Penfluridol-containing oral preparation and application thereof

Abstract

The invention relates to a penfluridol oral preparation with novel specifications. Each dosage unit contains 2.5 to 3 mg of penfluridol. When the medicament of the invention is used, the prior common method of taking 20 mg of the medicament is changed from once a week into once a day. The oral preparation is used for the maintenance treatment of schizophrenics after undergoing other psychotherapy and pharmacotherapy and having obviously relieved symptoms, prevents relapse, avoids the side effects of taking the medicament once a week, and is economical, effective and fewer in side effects than other maintaining medicaments.

Description

Technical field: [0001] The invention relates to an oral preparation of penfluridol, each preparation unit contains 2.5-3 mg of penfluridol, used for the maintenance treatment of schizophrenia patients, and is taken once a day, which improves the disadvantages of the original taking method and is economical. , effective, safe, no side effects and no recurrence after taking it all year round. Background technique: [0002] The main manifestations of schizophrenia are mania, paranoia, depression, fear and anxiety, auditory hallucinations, sensitivity and suspicion, obsessive-compulsive impatience, disordered thinking, nonsense, throwing things, impulsive injury, and inability to control oneself. During the illness, the patient may have an unfounded wrong idea, suspecting that someone is going to harm him, firmly believing that his spouse is having an affair, hearing someone talking about him, blaming him, threatening him, seeing strange images, smelling unpleasant smells, tryi...

AI Technical Summary

Problems solved by technology

4. Residual schizophrenia - the patient is currently free of delusions, hallucinations, or disruptive speech and behavior, but lacks motivation and interest in daily life

[0008] Therefore, if the above-mentioned drugs are used for maintenance treatment, there will be side effects in varying degrees, resulting in poor compliance of patients, and inability to take drugs for a long time, resulting in relapse

[0009] Penfluridol is an old drug that was launched in the 1960s. The current specifications are 10mg and 20mg. For the treatment of schizophrenia, the therapeutic effect is not as good as the second-generation olanzapine, risperidone, sulphate, and aripiprazole, or even inferior to the first-generation clozapine and perphenazine, and the side effects are large. The foreign instructions even The therapeutic dose was increased to 250mg, and the side effects were mostly extrapyramidal reactions, drowsiness, and elevated blood sugar.