36 results about "Anaesthesia local" patented technology

Sustained release local anesthetic formulations are administered intra articularly and / or into body spaces / cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release material prolonging the release of the local anesthetic and optionally and a pharmaceutically acceptable, i.e., non-toxic, augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable without the augmenting agent.

A formulation for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a non-toxic augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent. In preferred embodiments, the controlled release material is a low molecular weight, acid-terminated polymer. A further aspect of the invention is directed to such formulations which release the local anesthetic in two phases, the first a rapid "bolus" to initiate anesthesia and a second, slower release to maintain anesthesia.

The present invention relates to a composition for controlling viability of a tissue including a potassium channel opener or adenosine receptor agonist, a compound for inducing local anaesthesia and a compound for reducing the uptake of water by a cell in the tissue. The present invention also realtes to the use of the composition accordng to the invention for controlling viability of a tissue.

A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when inplanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.

A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.

Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. Also disclosed are kits comprising a local anesthetic, an alpha adrenergic receptor agonist and a low dose of an alpha adrenergic receptor antagonist.

The invention discloses a medicine for local anaesthesia and a preparation method of the medicine. The medicine comprises the following raw material medicines: Chinese angelica, cinnamon, pepper, fresh ginger, Schizonepeta, divaricate saposhnikovia root, clove, dried tangerine or orange peel, cyperus rotundus, sensitive plant, rhizoma nardostachyos, persimmon calyx, mint, radix bupleuri, henbane leaf, radix gentianae, coptis chinensis, semen strychni, patrinia, purslane, humifuse euphorbia herb, oldenlandia diffusa, root of rehmannia, sweet wormwood, cortex lycii radicis, pseudo-ginseng, rubia cordifolia, Loropetalum chinense, trogopterus dung and corydalis tuber. The medicine has the beneficial effects that the medicine has the advantages of wide clinical application safety range, zero toxic or side effect and good pain and blood stopping effects by utilizing the theory of traditional Chinese medicine, injection is not needed during use, only the medicine is needed to be dripped or smeared to an affected part needed to be operated for several times, and when the local tissue is found not to have a sense of pain, the operation can be carried out. The feared state of mind of a patient can be effectively eliminated, the feeling of the patient can be rapidly restored after the operation, and postoperative adverse reactions are reduced.

The invention belongs to the field of medical instruments and particularly relates to a homogenate aspirator for minimally invasive removal of sludged blood and a control method of the homogenate aspirator. The homogenate aspirator comprises a main operating rod, a homogenate cutter bit, a mesh cover, a soft endoscope, a handle, a mesh cover adjusting rod, a cutter bit switch, a mesh cover adjustor, a negative-pressure switch, a camera controller, a main switch, a power supply cavity, a negative-pressure suction tube, video equipment and a negative-pressure aspirator. By adoption of the homogenate aspirator, a traditional general anesthesia method can be replaced, and the problem of clearing of residual sludged blood in the thoracic cavity due to bleeding and drainage nonsmoothness of a patient suffering from traumas or subjected to cardiothoracic surgeries can be solved under local anaesthesia and minimally invasive conditions, so that an operating process of sludged blood clearing can be dramatically simplified, and safety is improved.

The invention discloses an intelligent training method and system for central venipuncture. The method comprises the steps of case selection, simulation of article preparation, pre-operation preparation simulation, simulated disinfection, simulation of local anesthesia, simulation of puncture catheterization, simulation of fixation and simulation of postoperative treatment. When simulation of puncture catheterization is carried out, the puncture position of the simulated puncture is detected, the puncture angle of a simulated puncture needle is detected, the puncture depth of the simulated puncture is detected, whether the puncture process is correct or not is judged, a guide wire or simulated guide wire placement depth is detected, the guide wire or simulated guide wire placement speed isdetected, the catheter or simulated catheter placement depth is detected, whether the guide wire and catheter placement process is correct or not is judged according to the detection result, and feedback is recorded; according to the intelligent training method and system for central venipuncture, an operator is guided to carry out simulated central venipuncture operation through prompt and timely feedback, the operation process is detected, timely given, judged and judged, the result is timely fed back to the operator, and the operator is guided to carry out operation.

The invention discloses a clinical local anesthesia quantitative spraying device for medical anesthesiology department, relates to the technical field of anesthesia spraying devices, and solves the problems that the dosage of sprayed anesthetic cannot be controlled during spraying of an existing spraying bottle, and the accuracy is poor. The quantitative spraying device for clinical local anesthesia in the medical anesthesiology department comprises a spraying quantitative assembly; and a medicine pushing piston is inserted into an inner medicine storage cylinder. When the device is used, the spray anesthesia assembly can extract and compress an anesthetic in the inner medicine storage cylinder for spray anesthesia, and the total spray amount of the spray anesthesia assembly can be controlled and adjusted by the spray quantification assembly during spray anesthesia, so that the device can adapt to quantitative spray anesthesia at different treatment parts and within different treatment ranges; use is convenient, spray anesthesia amount is accurate, and later recovery of a patient is not affected.

