228 results about "Drug side effects" patented technology

A method for assessing and analyzing one or more drugs, adverse effects and associated risks, and patient characteristics resulting from the use of at least drug of interest is disclosed. The method comprises the steps of selecting one or more cases for analysis, said cases describing the behavior between at least one drug of interest and a patient genotype; profiling statistically derived values from multiple cases related to the safety of the at least one drug, wherein at least one filter is employed for deriving said values; at least one data mining engine; and an output device for displaying the analytic results from the data mining engine. A system for performing the method is likewise disclosed.

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a therapeutically effective amount of ceruloplasmin or a functional derivative thereof. The neuroprotective composition is characterized in that it protects neuronal cells from reactive oxygen species such as .O2- and .OH. In a preferred embodiment, the neuroprotective composition further comprises an antioxidant consisting of catalase or of an amphiphilic physiological antioxidative solution comprising a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating infant jaundice. The traditional Chinese medicine composition comprises the components of isatis root, oriental wormwood, lalang grass rhizome, lysimachia christinae hance, cape jasmine, polyporus umbellatus, salvia miltiorrhiza, dandelion, plantain herb, fructus forsythiae, radix bupleuri, curcuma aromatic, polygonum cuspidatum, felwort, selfheal and liquorice. The traditional Chinese medicine composition shows a good effect on treating or preventing infant jaundice, and is low in side effect, and obviously worthy of clinical popularization.

The invention discloses a Chinese medicinal composition for treating gout and a preparation method thereof and belongs to the technical field of medicines. The Chinese medicinal composition is prepared from the following raw materials in parts by weight: 10-50 parts of edible tulip, 10-20 parts of notopterygium root, 5-20 parts of Chinese angelica, 5-15 parts of rhizoma smilacis glabrae, 5-10 parts of dried rehmannia, 5-15 parts of longhairy antenoron herb, 5-15 parts of honeysuckle, 1-10 parts of radix clematidis, 5-15 parts of medlar, 9-15 parts of the root of bidentate achyranthes, 9-15 parts of szechuan lovage rhizome, 5-15 parts of angelica root, 0.2-9 parts of kudzuvine root, 5.5-15 parts of white paeony root, 6-9 parts of glossy privet fruit and 10-15 parts of licorice root. The Chinese medicinal composition has the good treatment effect in treatment or prevention of gout, low side effects of the medicine and obvious clinical promotional value.

The invention discloses a preparation method of disulfide bond functionalized fluorescent mesoporous silica nanoparticles and application thereof and belongs to the technical field of medicines. The preparation method comprises the following steps: preparing mercapto-modified mesoporous silica nanoparticles; taking quinoline zinc and amino as modified groups, carrying out a room temperature reaction in a light-shielded manner, thereby obtaining the disulfide bond functionalized fluorescent mesoporous silica nanoparticles. The fluorescent mesoporous silica nanoparticles have the particle size of 80-150nm, are stable in fluorescent property and can serve as a nanocarrier material for delivering antitumor drugs. The drug loading capacity can be effectively improved, drug release can be controlled, and side effects of the drug are decreased, so that related cancers are effectively treated.

The invention discloses a method for predicting a drug side effect relationship based on a graph neural network. The method is used for solving the problem of how to express nodes in the network by using a deep learning method and fully considering information of edges and nodes. The method comprises the following steps: collecting drug data for preprocessing, and establishing relationships between drugs and between side effects of the drugs; constructing a drug side effect heterogeneous network model; and using a graph neural network to carry out vectorization representation on nodes and multi-relation edges in the network. According to the method, a multi-relation network is constructed, and nodes in the network are represented by utilizing a neural network; and crawling is carried out through public data of different platforms, thus features of drugs are described more comprehensively, data acquisition is convenient and rapid, the data are preprocessed and then analyzed, the miningeffect is enhanced, the quality of the mining data is improved, a heterogeneous network model capable of representing multi-modal data is constructed, a graph neural network method is used, and pointand edge information is combined.

The invention relates to the technical field of medicines and particularly relates to a traditional Chinese medicine composition for treating infantile asthma and a preparation method thereof. Aiming at the deficiency in the prior art that the existing chemical treating medicine for treating infantile asthma is great in hepatotoxicity and poor in curative effect, the invention provides the traditional Chinese medicine composition for treating infantile asthma. The traditional Chinese medicine composition for treating infantile asthma comprises the following components in parts by weight: 10-50 parts of purple perilla, 10-20 parts of scaphium scaphigerum, 5-20 parts of folium mori, 5-15 parts of aster, 5-10 parts of jasmines, 5-15 parts of poria cocos, 5-15 parts of flos farfarae, 1-10 parts of codonopsis pilosula, 5-15 parts of felworts, 9-15 parts of astragalus membranaceus, 9-15 parts of coptis chinensis, 5-15 parts of elsholtzia, 1.5-9 parts of ephedra, 5.5-15 parts of radix paeoniae alba, 6-9 parts of schisandra chinensis and 10-15 parts of liquorice. The traditional Chinese medicine composition provided by the invention has a good treatment effect in the field of treating or preventing infantile asthma, is less in side effect of medicines and has a remarkable clinical promotional value.

