37 results about "Monensin Sodium" patented technology

Disclosed are compounds of formula (I) and formula (II): (I) (II) wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.

The present disclosure relates to a pharmaceutical composition, a health functional food composition, and a method for preventing or treating a brain disease or diabetes. The pharmaceutical composition, health functional food composition, and method includes at least one active ingredient that is chlorhexidine, thioguanosine, mebendazole, fenbendazole, colchicine, farnesol, trimethobenzamide hydrochloride, disulfuram, azathioprine, mebeverine hydrochloride, zaprinast, tosufloxacin hydrochloride, efavirenz, thiostrepton, probenecid, entacapone, harmine hydrochloride, flunisolide, thimerosal, hexestrol, sulfaquinoxaline sodium salt, monensin sodium salt, raloxifene hydrochloride, 2-chloropyrazine, or topotecan.

The invention provides a method for extracting monensin sodium by a methanol extraction method, belongs to the field of biopharmaceuticals and engineering, and is mainly used for producing a monensin pure substance (sodium salt mode) by a fermentation method. The method comprises the following steps: culturing strains in a sand soil tube; culturing strains on an inclined surface; preparing first order seed culture solution and second order seed culture solution; preparing fermentation liquor; making a filter cake; dissolving and releasing the filter cake; extracting the filter cake; and decoloring the filter cake. The method is characterized in that the process of extraction adopts mycelium with moisture content of between 20 and 30 percent, adds 5 to 8 times of methanol of which the concentration is between 60 and 90 percent to the mycelium according to weight ratio, adjusts the temperature at between 15 and 35 DEG C, and stirs the mixture for 30 to 40 minutes to ensure that the mixture is sufficiently dissolved; and a finished product is prepared through activated carbon decoloration, filtration, crystallization, separation, drying and package. The method has high product extraction rate, namely reaching over 90 percent, low cost, good product quality, namely the product is in accordance with the requirement of the monensin sodium pure substance of an American USP standard, and high economic benefit, and can be widely applied in the field of biopharmaceuticals and engineering.

The invention relates to a preparation method of monensin crystal or its sodium salt. The method is to directly dry monensin fermented liquid to obtain monensin after pretreatment, decolorization and precipitation, organic solvent dissolution, crystallization and rinsing. Monensin crystals or salted with alkali and spray-dried to obtain monensin sodium salt. The invention abandons the conventional crystallization process, realizes the preparation method of increasing the yield of monensin, reducing the cost, and improving the quality of the crystal and finished product through extraction, crystallization and synthesis processes, and is suitable for industrial production.