97results about How to "Suppress bitterness" patented technology

Nucleotides that block the bitter taste of foods, beverages, pharmaceutically active oral dose preparations, cosmetics and other bitter compounds that come into contact with taste tissue. The nucleotides consist of a purine or pyrimidine group, or derivative thereof, and an ionizable phosphate or other anionic organic molecule.

The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and / or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders. The compositions and methods of the present invention provide significant value in terms of patient acceptability, convenience, and compliance.

The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and / or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also generally relates to pharmaceutical compositions comprising one or more active pharmaceutical ingredients, such as azelastine or pharmaceutically acceptable salts or esters thereof including azelastine hydrochloride, particularly wherein the compositions are provided in unit dosage form. In certain embodiments, the invention provides such unit dosage pharmaceutical compositions comprising azelastine hydrochloride formulated for use as nasal sprays and / or ocular solutions or drops. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of a variety of allergic and non-allergic conditions, particularly conjunctivitis, sinusitis, rhinitis and rhinosinusitis. The compositions and methods of the present invention provide significant value in terms of patient acceptability, convenience, and compliance.

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and / or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also generally relates to pharmaceutical compositions comprising one or more active pharmaceutical ingredients, such as azelastine or pharmaceutically acceptable salts or esters thereof including azelastine hydrochloride, particularly wherein the compositions are provided in unit dosage form. In certain embodiments, the invention provides such unit dosage pharmaceutical compositions comprising azelastine hydrochloride formulated for use as nasal sprays and / or ocular solutions or drops. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of a variety of allergic and non-allergic conditions, particularly conjunctivitis, sinusitis, rhinitis and rhinosinusitis. The compositions and methods of the present invention provide significant value in terms of patient acceptability, convenience, and compliance.

The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and / or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders. The compositions and methods of the present invention provide significant value in terms of patient acceptability, convenience, and compliance.

The present invention discloses compositions, comprising a lipid-polymer matrix to mask the bitter or unpleasant taste of the medicament. The lipid or a blend of lipids, are used in combination with the pH dependent polymer where the said polymer is acid soluble or swellable The process for the preparation of taste masked pharmaceutical compositions of the bitter drugs comprising the said lipid-polymer compositions are disclosed. The concomitant use of the acid soluble polymer, which remains collapsed at the pH of saliva, inhibits the release of drug at that pH and hence they further help in bitterness inhibition. The said compositions deliver substantial amount of the bitter drug immediately at the gastric pH with improved palatability.

The present invention relates to the discovery of a novel haplotype of the human taste receptor hT2R50 in the T2R taste receptor family that responds to particular bitter ligands, i.e., 2-acetylpyrazine and ethylpyrazine. The present invention also relates to the use of this novel haplotype in assays for identifying ligands that modulate the activation of the hT2R50 taste receptor. These compounds potentially may be used as additives in foods, beverages and medicinals for modifying (blocking) hT2R50-associated bitter taste.

The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

Nucleotides that block the bitter taste of foods, beverages, pharmaceutically active oral dose preparations, cosmetics and other bitter compounds that come into contact with taste tissue. The nucleotides consist of a purine or pyrimidine group, or derivative thereof, and an ionizable phosphate or other anionic organic molecule.

Provided is a drug formulation for mouth or pharynx to be used for medical care or treatment for serious stomatitis caused by a side effect of an anti-tumor agent or the like, and for anesthesia in the pharynx, with remarkably suppressed discomfort due to bitter taste although it contains a local anesthetic as a main efficacious component. The drug formulation of the present invention comprises a local anesthetic as an efficacious component, and a weak acid, its pharmaceutically acceptable salt or a mixture thereof, wherein the mixing ratio of the weak acid to the local anesthetic is 1:1 or more by mole ratio.

A composition of an oral medicine or an oral medicine which can prevent an unpleasant taste of the medicine is herein disclosed. It is granules, powders, syrups and the like which is prevented from an unpleasant taste, comprising a basic medicine having an unpleasant taste and an anionic polymer such as carrageenan.

