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43 results about "Oxygen binding" patented technology

Oxygen binding capacity is the maximum amount of oxygen that can be bound to hemoglobin, abbreviated as Hb, which is the main protein found inside of red blood cells, which is a main component of blood. As it turns out, there are two major ways for oxygen to move around in the blood.

Chemically cleavable 3'-o-allyl-DNTP-allyl-fluorophore fluorescent nucleotide analogues and related methods

This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3′-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods of nucleic acid sequencing employing the nucleotide analogue.
Owner:THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK

Implantable biosensor and methods of use thereof

Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.
Owner:METRONOM HEALTH

Method for production of thin-film semiconductor device

InactiveUS20080182368A1Fixed charge is reducedDecrease of interface stateTransistorSolid-state devicesOxygen deficientMaterials science
Disclosed herein is a method for production of a thin-film semiconductor device which includes, a first step to form a gate electrode on a substrate, a second step to form a gate insulating film of silicon oxynitride on the substrate in such a way as to cover the gate electrode, a third step to form a semiconductor thin film on the gate insulating film, and a fourth step to perform heat treatment in an oxygen-containing oxidizing atmosphere for modification through oxygen binding with oxygen-deficient parts in the silicon oxynitride film constituting the gate insulating film.
Owner:JAPAN DISPLAY INC

Implantable Biosensor and Methods of Use Thereof

Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.
Owner:METRONOM HEALTH

Biodegradable nanoparticles as novel hemoglobin-based oxygen carriers and methods of using the same

ActiveUS8808748B2Low oxygenation of tissueLow oxygenationPowder deliveryPeptide/protein ingredientsEthylene oxideHemeprotein
Compositions of matter and methods for making, storing and administering artificial blood substitutes. Artificial blood substitutes may have oxygen carriers that encapsulate an oxygen-binding compound in a polymer vesicle. Oxygen-binding compounds may include hemoglobin, myoglobin, or other oxygen binding compounds having characteristics similar to hemoglobin. Oxygen carriers may include nanoparticles, polymers and / or polymersomes comprising of poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) and related diblock copolymers of poly(ethylene oxide)-block-poly(γ-methyl ε-caprolactone) (PEO-b-PMCL). The oxygen carriers may have tunable oxygen-binding capacities, uniform and appropriately small size distributions, and human bloodlike viscosities and oncotic properties.
Owner:POSEIDA THERAPEUTICS INC

Catalyst for cathode in fuel cell

A catalyst particle having high oxygen reduction reactivity and low methanol oxidation reactivity, a supported catalyst comprising the catalyst particle, and a fuel cell using a cathode comprising the supported catalyst are provided. The whole catalyst particle or at least the surface of the catalyst particle includes an alloy of two or more metals selected from the group consisting of Fe, Co, Ni, Rh, Pd, Pt, Cu, Ag, Au, Zn, and Cd. The alloy has a stronger oxygen-binding force than platinum or a weaker hydrogen-binding force than platinum.
Owner:SAMSUNG SDI CO LTD

Process for producing polyether

The present invention provides a process for efficiently obtaining polyethers having its high degree of polymerization by easily polymerizing substituted epoxides which could hardly or could not be made so far to provide a high degree of polymerization. That is, a polyether is obtained by a process which comprises ring-opening-polymerizing at least one substituted epoxide, except for propylene oxide and epihalohydrin, in the presence of a rare earth metal compound represented by the formula (I) and a reducing compound:Wherein M represents a rare earth element selected from Sc, Y and lanthanide, and L1, L2 and L3 are same as or different from each other and each of them represents an oxygen-binding ligand.
Owner:KAO CORP

Biodegradable nanoparticles as novel hemoglobin-based oxygen carriers and methods of using the same

ActiveUS20110256225A1Low oxygenation of tissueLow oxygenationPowder deliveryBiocideEthylene oxideBlood substitute
Compositions of matter and methods for making, storing and administering artificial blood substitutes. Artificial blood substitutes may have oxygen carriers that encapsulate an oxygen-binding compound in a polymer vesicle. Oxygen-binding compounds may include hemoglobin, myoglobin, or other oxygen binding compounds having characteristics similar to hemoglobin. Oxygen carriers may include nanoparticles, polymers and / or polymersomes comprising of poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) and related diblock copolymers of poly(ethylene oxide)-block-poly(γ-methyl ε-caprolactone) (PEO-b-PMCL). The oxygen carriers may have tunable oxygen-binding capacities, uniform and appropriately small size distributions, and human bloodlike viscosities and oncotic properties.
Owner:POSEIDA THERAPEUTICS INC

