31 results about "Calciferols" patented technology

An oral composition, suitable as a hypoglycemic agent, includes an isolate from the leaves of Gymnema sylvestre, having a specified molecular weight. The isolate has a molecular weight at least about 3000 Daltons as determined by molecular weight cut-off filtration. Glucose metabolism in a human patient can be regulated by dosage forms that contain the aforesaid isolate from the leaves of Gymnema sylvestre, in combination with a non-metabolizable, water-swellable polysaccharide such as the exudate of Sterculia urens, and a water-soluble polysaccharide such as guar gum. Optionally, the present oral compositions can include a physiologically acceptable calcium source, a physiologically acceptable metal carbonate salt, a physiologically acceptable chromium salt, and / or a physiologically acceptable vanadium compound. In addition, antioxidants such as ascorbic acid, cholecalciferol, d-α-tocopherol, the carotenoids, lycopene, lutein, and the like, can be included as well. The present compositions are useful for amelioration of cholesterolemia, obesity, chronic complications of diabetes and prophylaxis for patients predisposed to the foregoing.

An implant to be used as medical or dental implant, comprising a metallic or polymeric base which is covered by the vitamin D precursor cholecalciferol. The implant can be obtained by direct covering of the polymeric or metallic base with a solution comprising cholecalciferol or also covering the base with the 7-dehydrocholesterol (7-DHC), and subsequently irradiated with UV light to induce the formation of cholecalciferol. Optionally, the coating of the implant may include an antioxidant such as vitamin E. This implant enhances osseointegration in compromised patients by means of the endogenous synthesis and activity of vitamin D in hard and mineralized tissue regeneration. Furthermore, a method to obtain these implants which comprises coating the surface of the implant directly with cholecalciferol or with a specific concentration of 7-DHC and irradiated with UV light to induce the formation of cholecalciferol.

The invention relates to an anti-stress compound premix feed for laying fowls as well as a preparation method and application of the anti-stress compound premix feed. The premix feed is composed of the following raw materials in parts by weight: 160-240 parts of citric acid, 80-160 parts of fumaric acid, 8-15 parts of a plant essential oil compound, 2-5 parts of 25-hydroxy cholecalciferol, 0.15-0.75 part of ammonium sulfate nitrate, 6-15 parts of nicotinamide, 0.2-0.5 part of riboflavin, 0.2-0.5 part of D-calcium pantothenate, 1-2 parts of pyridoxine hydrochloride, 20-36 parts of DL-alpha-tocopheryl acetate, 0.4-0.7 part of menadione sodium bisulfite, 1-4 parts of biotin, 0.3-0.9 part of vitamin B12, 10-30 parts of phytase, 1-5 parts of protease, 2-10 parts of DL-methionine, 20-60 parts ofselenium yeast, 50-150 parts of calcium hydrophosphate and 200-600 parts of a carrier. The premix feed provided by the invention can significantly improve the stress intestinal injury of the laying fowls and improve the digestive absorption capacity, and finally achieves the effects of relieving the stress of the laying fowls, reducing the dirty egg rate, improving the egg laying rate in a stressstate, improving the egg quality and the breeding performance of breeding fowls, reducing the dirty egg rate, improving the fertilization rate and the hatching rate and increasing the economic benefits of farmers.

The invention discloses a new preparation method of a derivative A of a key Ayr calciferol intermediate (Z)-2-((3R,4R,5R)-3,5-dihydroxy-4-(3-hydroxy-propoxy)-2-methylene cyclohexyl) ethanol. The method comprises the following steps: performing 3,5-hydroxy protection on a compound 1 serving as a starting material, then reacting the protected compound 1 with R2O(CH2)3X to protect 4-hydroxy, oxidizing with a permanganate to obtain 1,2-hydroxy, performing further oxidation and wittig reaction to obtain 2-methylene, reducing, oxidizing, reacting the oxidized product with trimethyl silicon-based ethyl acetate, and performing DiBAL-H reduction to obtain a compound A. Compared with the prior art, illumination reaction is not used in the new route, so that the operation is simple and amplification is facilitated; and the used raw materials are cheap and readily available natural products, and all chiral centers are introduced from the raw materials, so the cost is low and the quality of the compound A is easy to control.

A pharmaceutical composition or kit of parts comprising at least three ingredients from a HMG-CoA reductase inhibitor, a leukotriene antagonist, a proton pump inhibitor, melatonin or a melatonin receptor agonist, a bioavailable preparation of a curcuminoid, a calciferol derivative, a compound from the group consisting of metformin and phenformin, valproate, minocycline and chloroquine and one or more pharmaceutically acceptable carriers or excipients.