Provided is a taste-improving agent for potassium-chloride-containing foods and beverages that is capable of effectively improving the unfavorable taste typical of potassium chloride, such as bitterness and acridity, without negatively affecting the taste of such foods and beverages. Also provided is a process for producing highly-palatable potassium-chloride-containing foods and beverages having reduced bitterness and acridity of potassium chloride. The process involves the use of enzyme-decomposed seaweed, which is obtained by decomposing seaweed with an enzyme, in order to improve the taste of potassium-chloride-containing foods and beverages. The enzyme-decomposed seaweed is preferably a product obtained by decomposing seaweed with at least one type of enzyme selected from the group consisting of cellulase, glucanase, pectinase, alginate lyase, mannanase, and protease.

The invention disclose a taste correction method for oral liquid preparation of traditional Chinese medicine containing ethyl alcohol, and the taste correction method comprises the following steps of adding an auxiliary material used for correcting taste into the oral liquid preparation of traditional Chinese medicine containing ethyl alcohol, dissolving and mixing evenly. The taste correction method provided by the invention can eventually achieve the purpose that the needs of different groups can be met and the bad taste of the oral liquid preparation of traditional Chinese medicine containing ethyl alcohol can be corrected. The taste correction method has the advantages that the operation is simple, the application is wide, the product taste is significantly improved, and the method is suitable for industrialized production, can ensure the different needs of different groups on medicine taste, meet the needs of special populations on taste correction agent, and the products are suitable for old people, children, and diabetes.

Provided is a refreshing composition to be used in foods, drinks, compositions for oral cavity and perfume compositions having a pleasant, refreshing feeling of menthol imparted thereto, said refreshing composition being capable of enhancing the refreshing feeling without increasing the content of menthol, improving the long-lasting properties of the refreshing feeling and having good handling properties when added to products such as chewing gums. A powdery refreshing composition that is prepared by contacting a mixture in an atomized state with a cold gas stream and thus powdering the mixture, said mixture containing a refreshing substance comprising menthol and menthol analogue(s), preferably menthol and one or more kinds of menthol analogues selected from the group consisting of menthyl 3-hydroxybutyrate, menthyl lactate, menthyl glutarate, 3-L-menthoxypropane-1,2-diol, menthyl acetate, isopulegol, N-{(ethoxycarbonyl)methyl}-p-menthane-3-carboxamide and menthone 1,2-glyceryl acetal, together with a stabilizer.

It is an object of the present invention to provide a powder, a granule, an orally-disintegrating tablet, and the like that contain a drug causing bitterness, and that can suppress the bitterness in the mouth and improve solubility thereof in the stomach. The present invention provides a drug-containing granule comprising (a) a core particle that contains a drug causing bitterness, and (b) a masking coating that coats the core particle,wherein the masking coating contains:at least one polymer selected from methacrylic acid copolymer S, methacrylic acid copolymer L, methacrylic acid-ethyl acrylate copolymer, ethyl acrylate-methyl methacrylate copolymer, and ethyl acrylate-methyl methacrylate-ethyl ammonium trimethyl chloride methacrylate copolymer; andat least one diluent selected from D-mannitol, lactose, trehalose, xylitol, maltitol, and erythritol, an orally-disintegrating tablet comprising the drug-containing granule, and the like.

A food product, preferably a beverage, suitable for ingestion by humans and having at least 300 mg of potassium ion per 100 g serving, the potassium being from both one or more inorganic sources and one or more organic sources. The food product preferably has no fewer than 25 kcals and has fewer than 75 kcal per 100 g serving. By combining the high potassium levels with minimal calories, the food of the invention permits enjoyment of the benefits of high potassium in a food without the negative of high caloric intake.

