a preparation method and application thereof. A thiazole unit-containing steroid derivative is as shown ina formula I as shown in the following descriptions. The invention also provides a pharmacologically acceptable salt of the thiazole unit-containing steroid derivative. The preparation method providedby the invention is started from simple and easily obtained raw materials; the thiazole heterocyclic ring-containing steroid derivative is obtained through three steps of reactions. The thiazole heterocyclic ring-containing steroid derivative provided by the invention belongs to a compound with a brand-new structure, has better antiviral activity, and is suitable for the preparation of an antiviral medicine.
Owner:HUBEI BIOPESTICIDE ENG RES CENT
Amide-containing ferulic acid derivative as well as preparation method and application thereof
PendingCN114195691ANovel structureGood antiviral activityBiocideOrganic compound preparationDiseaseNatural product
The invention belongs to the technical field of drug synthesis and agricultural disease control, and particularly relates to an amide-containing ferulic acid derivative as well as a preparation method and application thereof. The synthesized amide-containing ferulic acid derivative compound can be applied to preparation of plant virus resisting agents and can effectively inhibit diseases such as tomato spotted wilf virus and cucumber mosaic virus disease. The compounds Y1, Y2, Y8, Z1 and Z2 in the amide-containing ferulic acid derivative disclosed by the invention show relatively good inhibitory activity on tomato spotted wilf virus and cucumber mosaic virus. Wherein the compound Y2 shows relatively good passivation activity on tomato spotted wilf virus and cucumber mosaic virus, and is superior to positive control medicaments such as ferulic acid, ningnanmycin and virazole. The compound can be used as a medicine or medicament for preventing and treating diseases such as tomato spotted wilf virus and cucumber mosaic virus. The structure of the material is derived from natural products, and the material is environment-friendly, easy to metabolize and degrade, simple in preparation process, relatively stable in physicochemical property and wide in application prospect.
Owner:GUIZHOU UNIV
Antiviral activity possessed compound and preparation method thereof
InactiveCN1289510CGood water solubilityImprove stabilityDigestive systemAntiviralsWater solubleVirus
The invention discloses a novel compound having a general formula discloses in the specification, a process for preparing the compound, and novel intermediate compound related in the compound synthesizing flow path. The compound provided by the invention can be used for preparing multiple pharmaceutical preparations for treating a plurality of diseases caused by virus infection.
Owner:CHENGDU DIAO JIUHONG PHARMA FAB
Application of Lens culinaris agglutinin in preparation of medicine for preventing and treating infectious diseases caused by coronavirus
ActiveCN113274484AGood antiviral activityEnhanced inhibitory effectCompound screeningApoptosis detectionCytotoxicityInfective disorder
The invention discloses an application of Lens culinaris agglutinin in preparation of a medicine for preventing and treating infectious diseases caused by coronavirus. It is found for the first time that Lens culinaris agglutinin can simultaneously show good antiviral activity on SARS-CoV-2 and SARS-CoV-2 epidemic mutant strains, has a remarkable inhibition effect, does not show cytotoxicity, can be used as a candidate drug for inhibiting SARS-CoV-2 and SARS-CoV-2 epidemic mutant strains, and has a wide application prospect.
Owner:NAT INST FOR FOOD & DRUG CONTROL
Preparation method of attenuated salmonella transferring chicken gamma interferon
InactiveCN102250919AGood antiviral activityEasy storageBacteriaMicroorganism based processesInterferonInterferon alpha
The invention belongs to the biotechnology field, in particular discloses a preparation method of attenuated salmonella transferring chicken gamma interferon. The preparation method is characterized by comprising the following steps: amplifying a gene sequence of a maturation protein of the chicken gamma interferon (chIFN-gamma); obtaining a recombinant eukaryotic expression plasmid; detecting a chIFN-gamma activity unit expressed by the recombinant eukaryotic plasmid; electrically transferring the recombinant plasmid pVAX1<c>-chIFN-gamma into the attenuated salmonella to obtain a strain. By the adoption of the attenuated salmonella transferring chicken gamma interferon, the problems that the interferon is easy to be degraded by gastric acid after being orally taken by the chicken and the protein purifying step is fussy can be avoided effectively. The chIFN-gamma can be prepared by bacteria fermentation, and is easy to store; the chIFN-gamma has obvious NDV (Newcastle disease virus) protection force for chicken, and can provide guarantee for preventing and treating the viral diseases such as NDV in a scale chicken house.
