Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Swine bile phthalate eye drops and preparation method thereof

A technology of bile salts and eye drops, which is applied in the field of medicine, can solve the problems of limited clinical application, high price, and limited sources of bear bile powder, and achieve the effects of less toxic side effects, less irritation, and stable performance

Active Publication Date: 2012-11-14
陕西靓双瞳医疗科技发展有限公司
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limited source and high price of bear bile powder, its clinical application is more and more limited.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The porcine bile salt eye drops of the present embodiment consists of the following components by weight percentage: 0.1% of porcine bile salt, 0.1% of thickener, 0.6% of sodium chloride, 0.01% of ethyl p-hydroxybenzoate, and the balance It is water for injection; the thickener is sodium hyaluronate;

[0023] The preparation method of described porcine bile salt comprises the following steps:

[0024] Step 1, filter the pig bile, then add 5 times the volume of the filtrate to the filtrate to clarify the saturated lime water, filter with a filter cloth after boiling for 40 minutes;

[0025] Step 2, the pH value of the filtrate boiled and filtered in step 1 is adjusted to 2 with hydrochloric acid, and bile acid is separated out;

[0026] Step 3, wash the bile acid described in step 2 with water, then dissolve the cleaned bile acid in absolute ethanol, filter, add an alkaline solution to the filtrate to adjust the pH value of the filtrate to 9, and adjust the pH value Th...

Embodiment 2

[0030] The porcine bile salt eye drops of the present embodiment is made up of the following components by weight: 3% porcine bile salt, 5% thickening agent, 0.85% sodium chloride, 0.1% ethyl p-hydroxybenzoate, and the balance It is water for injection; the thickener is methyl cellulose;

[0031] The preparation method of described porcine bile salt comprises the following steps:

[0032] Step 1, filter the pig bile, then add 4 times the volume of the filtrate to the filtrate to clarify the saturated lime water, filter with a filter cloth after boiling for 20 minutes;

[0033] Step 2, the pH value of the filtrate boiled and filtered in step 1 is adjusted to 3 with hydrochloric acid, and bile acid is separated out;

[0034] Step 3, wash the bile acid described in step 2 with water, then dissolve the cleaned bile acid in absolute ethanol, filter, add an alkaline solution to the filtrate to adjust the pH value of the filtrate to 10, and adjust the pH value The filtrate is boile...

Embodiment 3

[0038] The porcine bile salt eye drops of the present embodiment is made up of the following components by weight: 0.5% porcine bile salt, 0.5% thickening agent, 0.8% sodium chloride, 0.08% ethyl p-hydroxybenzoate, and the balance It is water for injection; the thickener is carbomer;

[0039] The preparation method of described porcine bile salt comprises the following steps:

[0040] Step 1. Filter the pig bile, then add 4.5 times of the volume of the filtrate to the filtrate to clarify the saturated lime water, and filter it with a filter cloth after boiling for 30 minutes;

[0041] Step 2, the pH value of the filtrate boiled and filtered in step 1 is adjusted to about 2.5 with hydrochloric acid, and bile acid is separated out;

[0042] Step 3, wash the bile acid described in step 2 with water, then dissolve the cleaned bile acid in absolute ethanol, filter, add an alkaline solution to the filtrate to adjust the pH value of the filtrate to about 9.5, and adjust the pH value...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses swine bile phthalate eye drops, consisting of the following compounds in percentage by weight: 0.1%-3% of swine bile phthalate, 0.1%-5% of thickening agent, 0.6%-0.85% of sodium chloride, 0.01%-0.1% of ethyl-para-hydroxybenzoate, and the balance of water for injection; and the thickening agent is one or more of sodium hyaluronate, methylcellulose and carbomer. Moreover, the invention further discloses a preparation method of the eye drops. According to the bile phthalate eye drops, swine bile phthalate is used as a main compound for preparing the swine bile phthalate eye drops according to the preparation requirement of eye drops; the preparation technology is simple and reasonable; the prepared eye drops is stable in performance, safe and reliable, has antivirus and anti-inflammatory effects, and is used for clearing heat and detoxicating, calming the liver and improving eyesight, and treating viral keratitis and conjunctivitis caused by liver-fire flaming and hot eye hurting symptoms; and the product has the characteristics of determined curative effect, little toxic or side effect, little irritation, and the like, and is suitable for clinical application and industrial large-scale production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pig bile salt eye drop and a preparation method thereof. Background technique [0002] Viral keratitis and conjunctivitis are common ophthalmic diseases, caused by a variety of viruses, highly contagious, and easily co-infected with other diseases. The most common clinical viral keratitis and conjunctivitis mainly include herpes simplex, herpes zoster, epidemic keratitis and conjunctivitis. [0003] Herpes simplex keratitis is the most common viral keratitis with a high incidence. Because of its clinical characteristics such as easy recurrence, protracted healing, and resistance to drug treatment, it is a major blinding eye disease and has become one of the most troublesome eye diseases for ophthalmologists. [0004] Epidemic keratitis and conjunctivitis is a worldwide widespread eye infectious disease, which has a wide incidence in recent years. Its clinical fea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/575A61K9/08A61P27/02A61P31/12A61P31/22C07J9/00
Inventor 王养正朱秀萍潘士印刘先宁杨华银勇肖湘华
Owner 陕西靓双瞳医疗科技发展有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com