59 results about "Viral keratitis" patented technology

The invention belongs to the field of medicines and particularly relates to a new application of an iridoid glycoside compound, genipin-1-[beta]-D-gentiobioside, and a composition composed by compounding the genipin-1-[beta]-Dgentiobioside with other components as effective components for preparing antiviral drugs, antibacterial drugs, fever alleviating drugs, inflammation resistant drugs and anti-oxidizing drugs. The iridoid glycoside compound and the composition can be used for treating acute respiratory infection, flu, pneumonia, viral hepatitis type B, herpes zoster, herpes viral keratitis, viral myocarditis, Epstein-Barr virus infection, retrovirus infectious diseases and bacterial infectious diseases.

The eye drop is prepared with bear bile powder as medicine material and phosphate solution as buffering agent. It has the functions of bacteriostasis, resisting virus, strengthening eyesight, clearing away heat, etc. It is used in treating acute bacterial conjunctivitis, epidemic viral keratitis and has high curative effect and short treating period.

A traditional Chinese medicine for remedying the recrudescent herpes viral keratitis belongs to the traditional Chinese medicine for remedying the keratitis. The components contain: 20g of heterophylly falsestarwort roots, 15g of unprepared milkvetch roots, 15g of parched largehead atractylode, 10g of angelica, 10g of heartleaf houttuynia, 10g of ash barks, 10g of cicada sloughs, 10g of divaricate saposhnikovia roots, 10g of pale butterfly bush flowers and 3g of liquorice. The invention has the auxiliary prescriptions that for the patient with the serious symptom of the corneal stimulation, 15g of honeysuckle and 15g of weeping forsythia capsules are added; for the patient with the corneal stroma oedema, 12g of tuckahoe is added. The dosage materials in the prescription are all made from natural traditional Chinese herbal medicines by the traditional processing method. The materials can be easily gotten; the prescription and the preparation method are simple; the expense for preparing the medicine is low. The compatibility of the traditional Chinese herbal medicines is simple; the medicines used in the medicine prescription are all natural herbal medicines which can be conveniently gotten and used; the manufacturing method is simple; the curative effect after being taken is good; the medicine price is cheap, and the medicine is especially fit for people who live at the remote small villages away from villages and towns to use. The treatment expense for the patient with the disease of the recrudescent herpes viral keratitis is low, which solves the treatment problem, which is caused by low family income, poor living and lack of local medical treatment condition.

The invention provides a traditional Chinese medicine composition for curing herpes simplex viral keratitis. Bulk drugs of the traditional Chinese medicine composition include butterflybush flowers, eriocaulon buergerianum, flatstem milkvetch seeds, fructus broussonetiae, calamine, barks of ash, folium mori, centipeda minima, groundsel, fruit of glossy privet, isatis roots, ginseng leaves, astragalus mongholicus, radix paeoniae alba, radix bupleuri, coptis chinensis, mulberries, piemarker, leonurus, roots of red-rooted salvia, poria cocos, mile swertia, plantain herb and concha haliotidis. The traditional Chinese medicine composition for curing herpes simplex viral keratitis can be used for adjusting the immune system, improves the immunologic function, is anti-inflammatory and antiviral, effectively avoids recurrence, and has the advantages of improving the curative effect, shortening the treatment course, reducing the recurrence rate and complication and quickening the vision recovery compared with simple western medicine treatment.

The invention belongs to the field of medicines, relates to compound eye drops and a preparation method thereof, and concretely relates to compound eye drops treating viral keratitis, viral conjunctivitis, acute and chronic conjunctivitis and other eye diseases and a preparation method of the eye drops. The eye drops comprise the following medicinal compositions: 50-500 g of radix isatidis, 50-500 g of folium isatidis, 50-500 g of herba dendrobii, and 0.1-1 g of vitamin B12 powder. The compound eye drops have the advantages that the employed medicines accord with stipulation of Chinese pharmacopoeia and are safe and reliable. The medicines are compatible with each other, and the compound eye drops have the efficacy of resisting inflammation, resisting allergy and nourishing cornea tip trigeminal nerve, and have the characteristics of definite therapeutic effect, rapid effectiveness, high cure rate, no side effect and the like.

