46 results about "Site selectivity" patented technology

An apparatus and process for mixing and depositing a strand reinforced concrete mix at a job site from a concrete delivery truck including a mixer on the truck for mixing separate concrete ingredients at a job site, which truck further includes a fiber strand chopping device on the truck disposed and adapted to introduce chopped fiber strand lengths into the separate concrete ingredients and water and deposit the mix selectively at the job site without clumping and grouping of the fiber strand lengths in the mix.

Reactions that directly install nitrogen into C—H bonds of complex molecules are significant because of their potential to change the chemical and biological properties of a given compound. Selective intramolecular C—H amination reactions that achieve high levels of reactivity, while maintaining excellent site-selectivity and functional-group tolerance is a challenging problem. Herein is reported a manganese perchlorophthalocyanine catalyst [MnIII(ClPc)] for intermolecular benzylic C—H amination of bioactive molecules and natural products that proceeds with unprecedented levels of reactivity and site-selectivity. In the presence of Brønsted or Lewis acid, the [MnIII(ClPc)]-catalyzed C—H amination demonstrates unique tolerance for tertiary amine, pyridine and benzimidazole functionalities. Mechanistic studies indicate that C—H amination proceeds through an electrophilic metallonitrene intermediate via a stepwise pathway where C—H cleavage is the rate-determining step of the reaction. Collectively these mechanistic features contrast previous base-metal catalyzed C—H aminations.

An adjustable light fixture and lighting system are selectively adjustable in the field and provide even light distribution across a space. A housing is selectively adjustable to a selected housing length and is mountable to the surface. A tray mountable to the housing includes plates which are selectively adjustable relative to one another to a selected tray length. Each plate includes a plurality of electroluminescent light sources providing uniformly luminous light across the light fixture. Overlap of plates varies the tray length and blocks light from light sources on one plate by the opposite plate. Evenly distributed light is therefore provided with no bright or dark spots. A lighting system of a plurality of light fixtures electrically connected to one another includes at least one adjustable light fixture, and preferably at least one stationary light fixture of fixed length. Methods of installation are also disclosed.

The invention provides simple small molecule, non-heme iron catalyst systems with broad substrate scope that can predictably enhance or overturn a substrate's inherent reactivity preference for sp3-hybridized C—H bond oxidation. The invention also provides methods for selective aliphatic C—H bond oxidation. Furthermore, a structure-based catalyst reactivity model is disclosed that quantitatively correlates the innate physical properties of the substrate to the site-selectivities observed as a function of the catalyst. The catalyst systems can be used in combination with oxidants such as hydrogen peroxide to effect highly selective oxidations of unactivated sp3 C—H bonds over a broad range of substrates.

The invention discloses a method of separating histidase enantiomer by a chitosan-modified gold nanochannel film. The method comprises the following steps: by taking a polycarbonate film and an aluminum oxide film as base films, adopting a chemical deposition method to prepare a gold nanochannel film; self-assembling chitosan onto the pore wall of the gold nanochannel to form a functional nanochannel film with chiral site selectivity on the surface; and separating D-histidine, L- histidine in a chiral manner by utilizing excellent separation ability of the nanochannel. During detection, silver sol is used as a surface enhanced Raman substrate to enhance SERS (surface enhanced raman scattering) effect of D-histidine, L-histidine, so that selectivity and sensitivity of the substance are improved to detect the D-histidine and the L-histidine at the same time. The invention provides a quicker and more convenient method for separating and detecting the chiral substance by constructing a coupling device of a nanochannel separating tank and an SERS detecting system, and shows unique advantages and wide application prospect of the method.

An on-spot selectively activated hydrophobic slide / microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing a functional group protected by a protecting group, wherein the functional group is imide or cyclic amide, and the protecting group is a photo acid group such as a tosyloxy group. The hydrophobic copolymer coated on a substrate is then subjected to selective photolithographical activation so that the slide will have functional active copolymer spots separated by inactive copolymers. The resulting slide is suitable for the preparation of high-density and high-efficiency bio-chip / microarray.

Techniques for performing optical proximity correction on a layout design or portion thereof are provided with various implementations of the invention. With various implementations of the invention, movement and simulation of selected edge fragments is disabled during the optical proximity correction process. The operations of the optical proximity correction process, such as for example simulation and displacement of edge segments, is then performed for the edge fragments that remain enabled. With further implementations of the invention, a simulation site is defined for ones of the edge fragments. The operations of the optical proximity correction process, such as for example simulation and displacement of edge segments, is performed for each simulation site. Additionally, during the optical proximity correction process, the simulations sites may be moved and or removed individually based on various conditions.

