229 results about "Conjunctivitides" patented technology

The compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof specifically binds CCR5, so it is useful for preventing and / or treating CCR5-related diseases, for example, various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation, immunosuppression, psoriasis, multiple sclerosis, etc.), infectious diseases (infection with human immunodeficiency virus, acquired immunodeficiency syndrome, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacterial infection diabetes cancer metastasis and so on.Wherein all symbols in formula are as defined in the specification

A cellular constituent is lysed from, produced by and / or isolated from one or more bacteria from the genus Bacteroides, and the cellular constituent, a derivative thereof, and / or one or more bacteria from the genus Bacteroides, or a modified form thereof, is employed in compositions and methods for modulating an inflammatory response. Such methods include methods of treating, delaying the onset of or reducing the symptoms of one or more inflammatory conditions / diseases, including corporal or gastrointestinal inflammation, for example, Irritable Bowel Syndrome, Crohn's Disease, or colitis, and / or associated diseases such diabetes, asthma, multiple sclerosis, cancer, rheumatoid arthritis, gingivitis, atopic diseases, for example, hay fever, food allergies, eczema, rhinitis, dermatitis, conjunctivitis, atopic syndrome and keratosis pelaris, ocular inflammatory disease, strokes, cardiovascular disease, depression, atherosclerosis and hypertension, and comprise administering a composition comprising one or more natural and / or modified bacteria of the genus Bacteroides, and / or a cellular constituent lysed from, produced by, or isolated from one or more natural and / or modified bacteria from the genus Bacteroides, or a derivative thereof.

The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and / or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders. The compositions and methods of the present invention provide significant value in terms of patient acceptability, convenience, and compliance.

The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and / or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also generally relates to pharmaceutical compositions comprising one or more active pharmaceutical ingredients, such as azelastine or pharmaceutically acceptable salts or esters thereof including azelastine hydrochloride, particularly wherein the compositions are provided in unit dosage form. In certain embodiments, the invention provides such unit dosage pharmaceutical compositions comprising azelastine hydrochloride formulated for use as nasal sprays and / or ocular solutions or drops. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of a variety of allergic and non-allergic conditions, particularly conjunctivitis, sinusitis, rhinitis and rhinosinusitis. The compositions and methods of the present invention provide significant value in terms of patient acceptability, convenience, and compliance.

The present invention relates to a novel combination of a soft steroid, in particular loteprednol, and at least one antihistamine, such as, for example, azelastine and / or levocabastine, for simultaneous, sequential or separate administration in the local treatment of allergies and airway disorders, for example of allergic rhinitis (rhinoconjunctivitis).

The present invention is an ophthalmic composition containing a relatively high concentration of olopatadine. The composition is typically an ophthalmic aqueous solution containing relatively high concentrations of olopatadine solubilized within the solution. The composition is preferably capable of providing enhanced relief from symptoms of ocular allergic conjunctivitis, particularly late phase symptoms of ocular allergic conjunctivitis.

The present invention relates to anti IL13 antibodies that hind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.

The invention discloses azithromycin gel eye drops and a preparation process thereof. The eye drops are prepared from a main medicine, namely azithromycin and excipients such as an adhesive, a gel matrix, an isotonic regulator, a preservative, an antioxidant, a buffering agent and the like. The adhesive, namely polycarbophil in the eye drops can increase the biological adhesion of the eye drops, so that the detention time of medicines in eyes is further prolonged. The invention provides a practical, convenient and reliable ophthalmic preparation for treating bacterial conjunctivitis, and solves the problems that the detention time of medicines in an eye drop formulation in the eyes is short, the medicines are not easy to absorb, the bioavailability is low and the like.

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof:are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

The invention relates to the technical field of antibodies, and especially relates to a human thymus stromal lymphopoietin monoclonal antibody and an application thereof. The TSLP antibody can be specifically combined with hTSLP, has high affinity, and can effectively inhibit the combination of TSLP and a receptor thereof so as to inhibit activation of a downstream signal path and activation of immune cells by TSLP. The TSLP antibody has great significance in detection of the content of hTSLP and allergic asthma, and diagnosis, treatment and prognosis of inflammatory or allergic inflammatory diseases such as chronic obstructive pulmonary disease, allergic dermatitis, allergic rhinitis, allergic nasosinusitis, eosinophilic granulocytic esophagitis, allergic conjunctivitis, inflammatory bowel disease or atopic dermatitis.

The present invention relates to a sterile ophthalmic composition comprising castor oil and a medium chain triglyceride, to its use in medicine, in particular for the treatment and / or prevention of an ocular disease selected from the group consisting of dry eye, conjunctivitis, dermatitis, blepharitis, entropion, floppy eyelid syndrome, thyroid ophthalmopathy, pterygium, conjunctivochalasis, epithelial damage induced by preservatives, epithelial or anterior chamber damage induced by ocular surgery, limbal cell deficiency, corneal ulcers induced by physical or chemical agents, keratitis, episcleritis and uveitis.