The invention relates to a penfluridol oral preparation with novel specifications. Each dosage unit contains 2.5 to 3 mg of penfluridol. When the medicament of the invention is used, the prior common method of taking 20 mg of the medicament is changed from once a week into once a day. The oral preparation is used for the maintenance treatment of schizophrenics after undergoing other psychotherapy and pharmacotherapy and having obviously relieved symptoms, prevents relapse, avoids the side effects of taking the medicament once a week, and is economical, effective and fewer in side effects than other maintaining medicaments.

A neuroprotective composition for protecting neuronal cells against oxidative stress and methods for using and preparing the same. More particularly, the neuroprotective composition of the invention comprises a mixture of pyruvate, antioxidant, and lipid(s) such as fatty acids. The neuroprotective composition could be used for the treatment of brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, the diminution of drugs side effects and for preservation of neuronal grafts.

The present invention relates to a method for maintaining the increased intracellular p53 level, induced by a platinum-based anticancer drug, and an application thereof and, more specifically, to a method for maintaining the increased intracellular p53 level in cells by administering a platinum-based anticancer drug and siRNA to ubiquitin ligase for p53 to a subject in need thereof in combination and sequentially, and a composition for promoting cancer cell apoptosis using the same.According to the method of the present invention, the increased intracellular p53 expression level can be maintained for a long period of time in spite of the treatment with a low-concentration platinum-based anticancer drug, thereby effectively inducing the apoptosis of cancer cells and minimizing the drug side effect caused by the administration of the platinum-based anticancer drug, and thus the present invention can be favorably used in the prevention of cancer or the development of cancer medicines.

The invention belongs to the technical field of traditional Chinese medicine and relates to a traditional Chinese medicine composite for treating haemorrhoids and the application thereof. The traditional Chinese medicine composite is prepared with portulaca oleracea, myrrh, panax pseudoginseng, mastix, rheum officinale, musk, dandelion, lonicera japonica, fresh rehmannia roots, honeysuckle stems, radix sanguisorbae, golden cypress, fructus forsythiae, pagoda tree fruits and liquorice. The traditional Chinese medicine composite is reasonable in medicine composition, remarkable effects of relieving swelling and pains, promoting blood circulation, removing blood stasis and clearing away heat and toxic materials in treating the haemorrhoids are achieved, the therapeutic effect of the composite is obvious, the medicine side effect is little, and the significant clinic promotion value is achieved.

The invention belongs to the field of synthetic drugs, and relates to an application of geniposide in alleviating side effects of glucocorticoid, and an application of compounds represented by the formula I or pharmaceutically acceptable salts, esters, or prodrugs in preparation of drugs for alleviating side effects of glucocorticoid. The molecular action mechanism of the compounds in alleviatingthe side effects of glucocorticoid drugs has important clinical significance for developing new drugs.

The invention relates to an external preparation on the skin, which has obvious effects of inflammation reduction, itching relief and sanitization; active The components contain: rhubarb, turmeric root tuber, sublimed sulfur, baical skullcap root, radix glycyrrhizae, borneol, menthol and adrenal cortex hormone; calculated as pharmacological raw materials, the weight proportion of the active components rhubarb, turmeric root tuber, sublimed sulfur, baical skullcap root, radix glycyrrhizae, borneol and menthol are: 1 to 99 portion of rhubarb, 1 to 80 portion of turmeric root tuber, 1 to 70 portion of sublimed sulfur, 1 to 20 portion of baical skullcap root, 0.1 to 18 portion of radix glycyrrhizae, 0.1 to 10 portion of borneol, 0.1 to 10 portion of menthol and 0.1 to 10 portion adrenal cortex hormone. After smeared on the illness, the preparation has strong and quick disinfectant effect, can clean and care the skin, with good safety, little adverse reaction and low recurrence rate. In particular, when the skin is injured and a chronic disease is led, the preparation can still be used repeatedly for a long time, with obvious effect, convenience in us, and without side effect of hormones medicine.

