40 results about "Butyrolactone I" patented technology

A γ-butyrolactone compound as shown in Formula (I) and pharmaceutical composition thereof: wherein X═N, O, S, Se; and A and B are selected from substituents having the following formula: wherein R1, R2, R3, R4, and R5 are selected from a hydrogen atom, a halogen atom, a hydroxyl group, a mercapto group, an amino group, an alkoxy group, and a nitro group. The γ-butyrolactone compound and pharmaceutical composition thereof butyrolactone have inhibitory effects on hepatoma, ovarian cancer, breast cancer, lung cancer, malignant glioblastoma or colorectal carcinoma, and are cytotoxic with high specificity to inhibit Paclitaxel-resistant tumour cells at later stage of chemotherapy without any damage on normal cells.

Disclosed is a two-step, continuous hydrogenation process for the preparation of 3-methyl-tetrahydrofuran from alpha-methylene-gamma-butyrolactone, which comprises a first step of subjecting alpha-methylene-gamma-butyrolactone to hydrogenation to synthesize 2-methyl-gamma-butyrolactone; and the second step of hydrogenating the 2-methyl-gamma-butyrolactone formed in the first step. The above process enables the production of the objective highly-pure 3-methyl-tetrahydrofuran free from alcohol in high efficiency and high conversion through simple production steps.

The present invention relates to a novel process for the preparation of optically enriched substituted R(+)beta-benzyl-gamma-butyrolactones of the general formula 1, wherein, R1 and R2 independently represent the following groups, R1=R2=H, OH, -OCnH2n+1 (n=1 to 8), NH2, and / or CF3, R1 and R2 together represents -O(CH2)mO- where m=2 to 4.

A method of detecting hypoxia. Detecting hypoxia includes detecting, in exhaled breath, at least one indicator for hypoxia. The at least one indicator is selected from the group consisting of pentanal, 2-pentanone, 2-hexanone, 2-heptanone, 2-cyclopenten-1-one, and 4-butyrolactone.

The present invention relates to a process for the preparation of Gamma-butyrolactones.

The present invention provides a preparation method of Piscicanide hydrochloride intermediate, which is characterized in that it comprises: Step 1, butyrolactam (I) and γ-butyrolactone (II) undergo polymerization reaction under strong base and predetermined conditions Generate N-(3-carboxypropyl) butyrolactam (Ⅲ); Step 2, N-(3-carboxypropyl) butyrolactam (Ⅲ) is cyclized at high temperature in monoisopropyl malonate solvent and Condensation with malonate monoester salt to generate 7α-double condensed pyrrolidine-acetate; a better choice is to generate 7α-double condensed pyrrolidine-acetate isopropyl ester (Ⅴ). Step 3, 7α-biscondensed pyrrolidine-acetate is hydrolyzed in acid to generate the corresponding pharmaceutically acceptable salt. The preparation method of the invention avoids expensive or difficult-to-obtain raw materials, avoids the use of liquid ammonia in the synthesis process, reduces reaction steps, is simple to operate, has few wastes and high yield.

The present invention relates to the technical field of extracting polypeptides from clams. In order to further improve the extraction rate of clam oligopeptides, the method of the present invention provides a method for extracting clam oligopeptides. The ionic liquid EMIMBF4 and γ-butyrolactone are in a volume ratio of 1: 1 The binary system obtained by compounding is applied to the preparation of clam oligopeptides, and a pulsed electric field is applied at low temperature to decompose clam visceral tissues, and then enzymatically hydrolyzed, separated, and purified under optimized enzymatic hydrolysis conditions to obtain clam oligopeptides. In the clam oligopeptide preparation method of the present invention, ionic liquid EMIMBF4 and γ-butyrolactone are mixed at a ratio of 1:1 to make a compound solvent, treated at low temperature in conjunction with a pulsed electric field, and then enzymatically hydrolyzed by alkaline protease to extract the obtained clam oligopeptide The efficiency is improved, and the biological activity is also improved to a certain extent, and the degreasing process of 0.1mol / L sodium hydroxide solution is omitted.