55 results about "Hydroxyquinoline derivatives" patented technology

The present invention relates to a method for the treatment, amelioration and/or prophylaxis of a neurological condition, in particular neurodegenerative disorders which comprises the administration of an effective amount of a compound of formula (I): to a subject in need thereof. The present invention also relates to a compound of formula (II) and processes for its preparation.

The invention relates to a preparation method of a fluorescence enhanced fluorescent molecular probe for detecting mercapto-containing amino acids, and an application of the probe, and concretely relates to a preparation method of a 7-hydroxyquinoline derivative and an application of the 7-hydroxyquinoline derivative in the mercaptoamino acid detection. The fluorescent probe is a pure probe synthesized through directly reacting the 7-hydroxyquinoline derivative with dimethyl sulfate. The largest absorption wavelength of the molecule of the probe is 315nm; and the absorption wavelength of the probe molecule redshifts to 406nm from 315nm with the addition of the mercapto-containing amino acids, the intensity of a fluorescent spectrum at 505nm is continuously enhanced, and very strong green fluorescence is emitted. The probe molecule has the advantages of high detection sensitivity, strong identification capability on the mercapto-containing amino acids, and fast response speed, and has detection limits of Cys, GSH and Hcy mercaptoamino acids being 23nM, 52nM and 5.3nM respectively, and like probes have important application values in the biochemical field and the like.

The invention discloses two halogenated 8-hydroxyquinoline platinum (II) complexes and a synthesis method and application thereof. The structures of the halogenated 8-hydroxyquinoline platinum (II) complexes are shown in the formula (I), and the synthesis method comprises the steps that an 8-hydroxyquinoline derivative and dichloro bis(dimethyl sulfoxide) platinum are taken and subjected to a coordination reaction in a polar solvent, and the halogenated 8-hydroxyquinoline platinum (II) complexes are obtained. It is shown through experiments carried out by an applicant that the halogenated 8-hydroxyquinoline platinum (II) complexes have good activity of inhibiting the proliferation of certain tumor cell strains and can selectively inhibit the growth of bladder cancer T-24 cells, and the apoptosis of the tumor cells is induced under the function of targetedly interfering with mitochondria; meanwhile, the toxicity of the complexes to human normal cells HL-7702 is low. The structures of the halogenated 8-hydroxyquinoline platinum (II) complexes and the structure of the 8-hydroxyquinoline derivative are shown in the following formulas (I) and (II) respectively, wherein the formulas (I)and (II) are shown in the description, and R1 represents Cl or Br.

The invention discloses an iridium complex constructed based on 8-hydroxyquinoline derivative and 2-phenylpyridine iridium dimer and a synthesis method and application thereof. The synthesis method ofthe iridium complex comprises the following steps: putting a 2-phenylpyridine iridium dimer and an 8-hydroxyquinoline derivative into an organic solvent, and performing reacting under a heating or non-heating condition to obtain the corresponding target complex. A test result of an applicant shows that the complex has remarkable biological activity (the activity is remarkably higher than that ofligands and cisplatin of cervical cancer and ovarian cancer cells) on cervical cancer and ovarian cancer cells, and meanwhile, the toxicity of the complex on human normal hepatocytes is extremely low(IC50 is greater than 80 [mu] M); and moreover, the complex disclosed by the invention can also be used for fluorescence localization in tumor cells, and can be developed into a targeting anti-cancerdrug for fluorescence localization targeting mitochondria.

The invention discloses a ternary complex formed by rare earth elements and 2-pyridine carboxaldehyde thiosemicarbazone Schiff base and 8-oxyquinoline or derivatives thereof as well as a preparation method and application of the ternary complex as an antibacterial agent. The chemical formula of the rare earth ternary complex is: Ln(L)Hq(NO3)3C2H5OH.CH3OH, Ln(L)(HqM)2(NO3)C2H5OH.CH3OH; Ln(L)(HqS)2(NO3) C2H5OH.CH3OH, wherein the Ln is a rare earth ion; the L is 2-pyridine carboxaldehyde thiosemicarbazone Schiff base; the Hq is 8-oxyquinoline; the HqM is a 8-oxyquinoline derivative connected with an electron donating group on the quinoline ring 2-position; and the HqS is a 8-oxyquinoline derivative connected with an electron withdrawing group on the quinoline ring 5-position. The rare earth ternary complex has the advantages of good chemical stability, heat stability and lipid solubility, strong antibacterial activity and little pollution.

