The invention particularly relates to an application of a quick interconnection protocol QUIC in a distributed database system. According to the application of the quick interconnection protocol QUICin the distributed database system, when nodes in a database cluster perform network interconnection to transmit service data, the QUIC protocol is used for connection, and a gRPC server node monitorsa network address based on the QUIC protocol, receives application data when the data arrives and replies a response; and a gRPC client node establishes QUIC protocol connection with the gRPC serverthrough dialing, sends application data through a QUIC channel and waits for response, thereby improving the node connection speed and saving the overhead of system resources. According to the application of the quick interconnection protocol QUIC in the distributed database system, when nodes in a database cluster are increased on a large scale, network connection between the nodes can be established quickly, the expenditure of system resources is effectively reduced, and stable operation and quick capacity expansion of the distributed database system are guaranteed.