The invention discloses a preparation method of a novel human adipose-derived stem cell preparation. The preparation method comprises the following steps of: S1, performing medical examination on a donor, and then under the state of local anaesthesia, acquiring adipose by swelling method liposuction; S2, respectively performing digestion treatment on the obtained adipose in 0.2%-0.4% of mixed collagenase and 0.25% of Trypsin-EDTA digestive fluid, adding a trypsin inhibitor, performing uniform mixing, ending digestion, then performing centrifuging, cleaning bottom cells with PBS, and performingfiltration so as to obtain primary substitute adipose stem cells; S3, culturing the primary substitute adipose stem cells to obtain massive adipose stem cells; and S4, performing detection and frozenstorage. The adipose stem cells finally prepared by the preparation method are high in survival rate, uniform in cellular morphology size and safe and reliable to use, and the possibility of allergyand infection with exogenous pathogeny in the use process is eliminated.

The present invention provides a local cryoanesthesia device which sprays a coolant on a treatment site to cryoanesthetize the treatment site so as to be able to more rapidly and accurately regulate the temperature of the coolant sprayed on the treatment site. The local cryoanesthesia device comprises: a housing which forms an outward form and from which the coolant is sprayed; a spraying unit which is installed in the housing to spray the coolant; a cooling temperature regulator which is connected to the spraying unit to apply thermal energy to the sprayed coolant for temperature regulation;and a control unit which is connected to the cooling temperature regulator to control the cooling temperature regulator. Accordingly, the cryoanesthesia device has the functions of measuring and regulating the temperature of the coolant, and is thus capable of applying the coolant to the treatment site within a safe temperature range according to the purpose of treatment, thereby enabling a desired treatment purpose such as local anesthesia to be safely and rapidly accomplished without side effects such as cytoclasis.

An extended duration anesthetic includes a short duration local anesthetic in a dilute solution and a long duration local anesthetic. The long duration local anesthetic is maintained in a powdered form until the time of administration. Premeasured quantities of the dilute solution and powdered long duration local anesthetic in a kit allow for quick preparation of a solution with desired concentrations of both short duration local anesthetic and long duration local anesthetic at the time of administration.

The invention discloses a multifunctional auxiliary anesthesia device for clinical anesthesia department, which comprises a PC client and a keyboard and mouse input device electrically connected with the PC client, and the PC client is also electrically connected with a device main body; the device main body It includes a sliding cylinder and a vacuum pump fixedly installed on the outer wall of the sliding cylinder. The vacuum pump sucks out the air in the main body of the device through an air suction pipe; the upper end of the sliding cylinder is also sealed and buckled with a cylinder cover. The beneficial effect is that the multifunctional auxiliary anesthesia device for clinical anesthesia department of the present invention is not only suitable for general anesthesia operation, but also suitable for local anesthesia, with rich functions and good practicability.

The invention discloses a clinical local anesthesia spraying device for the anesthesiology department, which relates to the technical field of local anesthesia spraying devices. The use amount of the anesthetic is adjusted. The device specifically comprises a base and a pressing assembly, a protective plate is arranged on the outer wall of the top of the base, a hollow column is movably connected to the outer wall of the top of the protective plate, an anesthetic box is arranged on the outer wall of the top of the hollow column, a limiting ring is arranged on the outer wall of the circumference of the hollow column, and a connecting column is arranged on the outer wall of the bottom of the limiting ring; a clamping plate is arranged on the outer wall of the bottom of the connecting column, a rotating column is arranged on the circumferential inner wall of the clamping plate, and a rotating cylinder is arranged on the outer wall of the bottom of the rotating column. The anesthetic can be stored by arranging the anesthetic box, the hollow column is arranged to be of a hollow structure, the anesthetic can be guided into the rotating column through the hollow column and finally guided out through an arc-shaped hole formed in the rotating cylinder, and therefore local anesthesia can be conveniently achieved after the anesthetic is atomized subsequently.

