41 results about "Cleft palates" patented technology

A combination of an anti-androgenic gestagen at a daily dose of from an ovulation-inhibiting dose up to at most twice the ovulation-inhibiting dose and from 0.1 to 10 mg of (6S)-5-methyltetrahydrofolate are used to produce a pharmaceutical preparation for therapeutically treating endometriosis while simultaneously reducing therapy side effects including the negative effect on bone density and / or bone metabolism, reducing the risk of osteoporosis and, in the event of pregnancy, reducing the risk of congenital malformations, such as medullary tube defects, cleft lip, cleft jaw, or cleft palate, and the risk of pregnancy complications, such as detachment of the placenta and premature birth. The preparation is suitable for long-term administration, which continues daily for at least 169 days to at least two years.

A nursing device for feeding infants with a cleft lip and / or cleft palate includes upper and lower portions. The upper portion includes a bottle with an opening in its top for containing a liquid, a nipple and a screw cap for maintaining the nipple in sealing engagement with the opening. A submersible pump is disposed in the bottom of the bottle and connected to an opening in the nipple by a tube. A lower portion of the device includes a motor and a magnetic coupling for activating the pump. A microprocessor control timer regulates the timing and flow of a feeding cycle with a display for help in regulating the feeding cycle.

A nursing device for feeding infants with a cleft lip and / or cleft palate includes a nipple body and a tube operatively attached at one end to a pump for pumping liquid and operatively attached at the other end to the nipple body. The tube passively regulates the amount of liquid being pumped, ensuring that the infant can feed with minimal mess from the infirmities of cleft lip and / or cleft palate. The nipple body includes an outer flange and a cap for sealing engagement with the top of a nursing bottle. A shield can be used to cover the nipple body, which serves to protect and form a temporary reservoir for the liquid dispensed through the nipple body.

The invention discloses a tissue engineering bone for repairing a cleft palate defect of a maxillofacial region and a preparation method. The tissue engineering bone comprises a double-layer porous scaffold and hydrogel, wherein pores of the scaffold are filled with the hydrogel. The double-layer degradable tissue engineering bone prepared by the preparation method is completely matched with the cleft palate defect of a patient, and can accurately restore the original palate structure and function of the patient, so that a series of problems such as donor site trauma, malformation, scars and pain caused by current autogenous bone transplantation and inevitable defects such as limited sources are avoided; and meanwhile, the tissue engineering bone is degradable, so that normal growth and development of the jaw bone are not affected.

A nursing device for feeding infants with a cleft lip and / or cleft palate includes upper and lower portions. The upper portion includes a bottle with an opening in its top for containing a liquid, a nipple and a screw cap for maintaining the nipple in sealing engagement with the opening. A submersible pump is disposed in the bottom of the bottle and connected to an opening in the nipple by a tube. A lower portion of the device includes a motor and a magnetic coupling for activating the pump. A microprocessor control timer includes means for regulating the timing and flow of a feeding cycle with a display for help in regulating the feeding cycle. Alternatively, the motor, pump, controls, and power supply may be disposed at the top of the bottle as a removable unit.

Methods and devices for facilitating the treatment and repair of nasal sinus afflictions utilizing devices that are positioned within proximity of the nasal sinus and the afflicted location. The methods and devices are particularly beneficial for the treatment of sinusitis, broken noses, sleep apnea, cleft palates and deviated septums. In addition, the devices may enhance and expedite patient recovery and reduce or mitigate bleeding.

The invention especially relates to application of tamoxifen and a method for constructing a cleft palate animal model, belonging to the field of genetic engineering technology. Research results of the invention show that a female mouse (Tgfbr1<f / f>K14Cre+) is mated with a male mouse (Tgfbr1<f / f>K14Cre-), or a female mouse (Tgfbr1<f / f>K14Cre-) is mated with a male mouse (Tgfbr1<f / f>K14Cre+), and Tgfbr1 gene knockdown can be performed on a fetal mouse thereof under the induction of tamoxifen; so the cleft palate animal model is constructed. In the mouse constructed by using the method of the invention, Tgfbr1 genes in palatal epithelial cells are knocked out, and interference of other factors in the cleft palate model is reduced.

The invention provides swelling-eliminating, pain-relieving, itching-relieving and skin-nourishing hand-foot chap paste and a preparation method thereof. The paste comprises the following substances: a bletilla striata extraction liquid, a red date extraction liquid, a flowers carthami extraction liquid, a banana peel extraction liquid, an apple peel extraction liquid, a garlic extraction liquid, a radix polygonati officinalis extraction liquid, orange peel juice, egg oil, beewax, lithospermum soaked oil, sesame oil, a natural emulsifier GOC, an all-round emulsifier, glycerin, sodium carboxymethylcellulose, sodium alginate, essence, ethylparaben, distilled water, 1,2-propylene glycol and the like. Compared with the prior art, the paste has the advantages of being small in side effect, good in compliance, good in moisture retention and the like. As the extraction liquids, comprising a lot of polysaccharides, lipid, vitamins and the like, of natural medicines are adopted, the paste also plays roles of improving local blood circulation, nourishing and moisturizing skin, preventing bacteria and oxidization and delaying skin ageing while treating skin chap.