The invention relates to a barbary wolfberry fruit chrysanthemum radix puerariae substituted tea and a preparation method thereof. The barbary wolfberry fruit chrysanthemum radix puerariae substituted tea is prepared by packaging the following raw materials with three-dimensional tea bags: barbary wolfberry, chrysanthemums, radix puerariae, haws, radish seed, Chinese yam, dried orange peel and poria cocos. The preparation method of the barbary wolfberry fruit chrysanthemum radix puerariae substituted tea comprises the following steps: firstly crushing the raw materials, pelletizing the crushed raw materials, then sequentially picking and choosing, screening, washing, baking and disinfecting raw material components, placing the disinfected raw material components in the three-dimensional tea bags by a pelleter according to the components and a weight ratio, finally loading the three-dimensional tea bags in boxes, and delivering the boxes out of warehouses. The barbary wolfberry fruit chrysanthemum radix puerariae substituted tea has the efficacies of clearing heat and removing toxicity, quieting the heart and soothing the nerves, neutralizing the effect of alcoholic drinks for invigorating the stomach, and neutralizing the effect of alcoholic drinks for protecting the liver, can decompose the alcohol, and has definite effects of alleviating deficiency of the liver-yin and kidney-yin, soreness and weakness of waist and knees, dizziness, cough due to consumption and the like. The completely new independent three-dimensional tea bags are adopted, so that the barbary wolfberry fruit chrysanthemum radix puerariae substituted tea is convenient and swift and can be immediately drunk after being brewed, the tedious process of cleaning the tea is avoided, the worry that people drink dregs of a decoction when drinking the water can be avoided, and cleaning teacups is also more convenient.

The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and / or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders.

The invention relates to colla corii asini and Chinese wolfberry substitutional tea and a preparation method thereof. The colla corii asini and Chinese wolfberry substitutional tea which is packaged in three-dimensional tea bags is prepared from the following raw materials by weight: 0.9-1.1g of colla corii asini, 0.7g of Chinese wolfberries, 0.5g of kudzu vine roots, 0.8g of peach kernels, 0.5g of poria cocos, 0.7g of Chinese yam, 0.7g of radix angelicae and 0.7g of mulberries. The colla corii asini and Chinese wolfberry substitutional tea has the functions of nourishing the heart and calming the nerves, nourishing blood and tonifying Yang, tonifying spleen and appetizing, moistening skin and maintaining beauty, resisting fatigue, anoxia and cold, tonifying brain, delaying senescence and the like. The tea packaged in brand-new independent three-dimensional tea bags is convenient and efficient and instant, the tediousness of washing the tea is avoided, and people do not worry about drinking herb residues when drinking water. The tea cup is also relatively convenient to clean.

Provided are: an elimination agent that is for oral cavity biofilms and that comprises (A) an [alpha]-olefin sulfonate and (B) a condensed phosphate (B-1) and / or an amphoteric surfactant (B-2); and an oral cavity composition comprising component (A) and component (B) and having a high elimination effect with respect to oral cavity biofilms.

The present invention relates to a lotus leaf and haw tea substitute and a preparation method thereof. The lotus leaf and haw tea substitute is prepared from the following raw materials packaged with three-dimensional tea bags: lotus leaves, haws, poria cocos, Chinese yam, jujube and finger citron. The preparation method includes the following steps: first, crushing and granulating the raw materials, successively picking, screening, washing, drying and sterilizing ingredients of the raw materials, then putting the ingredients into the three-dimensional tea bags by a granulating machine according to the weight ratio of each ingredient, and finally boxing the three-dimensional tea bags and delivering the finished products from storage. The lotus leaf and haw tea substitute has effects in activating blood circulation to dissipate blood stasis, eliminating summer heat and relieving restlessness, reducing blood fat, reducing weight, dredging blood vessel, etc. The lotus leaf and haw tea substitute adopts entirely new independent three-dimensional tea bags, and is convenient, quick, and instant ready to drink after brewing, eliminating the need for cumbersome tea washing process; also, customers do not need to worry about the dregs of decoction when drinking water; and it is more convenient to wash teacups.

