40 results about "Butyrolactone I" patented technology

A γ-butyrolactone compound as shown in Formula (I) and pharmaceutical composition thereof: wherein X═N, O, S, Se; and A and B are selected from substituents having the following formula: wherein R1, R2, R3, R4, and R5 are selected from a hydrogen atom, a halogen atom, a hydroxyl group, a mercapto group, an amino group, an alkoxy group, and a nitro group. The γ-butyrolactone compound and pharmaceutical composition thereof butyrolactone have inhibitory effects on hepatoma, ovarian cancer, breast cancer, lung cancer, malignant glioblastoma or colorectal carcinoma, and are cytotoxic with high specificity to inhibit Paclitaxel-resistant tumour cells at later stage of chemotherapy without any damage on normal cells.

Disclosed is a two-step, continuous hydrogenation process for the preparation of 3-methyl-tetrahydrofuran from alpha-methylene-gamma-butyrolactone, which comprises a first step of subjecting alpha-methylene-gamma-butyrolactone to hydrogenation to synthesize 2-methyl-gamma-butyrolactone; and the second step of hydrogenating the 2-methyl-gamma-butyrolactone formed in the first step. The above process enables the production of the objective highly-pure 3-methyl-tetrahydrofuran free from alcohol in high efficiency and high conversion through simple production steps.

The present invention relates to a novel process for the preparation of optically enriched substituted R(+)beta-benzyl-gamma-butyrolactones of the general formula 1, wherein, R1 and R2 independently represent the following groups, R1=R2=H, OH, -OCnH2n+1 (n=1 to 8), NH2, and / or CF3, R1 and R2 together represents -O(CH2)mO- where m=2 to 4.

The invention relates to a preparation method of a compound alpha-acetyl-gamma-butyrolactone represented by a formula (I). According to the invention, the compound of the formula (II) and ethyl acetate are subjected to condensation, acidification, and rectification under the existence of calcium oxide, such that the compound represented by the formula (I) is obtained. The compound is an important intermediate used for preparing vitamin and chlorophyll raw materials.

A method of detecting hypoxia. Detecting hypoxia includes detecting, in exhaled breath, at least one indicator for hypoxia. The at least one indicator is selected from the group consisting of pentanal, 2-pentanone, 2-hexanone, 2-heptanone, 2-cyclopenten-1-one, and 4-butyrolactone.

A method for continuously synthesizing N-methylpyrrolidone and N-ethylpyrrolidone, the method is carried out in a microreactor, and gamma-butyrolactone solution and corresponding alkylamine solution are continuously passed through a microreactor to synthesize N-methylpyrrolidone and N-ethylpyrrolidone. Wherein, the microreactor includes a reaction section and a reaction suppression section, and the reaction mixture is carried out under the condition that the residence time of the reaction mixture is 1 to 30 minutes, and wherein the γ-butyrolactone solution and the corresponding alkylamine solution Both use ethylene glycol as a solvent, the molar ratio of alkylamine and γ-butyrolactone in the reaction mixture is 1.0-1.6, and the concentration of the γ-butyrolactone solution is 0.5-2 mol / L. The invention can shorten the synthesis process time of N-methylpyrrolidone and N-ethylpyrrolidone from several hours to within 30 minutes, and meanwhile, the yield of the product reaches more than 90%.

The present invention relates to a process for the preparation of Gamma-butyrolactones.

The present invention provides a preparation method of Piscicanide hydrochloride intermediate, which is characterized in that it comprises: Step 1, butyrolactam (I) and γ-butyrolactone (II) undergo polymerization reaction under strong base and predetermined conditions Generate N-(3-carboxypropyl) butyrolactam (Ⅲ); Step 2, N-(3-carboxypropyl) butyrolactam (Ⅲ) is cyclized at high temperature in monoisopropyl malonate solvent and Condensation with malonate monoester salt to generate 7α-double condensed pyrrolidine-acetate; a better choice is to generate 7α-double condensed pyrrolidine-acetate isopropyl ester (Ⅴ). Step 3, 7α-biscondensed pyrrolidine-acetate is hydrolyzed in acid to generate the corresponding pharmaceutically acceptable salt. The preparation method of the invention avoids expensive or difficult-to-obtain raw materials, avoids the use of liquid ammonia in the synthesis process, reduces reaction steps, is simple to operate, has few wastes and high yield.