The invention discloses a special traditional Chinese medicine extracting solution for local anaesthesia. The special traditional Chinese medicine extracting solution is prepared from the following main raw materials in parts by weight: 20-45 parts of schizonepetaspike, 20-45 parts of turmeric, 20-45 parts of hairyvein agrimony, 20-45 parts of flos daturae, 30-50 parts of ixeris sonchifolia hance, 30-50 parts of cissampeline methiodide, 30-50 parts of mint, 1-5 parts of pepper and 1-5 parts of willow branches. Clinical treatment for multiple years proves the special traditional Chinese medicine extracting solution has a good treatment effect on local anaesthesia and muscular pain and weakness caused by local anaesthesia, and has the advantages of significant effect and accurate medicine effect.

The invention discloses a high-performance liquid chromatography method for detecting 16 kinds of local anesthetic components in adult products for external use. The high-performance liquid chromatography is used for detection, and the detection includes the following steps: firstly preparing a test solution; and then using high-performance liquid chromatography to detect The test solution is tested; a sub-3 micron core-shell column is used, which is suitable for the detection of 16 local anesthetic components. The present invention improves the sample processing, improves the detection recovery rate and accuracy through the setting of the chromatographic column and the chromatographic analysis conditions, makes the operation process simpler and faster, can significantly improve the sensitivity of the detection method, and has strong practicability. It is an external product for adults Provide support for the prevention and control of 16 local anesthetic component residues.

The invention provides a lead screw transmission mechanism and an oral local anesthesia booster, and belongs to the field of medical instruments. The lead screw transmission mechanism used for being installed on the oral local anesthesia booster comprises a lead screw main body, a transmission nut, a motor, a guide member, a first Hall sensor assembly and a controller, wherein an output shaft of the motor is in drive connection with the lead screw main body; the transmission nut is in screwed connection with the lead screw main body; the transmission nut is slidably connected to the guide member; a transmission lead screw rotates to drive the transmission nut to do reciprocating motion relative to the guide member; the first Hall sensor assembly is in signal connection with the controller, and is used for detecting the rotating speed of the motor; the controller is in control connection with the motor. The lead screw transmission mechanism applied to the oral local anesthesia booster can accurately control the injection amount of drugs and improve the injection safety of the drugs, is convenient and rapid to operate, and sensitive to control, and can be made to be of a pen type for convenience of operation.

The local anesthesia device comprises a bottom frame, a bottom plate, a lifting plate and a placement barrel, a rectangular through area is formed in the middle of the bottom frame, a sliding block is fixed to the side, corresponding to a sliding groove of the bottom frame, of the bottom plate, the sliding block is slidably connected into the sliding groove of the bottom frame, and the lifting plate is movably connected to the bottom plate through the action of a limiting rod and a threaded rod; one side of the bottom end of the placement barrel is rotationally connected to the other side of the circular penetrating area through a rotating shaft, limiting plates are fixed to the positions, close to the arc-shaped rods, of the outer side of the bottom end of the placement barrel, arc-shaped through holes are formed in the ends of the limiting plates, and the arc-shaped rods are slidably connected into the arc-shaped through holes; a needle cylinder clamping plate is movably connected into the containing cylinder, and a needle penetrating area is formed in the middle of the needle cylinder clamping plate. According to the injection device, the inclination angle of the containing cylinder can be adjusted according to the injection angle, the height of the lifting plate can be adjusted according to the injection depth, the height of the needle cylinder clamping plate can be finely adjusted according to the injection depth, the efficient and accurate injection process of anesthetics can be completed, and the injection device is efficient and practical.

The invention discloses an adjustable and controllable spraying device for local anesthesia in the anesthesiology department. The adjustable and controllable spraying device comprises a bottom plate, universal wheels are fixedly installed on the two sides of the bottom of the bottom plate, an equipment box is fixedly installed at the top of the bottom plate, a U-shaped frame is fixedly installed at the top of the equipment box, and an electric telescopic rod is fixedly installed in an inner cavity of the U-shaped frame. According to the adjustable and controllable spraying device for local anesthesia in the anesthesiology department, a third driving motor drives a second lead screw to rotate, under the threaded transmission action of the second lead screw and a transmission base, the transmission base drives an L-shaped connecting pipe to reciprocate front and back, and then an atomizing nozzle is driven to reciprocate front and back; according to the anesthetic spraying device, the atomizing nozzle moves at a constant speed and sprays anesthetic to a patient, the atomizing nozzle is mechanically driven to move, the anesthetic can be evenly sprayed to an operation area of the patient, the situation that the anesthetic is too much in part of the area and too little in part of the area is avoided, and the anesthetic effect is good.