The invention discloses healthcare multi-flavor broad beans capable of regulating the spleen and harmonizing the stomach. The healthcare multi-flavor broad beans are prepared from the following raw materials: broad beans, mixed rice powder, semen coicis, Chinese dates, beef, pork lean, chicken, pumpkin, hyacinth beans, soya beans, semen juglandis, haws, chilli powder, pricklyash peel, fresh ginger, cortex cinnamomi, traditional Chinese medicine powder A, traditional Chinese medicine powder B, a nutrition additive, edible salt and edible oil. The invention also provides a preparation method of the healthcare multi-flavor broad beans capable of regulating the spleen and harmonizing the stomach. During preparation of the multi-flavor broad beans, the broad beans, the condiments, the traditional Chinese medicine powder and the nutrition additive are mixed and then the obtained mixture is decocted, so that the pungent smell of the traditional Chinese medicines is covered by the fragrance of the condiments; furthermore, the healthcare ingredients of the traditional Chinese medicines permeate into the broad beans, and the broad beans are endowed with the healthcare efficacies of regulating the spleen and harmonizing the stomach; and by virtue of frying the nutrient substances to be cooked, mixing the fried nutrient substances with the rice powder, wrapping the surfaces of the broad beans with the obtained mixture and then performing deep-frying, the multi-flavor broad beans are endowed with rich nutritional ingredients, and meanwhile, the multi-flavor broad beans have crisp taste.

To reduce the bitterness of a packaged beverage which contains a high concentration of non-polymer catechins, without deteriorating the flavor of the beverage, provided is a packaged beverage including 0.05 to 0.5% by mass of (A) non-polymer catechins and (B) a sweetening agent selected from the following sweetening agents (B1), (B2), (B3), and (B4): (B1) 0.0001 to 0.5% by mass of glycyrrhizin; (B2) 0.00001 to 0.005% by mass of thaumatin; (B3) 0.01 to 5% by mass of (b31) sorbitol and 0.001 to 5% by mass of (b32) a sweetening agent other than sorbitol, in which a ratio of (b32) / (b31) (mass ratio) is 0.01 to 100; and (B4) 0.01 to 5% by mass of (b41) erythritol and 0.01 to 5% by mass of (b42) one or more kinds selected from glucose, fructose, a glucose-fructose syrup, and a fructose-glucose syrup.

Provided is a packaged effervescent beverage having a high concentration of catechins, having both reduced bitterness and adequate sweetness, and not undergoing a substantial reduction in the catechin content even after long storage albeit containing a sweetener.The packaged effervescent beverage having a purified product of tea extract added thereto, comprising:(A) from 0.08 to 0.5 mass % of non-polymer catechins,(B) from 0.0001 to 20 mass % of a sweetener, and(C) a carbon dioxide gas, whose gas volume ranges from 0.5 vol. % to 4.0 vol. %,wherein:(D) a non-epicatechin percentage in the non-polymer catechins is from 5 to 25 mass %,a percentage of (E) gallates in (A) the non-polymer catechins ([(E) / (A)]×100) is from 5 to 55 mass %,(F) the beverage has a pH of from 2.5 to 5.1; anda mass ratio of (G) caffeine to (A) the non-polymer catechins [(G) / (A)] is from 0.0001 to 0.16.

Disclosed is a flavor improving agent that is a fraction derived from fruit juice or squeeze. A fraction wherein the amount of substance ratio between polyphenols and saccharides, the latter after acid hydrolysis of the fraction, (polyphenol / saccharide) is 0.1-10, and even more preferably, wherein the amount of substance ratio of the polyphenol and the saccharide before acid hydrolysis of the fraction (polyphenol / saccharide) is 1-100, and is used as a flavor improving agent. Such fraction are obtained with a method such as by a fruit juice or squeeze being absorbed onto a synthetic resin adsorbent and the adsorbed components being eluted by a solvent, or by extracting fruit juice or squeeze with ethanol. The flavor improving agent has flavor improving effects such as suppressing sourness, bitterness and astringency of foods and beverages, reducing harsh taste, contributing to a juice-like feel and contributing to a richness. In addition to foods and beverages, the flavor improving agent can also be added to pharmaceutical products or oral care products and the like, as well as to flavor composition.

