Low-toxicity iridium complexes and synthesis method and application thereof
A synthesis method and complex technology, applied in the field of medicine, can solve problems affecting patients' health and normal medical treatment, and achieve significant biological activity
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0030] Embodiment 1: the synthesis of complex Ir1
[0031] In a 100.0mL round bottom flask, add 2.0mmol of chloroquinaldol (H-QL1) and 1.0mmol of 3-methyl-2-phenylpyridine iridium dimer, then add 28.7mL of organic solvent (by 28.0mL ethanol and 0.7mL of acetone), stirred and dissolved, and reacted at 85°C until complete (about 5h), stopped the reaction, cooled to room temperature, and reddish-brown crystals were precipitated, collected and dried to obtain a reddish-brown solid product. Yield 95.3%.
[0032] The product obtained in this embodiment is characterized:
[0033] (1) X-ray single crystal diffraction
[0034] The reddish-brown crystal with perfect surface structure was measured by single crystal diffraction to determine its crystal structure. The obtained crystallographic and structural correction data are shown in Table 1 below, and the data of some bond lengths and angles are shown in Table 2 and Table 3 below. The crystal structure of reddish-brown crystals is a...
Embodiment 2
[0054] Embodiment 2: the synthesis of complex Ir1
[0055] Example 1 was repeated, except that the organic solvent was changed to consist of 1.0 mL of ethanol, 5.0 mL of DMF and 14.0 mL of dichloromethane; the reaction was changed to 35° C. (about 18 h to complete the reaction).
[0056] The result is reddish-brown crystals. Yield 90.12%.
[0057] Single crystal diffraction analysis, elemental analysis, infrared analysis and mass spectrometry analysis were performed on the product obtained in this example, and it was determined that the obtained reddish-brown crystal was the target complex Ir1.
Embodiment 3
[0058] Embodiment 3: the synthesis of complex Ir2
[0059] In a 100.0mL round bottom flask, add 2.0mmol of 5,7-dibromo-8-hydroxyquinoline (H-QL5) and 1.0mmol of 3-methyl-2-phenylpyridine iridium dimer, and then Add 20.0mL of organic solvent (consisting of 10.0mL of ethanol and 10.0mL of water), stir to dissolve, carry out the reaction at 100°C until complete (about 47h), stop the reaction, cool to room temperature, reddish-brown crystals precipitate, collect the crystals , dried to obtain a reddish-brown solid product. Yield 79.6%.
[0060] The product obtained in this embodiment is characterized:
[0061] (1) X-ray single crystal diffraction
[0062] The reddish-brown crystal with perfect surface structure was measured by single crystal diffraction to determine its crystal structure. The obtained crystallographic and structural correction data are shown in the above Table 1, and some bond length and bond angle data are shown in the following Table 5 and Table 6 respectivel...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com