The present invention relates to the technical field of extracting polypeptides from clams. In order to further improve the extraction rate of clam oligopeptides, the method of the present invention provides a method for extracting clam oligopeptides. The ionic liquid EMIMBF4 and γ-butyrolactone are in a volume ratio of 1: 1 The binary system obtained by compounding is applied to the preparation of clam oligopeptides, and a pulsed electric field is applied at low temperature to decompose clam visceral tissues, and then enzymatically hydrolyzed, separated, and purified under optimized enzymatic hydrolysis conditions to obtain clam oligopeptides. In the clam oligopeptide preparation method of the present invention, ionic liquid EMIMBF4 and γ-butyrolactone are mixed at a ratio of 1:1 to make a compound solvent, treated at low temperature in conjunction with a pulsed electric field, and then enzymatically hydrolyzed by alkaline protease to extract the obtained clam oligopeptide The efficiency is improved, and the biological activity is also improved to a certain extent, and the degreasing process of 0.1mol / L sodium hydroxide solution is omitted.

The invention relates to the technical field of polypeptide extraction from clams. In order to further improve the extraction rate of the clam oligopeptides, the invention provides an extraction method of the clam oligopeptides. A binary system obtained by compounding ionic liquid EMIMBF4 and gamma-butyrolactone according to a volume ratio of 1:1 is applied to the preparation of the clam oligopeptides; a pulse electric field is applied at a low temperature for decomposing internal organ tissues of the clams; then, enzymolysis, separation and purification are performed under an optimized enzymolysis condition; and the clam oligopeptides are obtained. The preparation method of the clam oligopeptides has the advantages that a compounding solvent prepared by mixing the ionic liquid EMIMBF4 andthe gamma-butyrolactone according to a ratio of 1:1 is added; low-temperature cooperative pulse electric field treatment is performed; then, enzymolysis is performed by using alkaline proteases; theextraction rate of the obtained clam oligopeptides is improved; the bioactivity is improved to a certain degree; and the degreasing process of 0.1 mol / L sodium hydroxide solution is omitted.

The invention discloses a chiral γ-butyrolactone derivative, a synthesis method and application thereof. Its structure is shown in formula (1); wherein, Ar 1 、Ar 2 and Ar 3 Each independently is phenyl, halogenated phenyl, nitro-substituted phenyl, C 1～4 Alkyl substituted phenyl, C 1～4 Alkoxy substituted phenyl, C 1～4 Haloalkyl is substituted for phenyl, naphthyl or halonaphthyl. The derivatives described in the present invention have a novel structure, and have good anti-cancer effects, especially for human breast cancer cells (MCF-7) and human lung adenocarcinoma cells (A549), and have good inhibitory effects, It exhibits good anti-breast cancer and lung cancer cell effects, and can be prepared as an anti-breast cancer and lung cancer drug for application; in addition, the preparation method of the compound is simple, using cheap and easy-to-obtain compounds as raw materials, and has mild reaction conditions, The invention has beneficial effects such as few reaction steps, fast reaction, less waste generated, simple and safe operation, high atom economy, high selectivity, and high yield.

The invention discloses a preparation method of (R)-3-propyl-gamma-butyrolactone. The method comprises the following steps: with (S)-3-hydroxyl-gamma-butyrolactone as an initial raw material, activating hydroxyl by using sulfonate, reacting the hydroxyl-activated compound with a Grignard reagent in the presence of a copper catalyst, a cocatalyst and a nitrogen-containing compound to generate (R)-3-propyl-gamma-butyrolactone. The preparation method has the advantages that the process route is simple, the raw materials are cheap and easy to obtain, the synthesis route is short, the reaction conditions are mild, the operation is simple and convenient, the yield is high, and the stereoselectivity is good, the problems of the prior art that chiral separation and chiral column separation are needed in reaction, the yield is low and the chemical selectivity is poor are solved, and an important value is provided for the process research of brivaracetam.