The present invention relates to topical ophthalmic compositions for treating or preventing epithelial lesions or ophthalmic disorders, including dry eye or keratoconjunctivitis sicca.

The invention relates to a traditional Chinese medicinal composition for treating acute infectious conjunctivitis. The traditional Chinese medicinal composition comprises, by weight, 5-25 parts of honeysuckle flower, 5-20 parts of Weeping Forsythia, 5-20 parts of Lophatherum gracile, 4-10 parts of licorice, 5-20 parts of Cypripedium margaritaceum Franch, 5-20 parts of chrysanthemum, 5-20 parts of Equisetum ramosissimum, 5-20 parts of Herba Houttuyniae, 5-20 parts of Fructus Viticis, 5-20 parts of coptis, 5-20 parts of periostracum cicadae and 5-20 parts of Flos Buddlejae. The traditional Chinese medicinal composition which has the efficacies of heat clearing and detoxifying, liver clearing and eyesight improving, wind dispelling and heat radiating, and liver calming and kidney solidifying has the advantages of substantial acute curing infectious conjunctivitis effect, reliable effect, wide component medicine sources, simple preparation, mild medicinal property, and no toxic side effect.

The invention discloses compounds having virus resistance and a composition thereof. The composition comprises one or more of the 13 compounds comprising 6'-O-caffeoyl deacetyl asperulosidic acid methyl ester. The compounds having virus resistance and the composition thereof can be extracted from plants and can also be prepared by synthesis. The composition comprising the compounds having virus resistance can prevent and treat viral infection-caused diseases such as influenza, myocarditis, conjunctivitis, viral pneumonia, encephalitis, leukemia, hepatitis B, hepatitis C, AIDS, genitourinary system infection, EB virus infection, human papillomavirus infection and cytomegalovirus infection. The composition can be prepared into an oral preparation, an injection, a spray, a subcutaneous injection and an anus suppository.

The eye drop is prepared with bear bile powder as medicine material and phosphate solution as buffering agent. It has the functions of bacteriostasis, resisting virus, strengthening eyesight, clearing away heat, etc. It is used in treating acute bacterial conjunctivitis, epidemic viral keratitis and has high curative effect and short treating period.

A composition comprises besifloxacin in an amount effective for treating or controlling an infection caused by an antibiotic-resistant bacterium. Such a composition can be administered to a subject for the treatment or control of bacterial conjunctivitis caused bay an antibiotic-resistant bacterium.

The present invention relates to an aqueous formulation to be instilled into the eye, or in which to pre soak or store an object to be inserted into the eye, such as a contact lens, an ointment, or a solid device to be inserted into the conjunctival sac. The preparations disclosed are utilized for the treatment of a tear film and ocular surface disorder known as keratoconjunctivitis sicca or dry eye syndrome. In general, the preparations of this invention are also effective for the relief of symptoms of eye irritation, such as those caused by dry environmental conditions or by contact lens wear. In accordance with the present invention, the ophthalmic preparation includes a glycomacropeptide component, similar to that found at the normal human ocular surface and in one exemplary and preferred embodiment, the glycomacropeptide is derived from mammalian milk, preferably bovine.

Embodiments of the invention relate to single nucleotide polymorphisms (SNPs) in Thrombospondin 1 gene (THB-S1) that are herein linked to an increased risk for dry eye (also known as keratoconjunctivitis). The polymorphisms disclosed herein are directly useful for the diagnosis of an increased risk for dry eye, as well as for the determination of patient treatment pre- and post-surgery (e.g. pre and post refractive eye surgery) or in a patient having a condition associate with dry eye (e.g. diabetes, lupus, scleroderma, Sjogren's syndrome, thyroid disorders, vitamin A deficiency, and rheumatoid arthritis). Computer systems and medium are also enclosed. The SNPs can be present in unique combinations, or as specific haplotypes indicative of dry eye. The SNPs linked to an increased risk for dry eye include rs1478604, rs2228261, and rs2292305.

The present invention relates to a Chinese medicine eye preparation for curing chronic conjunctivitis. It is made of the Chinese medicinal materials of lonicera flower, buddleia flower, wild chrysanthemum flower, peppermint, pearl and borneol as raw material.

The invention discloses a Chinese medicinal composition for treating conjunctivitis, belonging to the technical field of Chinese medicines. The Chinese medicinal composition is prepared from 15 parts of baikal skullcap root, 6 parts of honeysuckle flower, 10 parts of divaricate saposhnikovia root, 10 parts of virgate wormwood herb, 10 parts of szechuan lovage rhizome, 20 parts of dandelion, 20 parts of cicada shell, 10 parts of gentian, 5 parts of white paeony root, 5 parts of mint and 10 parts of liquoric root. The Chinese medicinal composition has good treatment effects on the aspect of treatment of inflammatory conjunctivitis, bacterial conjunctivitis, viral conjunctivitis and allergic conjunctivitis, and has a remarkable clinical popularization value.