The invention relates to a medicinal preparation for treating virus ceratitis and its preparing process, wherein the preparation is made from fifteen kinds of Chinese medicinal herbs including selfheal, feather cockscomb seed, butterflybush flower, cape jasmine, wild chrysanthemum flower, radix paeoniae rubrathe, bark of peony root, Ligusticum wallichii, capsule of weeping forsythia, arctium fruit, honeysuckle flower, mentha, plantain seeds and herba equiseti hiemalis.

The present invention provides a traditional Chinese medicine preparation for treating senile cataract and viral keratitis, which is characterized in being prepared from traditional Chinese medicine raw materials according to parts by weight: 2-15 of self-heal, 2-10 of croton crassifolius geisel, 2-15 of pipewort flos eriocauli, 3-15 of scouring rush, 3-10 of vespertilio superans, 2-15 of chrysanthemum, 3-15 of wolfberry fruit, 2-15 of Chinese dodder, 3-15 of Chinese atractylodes rhizome, 5-20 of Danshen root, 3-15 of dalbergia wood, and 3-15 of logwood. The invention has special good effect on senile cataract caused by deficiency of the liver and the kidney, insufficiency of essence and blood, insufficiency of the spleen, stagnated heat of the liver channel, and the like. The statisticaldata of using the invention to treat 326 eyes shows that the vision of 316 eyes is enhanced, and the total effective rate is 96.9%, wherein, for outstanding treatment effect, the vision of 209 eyes are enhanced by 3-5 rows, and the effective rate is 64.1%; and for effective treatment, the vision of 107 eyes is enhanced by 1-2 rows, and the effective rate is 32.8%.

Disclosed is a common ocular surface disease diagnosis system based on an intelligent terminal. The common ocular surface disease diagnosis system comprises an information acquisition module, a data processing module and a diagnosis and treatment suggestion module, wherein the information acquisition module is installed on the intelligent terminal, and comprises an image acquisition unit, a questionnaire acquisition unit and a basic information acquisition unit; the data processing module is connected with the information acquisition module, and comprises a questionnaire processing module andan intelligent picture classification module, wherein the questionnaire processing module is used for receiving the questionnaire information input by the questionnaire acquisition unit and giving a corresponding ocular surface disease evaluation score; the intelligent picture classification module is used for classifying the input ocular surface pictures by using an ocular surface model stored inthe intelligent picture classification module or in a cloud end, and obtaining classification results of normal ocular surface, viral keratitis, bacterial keratitis, fungal keratitis, pterygium, conjunctivitis and ocular surface tumors; and the diagnosis and treatment suggestion module is connected with the data processing module, receives the evaluation score of the questionnaire processing module and / or the classification result of the intelligent picture classification module, and outputs a corresponding diagnosis and treatment suggestion according to the evaluation score and / or the classification result.

The invention relates to a traditional Chinese medicine for treating herpes zoster and herpes simplex viral keratitis. The traditional Chinese medicine is capable of solving the problem of drug use of herpes zoster and herpes simplex viral keratitis. According to the technical scheme, the traditional Chinese medicine is produced through medicine raw materials of, by weight, 8g to 12g of coptis roots, 5g to 7g of rhubarb, 13g to 17g of radix scutellariae, 13g to 17g of chrysanthemum, 25g to 35g of periostracum cicada, 10g to 14g of radix saposhnikoviae, 13g to 17g of feather cockscomb seeds, 13g to 17g of angelica sinensis, 10g to 14g of peach kernels, 8g to 12g of red flowers, 5g to 7g of scorpio, 10g to 14g of lumbricus and 5g to 7g of liquorice. The traditional Chinese medicine is rich in material, low in price, provided with effects of dehumification and detoxification, heat clearing and eye brightening and meridian activation and pain stopping, capable of being used for treating herpes zoster and herpes simplex viral keratitis effectively, good in treatment effect, safe in use and innovative in herpes zoster and herpes simplex viral keratitis treatment medicine.