The invention belongs to the field of medicinal chemistry, and in particular relates to a new crystal form A of docalciferol and a preparation method thereof. The invention also relates to a pharmaceutical composition containing the new crystal form A of docalciferol and its role in the treatment of osteoporosis Hyperparathyroidism or secondary hyperparathyroidism. The new crystal form A of docalciferol, using Cu-Kα radiation, X-ray powder diffraction at 2θ angles at 7.82, 8.51, 12.06, 13.01, 15.60, 17.05, 17.82, 18.71, 19.35, 20.06, There are diffraction peaks at 20.37, 20.62, 21.98, 22.68, 22.90, 23.81, and 24.79. At the same time, the invention also discloses a process improvement scheme for preparing high-purity doxercalciferol, which has simple steps, easy operation, short time consumption and low cost, and is very beneficial to large-scale industrial production.

The present invention relates to a method for enzymatic resolution and preparation of compound 1A, more precisely, the enantiomer separation and recycling method is to first treat compound 1 or 9 with enzymes to obtain compound 1A and compound 7; Selective saponification, oxidation, reduction to obtain compound 1; the obtained compound 1 can enter the cycle of step a-d or a-e again to achieve the purpose of enantiomeric resolution and recycling.

Disclosed herein are devices for stimulating the photo biochemical synthesis of vitamin D3-cholecalciferol in the body. The device includes a housing (1), a power section (2) located in the housing, a section (3) for parameter-setting and for narrowband UVB radiation regulation, a screen or touch screen (4) for visualization, a source (5) for narrow-band UVB radiation, and a module (6) for uniform distribution of the narrow-band UVB radiation, which can be in direct contact with the skin. The technical result of the claimed invention is to provide stimulation of the synthesis of the required daily dose of vitamin D3-cholecalciferol using low intensity narrow-band radiation in the UVB range, which makes it possible to increase the concentration of vitamin D3-cholecalciferol to the required daily norm.

The invention discloses a new preparation method of a derivative A of a key Ayr calciferol intermediate (Z)-2-((3R,4R,5R)-3,5-dihydroxy-4-(3-hydroxy-propoxy)-2-methylene cyclohexyl) ethanol. The method comprises the following steps: performing 3,5-hydroxy protection on a compound 1 serving as a starting material, then reacting the protected compound 1 with R2O(CH2)3X to protect 4-hydroxy, oxidizing with a permanganate to obtain 1,2-hydroxy, performing further oxidation and wittig reaction to obtain 2-methylene, reducing, oxidizing, reacting the oxidized product with trimethyl silicon-based ethyl acetate, and performing DiBAL-H reduction to obtain a compound A. Compared with the prior art, illumination reaction is not used in the new route, so that the operation is simple and amplification is facilitated; and the used raw materials are cheap and readily available natural products, and all chiral centers are introduced from the raw materials, so the cost is low and the quality of the compound A is easy to control.

The invention discloses a content calculation method of a doxercalciferol injection. The method comprises: destroying doxercalciferol by means of a sodium hydroxide water solution to generate a doxercalciferol precursor and 5,6-trans-doxercalciferol, and doxercalciferol and 5,6-trans-doxercalciferol response factors under given chromatographic conditions; calculating the concentration of a doxercalciferol standard substance before destroying, the concentration of the 5,6-trans-doxercalciferol generated after destroying, and the concentration of the non-destroyed doxercalciferol, so as to obtain the concentration of the doxercalciferol precursor after destroying; calculating a precursor response factor according to the peak area of the doxercalciferol precursor after destroying, so that the precursor response factor can be converted into a correction factor of the doxercalciferol, and the correction factor can be directly substituted for calculation when the content of the injection is tested. The method has operability through practice test, the degree of transforming the doxercalciferol into the precursor is not required, the accuracy is high, the method is simple and convenient, and the content of the doxercalciferol in the injection can be effectively controlled.

The invention discloses slimming cereal nutrition powder with a weight losing function, and relates to the technical field of food processing. The slimming cereal nutrition powder comprises the following components: oatmeal, dried skim milk, puffed corn flour, inulin, crystalline fructose, peony seed oil powder, quinoa flour, buckwheat flour, guar gum, freeze-dried strawberry particles, freeze-dried blueberry particles, edible essence, sodium, vitamin A acetate, cholecalciferol, dl-alpha-tocopherol acetate, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, L-sodium ascorbate, nicotinic acid, D-calcium pantothenate, calcium carbonate, ferric pyrophosphate and zinc gluconate. The oatmeal, the quinoa flour, the buckwheat flour, the skimmed milk powder and the like are taken as main materials, and the peony seed oil powder, the freeze-dried fruit particles, the puffed corn flour, the inulin and various vitamins and minerals are added, so that the slimming cereal nutrition powder has the characteristics of balanced nutrition, low calorie, blood fat regulation and cholesterol reduction, and meets the requirements of modern people on management of own figures and comprehensive nutrition. The application prospect is wide.

We disclose treating hyperglycemia in a human with 25-hydroxyyitamin D3 (calcifediol). Blood glucose is reduced to a level which is closer to normal than baseline. Vitamin D3 (cholecalciferol) may optionally be used together with 25-hydroxy vitamin D3. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.