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Matrine eye drip liquid, and producing method

A technology of matrine and eye drops, which is applied in the field of human medicine and can solve the problems of large volume, inconvenience for patients, and low bioavailability

Inactive Publication Date: 2007-10-10
沈阳海普科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Only a small part of the liquid medicine mixed with tears enters the eye through the cornea, and most of it is discharged from the lacrimal duct, so the bioavailability is very low
Simultaneous application of two kinds of eye drops is not only bulky, but also deeply inconvenient for patients

Method used

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  • Matrine eye drip liquid, and producing method
  • Matrine eye drip liquid, and producing method
  • Matrine eye drip liquid, and producing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Operation method

[0048] (1) Add 80% water for injection in the liquid preparation container and heat to 80°C;

[0049] (2) Add matrine and sodium chloride, stir to dissolve; adjust the pH value to 7.0±0.3

[0050] (3) Add ethyl p-hydroxybenzoate, stir to dissolve;

[0051] (4) Add sodium hyaluronate solution (swell and dissolve with a small amount of water for injection in advance);

[0052] (5) Add water for injection to the full amount, and stir evenly;

[0053] (6) The pH value of the solution should be 6.7-7.3, if necessary, adjust with dilute hydrochloric acid or sodium hydroxide;

[0054] (7) After passing the inspection of the intermediate product, boil it for 15 minutes;

[0055] (8) Filtration with a 0.1 μm sterile filter;

[0056] (9) Fill it in an 8ml plastic eye drop bottle under aseptic conditions, and cover the anti-theft cap.

[0057] (10) Check the clarity and pack it.

[0058] The above ingredients and weight percentage are: 0.25% of...

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Abstract

An eyedrops of matrine for treating bacterial or viral keratitis and conjunctivitis, xerophthalmia, and eyeground arteriosclerosis is prepared through heating the water for injection, stirring while adding matrine and sodium chloride, regulating pH=6.5-7.5, stirring while sequentially adding ethyl p-hydroxybenzoate, sodium hyaluronate and the water for injection, boiling, aseptic filtering, cooling, and loading in containers.

Description

technical field [0001] The invention relates to the technical field of medicines for human use, in particular to matrine eye drops and a production method thereof. Background technique [0002] As we all know, keratitis and conjunctivitis are eye diseases caused by bacteria or viruses, which seriously affect the health and vision of human eyes. At present, the clinical treatment of bacterial conjunctivitis and keratitis generally requires antibiotics combined with corticosteroids; for viral eye infections, antiviral drugs combined with antibiotics are used to control secondary infections. The maximum capacity of the liquid in the conjunctival sac of a normal person is 20-30 μl, and in addition to 10 μl of normal tear fluid, it can hold a maximum of 20 μl of liquid medicine. Only a small part of the liquid medicine mixed with tears enters the eye through the cornea, and most of it is discharged from the lacrimal duct, so the bioavailability is very low. The simultaneous app...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K47/36A61K9/08A61P27/02
Inventor 闫凤春
Owner 沈阳海普科技有限公司
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