The invention discloses an external medicine for treating keratitis, especially for treating viral keratitis, comprising borneol, pearls, natural indigo, musk, bear bile, bezoar, calamine, cuttlebone as raw materials, processed by grinding into powder mixture, with obvious drug effect and short administration time, low recurrence rate.

The invention relates to a traditional Chinese medicine for treating viral keratitis. The invention belongs to a Chinese herbal medicine and an extracting medicine thereof, namely, a traditional Chinese medicine used for treating the viral keratitis, which in particular relates to a traditional Chinese medicine which is taken orally and applied externally for treating the viral keratitis. The invention provides a traditional Chinese medicine for treating the viral keratitis, with combination of oral taking and external application, good curative effect and no side effect. The invention comprises the following decoction raw material medicines: 6-13g of honeysuckle, 10-15g of radix isatidis, 9-15g of self-heal, 3-10g of root-bark of tree peony, 10-15g of wild chrysanthemum flower, 10-30g of dandelion, 3-10g of plantain seed, 3-15g of astragalus root, 3-10g of white peony root, 10-30g of kernel of Job stears, 9-15g of radix codonopsis pilosulae, 3-9g of angelica, 9-15g of one-leaf wormwood, 9-15g of mahonia stem, 10-20g of giant knotweed, 5-9g of spica schizonepetae, 3-10g of cicada slough, 3-6g of radix platycodi, 10-15g of radix puerariae, 10-15g of sophora flower, 6-12g of vegetable sponge and 3-10g of rehmannia root; the orally-taken traditional Chinese medicine decoction for treating the viral keratitis is cautious for a pregnant woman to use.

The invention relates to the technical field of organisms, and particularly relates to a loop-mediated isothermal amplification (LAMP) primer group for amplifying an I-type herpes simplex virus and a kit and application thereof. The primer group comprises six primers of nucleotide sequences shown in SEQ ID NO:1-6. The invention also provides a kit for detecting a herpes virus I (HSV-I), and a method for detecting the HSV-I in a non-diagnostic target. An experiment proves that the primer provided by the invention is subjected to the HSV-I detection, and the accuracy can be up to 100%. No false positive phenomenon is generated in the process of utilizing a clinical common virus as a contrast to detect. Furthermore, the sensitivity of the primer provided by the invention in the HSV-I detection can be up to 101 copies / mu L. Thus, the LAMP primer group and the kit are applicable to quick diagnosis of diseases such as HSV-I viral keratitis, HSV-I viral conjunctivitis and HSV-I viral retinitis by clinics and primary physicians.

An eyedrops of matrine for treating bacterial or viral keratitis and conjunctivitis, xerophthalmia, and eyeground arteriosclerosis is prepared through heating the water for injection, stirring while adding matrine and sodium chloride, regulating pH=6.5-7.5, stirring while sequentially adding ethyl p-hydroxybenzoate, sodium hyaluronate and the water for injection, boiling, aseptic filtering, cooling, and loading in containers.

The invention discloses human normal corneal epithelium cells and an application thereof. The cells are named as human normal corneal epithelium cells HNCEC / HL-008, and preservation number of the human normal corneal epithelium cells is CCTCC NO: 201550. The cell strain is prepared from a para-pterygium normal limbal tissue sample excised from an operation on a pterygium patient; based upon karyotype analysis, the cells are identified as human normal diploid cells; the cells, observed under a microscope, are represented as epithelial cells which are closely distributed, clear in cell boundary, strong in three-dimensional effect and polygonal; the cells can constantly maintain a uniform morphology for 65 days and can still achieve normal growth under a proliferative status, and the cells, under a three-dimensional culture condition, have a normal differentiation function. The human normal corneal epithelium cells are applicable to physiological research of human normal cells, drug toxicity research and detection of in-vitro normal cells as well as pathogenesis research of cornea and related cornea diseases including viral keratitis.

