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Antiviral eye drop containing zedoary oil

A technology of eye drops and curcuma oil, applied in the field of ophthalmic antiviral infection treatment, can solve problems such as drug resistance and difficult treatment, achieve long residence time, good social and economic benefits, avoid gastrointestinal irritation and other Effects of side effects

Inactive Publication Date: 2007-03-21
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drug resistance often occurs when antiviral drugs are used alone in clinic, and the treatment is quite difficult

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Prescription: Curcuma Oil 2g

[0009] Polyethylene glycol hydrogenated castor oil 10g

[0010] Hydroxypropyl-β-cyclodextrin 30g

[0011] Hydroxypropyl Methyl Cellulose 40g

[0012] borneol 0.5g

[0013] Ethylparaben 0.3g

[0014] Add water for injection to 1000mL

[0015] Preparation process:

[0016] (1) Weigh the prescribed amount of hydroxypropyl methylcellulose, sprinkle it in 600mL water for injection, and let it swell and dissolve naturally.

[0017] (2) Weigh the prescribed amount of ethylparaben, dissolve it in about 100mL of hot water for injection, let it cool, add it to the above-mentioned hydroxypropyl methylcellulose, stir, and mix well. called liquid A.

[0018] (3) Take 500 mL of the above liquid A, add the prescribed amount of hydroxypropyl-β-cyclodextrin, heat and stir to dissolve, filter with a microporous membrane, add the prescribed amount of curcuma oil and polyethylene glycol hydrogenated castor oil to the filtrate, Stir at a constant tempe...

Embodiment 2

[0021] Prescription: Curcuma Oil 1g

[0022] Hydroxypropyl-β-cyclodextrin 25g

[0023] Hydroxypropyl Methyl Cellulose 46g

[0024] Sodium chloride 90g

[0025] Thimerosal 0.2g

[0026] Add water for injection to 1000mL

[0027] Preparation process:

[0028] (1) Put 25g of β-cyclodextrin in a beaker, add about 750ml of distilled water, heat to 80°C on a magnetic stirrer, stir to dissolve, slowly add 1g of zedoary oil under stirring (about 1000r / min), and keep warm Stir at 50°C to 80°C for 2 hours; stop heating and continue to stir to room temperature to obtain a solution of zedoary oil-hydroxypropyl-β-cyclodextrin inclusion compound.

[0029] (2) Take the above-mentioned zedoary oil-hydroxypropyl-β-cyclodextrin inclusion compound solution, add 90g of sodium chloride, 0.2g of thimerosal, add distilled water to 1000ml, stir and dissolve, filter with a 0.22μm filter membrane, and pack separately, namely have to.

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PUM

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Abstract

The present invention is one kind of eye drop containing zedoary oil and its preparation process. The eye drop consists of zedoary oil, solubilizer, absorption promoter, biological adhesive, isoosmotic regulator, bacteriostat and solvent. It has antiviral effect, antibiotic effect, antiphlogistic effect and effect of promoting body's immune reaction, so that it may be used to treat various kinds of viral keratitis. The present invention has high curative effect, simple preparation process and excellent application foreground, and the preparation process is suitable for industrial production.

Description

Technical field [0001] The invention relates to an effective part of a traditional Chinese medicine - curcuma oil - which is made into a viscous eye drop for the first time, and is applied to the treatment of ophthalmic antiviral infection. Background technique [0002] Viral keratitis is corneal inflammation caused by viral infection. Herpes simplex virus keratitis and herpes zoster virus keratitis are the most common and seriously endanger visual function. Herpes simplex virus keratitis often has a history of relapse. It is characterized by protracted course of disease, ineffectiveness of antibiotic treatment, exacerbation of the condition by application of adrenal corticosteroids, and specific relapse inducement; herpes zoster virus keratitis is characterized by strings of beads appearing on the skin along the distribution area of ​​the trigeminal nerve endings. Herpes is mostly limited to the distribution area of ​​the first branch of the trigeminal nerve, and the skin l...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K47/40A61P31/12A61P27/02
Inventor 李校堃项琪姚崇舜
Owner WENZHOU MEDICAL UNIV
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