Adhesive compositions exhibit improved adhesion and conductivity by the addition of a metal salt of 8-quinolinol or of an 8-quinolinol derivative as a corrosion inhibitor. The metal salt of 8-quinolinol or of an 8-quinolinol derivative is formed by coordination with a metal selected from the group consisting of Cu, Be, Mg, Ca, Sr, Ba, Zn, Cd, Al, Ga, In, TI, Yt, La, Pb, Sb, Bi, Cr, Mo, Mn, Fe, Co, Ni, Pd, Ce, and Pr. Examples of quinolinol derivative salts have the structures:

The invention discloses an iridium complex constructed based on a 8-hydroxyquinoline derivative and a 1-phenylpyrazole iridium dimer as well as a synthesis method and application of the iridium complex. The synthesis method of the iridium complex comprises the following steps: putting the 1-phenylpyrazole iridium dimer and the 8-hydroxyquinoline derivative into an organic solvent, and reacting under a heating or non-heating condition to obtain the corresponding target complex. A test result shows that the complex has remarkable biological activity (the activity is remarkably higher than that of ligand and cisplatin the complex) on cervical cancer and ovarian cancer cells, and meanwhile, the toxicity of the complex on human normal hepatocytes is extremely low (IC50 is greater than 80 [mu] M); on the other hand, the complex disclosed by the invention can also be used for fluorescence localization in tumor cells, and can be developed into a targeting anti-cancer drug for fluorescence localization targeting mitochondria.

Disclosed is an organic light-emitting device which includes a substrate, an anode layer, a hole transmission layer, an electronic barrier layer, a light-emitting layer, an n-type doped barrier layer, an n-type doped electronic transmission layer and a cathode layer. The material of the n-type doped barrier layer is formed through mixing of an organic material and an organic metal compound, wherein the organic material is 4,7-diphenyl-o-phenanthroline or 2-(4-biphenylyl)-5-(4-tertiary butyl) phenyl-1,3,4-oxadiazole. The organic metal compound is formed through cooperation of one of beryllium, gallium, zinc, indium and aluminum and one of hydroxyquinoline, hydroxyquinoline derivative, hydroxyl benzoquinoline, and hydroxyl benzoquinoline derivative, wherein the organic material covers 30-70% of the material of the n-type doped barrier layer by mass. The organic light-emitting device is higher in light-emitting efficiency and longer in service life. Moreover, a preparation method for the organic light-emitting device is also provided.

The invention discloses an organic light-emitting device which comprises a transparent substrate, an anode, a hole transfer layer, an electron blocking layer, a light emitting layer, a hole blocking layer, an electron transfer layer and a cathode which are sequentially stacked, wherein the hole blocking layer is made from an organometallic complex, the ligand of the organometallic complex is hydroxyquinoline, hydroxyquinoline derivative, hydroxyl benzoquinoline or hydroxyl benzoquinoline derivative. The hole blocking layer of the organic light-emitting device is made from an organometallic complex, the film formation quality of the organometallic complex is good so as to be good for preventing the diffusion of a hole to the light emitting layer, and compared with a traditional organic light-emitting device, the luminous efficiency is improved. The invention further provides a preparation method of the organic light-emitting device.