The invention provides a new hydrochloric acid 2-(1-ethyl propyl) moroxydine which can be obtained by chemical synthesis and has the advantages of low price of needed raw materials, easily obtained raw materials, simple and convenient preparation method, higher yield and suitability for industrialized production. The pharmacological activity experiment proves that compared with hydrochloric acid moroxydine, the hydrochloric acid 2-(1-ethyl propyl) moroxydine has the remarkably enhanced activity of in vivo resisting hepatitis B virus, hepatitis C virus, influenza virus, pneumovirus and herpes simplex virus, and the toxicity is one time lower than that of the hydrochloric acid moroxydine. Therefore, the new hydrochloric acid 2-(1-ethyl propyl) moroxydine can be applied to prepare antiviral drugs, especially anti-flu drugs, hepatitis C resisting drugs, hepatitis B resisting drugs, pneumovirus resisting drugs and herpes simplex viral keratitis resisting drugs.

The invention relates to a traditional Chinese medicine for treating viral keratitis. The traditional Chinese medicine is prepared from raw medicinal materials in parts by weight as follows: 12 parts of divaricate saposhnikovia roots, 15 parts of notopterygium roots, 15 parts of cicada sloughs, 15 parts of platycodon roots, 15 parts of cape jasmine fruits, 12 parts of Chinese angelica and 12 parts of red peony roots. Clinical experiments prove that the traditional Chinese medicine can treat the viral keratitis safely and effectively.

The eye drop is prepared with bear bile powder as medicine material and phosphate solution as buffering agent. It has the functions of bacteriostasis, resisting virus, strengthening eyesight, clearing away heat, etc. It is used in treating acute bacterial conjunctivitis, epidemic viral keratitis and has high curative effect and short treating period.

The present invention is one kind of eye drop containing zedoary oil and its preparation process. The eye drop consists of zedoary oil, solubilizer, absorption promoter, biological adhesive, isoosmotic regulator, bacteriostat and solvent. It has antiviral effect, antibiotic effect, antiphlogistic effect and effect of promoting body's immune reaction, so that it may be used to treat various kinds of viral keratitis. The present invention has high curative effect, simple preparation process and excellent application foreground, and the preparation process is suitable for industrial production.

The invention discloses an oral medicine for treating viral keratitis and a preparation method for the oral medicine. The medicine is prepared from the following components in parts by mass: 1-3 parts of fructus forsythia, 1-3 parts of honeysuckle flower, 1-3 parts of mint, 1-3 parts of dandelion, 1-3 parts of platycodon grandiflorum, 1-3 parts of schizonepeta, 1-3 parts of fried mulberry bark, 1-3 parts of bamboo leaves, 1-3 parts of liquorice, 1-3 parts of reed rhizome, 1-3 parts of folium mori, 1-3 parts of chrysanthemum, 1-3 parts of akebiaquinata, 1-3 parts of scutellaria baicalensis and 1-3 parts of felwort. The preparation method for the medicine comprises the following steps: purchasing high-quality and clean first-class fructus forsythia, honeysuckle flower, mint, dandelion, platycodon grandiflorum, schizonepeta, fried mulberry bark, bamboo leaves, liquorice, reed rhizome, folium mori, chrysanthemum, akebiaquinata, scutellaria baicalensis and felwort according to the mass parts, respectively removing the impurities and dust, putting into a medicine bag, and tying up the opening of the bag; soaking the tied medicine bag in cold boiled water for half an hour, subsequently putting the soaked medicines and the clear liquor for soaking the medicines into an integrated drug-decocting machine, and adding a proper amount of cold boiled water for boiling twice, wherein boiling is carried out for 35 minutes for a first time, then the decoction is filtered, slight hot boiled water is added, boiling is carried out for 25 times for a second time; mixing the decoctions, and concentrating the decoctions to be 1710 ml of 50% traditional Chinese medicine decoction.

