67 results about "Isotopomers" patented technology

A process and an apparatus for isotope ratio analysis, the process having the following steps: performing a liquid chromatography process and thus providing an eluate which comprises at least one liquid carrier fluid and at least one analytes, collecting a portion of interest from the eluate, processing the eluate portion to form at least one gaseous conversion products of the analytes, and supplying the gaseous conversion products, especially with gaseous carrier fluid, to an isotope analyzer and determining the isotrope ratios.

The invention provides a mechanism for semi-quantitatively measuring individual isotopomer species of a molecule using gas chromatograph mass spectrometry. The method allows for semi-quantitatively tracking the movement of ions by measuring the individual isotopomer species of a molecule.

The invention is directed to luminescent materials containing isotopically-enriched atomic elements and methods of making these luminescent materials. Individual embodiments of the invention include isotopically-enriched ZnO:Zn, ZnS:Cu:Cl, Zn₂SiO₄:Mn, Y₂O₂S:Eu, Gd₂O₂S:Tb and CaWO₄ phosphors as well as methods of synthesizing these luminescent materials using isotopically-enriched starting materials.

Provided herein are Aminopurine Compounds having the following structures wherein R1, R2, and R3 are as defined herein, composition comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma. Provided herein are compounds having the following formula (I) and pharmaceutically acceptable salts, tautomers, isotopologues, and stereoisomers thereof, wherein R1, R2 and R3 are as defined herein.

The present invention aims at providing a method and apparatus for analyzing a mass spectrum on which multivalent ion peaks originating from a target compound appear, and calculating the mass of the target compound. First, each peak on the mass spectrum is analyzed to detect isotopic clusters, and the valence and the representative point (m/z value) of each isotopic cluster are obtained (S1 through S3). Since the range of the m/z value of the component which is added to or desorbed from the compound is limited, by using this factor, the isotopic clusters originating from the same compound are deduced. By combining the deduced isotopic clusters, the candidates for the m/z value of the added/desorbed component are deduced (S5). Among the plurality of selected candidates, clearly abnormal candidates are eliminated by using a plurality of conditions such as the degree of distribution of the m/z values and the similarity of the relative intensities of the representative points of the isotopic clusters (S6 through S9). The candidate having the smallest distribution of m/z values or the candidate having the highest similarity of the relative intensities of the representative points is finally selected. After the m/z value of the added/desorbed component is determined, the mass of the compound is calculated (S 10 through S16).

The invention relates to heterocyclic compounds and the application thereof in medicine. Specifically, the invention discloses heterocyclic compounds as shown in formula I, or isotopically-labeled compounds thereof, or optical isomers, geometric isomers, tautomers or a mixture of isomers thereof, or medicinal salts thereof, or prodrugs thereof. The invention also relates to application of these compounds in medicine.

This invention provides a preparation method for zirconium thin films. A dual ion beam epitaxy apparatus with the function of mass separation and characteristics of energetic ion deposition is adopted and zirconium chloride of which purity is not highly required serves as raw materials and is sputtered to a sanitized substrate with single isotopic pure low-energy argon ion beam. First, a thin film of zirconium nitride as block layer and buffer layer preventing reactions between zirconium ion and the substrate is prepared with the consequent isotopic pure low-energy zirconium ion beam and nitrogen ion beam, and then a zirconium film is deposited by epitaxy of single isotopic pure low-energy zirconium ion beam. By exactly controlling the energy of zirconium ion beam, the amount of deposition agents, beam density, beam shape and growing temperature, low-cost deposition and low-temperature epitaxy of zirconium which has a high melting point and is difficult to purify can be realized in ultravacuum cultivation room with high purity and high crystallization quality. This technique is convenient to modulate and optimized and is economical to manufacture zirconium thin films.

The invention relates to the field of oilfield development, and provides a device and a method for nested layered injection of isotopic tracers. The device comprises an injection container, a water injection pipeline, and valves, and also comprises a sleeve, an oil pipe, a central pipe, and a packer. In the method, through controlling the switches of the valves, the isotopic tracer is injected into corresponding oil layers respectively through the sleeve, the oil pipe, and the central pipe, so as to realize layered injection of the isotopic tracer. The nested layered injection device and the layered injection method realize layered injection of different kinds of isotopic tracers, and injection volume of the isotopic tracer of each oil layer is accurately controlled, accurate monitoring of the isotopic tracer of each oil layer is realized. The device and the method have significant value for determining oil reservoir parameter distribution, reservoir exploitation evaluation, follow-up development scheme design determination, adjustment, and implementation.