The invention belongs to the technical field of medicines, relates to a traditional Chinese medicinal composition and a preparation method of the composition, in particular to a traditional Chinese medicinal composition for treating diabetic nephropathy combined hypertensive nephropathy and a preparation method of the composition. The traditional Chinese medicinal composition aims to overcome the defects in the prior art that the chemotherapeutic drugs for treating the diabetic nephropathy combined hypertensive nephropathy is high in hepatotoxicity and poor in the curative effect. The traditional Chinese medicinal composition for treating diabetic nephropathy combined hypertensive nephropathy comprises the following components: 10-50 parts of herba epimedii, 10-20 parts of bark of eucommia, 5-20 parts of dried rehamnnia root, 5-15 parts of sealwort, 5-15 parts of the root of kudzu vine, 1-10 parts of ginseng, 5-15 parts of medlar, 9-15 parts of radix astragali, 9-15 parts of glossy privet fruit, 5-15 parts of platycodon grandiflorum, 1.5-9 parts of radix ophiopogonis, and 5.5-15 parts of pinellia ternate. The traditional Chinese medicinal composition can achieve a good curative effect for treating or preventing diabetic nephropathy combined hypertensive nephropathy, is low in side effect, and has an obvious clinical promotional value.

The invention discloses a preparation method for drug targeting controlled release nano-particle eye drops, which pertains to the preparation methods of eye preparations. The invention firstly dissolves certain portions by weight of drug and biodegradable polymer in organic solvent so as to obtain solution A; additionally, certain portions by weight of cholesterol modified chitosan is dissolved in water, and solution B is obtained by stirring and rotating; the two are mixed and stirred till the organic solvent is fully volatilized; the drug-carrying polymer nanoparticles are obtained by centrifugal separation, water washing and drying; and then the eye drops are prepared by the general preparation method of the industry of eye drops. The eye drops which are prepared by the method of the invention can ensure the effective drug treatment concentration without the need of frequent and high-concentration drug delivery, can significantly prolong the eye surface acting time of the drug and release the drug continuously and constantly, the eye surface retention time of the drug-carrying particles of the eye drops can be up to six hours, the efficacy is improved and the side effects of the drug are reduced simultaneously.

The invention belongs to the field of computer science, and discloses a biological network link prediction method based on a meta-path and a bidirectional encoder. The method comprises the following steps: constructing a multi-source heterogeneous drug information network, and simultaneously designing a plurality of semantic paths for sequence sampling to form a large-scale semantic information base; organically fusing a depth Transformer encoder and a mask language model (mask language model) to design a depth two-way encoding representation model, and effectively extracting a low-latitude representation vector of each node; and finally, carrying out biological link prediction on a disease protein association relationship, a protein-drug interaction relationship, a drug side effect association relationship and the like by utilizing an induction matrix complementation technology, so as to complete a drug research and development technical system from disease to target to drug to side effect.

The invention relates to a virus capping system polypeptide inhibitor for controlling coronavirus and a method for inhibiting the activity of the coronavirus capping system by utilizing the polypeptide inhibitor. The polypeptide inhibitor comprises the polypeptide with the following amino acid sequence: 1) an amino acid sequence shown in SEQ ID No.1, 2) a sequence which has equivalent functions, is derived from the sequence shown in SEQ ID No.1 and is obtained by replacing, adding and / or deleting one or more amino groups in the amino acid sequence shown in SEQ ID No.1, or 3) a truncated sequence of the sequence shown in SEQ ID No.1, wherein the truncated sequence at least comprises GGASCCLYCRCH. The inhibitor has extremely high specificity, overcomes the defect that the traditional virus capping system inhibitors have low specificity and simultaneously overcomes the defect that the present nonspecific treatment drugs have high side effects and are easy to cause sequelae as a guide drug for controlling coronavirus.

The invention discloses a preparation method of controlled-release aspirin powder. The preparation method of the controlled-release aspirin powder comprises the steps of preparing a hollow nanosilicon dioxide drug carrier, loading aspirin on the hollow nanosilicon dioxide drug carrier and carrying out secondary coating on the loaded aspirin. The prepared aspirin-loaded drug carrier is immersed in nanosilicon dioxide ethyl alcohol sol, and stirring or ultrasonic treatment is carried out for 0.5-1 hour, so that secondary coating is carried out on the loaded aspirin by virtue of nanosilicon dioxide particles, and the coating thickness is optimized to be 10-20nm; in simulated body fluid, the release rate of the loaded aspirin subjected to the secondary coating in 24 hours is 40-55%, and the release rate of the loaded aspirin subjected to the secondary coating in 48 hours is 70-90%. The preparation method of the controlled release aspirin powder has the advantages that the problem that the existing controlled release aspirin medicine is high in release rate is solved, long-acting controlled release and controlled release can be realized, medication is easy, and the drug side effect is reduced.