Hemoglobin Overexpression in Fungal Fermentations

The present invention relates to fungal host cells that are transformed with a nucleic acid construct encoding a fungal oxygen-binding proteins or fragments thereof that comprise the oxygen-binding domain. Upon transformation of the host cell with the construct, the oxygen-binding protein confers to the host cell improved fermentation characteristics as compared to untransformed host cells. These characteristics include e.g. increases in oxygen uptake rates, biomass densities, volumetric productivities and / or product yields. The invention further relates to fermentation processes in which the host cells are used and to fungal oxygen binding proteins, in particular fungal flavohemoglobins and hemoglobin domains, and to nucleotides sequences encoding these proteins.
Owner:DSM IP ASSETS BV

Catalyst for cathode in fuel cell

A catalyst particle having high oxygen reduction reactivity and low methanol oxidation reactivity, a supported catalyst comprising the catalyst particle, and a fuel cell using a cathode comprising the supported catalyst are provided. The whole catalyst particle or at least the surface of the catalyst particle includes an alloy of two or more metals selected from the group consisting of Fe, Co, Ni, Rh, Pd, Pt, Cu, Ag, Au, Zn, and Cd. The alloy has a stronger oxygen-binding force than platinum or a weaker hydrogen-binding force than platinum.
Owner:SAMSUNG SDI CO LTD

Enhancing spinosyn production with oxygen binding proteins

ActiveUS20120282657A1Increased spinosyn productionImproved and increased spinosyn productionBacteriaHaemoglobins/myoglobinsPolynucleotideBiology
The invention describes the integration of polynucleotides into chromosomal DNA of S. spinosa species, which are useful for the production of insecticides, integrants thereof, and also to the use of the integrants. The invention includes the stable integration and expression of an oxygen-binding protein, VHb, which results in increased spinosyn production.
Owner:CORTEVA AGRISCIENCE LLC

Method for constructing saccharopolyspora erythraea expression plasmid (pBlueV) containing vitreoscilla hemoglobin gene (vgb)

The invention provides a method for cloning a saccharopolyspora erythraea expression plasmid (pBlueV) containing a vitreoscilla hemoglobin gene (vgb), belonging to the technical field of gene engineering. In the method, based on the fact that VHb (hemoglobin) can be combined with oxygen to form an oxygenated state, the VHb intervenes the oxygen related metabolic pathway of cells, thereby changing the original biological metabolism mode of the cells under oxygen-limited conditions, promoting the cell growth and protein synthesis under oxygen-deficient conditions, directly or indirectly affecting the action principles of primary metabolism and secondary metabolism of aerobes, firstly constructing an Escherichia coli expression plasmid pQEV, expressing the VHb with biological activity, and further constructing the saccharopolyspora erythraea expression plasmid (pBlueV). In order to realize high-density culture of cells and high-yield fermentation of metabolic products under oxygen-limited conditions, the invention provides an important pathway for homologous recombination of vgb gene elements and saccharopolyspora erythraea chromosome genomes.
Owner:邢安辉 +2

Method for recombining Saccharopolyspora erythraea strain containing exogenetic vitreoscilla hemoglobin gene (vgb)

InactiveCN102234654AUltimate titer increaseUltimate cost-effectivenessFungiMicrobiological testing/measurementBinding stateFermentation
The invention belongs to the technical field of gene engineering, and provides a method for recombining a Saccharopolyspora erythraea strain containing exogenetic vitreoscilla hemoglobin gene (vgb). In the method, vitreoscilla hemoglobin (VHb) expressed by the vitreoscilla hemoglobin gene (vgb) can be combined with oxygen to form an oxygen-binding state, and intervenes several key steps or branch pints in cell metabolic paths related with oxygen in the mode, so that the cell growth speed is improved, the cell respiration intensity is improved and the critical oxygen concentration of cells is reduced. In large dissolved oxygen change, a constant respiratory rate is kept, and the cell culture density and exogenetic gene expression are improved under low oxygen condition. The method solves the problem that in a large-scale bioreactor, because thalli are positioned in a viscous, enclosed and complicated environment with rich nutrients, oxygen required by massive mycelia in an exponential phase is limited, and the yield of erythrocin is reduced. The method has important application value for the antibiotic fermentation industry and high density cell culture, which have high oxygen consumption and take dissolved oxygen as a limiting factor.
Owner:邢安辉 +2