The invention relates to the field of oil field exploitation, and provides an isotopic tracer layered injection device and method for a multi-zone oil reservoir. The device comprises an injection container, a water injection pipeline, and a valve. The device also comprises N packers and (N+1) eccentric water distributors, wherein the packers are respectively disposed between each two eccentric water distributors. The device also comprises quantitative water nozzles and dead plugs, which are used cooperatively with the eccentric water distributors. The device also comprises the (N+1) quantitative water nozzles. The method comprises the steps: enabling the quantitative water nozzle of one eccentric water distributor to be replaced by one dead plug; enabling the remaining eccentric water distributors to be communicated with an oil layer; slowly injecting isotopic tracer through the control of the opening/closing of the valve; and enabling the isotopic tracer to be injected into a target oil layer. The device and method can achieve the layered injection of different types of isotopic tracers, precisely control the injection amount of isotopic tracer at each oil layer, achieve the accurate monitoring of the isotopic tracer of each oil layer, and has great values for the determining of oil reservoir parameter distribution, reservoir development evaluation, the determining of the design, adjustment and execution of a subsequent development scheme.

A composition adapted for mass spectral analysis is disclosed as are methods of its use in mass spectral analyses. A contemplated composition contains a mass spectrally-determinable amount of each of (i) at least one analyte to be assayed and (ii) a standard compound. Each of the molecules of the standard compound contains one or the other of a pair of two stable isotopes of the same element that differ in molecular weight by at least two atomic mass units. Those two isotopes are present in the molecules of the standard compound in a predetermined ratio that is other than the naturally occurring ratio of those isotopes.

The invention provides a research method for simulating an SF6 overheat decomposition reaction based on a stable isotopic tracer method, which comprises the following steps of: constructing an SF6 insulation equipment local overheat experiment platform, controlling a fault temperature by using a temperature controller, and researching accurate injection of H218O and 18O2 with different concentrations. The method comprises the following steps: removing the influence of impurities in the air and impurities remaining on the surface of an experimental apparatus on the experiment, heating for a period of time, collecting the reacted mixed gas in the experimental apparatus, and analyzing the proportion of gas components and isotope compounds by GC/MS, thereby researching the interaction of trace oxygen and water and SFx in the SF6 thermal decomposition process. And analyzing the formation mechanism of the SF6 decomposition product. The experimental platform is designed according to the internal overheating fault condition of the gas insulation equipment so as to simulate the decomposition condition of SF6 under an actual fault.

A method for isotope measurement of charged species contained in a solution to be analyzed, particularly charged species having an isobaric interference, has the following consecutive steps:

• • a) in the capillary of a capillary electrophoresis device, the solution to be analyzed is inserted contiguously between a terminating electrolyte and a leading electrolyte that, respectively, are placed after the inlet and before the outlet of the capillary and contain ions of the same charge but with mobility inferior and superior to those of said species;
  • b) separating the species by using the capillary electrophoresis device according to the isotachophoresis mode; then
  • c) in the continuity of the preceding step, performing an isotope measurement of the species detected in the form of a substantially constant amplitude signal by using an inductively coupled plasma mass spectrometer (ICPMS) connected by direct coupling with the capillary electrophoresis device.

A method for determining a hydrocarbon concentration from drilling fluid includes pumping the drilling fluid into a wellbore and circulating a sample of the drilling fluid uphole from the wellbore so that δ¹³C isotopic signatures can be determined for one or more hydrocarbon components and for methane in the sample where the methane includes natural methane originating from the earth formation and artificially-produced methane caused by drill bit metamorphism (DBM). A processor is adapted to determine the concentration of the natural methane in the sample based in part on the δ¹³C isotopic signatures which may be performed during the drilling of the wellbore.

The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.

The invention relates to the field of oil field exploitation, and provides a layered injection device and method for an isotopic tracer. The device comprises an injection container, a water injection pipeline, and a valve. The device also comprises a packer and two eccentric water distributors, and also comprises a quantitative water nozzle and a dead plug, wherein the quantitative water nozzle and the dead plug cooperate with the eccentric water distributors for use. The method comprises the steps: enabling the quantitative nozzle of one eccentric water distributor to be replaced by one dead plug, enabling the other eccentric water distributor to be communicated with an oil layer, slowing injecting the isotopic tracer through the control of the opening and closing of the valve, and enabling the isotopic tracer to be injected to a target oil layer. The device and method can achieve the layered injection of different types of isotopic tracer, can precisely control the injection quantity of the isotopic tracer of the upper and lower oil layers, achieves the accurate monitoring of isotopic tracer of the two oil layers, and has high values for the determining of oil deposit parameter distribution, the development and assessment of a storage layer, and the design, adjustment and enforcement of determining a subsequent development scheme.