The invention discloses a bitter gourd beverage, which is prepared from bitter gourd juice, honey, sucrose, citric acid, potassium sorbate and purified water. The invention also discloses a production process of the bitter gourd beverage, which comprises squeezing bitter gourd juice, mixing with other raw materials, and filtering. The process for squeezing bitter gourd juice comprises cleaning bitter gourd with proper degree of ripeness, removing seeds, cutting into blocks, frying with green pepper for 2 min, dicing, boiling in water for 5 min, squeezing, and filtering. The bitter gourd has cold nature and bitter taste, acts in heart, spleen and stomach, and has the effects of clearing away summer-heat, improving eyesight, and clearing away toxic materials; and contains charantin and other active ingredients, and has the effects of reducing blood sugar and preventing and treating caner. The inventive bitter gourd beverage has little bitter taste, and can be consumed in summer as a health beverage for clearing away summer-heat, improving eyesight, reducing blood sugar and preventing and treating caner.

The invention provides asiatic wormwood rice cakes. The asiatic wormwood rice cakes are prepared from the following raw materials in parts by mass: 90 to 110 parts of asiatic wormwood, 250 to 350 parts of glutinous rice flour, 25 to 35 parts of fructus lycii, 80 to 120 parts of corn flour, 30 to 40 parts of raisins, 50 to 150 parts of white sugar, 290 to 310 parts of red bean paste and 95 to 100 parts of walnuts. The invention further provides a preparation method of the asiatic wormwood rice cakes. The asiatic wormwood rice cakes are unique in taste, abundant in nutrients, low in calories and healthy, have health effect and can also have the effects of dispelling warm and dispelling cold, warming blood and activating blood, losing weight, resisting bacteria, resisting viruses, resisting allergy, resisting blood coagulation, relieving cough and removing the phlegm and calming.

The invention discloses a preparation method of lily-bulb spina-date-seed sharpleaf-galangal-fruit tea capable of improving sleep quality. The preparation method of the lily-bulb spina-date-seed sharpleaf-galangal-fruit tea is characterized by comprising the following steps: taking lily bulbs, mulberry fruits, longan flesh, spina date seeds and sharpleaf galangal fruits as raw materials; washing the raw materials, and drying the washed materials until the water content is lower than 5%; transferring the dried materials into a sterilizing device so as to carry out sterilizing; transferring the sterilized materials into a stainless crushing machine so as to crush the sterilized materials into 40-80-mesh powder; and then, stirring and mixing the crushed powder according to proportion, and packaging the uniformly blended mixture by using three-dimensional tea bags, so that the lily-bulb spina-date-seed sharpleaf-galangal-fruit tea capable of improving sleep quality is prepared. The lily-bulb spina-date-seed sharpleaf-galangal-fruit tea capable of improving sleep quality is excellent in material selection, unique in flavour, convenient to eat, good in taste, and easy to be accepted by people. Medicinal and edible food materials are adopted as active ingredients, so that the lily-bulb spina-date-seed sharpleaf-galangal-fruit tea is free of any chemical additives, hormones and harmful substances; even being daily drunk, the lily-bulb spina-date-seed sharpleaf-galangal-fruit tea causes no burden to the body after long-term drinking. The lily-bulb spina-date-seed sharpleaf-galangal-fruit tea capable of improving sleep quality is a natural tea substitute; moreover, the lily-bulb spina-date-seed sharpleaf-galangal-fruit tea is also a daily natural tea beverage for the people who pursue high-quality live, and is capable of preventing diseases, calming the nerves and helping sleep.