A urea-vitamin e cream for treating chapped hands and feet and chapped hands and feet caused by keratotic tinea pedis

A technology for chapped hands and feet and tinea pedis, which is applied in the field of medicine, can solve the problems of high cost and energy consumption, and achieve the effects of not easy oil and water delamination, good stability, and good high temperature stability

Active Publication Date: 2018-09-07
上海正大通用药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of the preparation of this cream is that complex processes such as mixing and high-speed homogenization are required in the preparation process, and the stirring and homogenization equipment required in the preparation has produced excessive cost and energy consumption

Method used

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  • A urea-vitamin e cream for treating chapped hands and feet and chapped hands and feet caused by keratotic tinea pedis
  • A urea-vitamin e cream for treating chapped hands and feet and chapped hands and feet caused by keratotic tinea pedis
  • A urea-vitamin e cream for treating chapped hands and feet and chapped hands and feet caused by keratotic tinea pedis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The preparation of embodiment 1 urea vitamin E cream 1

[0056] The formula for Cream 1 is as follows:

[0057]

[0058] Cream 1 is prepared according to the following method:

[0059] (a) Heat polyethylene glycol-7-stearate (tefose63), caprylic capric glyceride (Labrasol) and liquid paraffin to 60°C to melt;

[0060] (b) Mix purified water, urea and 5 ppm catechin (the raw material of catechin needs to be crushed to a particle size of no more than 100 μm), and heat to 60°C;

[0061] (c) Mix step (a) with step (b) under continuous slow stirring (30rpm), stir and emulsify, and control the temperature at 60°C;

[0062] (d) Stir and cool the mixture obtained in step (c) to 25~50°C, add vitamin E and stir evenly to obtain urea vitamin E cream.

Embodiment 2

[0063] The preparation of embodiment 2 urea vitamin E cream 2

[0064] The formula for Cream 2 is as follows:

[0065]

[0066] Preparation Process:

[0067] (a) Heat polyethylene glycol-7-stearate (tefose63) and cetyl alcohol to 75°C to melt, then add light liquid paraffin and mix well, keeping the temperature at 75°C;

[0068] (b) Mix the purified water, urea and 4 ppm of catechin (the raw material of catechin should be crushed to a particle size of no more than 100 μm), and heat to 75°C;

[0069] (c) Mix step (a) with step (b) under continuous slow stirring (40rpm), stir and emulsify, and control the temperature at 75°C;

[0070] (d) Stir and cool the mixture obtained in step (c) to 25~50°C, add vitamin E and stir evenly to obtain urea vitamin E cream.

Embodiment 3

[0071] The preparation of embodiment 3 urea vitamin E cream 3

[0072] The formula for Cream 3 is as follows:

[0073]

[0074] Preparation Process:

[0075] (a) Heat polyethylene glycol-7-stearate, light liquid paraffin, white beeswax and Labrafil M1944 CS to 70°C to melt;

[0076] (b) Mix purified water, phenoxyethanol, urea and 3 ppm of catechin (the raw material of catechin should be crushed to a particle size of no more than 100 μm), and heat to 70°C;

[0077] (c) Mix step (a) with step (b) under continuous slow stirring (35rpm), stir and emulsify, and control the temperature at 70°C;

[0078] (d) Stir and cool the mixture obtained in step (c) to 25~50°C, add vitamin E and stir evenly to obtain urea vitamin E cream.

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Abstract

The invention relates to urea and vitamin E cream for treating hand and foot rahagades and rahagades caused by keratotic tinea hand or pedis. The cream contains urea, vitamin E, catechinic acid and polyoxyethylene-7-stearate. The fine cream with small and uniform particle size and good coating property can be prepared through low-speed stirring. The cream has higher high temperature stability, and oil-water layering does not occur easily. The cream is suitable for industrial production, production processes are simplified, energy is saved, and stability is higher.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a urea vitamin E cream for treating chapped hands and feet and chapped hands and feet caused by keratotic tinea pedis. Background technique [0002] Urea vitamin E cream is a commonly used product for treating chapped hands and feet. According to the urea vitamin E cream product disclosed by Shanghai General Pharmaceutical Co., Ltd., the cream prescription is: 150 mg of urea and 10 mg of vitamin E per gram; the auxiliary materials are: White petrolatum, cetearyl alcohol, glyceryl monostearate, liquid paraffin, white beeswax, macrogol octylphenyl ether (OP), glycerin, disodium edetate, lauryl Sodium Sulfate, Paraben (Ethylparaben), Sanhua Essence, Purified Water. What still needs to be improved on this formula is that when using polyethylene glycol octylphenyl ether (OP) as an emulsifier to prepare urea vitamin E cream, the problem of uneven particle size is likely t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/355A61K9/06A61K47/14A61P17/02A61K31/17
CPCA61K9/06A61K31/17A61K31/355A61K47/14A61K2300/00
Inventor 魏冬俞庆臻胡一波刘曲任寅马媛媛顾兆姝王军平
Owner 上海正大通用药业股份有限公司
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