Owner:山东步步赢生物科技有限公司
Sulphation modification method of codonopsis pilosula polysaccharide
InactiveCN101781372BEstablishing a Sulfation Modification MethodOptimizing Sulfation Modification ConditionsSulfationCodonopsis pilosula
Owner:NANJING AGRICULTURAL UNIVERSITY
Diazosulfide derivative and its synthesis and screening method for inducing anti-disease activity
InactiveCN100451009CGood antiviral activityOrganic chemistryMicrobiological testing/measurementBenzeneCyanide
A phenyl-thiobiazole derivative, its synthesis and screen of induced antiviral activity are disclosed. It consists of 7 kind cyanide substituted phenyl-anilidothioliazole-7-formamide derivative, 2 kind biacyl diazane derivative, 4 kind phenyl-anilidothioliazole-7-formamide derivative and 1 kind sulpho-phenyl-anilidothioliazole-7-formic ether. It achieves good TMV antiviral activity with tobacco tree inducing.
Owner:NANKAI UNIV
Method for preparing Nano silver sol
A process for preparing nano-Ag sol includes such steps as preparing the reverse-phase microemulsion from glucolipide-type surfactant, mixing the microemulsion containing reducer with the microemulsion containing silver nitrate while high-speed stirring, preparing Ag nanoparticles, demulsifying, separating, washing, and distributing them in nonpolar solvent. Its advantages are high stability and high antibacterial effect.
Owner:EAST CHINA UNIV OF SCI & TECH
Biphenyl diarylpyrimidine derivative containing chiral hydroxymethylene structure as well as preparation method and application thereof
ActiveCN111303046AEffective combinationImprove biological activityOrganic active ingredientsOrganic chemistry methodsEnantiomerDrug biological activity
The invention belongs to the technical field of medicines, and particularly relates to a biphenyl diarylpyrimidine derivative containing a chiral hydroxymethylene structure as well as preparation andapplication thereof. The biphenyl diarylpyrimidine derivative with the compound structure containing a chiral hydroxymethylene structure comprises medicinal salt, stereochemical isomers, hydrates andsolvates of the biphenyl diarylpyrimidine derivative, X-ray diffraction single crystals of polycrystals or eutectic crystals and single enantiomers of the biphenyl diarylpyrimidine derivative, and precursors and derivatives of the biphenyl diarylpyrimidine derivative with the same biological function. The invention also comprises a preparation method of the compound and an application of a composition containing one or more compounds in related medicines for treating AIDS and the like. In-vitro cell level anti-HIV-1 activity experiment results show that the small molecules have relatively strong anti-HIV-1 biological activity, can significantly inhibit virus replication in MT-4 cells infected by HIV-1 viruses, have relatively low cytotoxicity, and are expected to become anti-HIV candidatedrugs.
Owner:FUDAN UNIV
Application of wheat germ agglutinin in the preparation of products for inhibiting coronavirus
ActiveCN113244373BGood antiviral activityAvoid infectionPeptide/protein ingredientsAntiviralsAgglutininPharmaceutical drug
The invention discloses the application of wheat germ agglutinin in the preparation of products for inhibiting coronaviruses. The invention finds for the first time that the wheat germ agglutinin is effective against SARS‑CoV, MERS‑CoV, SARS‑CoV‑2 and SARS‑CoV‑2 mutant strains. It has good antiviral activity, and also shows certain antiviral activity to vesicular stomatitis virus (VSV), which can be used to treat and prevent infection caused by coronavirus, and can be used as a candidate drug for the prevention and treatment of coronavirus infection. Good application value.
Owner:NAT INST FOR FOOD & DRUG CONTROL
Antiviral compound and its preparation method and application
ActiveCN107056797BNew structureGood antiviral activityOrganic chemistryMicroorganism based processesAntiviral drugMicrobial transformation
The invention provides an antiviral compound and a preparation method and application thereof. A structural formula of the compound is shown as a formula I or a formula II. The compound is prepared through the following method that Mucor roxianus CGMCC 3.3447 is utilized as a converting bacterial strain to perform microbial conversion on cryptotanshinone to obtain the compound. Pharmacological experiments show that the compound can inhibit growth of A / H1N1 influenza virus. Therefore, the compound can be applied to researching antiviral active lead compound or preparing antiviral medicine. The formula I and the formula II are shown in the specification.
