The invention discloses a high-refractive index microsphere Mie scattering based schemochrome coating. The high-refractive index microsphere Mie scattering based schemochrome coating comprises the following components by mass: 1-4 parts of high-refractive index micron and nano microsphere, 15-20 parts of dispersion liquid, 0.1-3 parts of surfactant, and 1-6 parts of adhesive. The color of the schemochrome coating is from a single-layer or multi-layer local microcosmic ordered and macroscopic long-range unordered structure assembled on a matrix by high-refractive index microspheres with even grain size in the coating, and the color is one of the schemochrome, and is not relevant to the color of the high-refractive index microsphere. Compared with the color produced by other color producingstructures of the schemochrome, the color is visible under the natural light, irradiation by a special light source is not needed, or the specular reflection observation is not needed, and the color is brighter. In addition, by changing the grain size of the added high-refractive index microsphere, the schemochrome coating finally obtains the angular independent schemochrome of multiple colors like purple, blue, green, yellow and red.