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Ophthalmic gel for treating herpes simplex viral keratitis and preparation method of ophthalmic gel

A technology of viral keratitis and ophthalmic gel, which is applied in antiviral agents, sensory diseases, aerosol delivery, etc., can solve problems such as difficult to control HSK recurrence, cannot effectively promote corneal repair, etc., and achieve significant healing effect , no adverse reactions, the effect of inhibiting replication

Inactive Publication Date: 2012-11-07
何群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention only provides an ophthalmic gel for treating herpes simplex virus keratitis by overcoming the problem that existing antiviral drug preparations cannot effectively promote corneal repair, healing and regeneration, and it is difficult to control the recurrence of HSK

Method used

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  • Ophthalmic gel for treating herpes simplex viral keratitis and preparation method of ophthalmic gel
  • Ophthalmic gel for treating herpes simplex viral keratitis and preparation method of ophthalmic gel
  • Ophthalmic gel for treating herpes simplex viral keratitis and preparation method of ophthalmic gel

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Experimental program
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Embodiment Construction

[0048] Below in conjunction with chart and embodiment the present invention will be further described.

[0049] 1. Prescription of Xinmuan Eye Gel (1000 sticks, each stick contains 2g)

[0050]

[0051]

[0052] 2. Process steps

[0053] First prepare the PEG matrix melt, heat PEG4000 in a 70°C water bath to above the melting point to make it into a liquid state, add PEG400 and mix evenly under heat preservation to make it mutually soluble to form a transparent liquid heat preservation. In addition, ganciclovir was crushed into fine powder, passed through a 200-mesh sieve, accurately weighed, placed in a mortar, added polysorbate-80 to grind to make it evenly dispersed, then added honey to grind into a thick milky fine and uniform state, and finally The transparent liquid made by melting and mixing with PEG400 and PEG4000 is gradually added to the above-mentioned thick milky fine homogeneous substance according to the method of equal increase, and then fully ground to mak...

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Abstract

The invention discloses an ophthalmic gel for treating herpes simplex viral keratitis. The ophthalmic gel comprises five raw and auxiliary materials of ganciclovir, honeys, a mixture of polyethylene glycol 400 and polyethylene glycol 4000 and polysorbate 80. The ophthalmic gel is prepared by using new technologies of modern preparations and has stronger anti-herpes simplex viral actions and more obvious pesticide effects of promoting healing, repairing and regenerating of cornea than similar products, and the ophthalmic gel is safe for patients to take during usage.

Description

technical field [0001] The invention belongs to the field of ophthalmic preparations of Chinese and Western medicines, and in particular relates to the preparation and application of ophthalmic gels in the field of ophthalmic preparations. technical background [0002] Herpes simplex keratitis (HSK) is one of the most serious infectious eye diseases in the world today. The visual function is seriously endangered due to repeated attacks, and there is no effective drug to control the recurrence clinically, so it has become a major blinding eye disease. [0003] Among the drugs for the treatment of HSK, ganciclovir (GCV) is one of the most effective drugs among the existing anti-herpes simplex virus (HSV-1) drugs. immune inflammatory response; and poor effect on corneal repair, healing and regeneration. [0004] Scholars, researchers, and clinicians at home and abroad have done a lot of work to solve this worldwide problem, such as: adopting the method of combined application...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/522A61P31/22A61P27/02
Inventor 何群张湘晖张明亮张健伍参荣赵碧清王适
Owner 何群
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