The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine composition for treating infant jaundice and a preparation method thereof, aiming to overcome the defects in the prior art that the existing chemical therapeutic medicines for treating infant jaundice have large toxicity to the liver and have poor curative effect. The traditional Chinese medicine composition for preventing or treating infant jaundice comprises the following components: turmeric, oriental wormwood, mangnolia officinalis, common yam rhizome, cape jasmine, poria, radix pseudostellariae, ginseng, wolfberry, astragalus membranaceus, coptis chinensis, rhizoma alismatis, radix ophiopogonis, radix paeoniae alba, leonurus and liquorice. The traditional Chinese medicine composition has good effect on treating and preventing infant jaundice, has low side effects, and has remarkable clinical promotion value.

The invention relates to application of hydrogen saturated saline in preparation of drugs for stabilizing atherosclerotic plaques. The application has the advantages that a novel use of the hydrogen saturated saline is provided, and besides a function of inhibiting formation of atherosclerotic plaques, other functions of the hydrogen saturated saline such as stabilizing the atherosclerotic plaques and enabling the atherosclerotic plaques to be rarely vulnerable are disclosed for the first time; the hydrogen saturated saline is simple to prepare, high in injection concentration, convenient to use, free of explosion risk, low in cost and free of side effects; animal experiment results show that the hydrogen saturated saline has great therapeutic advantages, the risk of patients with vulnerable plaques to suffer drug side effects is greatly decreased, and the medical cost is greatly lowered.

The invention discloses a targeted vesicle drug prepared through erythrocyte. The vesicle drug wraps one or more of contents of to-be-wrapped cells without containing genetic materials or drugs. The vesicle drug utilizing the erythrocyte to perform cell preparation can wrap the bioactive substances of required cells removing nucleic acid to perform delivery, so that risks such as gene recombination and gene mutation of users caused by the containing of the genetic materials in cellular vesicles can be avoided, and therefore, the vesicle drug is safer. The vesicle drug can perform targeted delivery, so that treatment effects can be enhanced; targeted modification can be performed on the cellular vesicles, so that the drug can accurately reach disease sites, therefore, treatment effects canbe enhanced, and side effects of drugs can be reduced. Thus, cellular vesicle targeting carriers and drugs with higher safety and better treatment effects can be produced on a large scale through a method.

The invention discloses an application of panax japonicus polysaccharide, total saponins of panax japonicus, panax japonicus saponin V and a composition of panax japonicus polysaccharide and total saponins of panax japonicus in preparation of medicines for preventing and treating chronic obstructive pulmonary disease. The medicine containing the components is less in side effect, is originated from a single plant, is simple in component, and is definite in curative effect for preventing and treating COPD.

The invention relates to a medicament for treating cancer pain and postoperative pain and a preparation method thereof, in particular to a pure Chinese medicinal herb preparation for treating cancer pain and postoperative pain and a preparation method thereof, which are mainly used for solving the technical problems of large side effects, high prices and poor treatment effects on patients suffering from advanced cancer pain and postoperative pain existing in the conventional medicament for treating cancer pain and postoperative pain. According to the technical scheme, the medicament for treating cancer pain and postoperative pain consists of the following components in percentage by weight: 35-45 percent of pillbug, 10-15 percent of greater celandine herb, 10-15 percent of paniculate swallowwort root, 10-15 percent of white paeony root, 5-15 percent of turmeric, 1-5 percent of centipede and 5-15 percent of unprocessed liquoric root. A preparation process comprises the following steps of: preparing the components according to the percentage by weight; adding water for decocting twice, wherein water is added in an amount that the medicament surface is submerged; combining decocted filtrates obtained in the two times; concentrating to a concentrated solution of which the specific weight is 1.1.12-1:1.4; putting into a clean stainless steel drying disk; performing vacuum drying, and smashing; and screening with a screen of 80-100 meshes to obtain a particular internal dosage form.

A system, device and method to assist users with taking their prescription medications, vitamins, insulin (alert only) and over the counter drugs are disclosed herein. The present invention assists the user with (including but not limited to): organizing their pills, taking their medication on time, taking the proper dosage of medication, providing warnings to avoid multiple / duplicative dosages, provide reminders to the user to take their medication on time, or remind them if they forgot to take their medication, and provide information regarding side effects of the medication and alert the user to dangers / risks of taking conflicting medications. The device preferably dispenses medication automatically based on pre-defined scripts and algorithms.

