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Preparation method of disulfide bond functionalized fluorescent mesoporous silica nanoparticles and application thereof

A technology of mesoporous silica and nanoparticles, which can be applied to preparations for in vivo tests, medical preparations with non-active ingredients, and pharmaceutical formulas, etc. Side effects, the effect of stable fluorescence properties

Inactive Publication Date: 2018-07-24
HUBEI UNIV OF TECH
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  • Abstract
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Problems solved by technology

[0004] Among them, mesoporous silica materials with fluorescent functionalized pore walls are attracting increasing attention due to their stable fluorescent properties and can be used as fluorescent probes. The abnormal death of normal cells will affect the therapeutic effect; therefore, the design and preparation of new fluorescent functionalized mesoporous silica nanoparticles with less toxicity and high stability are crucial to the realization of their application in the field of drug delivery. important

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  • Preparation method of disulfide bond functionalized fluorescent mesoporous silica nanoparticles and application thereof
  • Preparation method of disulfide bond functionalized fluorescent mesoporous silica nanoparticles and application thereof
  • Preparation method of disulfide bond functionalized fluorescent mesoporous silica nanoparticles and application thereof

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[0038] In order to better explain the present invention, the main content of the present invention is further clarified below in conjunction with specific examples, but the content of the present invention is not limited to the following examples.

[0039] The invention discloses a preparation method of fluorescent mesoporous silica nanoparticles functionalized by disulfide bonds, which comprises the following steps:

[0040] 1) Preparation of ethanol dispersion of mercapto-modified mesoporous silica nanoparticles (CMS-SH): preparation of 25wt% (mass percent) cetyltrimethylammonium chloride (CTAC) aqueous solution: take 3.5g CTAC solution In 10.5mL of water, stir vigorously at room temperature for 20 min until clear;

[0041] Take 64mL of water, 10.5mL of ethanol, and 10.4mL of 25wt% CTAC aqueous solution and stir vigorously at room temperature for 10min, add 4.125mL of triethanolamine, and continue to stir vigorously for 15min until clarification is used as the stock solution; ...

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Abstract

The invention discloses a preparation method of disulfide bond functionalized fluorescent mesoporous silica nanoparticles and application thereof and belongs to the technical field of medicines. The preparation method comprises the following steps: preparing mercapto-modified mesoporous silica nanoparticles; taking quinoline zinc and amino as modified groups, carrying out a room temperature reaction in a light-shielded manner, thereby obtaining the disulfide bond functionalized fluorescent mesoporous silica nanoparticles. The fluorescent mesoporous silica nanoparticles have the particle size of 80-150nm, are stable in fluorescent property and can serve as a nanocarrier material for delivering antitumor drugs. The drug loading capacity can be effectively improved, drug release can be controlled, and side effects of the drug are decreased, so that related cancers are effectively treated.

Description

technical field [0001] The invention relates to mesoporous silica nanoparticles, which belong to the technical field of medicine, and in particular to a preparation method and application of disulfide bond-functionalized fluorescent mesoporous silica nanoparticles. Background technique [0002] The drug controlled release system can realize the targeted release of the drug at the lesion site, improve the efficacy of the drug, and reduce the toxic and side effects of the drug. An ideal drug controlled release system requires zero release of the loaded drug before reaching the target lesion site, and release after reaching the target target. [0003] Mesoporous silica nanoparticles (MSNs) have a wide range of applications in drug delivery systems, catalysis and adsorption, protein separation, etc., especially in drug delivery systems, showing incomparable advantages: large specific surface area (>900m 2 / g) and specific pore volume (>0.9 cm 3 / g), adjustable pore size ...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K47/10A61K47/36A61P35/00A61K49/00
CPCA61K47/02A61K47/10A61K47/36A61K49/0041A61K49/0052A61K49/0093
Inventor 刘明星王瑜
Owner HUBEI UNIV OF TECH
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