The invention relates to urea and vitamin E cream for treating hand and foot rahagades and rahagades caused by keratotic tinea hand or pedis. The cream contains urea, vitamin E, catechinic acid and polyoxyethylene-7-stearate. The fine cream with small and uniform particle size and good coating property can be prepared through low-speed stirring. The cream has higher high temperature stability, and oil-water layering does not occur easily. The cream is suitable for industrial production, production processes are simplified, energy is saved, and stability is higher.

The invention relates to application of an allograft acellular dermal matrix in oral diseases, in particular to application of the allograft acellular dermal matrix in the repairing of cleft lip and / or alveolar cleft, cleft palate and oral mucous membrane defect, the repairing of periodontal defect and gingival recession, the repairing of nasal mucosa, tooth implantation, the repairing of furcation involvement and the prevention of complications such as dry socket after impacted tooth extraction, and belongs to the technical field of biological medical material tissue engineering. The allograft acellular dermal matrix is a product improved by a process, the mechanical performance of the product is suitable for surgery, and the sewing strength of the product is 16-18N; the allograft acellular dermal matrix is free of immunological rejection, capable of fast inducing tissue regeneration, soft in texture after implantation, free of contour feeling and good in in-vivo compatibility and hasa stable stent and template effect.

The invention discloses a cleft palate speech initial and final automatic segmentation method and a cleft palate speech initial and final automatic segmentation system, which relate to the field of speech signal processing technologies, especially a cleft palate speech initial and final automatic segmentation technology. The invention aims to provide an initial and final automatic segmentation algorithm for cleft palate speech to solve the technical problem that an initial and final automatic segmentation algorithm for the cleft palate speech does not exist in the prior art. The cleft palate speech initial and final automatic segmentation method is characterized by carrying out the processing steps on a syllable including an initial: a quasi voiced initial and a quasi voiceless initial distinguish step, which is used for distinguishing whether the syllable is a syllable comprising a quasi voiced initial or one comprising a quasi voiceless initial; an initial and final segmentation step for the syllable comprising the quasi voiced initial; and an initial and final segmentation step for the syllable comprising the quasi voiceless initial.

The invention relates to a method for conditional knockout of Lox13 gene of a mouse and an application. The method comprises the steps that loxP loca of a Cre recombinase targeting sequence are added to the two ends of a key exon of an Lox13 gene; a conditional gene knockout carrier is constructed, and transfected with an embryonic stem cell (ESC); microinjection is conducted for making a floxed mouse capable of being used for conditional gene knockout; the floxed mouse is mated with a Cre mouse with corresponding tissue specificity; and the mouse of which an Lox13 gene can be knocked out at a specific tissue is obtained. The mouse obtained by the method serves as a model mouse for morbidity research on a cleft palate disease, so that the functions of the Lox13 gene in the tissue and the effects of the Lox13 gene in an embryonic development regulation mechanism can be illustrated in details. In addition, the mouse can serve as an animal model for researching the functions of the Lox13 gene, and has important application values.

A NiTi memory alloy type internal palatoschisis tractor is composed of a palatal steel supporter whose surface is matched with the palatal mucosa, a fixing belt ring fixed to the external side of saidpalatal steel supporter and surrounding on molar teeth, and a curved NiTi memory alloy bar fixed between said palatal steel supporter and palatal bone.

The invention belongs to a non-invasive treating method of congenital cleft palate in the medical field, especially relating to a shape appliance digitalizing method of a cleft palate alveolar bone, which comprises the following steps of: 1) obtaining the jaw arch fault information of a cleft palate alveolar bone by using the microscopic CT (computed tomography) technology, wherein the thickness of a scanning layer is 50 mu m; 2) moving the cleft palate alveolar bone segment of a maxillary arch solid model to approach to a normal maxillary arch form from an abnormal form in a simulation manner in reverse engineering software, and simulating and demonstrating the shape change process step by step; 3) obtaining a digitalized model of the cleft palate alveolar bone jaw arch in each stage in the process of remedying according to the simulation and demonstration; 4) manufacturing an appliance retention column digitalized model used in each stage of shaping the alveolar bone according to the digitalized model of the cleft palate alveolar bone jaw arch; and 5) automatically processing a prototype of an alveolar bone shape appliance by using the rapid forming technology. A digitalized designing and manufacturing method of the shape appliance of a cleft palate alveolar bone independent of the experience and handwork of a doctor is provided.

The invention discloses a three-dimensional culture method for palatal organs in vitro. The whole tissue from the inferior orbital edge to the corner of the mouth is taken from the embryonic palate in the early stage of development or in the developmental stage, embedded in a hydrogel support, and culture solution is added for three-dimensional culture. It can provide a three-dimensional growth environment similar to the body, avoid the use of expensive materials and processes, and has the advantages of simple operation and low cost. In addition, the biological characteristics of the palatal plate tissue can be adjusted by changing the composition of the hydrogel scaffold, which is suitable for different stages of embryonic development The tissue culture of normal and abnormal palate plate can be used for the study of the formation mechanism of cleft palate and the screening of drugs that promote the formation of palate plate.