Bacterial hemoglobin genes and their use to increase carotenoid production

Genes encoding bacterial oxygen binding proteins are provided. Recombinant expression of at least one of the present bacterial hemoglobin genes increased the growth characteristics and / or carotenoid production levels in microbial host cells grown under microaerobic conditions.
Owner:EI DU PONT DE NEMOURS & CO

Electrochemical device

ActiveUS20140162147A1Well formedExcellent oxygen absorbabilityFuel and secondary cellsCell electrodesPhysical chemistrySolvent
An electrochemical device including: a positive electrode including oxygen as a positive active material; a negative electrode including a lithium ion-intercalatable / deintercalatable material as a negative active material; and an electrolytic solution in fluid communication with the positive electrode and the negative electrode and including a solvent and an oxygen absorbing / desorbing material with an oxygen binding rate of about 60 to about 95% in a pure oxygen atmosphere.
Owner:SAMSUNG ELECTRONICS CO LTD

Packing structure including theft prevention electronic tag

The present invention provides a packing structure including a theft prevention tag, in which an anti-theft electronic tag is mounted to a ventilating packing element having contained therein a food-preserving agent such as an oxygen-binding agent, a moisture-proofing agent, or a freshness-keeping agent, and the ventilating packing element is easily built in a product wrapper, so that the anti-theft electronic tag is prevented from being damaged with a malicious intention, thereby further ensuring safety and security of products or articles.
Owner:LIPMEN

Low oxygen affinity mutant hemoglobins

Non-naturally occurring mutant hemoglobins rHb (.beta.N108Q) and rHb (.beta.L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (.beta.N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
Owner:CARNEGIE MELLON UNIV

Iron-containing chelating agent embedded MOF material as well as synthesis method and application thereof

The invention discloses an iron-containing chelating agent embedded MOF material, a synthesis method and application, the synthesis method comprises the steps of synthesizing the MOF material and synthesizing the iron-containing chelating agent embedded MOF material by taking the MOF material and ethylenediamine tetraacetic acid chelated iron as raw materials, encapsulating the ethylenediamine tetraacetic acid chelated iron in internal gaps of the MOF material to obtain the iron-containing chelating agent embedded MOF material. The adsorption performance of the MOF material is greatly improvedby utilizing a large number of chemical bonds easy for oxygen binding in ethylenediamine tetraacetic acid and the affinity of Fe element to oxygen, and the adsorbed material can be subjected to thermal desorption, so that the reutilization of the material is realized.
Owner:TIBET UNIV

Photoreduction method for hemoglobin-vesicle

A method and an apparatus for regenerating an oxygen-binding ability by reducing the methemoglobin contained in hemoglobin-vesicle by light irradiation. This method includes adding electron donors such as amino acids, saccharides, alcohols, and / or flavin derivatives in appropriate amounts to the inner aqueous phase of the hemoglobin-vesicle, applying light to the vesicle when the content of methemoglobin increases as a result of oxidation of hemoglobin, thereby reducing the metohemoglobin. In this manner, the oxygen-binding ability is recovered, thereby maintaining the function of the hemoglobin-vesicle.
Owner:WASEDA UNIV

An energy-saving combined beneficiation process for high-oxidation, high-combined oxygen-sulfur mixed copper ore

The invention provides an energy-saving combined ore dressing process for high-oxidation and high-bonding oxygen and sulfur mixed copper ore. The process comprises the steps of raw ore treatment, preparation of leaching solution, stirring and leaching, dynamic soaking selection, solid-liquid separation and washing and filtration of leached residue. The ore is crushed till the granularity is less than 10 millimeters, and the crushed ore with granularity of less than 3 millimeters is screened; sulfuric acid solution, the PH of which is less than 8, is used as the leaching solution; the raw ore is dynamically and continuously soaked for less than 24 hours, and the leachate is directly guided to an extraction process after PH value neutralization and micro pipe filtration; and the leached residue is separated by using a belt filter, and the filtered residue is treated in a flotation process to extract copper sulfide ore. According to the combined efficient washing and filtering process, dynamic soaking is adopted, the leachate is subjected to micro pipe filtration (the leachate with solid concentration of less than or equal to 3 percent in liquid can be filtered, and the solid content of the filtered liquid can be less than 50ppm), and the leached residue is separated by using the belt filter, so that the ore can meet the process requirement without fine crushing. By the process, the metal recovery rate of the high-bonding oxidized copper ore reaches over 80 percent, continuous production is realized, and energy consumption and production cost are comprehensively reduced.
Owner:云南楚雄矿冶有限公司