The invention discloses a method for preventing or treating conjunctivitis and herpes zoster palpebral dermatitis, bear gall powder used by the method, and a preparation method of the bear gall powder. The bear gall powder can be used for regulating blood lipid, lowering total cholesterol, preventing cardiovascular and cerebrovascular diseases and preventing atherosclerosis. Materials are subjected to ice crystallization during the preparation of the bear gall powder, and then freeze drying is performed to obtain the freeze-dried bear gall powder which can be called ice-crystalized bear gall powder. The Senbao ice-crystalized bear gall powder does not contain any auxiliary materials and chemical additives, can effectively regulate the blood lipid and lower the total cholesterol, can be effectively used for preventing cardiovascular and cerebrovascular diseases and atherosclerosis and preventing and treating solid tumor and blood system tumor, and can be particularly effectively used for preventing or treating the conjunctivitis and herpes zoster palpebral dermatitis.

A low-molecular-weight polysulfated hyaluronic acid derivative useful for prevention and / or treatment of an allergic disease. An agent for prevention and / or treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB);wherein n represents a number of 0 to 15; R′s each independently represent a hydrogen atom or an SO3H group etc.

The invention discloses an ophthalmic Blumea balsamifera oil preparation and a preparation method thereof. The ophthalmic preparation comprises eye drops, an eye ointment, an ophthalmic liposome and clathrate compound eye drops. The ophthalmic Blumea balsamifera oil preparation is prepared by adopting Blumea balsamifera oil as an active effective component and adding medicinal auxiliary materials for the ophthalmic preparation, and concretely comprises 0.15-1wt% of Blumea balsamifera oil, and the balance the auxiliary materials for the ophthalmic preparation. The ophthalmic preparation can effectively treat conjunctivitis, and tests prove that the ophthalmic preparation has the advantages of no irritable inflammation reaction, safe and stable use and definite therapeutic effects.

A Chinese medicine for treating acute conjunctivitis and keratitis and relaxing visual fatigue is prepared from bear gall and borneol. Its preparing process is also disclosed.

The invention relates to a composition for preventing or treating allergic diseases by using black rice extract and the therapeutic application of the composition. More specifically, the present invention relates to a composition for preventing or treating allergic diseases, which composition contains the following substances as active ingredients: pelargonidin, cyanidin glycoside or containing pelargonidin and Black rice extract of anthocyanins; the invention also relates to the therapeutic use of said composition. Anthocyanin, anthocyanin or black rice extract containing anthocyanin and anthocyanin inhibit the aggregation of eosinophils in the tissue, and thus have an inhibitory effect on allergic inflammation, so the above substances can be effectively For the prevention or treatment of allergic diseases associated with inflammation and eosinophil accumulation, such as allergic rhinitis, allergic conjunctivitis, asthma, chronic obstructive pulmonary disease, atopic dermatitis, allergic Sexual diarrhea etc.

A low-molecular-weight polysulfated hyaluronic acid derivative useful for treatment of an allergic disease. An agent for treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB);wherein n represents a number of 0 to 15; R's each independently represent a hydrogen atom or an SO3H group etc.

The invention relates to an eye-purposed in-vivo gel preparation prepared from pH (Potential Of Hydrogen) sensitive type baicalin, which comprises the following components in parts by weight: 0.05-10 parts of baicalin, 0.1-3 parts of pH sensitive material, 0.1-10 parts of thickening agent, 0.1-10 parts of isoosmotic adjusting agent, 0.001-3 parts of preservative and 80-100 parts of buffer solution of which the pH is 5-6.2. The invention also relates to a preparation method for the eye-purposed in-vivo gel preparation prepared from the pH sensitive type baicalin, and the application of the eye-purposed in-vivo gel preparation prepared from the pH sensitive type baicalin in preparing drugs capable of preventing and / or curing conjunctivitis, keratitis or cataract.

The invention relates to a traditional Chinese medicine for treating swine fever and a preparation method thereof. The traditional Chinese medicine comprises following traditional Chinese medicine raw materials in parts by weight: cordate houttuynia, sweet wormwood, isatis root, dandelion, reed rhizome, honeysuckle flower, radix scutellariae, fructus forsythiae, patrinia herb, coix seed, Chinese yam, balloonflower root, grosvenor momordica fruit, belamcanda rhizome, earthworm, radix scrophulariae, dried rehmannia root, dried orange peel, oldenlandia diffusa and motherwort. The traditional Chinese medicine is prepared by reasonable compatibility, and by steps of sterilizing, drying, smashing, cleaning, dipping, decocting for the first time, decocting for a second time, mixing, concentrating, drying and combining. The traditional Chinese medicine has an antiviral function and functions of clearing away heat, detoxifying, relieving cough, relieving asthma, eliminating phlegm, and the like, and has good curative effects for pneumonia, enteritis, tonsillitis, conjunctivitis, and the like which are caused by viruses. The traditional Chinese medicine overcomes a reproductive disturbance problem of sicken sows. The curative rate of the traditional Chinese medicine for acute and chronic swine fever can be higher than 95%. Long-term taking of the traditional Chinese medicine can boost body immunity of pigs. The traditional Chinese medicine avoids medicine residue, guarantees the pork quality, and prevents the swine fever.