The invention belongs to the field of metal ion probes, and in particular relates to an 8-hydroxyquinoline mercury ion rate type fluorescent probe and a preparation method thereof. The invention provides an 8-hydroxyquinoline derivative, wherein the molecular formula of the 8-hydroxyquinoline derivative is C20H15ClFNO. The invention also provides a preparation method of the 8-hydroxyquinoline derivative; meanwhile, the invention also provides application of the 8-hydroxyquinoline derivative or a product obtained by the preparation method to Hg<2+> detection. According to experimental detection, the compound prepared by the technical scheme provided by the invention only responds to Hg<2+> and has high specificity when serving as a fluorescent probe; when detecting the Hg<2+> at different concentrations, the compound has a good linear relation and can be applied to H<2+> quantitative detection; the compound has high sensitivity on H<2+> detection, interference of other metal ions except for the H<2-+> on the measurement result is low, and the detection method is reliable and stable. The technical defects of long response time and low detection sensitivity of mercury ion detection in the prior art are solved.

This invention provides a luminescent organic polymer metal complex represented by polyQ M K n-1 (1) which is obtained by the reaction of a polymer ligand (polyQ) with an 8-hydroxyquinoline derivative introduced to its side chain through a spacer group, an 8-hydroxyquinoline derivative ligand (K) and a divalent to tetravalent metal ion (M n+ ) wherein the 8-hydroxyquinoline derivative ligand (K) has a bulky substituent. This invention also provides a luminescent organic polymer metal complex composition comprising said luminescent organic polymer metal complex and additionally a low-molecular-weight ligand and a process for producing the same.

The invention discloses a 2-vinyl-8-bioquin derivative, which preparation method comprises that 2-bioquin-8-bioquin and aromatic aldehyde are added into acetic anhydride to be dissolved, heated, refluxed and reacted at 120-140DEG C for 40-96h, the reaction product is separated and purified via column chromatography to obtain the pure 2-vinyl-8-bioquin derivative. The inventive 2-vinyl-8-bioquin derivative has significant oxidization resistance, better than strong antioxidant glutathione GSH which can eliminate free group. The inventive product can be used to prepare antioxidant, which further can accelerate the increment of mesenchymal stem cells in bone marrow, to prepare bone marrow mesenchymal increment accelerant.

The invention relates to an organic light-emitting device comprising a substrate, an anode layer, a hole transport layer, an electron blocking layer, a light emitting layer, an electron transport layer and a cathode layer. The electron transport layer includes at least one electron transport unit including an n type blocking portion stacked on the light emitting layer and an n type doped transport portion stacked at the n type blocking portion; the n type blocking portion is made of an organic metal complex that is formed by cooperation of one of beryllium, gallium, zinc, indium and aluminum and one of hydroxyquinoline, hydroxyquinoline derivative, hydroxybenzo[h]quinoline and hydroxybenzo[h]quinoline derivative; and the n type doped transport portion is made of a material containing an electron transport matrix material and an n type doping agent doped in the electron transport matrix material. According to the invention, the provided organic light-emitting device has advantages of high luminous efficiency and long service life. In addition, the invention also provides a preparation method of the organic light-emitting device.

Die attach adhesive compositions comprise a quinolinol or a quinolinol derivative as an adhesion promoter. An exemplary quinolinol derivative has the structure:

Die attach adhesive compositions exhibit improved adhesion and conductivity by the addition of a metal salt of 8-quinolinol or of an 8-quinolinol derivative as an adhesion and/or conductivity promoter. The metal salt of 8-quinolinol or of an 8-quinolinol derivative is formed by coordination with a metal selected from the group consisting of Cu, Be, Mg, Ca, Sr, Ba, Zn, Cd, Al, Ga, In, Tl, Yt, La, Pb, Sb, Bi, Cr, Mo, Mn, Fe, Co, Ni, Pd, Ce, and Pr. Examples of quinolinol derivative salts have the structures:

The invention belongs to the technical field of medicines, and particularly relates to a 4-hydroxyquinoline derivative as well as a preparation method and application thereof, the 4-hydroxyquinoline derivative can be used as a P-gp inhibitor to reverse drug resistance of K562/AO, A549/ADM, HepG2/ADM and MCF7/ADM doxorubicin resistance with high expression of P-gp, and achieves an anti-tumor treatment effect and has prospect.