A reductive cross coupling reaction process for functionalization of a nucleophilic alkene can be achieved. The nucleophilic alkene and a nucleophilic cross coupling partner compound can be reacted in the presence of an oxidizable alcohol and a suitable catalyst to form a reductive coupling product. Various additives can also be useful to refine the process such as by mitigating certain undesirable intermediates, facilitating specific site selectivity for various substitutions or reaction sites, etc. Chiral additives can be optionally used which act to provide asymmetric catalysis, e.g. allow for regioselective and stereoselective production of reductive coupling products. A reductive cross coupling pathway can include oxidizing the oxidizable alcohol to form a catalyst hydride. The nucleophilic alkene can be inserted into the catalyst hydride to form a catalyst-alkyl intermediate. Further, the catalyst-alkyl intermediate can be transmetallized with the nucleophilic cross coupling partner compound to form a transmetallated intermediate. The catalyst can be reductively eliminated to form the reductive coupling product and a reduced catalyst. Finally, the reduced catalyst can be oxidized under aerobic conditions, for example with oxygen, to form the oxidized catalyst and subsequent repetition through the cyclic pathway.

The invention relates to a concise synthesis method of 2-picoline methyl sulfide and related medicines, specifically using 2-picoline nitrogen oxide as a raw material, ethyl acetate or dichloromethane as a solvent, and reacting with trifluoroacetic anhydride The trifluoroacetate intermediate is obtained without purification, under the catalysis of lithium bromide or tetrabutylammonium bromide, using toluene or ethyl acetate as a solvent and then reacting with thiophenol to generate 2-picolyl sulfide. The method has the obvious advantages of simple operation, cheap and easy-to-obtain reagents, mild reaction conditions, wide substrate applicability, good site selectivity and high yield. In addition, the method has been successfully applied to the synthesis of omeprazole sulfide and rabeprazole sulfide, and the synthesis process does not require any catalyst.

A preparation method of N-2-pyrimidinyl-3-fluoroindole compound shown in formula (I), described method comprises the following steps: take acetonitrile solvent as reaction medium, add N shown in formula (III) ‑2‑pyrimidinyl indole compound, selectfluor, CuI and photocatalyst, react at room temperature under blue light irradiation for 2 to 5 hours, after the reaction is complete, the resulting reaction mixture is post-processed to obtain N‑2‑pyrimidinyl represented by formula (I) ‑3‑fluoroindoles. This type of compound is a kind of inhibitor compound that can significantly inhibit the activity of monoamine oxidase, especially I-2 and I-3 have high selectivity to MAO-A, which provides a research basis for the screening of antidepressant and anti-Parkinson drugs . The invention uses a photocatalyst to react under blue light irradiation and room temperature, has mild reaction conditions, high site selectivity, high reaction efficiency, greenness and environmental protection, and the reaction yield can reach 85%.

A highly pressure-sensitive adhesive optical transparent pressure-sensitive adhesive body or optical transparent pressure-sensitive adhesive laminate which stably provide peeling site selectivity between both sides of the transparent pressure-sensitive adhesive body and a release sheet in the case of pasting, whereas stably and easily express peeling site selectivity between both sides of the transparent pressure-sensitive adhesive body in the case of rework, that is, re-pasting, as well as superior adhesion stability after pasting, and a method for producing the same. An optical transparent pressure-sensitive adhesive body and the like having pressure-sensitive adhesive surface (a) and pressure-sensitive adhesive surface (b) having different pressure-sensitive adhesive property from each other, and being formed with an addition reaction type silicone gel, characterized in that pressure-sensitive adhesive performance (Ga) of pressure-sensitive adhesive surface (a) and pressure-sensitive adhesive performance (Gb) of pressure-sensitive adhesive surface (b) satisfy a relationship of Ga < Gb, and pressure-sensitive adhesive performance (Ga) and pressure-sensitive adhesive performance (Gb) have 5 to 32 in ball number and 2 to 12 in ball number difference in the tilt type ball tack test (tilt angle: 30 degrees) according to JIS Z0237; and that pressure-sensitive adhesive surface (a) and pressure-sensitive adhesive surface (b) are formed by tightly adhering an uncured raw material of said addition reaction type silicone gel to different release film (A) and release film (B) and thermal-curing them, and the release film (A) and the release film (B) have a release treatment layer comprising a fatty acid amide type additive.

The invention discloses a method for preparing a trifluoromethylated polypeptide compound represented by formula (II), the method comprising the following steps: using a mixed solvent of DMF and water with a volume ratio of 1:1-4 As the reaction medium, the polypeptide compound as shown in formula (I) and 1-(trifluoromethyl)-1,2-phenyliodyl-3(1H)-ketone react 3-3 at room temperature under blue light in photocatalyst After 8 hours, after the reaction is complete, the resulting reaction mixture is post-treated to obtain trifluoromethylated polypeptide compounds represented by formula (II). The present invention drives the reaction under visible light irradiation, and the reaction solvent is a mixed solvent of DMF and water, which is more in line with the concept of green chemistry, green, and environmentally friendly. The product can be prepared in one step, the operation process is simple, and the source of raw materials has been commercialized and easily obtained. Using photocatalyst, it has good catalytic performance, mild reaction conditions and high site selectivity.