The invention discloses hematodialysis concentrate A powder. The hematodialysis concentrate A powder is prepared from components in parts by weight as follows: 160-220 parts of sodium chloride, 5-8 parts of potassium chloride, 6-9 parts of calcium chloride, 3-4 parts of magnesium chloride, 6-10 parts of citric acid and 0-70 parts of glucose. The disclosed hematodialysis concentrate A powder is excellent in stability, not prone to caking, long in guarantee life and excellent in dissolution rate and dissolution effect. Besides, the invention also discloses a preparation process of the hematodialysis concentrate A powder. The preparation process is simple, automatic subpackaging can be realized, a large quantity of manual costs are saved, the production efficiency is improved, less waste is discharged in the production process, and the preparation process is energy-saving, environmentally friendly and favorable for popularization and use.