The invention relates to a viral keratitis treating decoction drug and a preparation method thereof, wherein the drug comprises, by mass, 1-3 parts of forsythia suspensa, 1-3 parts of lonicera japonica, 1-3 parts of peppermint, 1-3 parts of platycodon grandiflorus, 1-3 parts of nepeta cataria, 1-3 parts of stir-fried mulberry bark, 1-3 parts of dandelion, 1-3 parts of bamboo leaf, 1-3 parts of licorice root, 1-3 parts of rhizoma phragmitis, 1-3 parts of mulberry leaf, 1-3 parts of chrysanthemum, 1-3 parts of caulis akebiae, 1-3 parts of gentiana scabra bunge, and 1-3 parts of scutellaria baicalensis. The preparation method comprises: selecting high-quality and clean grade-one forsythia suspensa, lonicera japonica, peppermint, platycodon grandiflorus, nepeta cataria, stir-fried mulberry bark, dandelion, bamboo leaf, licorice root, rhizoma phragmitis, mulberry leaf, chrysanthemum, caulis akebiae, gentiana scabra bunge, and scutellaria baicalensis, respectively removing impurities and dust, loading into a drug bag, bundling the opening for spare, placing the obtained drug bag into clean water, soaking for about half an hour, placing the soaked drug into a drug decocting machine by adopting the permeating of the water into the drug organization as the degree, injecting cold boiled water until the cold boiled water level 42 mm higher than the drug level, carrying out primary boiling for 35 min, filtering to take the drug liquid, injecting slightly-warm boiling water, carrying out secondary boiling for 30 min, and carrying out merged concentration to obtain 1665 ml of the 50% traditional Chinese medicine liquid.

A quick-acting eye drops without irritation and drug tolerance for treating conjunctivitis, trachoma, keratitis, dacryocystitis, visional fatigue, etc is prepared from coptis root, pale butterflybush flower and monoxydine hydrochloride. Its advantages are high curative effect and quickly taking its effect.

The invention discloses swine bile phthalate eye drops, consisting of the following compounds in percentage by weight: 0.1%-3% of swine bile phthalate, 0.1%-5% of thickening agent, 0.6%-0.85% of sodium chloride, 0.01%-0.1% of ethyl-para-hydroxybenzoate, and the balance of water for injection; and the thickening agent is one or more of sodium hyaluronate, methylcellulose and carbomer. Moreover, the invention further discloses a preparation method of the eye drops. According to the bile phthalate eye drops, swine bile phthalate is used as a main compound for preparing the swine bile phthalate eye drops according to the preparation requirement of eye drops; the preparation technology is simple and reasonable; the prepared eye drops is stable in performance, safe and reliable, has antivirus and anti-inflammatory effects, and is used for clearing heat and detoxicating, calming the liver and improving eyesight, and treating viral keratitis and conjunctivitis caused by liver-fire flaming and hot eye hurting symptoms; and the product has the characteristics of determined curative effect, little toxic or side effect, little irritation, and the like, and is suitable for clinical application and industrial large-scale production.

The invention discloses an ophthalmic gel for treating herpes simplex viral keratitis. The ophthalmic gel comprises five raw and auxiliary materials of ganciclovir, honeys, a mixture of polyethylene glycol 400 and polyethylene glycol 4000 and polysorbate 80. The ophthalmic gel is prepared by using new technologies of modern preparations and has stronger anti-herpes simplex viral actions and more obvious pesticide effects of promoting healing, repairing and regenerating of cornea than similar products, and the ophthalmic gel is safe for patients to take during usage.

The invention discloses an externally applied traditional Chinese medicine composition used for treating viral keratitis, and belongs to the field of drugs used for treating keratitis. The externally applied traditional Chinese medicine composition is prepared from, by weight, 20 to 30 parts of elephantopus scaber, 10 to 20 parts of thesium chinense, 10 to 20 parts of chamomile, 5 to 10 parts of herba asari, 1 to 5 parts of halloysitum rubrum, 10 to 20 parts of radix polygalae, 8 to 15 parts of rhizoma paridis chinensis, 10 to 20 parts of oldenlandia diffusa, 10 to 20 parts of herba scutellariae barbatae, 8 to 15 parts of rhizoma polygoni cuspidati, 5 to 10 parts of corydalis bungeana, 10 to 20 parts of spica prunellae, 10 to 20 parts of emilia sonchifolia, 8 to 15 parts of radix prismatomeris connatae, 10 to 20 parts of caulis Lonicerae, 8 to 15 parts of radix tinosporae, 5 to 10 parts of pseudo-ginseng, 8 to 15 parts of mulberry leaf, 5 to 10 parts of fructus chaenomelis, and 5 to 10 parts of lignum sappan. The externally applied traditional Chinese medicine composition is applied to human body main and collateral channels, is capable of reaching the deep of focus of infection, clearing heat and cooling blood, detoxifying and inducing dieresis, removing edema and dispersing blood stasis, clearing liver fire, tranquilizing the mind and promoting the intelligence, removing nebula, improving immunity, and treating both manifestation and root cause of diseases; and no recurrence is caused.