Owner:INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
Gene segments for coding alpha interferons of pigs and application thereof
ActiveCN101818154BGood antiviral activityGood antiviral effectMicroorganism based processesGenetic engineeringNucleotideGamma interferon
Owner:SOUTH CHINA AGRI UNIV +1
Sesquiterpenoids with anti-influenza virus activity and their applications
ActiveCN113402369BGood antiviral activityConvenient researchOrganic chemistryHydroxy compound active ingredientsChemical compoundSesquiterpene
Owner:SOUTHERN MEDICAL UNIVERSITY
Compound with anti-rotavirus activity in Thalictrum scabrifolium Franch. var. leve Franch, and preparation method thereof
ActiveCN113234084ALow toxicityGood antiviral activityOrganic chemistryAntiviralsRotavirusChromatographic separation
The invention discloses a compound with anti-rotavirus activity in Thalictrum scabrifolium Franch. var. leve Franch, and a preparation method thereof. The compound is a chromone alkaloid compound, and the structural formula is as shown in formula (I). The preparation method of the compound comprises the following steps: preparing an extract by taking a Thalictrum scabrifolium Franch. var. leve Franch whole plant as a raw material; treating the extract by silica gel column chromatography to obtain a first eluate; concentrating the first eluate, and performing high-pressure liquid chromatography separation to obtain a second eluate; and finally, carrying out gel column chromatography on the second eluate to obtain the compound as shown in the formula (I). The new chromone alkaloid compound is extracted from the Thalictrum scabrifolium Franch. var. leve Franch whole plant as het raw material, and the compound has outstanding rotavirus resistance activity through rotavirus resistance experiments. The anti-rotavirus activity of the chromone alkaloid compound is disclosed for the first time, a new compound skeleton type is provided for antiviral drug screening, and the chromone alkaloid compound has important significance for development of new antiviral drugs.
Owner:YUNNAN MINZU UNIV
Application of lentil agglutinin in the preparation of drugs for preventing and treating infectious diseases caused by coronavirus
ActiveCN113274484BGood antiviral activityEnhanced inhibitory effectCompound screeningApoptosis detectionCytotoxicityInfective disorder
The invention discloses the application of lentil agglutinin in the preparation of medicines for preventing and treating infectious diseases caused by coronaviruses. The invention finds for the first time that lentil agglutinin can simultaneously treat SARS‑CoV‑2 and SARS‑CoV‑2 epidemics The mutant strain shows better antiviral activity, has significant inhibitory effect, and does not show cytotoxicity, and can be used as a candidate drug for inhibiting SARS-CoV-2 and SARS-CoV-2 epidemic mutant strains, and has broad application prospects.
Owner:NAT INST FOR FOOD & DRUG CONTROL
Sulfated modification method for improving ophiopogon japonicus polysaccharide anti-virus activity
ActiveCN102718883BOptimizing Sulfation Modification ConditionsStrong antiviral activityAntiviralsSulfationAnti virus
The invention relates to a sulfated modification method for improving ophiopogon japonicus polysaccharide anti-virus activity and belongs to the technical field of structural modification of Chinese herbal polysaccharides. The sulfated modification method includes extracting and purifying ophiopogon japonicus polysaccharides, performing sulfated modification by means of a chlorosulfonic acid-pyridine method, using the anti-virus activity of a product as an index, optimizing a reagent proportion, a reaction temperature and a reaction time by means of an L 9 (3 <4>) orthogonal experiment, and determining the best modification conditions that the mass ratio between chlorosulfonic acid and pyridine is 1:4, the reaction temperature is 60 DEG C, the reaction time is 2 hours. Accordingly, the obtained sulfated ophiopogon japonicus polysaccharides are the strongest in the anti-virus activity. The sulfated modification method for improving the ophiopogon japonicus polysaccharide anti-virus activity is capable of improving the anti-virus activity of the ophiopogon japonicus polysaccharides.
Owner:NANJING AGRICULTURAL UNIVERSITY
Rice black-streaked dwarf virus rnai polyvalent target gene sequence and application
InactiveCN103820442BGood antiviral activityVector-based foreign material introductionAngiosperms/flowering plantsGeneticsBacilli
Owner:INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
Artemisia-honeysuckle-flower-fructus gardeniae enema and preparation method and application thereof
InactiveCN112494558AGood antiviral activityReduce apoptosis rateNervous disorderMuscular disorderHand-foot-and-mouth diseasePharmaceutical drug
The invention belongs to the technical field of medicines and particularly relates to an artemisia-honeysuckle-flower-fructus gardeniae enema and a preparation method and application thereof. The enema is prepared from the following medicinal raw materials in parts by weight: 3-15 parts of honeysuckle flowers, 6-25 parts of artemisia apiacea and 1-2.99 parts of fructus gardeniae. The enema has theeffect of resisting CV-A6 and can be used for treating hand-foot-and-mouth diseases caused by CV-A6 infection.
Owner:SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
Natural anti- virus and composition comprising thereof
ActiveCN101843640AGood antiviral activityAntiviral activity is safe and effectiveBiocideBacteria material medical ingredientsMicroorganismSide effect
Disclosed herein are a natural antiviral agent having high inhibitory activity against a broad spectrum of viruses without adverse side effects, obtainable using lactic acid bacteria isolated from kimchi, and a composition comprising the natural antiviral agent. The natural antiviral agent is safe to the body and can be applied to compositions, such as fodder, beverages, food, medicine, and cosmetics, imparting antimicrobial activity thereto.
Owner:COTDE +1
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