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Preparation method of DL-hydroxy selenomethionine

A technology of hydroxyselenomethionine and hydroxyl, which is applied in the field of preparation of organic compounds, and can solve problems such as poor stability, difficulty in obtaining, and high cost of industrial production

Inactive Publication Date: 2021-06-01
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Claims
  • Application Information

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Problems solved by technology

The original research process route of DL-hydroxyselenomethionine is to use methyl lithium and selenium to prepare lithium methyl selenide in ether, and then react with α-hydroxybutyrolactone to prepare it. This process not only uses flammable and explosive Methyl lithium and ether, but also use the difficult-to-obtain α-hydroxybutyrolactone as a raw material, the industrial production cost is high (WO2006008190A2); another process route is to use methylselenol and acrolein to react to prepare 3-methylselenopropane Aldehydes, and then hydrolyzed after adding highly toxic reagents sodium cyanide or hydrogen cyanide, this route not only uses cyanide, hydrogen selenide, acrolein and other toxic reagents, but also selenium intermediates with poor stability The reaction route is long, the quality in the process is not easy to control, and the requirements for industrial production conditions are very harsh (CN109232342A)

Method used

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  • Preparation method of DL-hydroxy selenomethionine
  • Preparation method of DL-hydroxy selenomethionine

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Embodiment example

[0015] The present invention will be described in detail below using examples. However, the present invention is not limited to the forms shown in the examples, and the specific embodiments can be variously changed within the range described in the specific embodiments of the present invention.

[0016] 1 Preparation of α-bromo-γ-butyrolactone

[0017] Add 2.2ml of phosphorus tribromide to 100g of γ-butyrolactone, heat to 100°C under the protection of nitrogen, and slowly add 176.4g of bromine dropwise. After the dropwise addition, continue to keep warm and stir for 4 hours. After the reaction, concentrate under reduced pressure to remove the low boiling point. 172.5 g of the crude product of α-bromo-γ-butyrolactone was obtained, which was directly used in the next reaction.

[0018] 2 Preparation of α-hydroxy-γ-butyrolactone

[0019] Dissolve 217g of potassium carbonate in 1L of deionized water, heat to reflux, slowly add dropwise the crude product of 172.5 g of α-bromo-γ-b...

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Abstract

The invention belongs to the field of preparation of organic compounds. The invention provides a preparation method of DL-hydroxy selenomethionine. The method is characterized in that gamma-butyrolactone is used as a raw material, alpha-hydroxyl-gamma-butyrolactone is synthesized through alpha-bromination and hydroxylation, and then the alpha-hydroxyl-gamma-butyrolactone reacts with sodium methyl selenol to obtain the DL-hydroxyl selenomethionine. The method has the advantages of easily available raw materials, mild reaction conditions and low cost, and is suitable for large-scale preparation of DL-hydroxyselenomethionine.

Description

technical field [0001] The invention belongs to the field of preparation of organic compounds. The invention relates to a method for preparing DL-hydroxyselenomethionine. Background technique [0002] Selenium is an indispensable trace element in humans and animals, and has significant effects in preventing and inhibiting cancer and delaying aging. Human cancer, cardiovascular and cerebrovascular diseases, children's mental retardation, senile dementia and other 42 diseases are related to selenium deficiency. Selenium deficiency in animals can lead to increased mortality, muscle atrophy and other symptoms. Therefore, the World Health Organization defined selenium as an essential trace element for humans and animals in 1973. Inorganic selenium is the first-generation selenium source. Sodium selenite and sodium selenate can be used as feed additives. Although the price is low, they are mainly absorbed through simple diffusion, poor absorption by organisms, and low effective...

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Application Information

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IPC IPC(8): C07C391/00
CPCC07C391/00C07D307/33
Inventor 边广岭宋玲陈忠祥孙兆峰
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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