Ceramic gas discharge metal halide lamps

InactiveCN102272881AReliable startReliable ignition characteristicsGas discharge lamp detailsNoble gasShortest distance
A ceramic gas discharge metal halide (CDM) lamp (10) capable of retrofitting existing high pressure iodide (HPI) metal halide and high pressure mercury vapor (HP) lamps to achieve significant energy savings, the CDM lamp ( 10) has a ceramic discharge vessel (12) containing a pair of discharge electrodes (17, 18), a Penning mixture of the noble gases neon and argon, and a chemical filling comprising an oxygen partitioning agent and will Strong oxygen binders are limited to 5 mole percent or less. In a preferred embodiment, the discharge vessel (12) has an aspect ratio R of less than 2, a wall thickness t of up to 1.2 mm, a separation d between the discharge electrodes (17, 18) of up to 14 mm and the discharge vessel (12) outer wall The shortest distance between the discharge electrodes (17, 18) and the floating antenna (26) is up to 7mm.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV

Shape-preserving polymeric replication of biological matter

The present invention relates to a method of forming silica nanolayers on or within a biological sample, thereby capturing structural details that are present in the sample. The resultant silica composite or silica replica, in turn, can be employed as a template for a replica having those structural details captured in a polymer. Also provided herein are synthetic constructs including a polymeric replica, which can have any useful feature (e.g., oxygen-binding capacity).
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC

Biodegradable Nanoparticles as Novel Hemoglobin-Based Oxygen Carriers and Methods of Using the Same

ActiveUS20140335160A1Low oxygenation of tissueLow oxygenationBiocidePeptide/protein ingredientsEthylene oxideBlood substitute
Compositions of matter and methods for making, storing and administering artificial blood substitutes. Artificial blood substitutes may have oxygen carriers that encapsulate an oxygen-binding compound in a polymer vesicle. Oxygen-binding compounds may include hemoglobin, myoglobin, or other oxygen binding compounds having characteristics similar to hemoglobin. Oxygen carriers may include nanoparticles, polymers and / or polymersomes comprising of poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) and related diblock copolymers of poly(ethylene oxide)-block-poly(γ-methyl ε-caprolactone) (PEO-b-PMCL). The oxygen carriers may have tunable oxygen-binding capacities, uniform and appropriately small size distributions, and human bloodlike viscosities and oncotic properties.
Owner:POSEIDA THERAPEUTICS INC

Method for sintering high-temperature-resistant bonded oxygen-permeable oxide ceramics by doping-assisted diffusion reaction

The invention relates to a method for high temperature resistant bonding or bonding of oxide ceramic structural components made of mixed conducting oxide ceramics. The object of the present invention is to provide a possibility for high temperature resistant bonding of ceramic structural components made of mixed conductive substituted alkaline earth metal cobaltates, wherein in the case of dense membrane components the bonding should be gas-tight sexual. This object is achieved by a method for high-temperature resistant bonding of oxygen-permeable oxide ceramics based on substituted alkaline earth metal cobaltates by doping-assisted diffusion reaction sintering, wherein at least one bonding surface is provided with Cu-containing additives, and then heated to a temperature below the usual sintering temperature of the ceramic component up to 250K under the load of gravity or other force, and maintained at this temperature for 0.5 to 10 hours.
Owner:FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG EV

A hemoglobin oxygen carrier based on double chemical modification and its preparation method and application

ActiveCN111499732BImprove oxygen carrying/releasing activityEnhanced oxygen-carrying/evolving activityPeptide/protein ingredientsHaemoglobins/myoglobinsCarboxyl radicalBiophysics
The present invention relates to a hemoglobin oxygen carrier based on double chemical modification and its preparation method and application. In the hemoglobin oxygen carrier based on double chemical modification, two Val‑1 (α) residues are carboxymethylated, and two Lys ‑99(α) residues are intramolecularly cross-linked. Two of the Lys-99(α) residues are intramolecularly cross-linked, and the fumarimide bridge formed can change the electrostatic interaction of adult hemoglobin (HbA) molecules, stabilize the tense state (T state) of HbA, and reduce its Oxygen affinity; Val‑1(α) is located at the αα‑end of the central cavity of HbA, and can participate in the formation of salt bridges that help stabilize the structure of the relaxed state (R state). Carboxylation modification will destroy these salt bridges and reduce HbA The stability of the R state makes the quaternary structure of HbA shift from the R state to the T state, reducing the affinity of HbA for oxygen. The invention organically combines the two modification means, improves the stability of the HbA tetramer, enhances the electrostatic interaction, improves the binding state of the oxygen binding region and oxygen, and has strong oxygen carrying / releasing activity.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI
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