The invention discloses a nano-carrier material. The nano-carrier material comprises gold nano particles, a SiO2 layer wrapping the gold nano particles, and a DSPAMAM layer wrapping the SiO2 layer, and DSPAMAM is disulfide cross-linked PAMAM. The nano-carrier material is easy to prepare, preparation raw materials are easy to obtain, quantitative production is easy to realize, and the advantages ofAuNR, SiO2 and the DSPAMAM are integrated; the biocompatibility is good, and a CT imaging function and GSH responsiveness are realized; the drug and gene loading function is further realized; an anti-cancer drug, namely CUR and a functional gene (miRNA) can be efficiently co-delivered in treatment of prostatic carlcer; and RGD is used as a targeting polypeptide, the RGD polypeptide can promote enrichment of nano-materials in tumor cells, drug controlled release can be achieved, side effects of the drugs can be reduced, and efficient diagnosis and combined treatment of human prostate cancer can be further realized.

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating acute nephritis and a preparation method thereof. The traditional Chinese medicine composition for treating or preventing acute nephritis comprises the following components: 10-50 parts of fructus forsythia, 10-20 parts of gardenia jasminoides ellis, 5-20 parts of periostracum cicada, 5-15 parts of canscora melastomacea, 5-10 parts of paris polyphylla, 5-15 parts of lily, 5-15 parts of selfheal, 1-10 parts of rhizoma alismatis, 5-15 parts of medlar, 9-15 parts of fructus cnidii, 9-15 parts of ligusticum wallichii, 5-15 parts of radix angelicae, 0.2-9 parts of lalang grass rhizome, 5.5-15 parts of radix paeoniae alba, 6-9 parts of rhizoma zingiberis, and 10-15 parts of liquorice. The traditional Chinese medicine composition has excellent effect on the treatment or prevention of the acute nephritis, is low in drug side effects, and has remarkable clinical popularization value.

The invention discloses a diet intervention composite for preventing and curing recurrent oral ulceration. The diet intervention composite is prepared from the following components in percentage by weight: 22.5-67.5 of Se-enriched brown rice guangdong navigation No.1, 22.5-67.5 of polished rice guangdong navigation No.1, 2.5-6.5 of Chinese yam, 3.0-7.0 of poria and 0.3-1.5 of pericarpium citri reticulatae. A group of effective diet intervention food combination is provided for patients suffering from the recurrent oral ulceration and can be used for diet intervention food development, so that the group of diet food has the functions of promoting the healing of dental ulcer, tonifying spleen, improving unbalance of the intestinal flora, regulating inflammatory cytokine levels in the body and reducing blood fat and has laxative properties, and can effectively solve the problems of insufficiency of the spleen and constipation of patients, prevention of hyperlipidemia, reduction of prevalence rate. The food composite can be prepared into instant rice sticks, instant congees and the like, and is convenient to use, free of medicine side effects, safe to use and good in curative effect.

The invention relates to a traditional Chinese medicine plaster for preventing and treating motion sickness. The traditional Chinese medicine plaster can effectively solve the problems that the existing medicine is large in side effects and inconvenient to take. The technical scheme is as follows: the traditional Chinese medicine plaster is composed of the following raw material medicines by weight: 8-20 g of patchouli, 3-10 g of lavender, 10-30 g of lily, 8-20 g of cortex albiziae, 3-10 g of magnolia flower, 9-20 g of radix angelicae, 8-20 g of radix curcumae, 3-10 g of flos mume, 8-20 g of fingered citron, 8-20 g of rhizoma galangae and 5-20 g of acorus tatarinowii, the traditional Chinese medicine plaster disclosed by the invention has a good curative effect on motion sickness and is simple to make, low in cost and good in application cost, so that the traditional Chinese medicine plaster is an innovation on medicine for preventing and treating motion sickness.

The invention relates to a terbinafine hydrochloride solid dispersoid, which is composed of terbinafine hydrochloride and carrier materials, wherein the proportion by weight between the terbinafine hydrochloride and the carrier materials is 1 / 2-1 / 15. The invention further relates to a tablet prepared by the terbinafine hydrochloride solid dispersoid. Compared with the prior art, the terbinafine hydrochloride tablet has the advantages of (1) improving dissolution in vitro of terbinafine hydrochloride preparation; (2) solving the problem that the terbinafine hydrochloride is poor in oral administration absorption and low in biological availability; (3) covering harmful odor and irritation of the terbinafine hydrochloride; (4) keeping pesticide effects of large dose while reducing using quantity of active ingredients in the preparation per unit, and reducing drug side-effects; and (5) being simple in preparation process and suitable for industrial production.