The invention discloses a tree shrew herpes simplex keratitis (HSK) model building and evaluating method and application. Tree shrews are inoculated and infected with herpes simplex viruses (HSV-1) through eyes, a tree shrew HSK model is built, infection, virus incubation and reactivation of tree shrew eye tissue are researched and analyzed through silt-lamp examination, qPCR, qRT-PCR, immunohistochemistry, in-situ hybridization, in-vitro co-culture experiments, tissue live virus detection and viral genome quantification and other methods, and effectiveness and practicability of the tree shrew HSK model are identified and assessed. The tree shrew HSK model is built successively for the first time, infection of human being viral keratitis can be simulated better, and a better experimental animal model can be provided for a herpes simplex keratitis infection mechanism, antiviral drug evaluation and treatment research. The animal model is good in repeatability and stability; the building and evaluating method is easy to operate, the technology and equipment requirement is low, and the success rate is high.

Disclosed is a traditional Chinese medicine formula for treating viral keratitis. The formula is characterized by comprising components of: 20g of each of stamen nelumbinis, sparrow droppings, wild chrysanthemum flower, and polygala tenuifolia; 18g of each of notopterygium root, folium isatidis, blighted wheat and dried orange peel; 15g of each of fructus tribuli, sharpleaf galangal fruit, and motherwort fruit; 12g of each of dried radix rehmanniae, rheum officinale, fructus forsythia, and schizonepeta; 10g of each of mulberry leaf, raw artemisia argyi, and raw rhubarb; 8g of each of cordate houttuynia, arisaema heterophyllum, and rhizoma arundinis donacis; and 5g of isatis root. An application method comprises: grinding the medicinal materials into fine powder according to a ratio; adding a proper amount of honey for uniform mixing; externally applying 10g of the mixed medicine to a temple ipsilateral to the eye with viral keratitis, and covering the temple with gauze; and changing the medicine once a day. One treatment course is five days. According to the invention, problems that the existing conventional traditional Chinese medicine formula for treating viral keratitis is unsatisfactory in a therapeutic effect and long in therapy time; the viral keratitis is hard to cure and easily recurs; and there will be a risk of blindness for improper use of the medicine are overcome. The traditional Chinese medicine formula in the invention is suitable for treating viral keratitis.

The invention provides a pellet for oral administration and external use, and relates to a pharmaceutical preparation, in particular to a pellet preparation for both oral administration and external use. The invention also relates to a preparation method of the pellet preparation. The pellet preparation is prepared by the combination of the following pharmaceutical components: 20-90g of calamine (calcined), 6-30g of borneol, 35-90g of gentian extract, 1-4g of myrrh (prepared), 3-8g of musk, 4-20g of borax (calcined), 1-4g of mirabilite, 1-4g of natrii sulfas exsiccatus, 1-4g of mastic (prepared), 5-15g of alumen (calcined), 40-90% ethanol, 35-146g of MCC and 3.5-14.6g of micronized silica gel. The pellet preparation is a Chinese patent preparation for both oral administration and external use, is generally for external use in ophthalmology, and has curative effects of improving symptoms and traditional Chinese medical syndromes on viral keratitis (punctate keratitis), pterygium, acute and chronic catarrhal conjuntivitis and trachoma, thereby being an effective and safe traditional Chinese medicine preparation.