The invention discloses a blood perfusion device for an experimental animal. The device comprises an artery indwelling needle, a three-way valve, a constant flow pump, a perfusion device, an evacuation air pipe, an infusion heater and a venous indwelling needle. The artery indwelling needle, the three-way valve, the constant flow pump, the perfusion device, the evacuation air pipe, the infusion heater and the venous indwelling needle are sequentially connected through catheters. A rabbit is adopted as the experimental animal, a vascular access is built through an ear central artery and an ear edge vein by local anaesthesia, the blood perfusion operation is simplified, the pain of the experimental animal is reduced, and the influence on the experiment result is reduced. The indwelling needles are soft, the inner wall of the blood vessel cannot be hurt, the indwelling needles can remain for a long time, and frequent blood perfusion is facilitated. The artery end is connected with the three-way valve to facilitate blood sampling and injection of anticoagulant and other drugs. The inner volume of the perfusion device is 20 ml, the reduction of the blood volume of the rabbit in the blood perfusion process does not obviously influence the basic vital signs, blood in the system is input back to the body of the animal through the constant flow pump after the perfusion is finished, and blood losses are reduced. The infusion heater is arranged at the vein end, compensates the loss of the temperature of the extracorporeal circulation blood, and keeps the temperature of the experimental animal constant.

The invention relates to the field of medical anesthesia, in particular to a local anesthesia apparatus. The local anesthesia apparatus comprises a middle shaft, a hexagonal bracket, arc plates, sliding rods, through holes, scrapers and collecting boxes; the hexagonal bracket is fixedly connected to the middle shaft; the sliding rods are arranged on the hexagonal bracket in a sliding mode; the arc plates are fixedly connected to the sliding rods; a spring is arranged between each arc plate and the hexagonal bracket; the through holes are formed in the arc plates, and the collecting boxes are arranged in the corresponding through holes in a sliding mode; each collecting box is fixedly connected with one scraper; and one spring is arranged between each arc plate and the corresponding collecting box. The local anesthesia apparatus further comprises discharging plates, and each collecting box is provided with the corresponding discharging plate. The local anaesthesia apparatus further comprises a bent frame and a bent frame tube; the bent frame is fixedly connected with the bent frame tube; the bent frame tube slides on the middle shaft, and the local anaesthesia apparatus has the advantage that external auditory canals of different sizes can be cleaned.

The invention provides a front-end protection circuit and method of a medical local anesthesia plane monitor, the detection electrode is coupled to the input end of the amplifier, and the output end of the amplifier is connected to the detection signal input end of the monitor processing circuit; the protection The circuit includes a delayer, an OR gate, a counter, a switch tube, and a normally closed relay switch; wherein, the input end of the delayer and the enable input end of the amplifier are both connected to an enable output end of the monitor processing circuit. The structure of the invention is simple and efficient, and can accurately sense and discharge static electricity in time and fully. It can achieve the maximum isolation of the electrostatic discharge path.

The invention discloses a local anaesthesia injection device for percutaneous vertebroplasty. The local anaesthesia injection device for percutaneous vertebroplasty comprises a fixing sleeve, a sliding plate, a first containing hole, a first one-way valve, a sliding rod, a draining hole, a connecting plate, a second containing hole, a second one-way valve, a puncture needle, a connecting sleeve, afirst voidance hole and a first rubber pad. The local anaesthesia injection device for percutaneous vertebroplasty is ingenious in structure, powerful in function and easy to operate; by using the device, a medical worker can perform secondary anaesthesia on a patient without replacing the device with a new anaesthesia injection device, the labor intensity of the medical worker is relieved, and the patient is protected.

The urine collector comprises a urine sleeve matched with the crotch of the human body, the inner side of the urine sleeve is provided with a storage cavity, the two sides of the front end of the urine sleeve are each provided with a first bolt buckle, and the two sides of the rear end of the urine sleeve are each provided with a second bolt buckle; and rotary connecting pieces sleeve the first bolt buckle and the second bolt buckle and are positioned outside the urine sleeve. By means of the urine sleeve, the rotary connecting piece and the binding bands, the urine sleeve can be fixed to the crotch of the human body conveniently, genital organs can enter the urine collecting catheter conveniently through the horn-shaped collecting hopper, the depth of the urine collecting catheter is adjusted under cooperation of the first silica gel gasket and the second silica gel gasket, the urine collecting catheter can be attached to the human body, and urine enters the output head from the urine collecting catheter during urine collection; and under the cooperation of a first one-way check valve and a second one-way check valve, urine cannot flow back, the interior of the output head is pressurized by pressing the pressurizing air bag, the urine is stably introduced into the urine collecting bag from the conveying pipe to be collected, and the problem that the urine of a patient leaks in the local anesthesia operation is solved.

The present invention discloses a technical method for lifting a nasal columella base. The technical method includes the following steps: firstly, performing local anaesthesia on nasal columella, thatis, forming a needle eye with the diameter of 1 mm above the nasal columella by using a blunt stripper to perform local anaesthesia; and secondly, performing blunt dissection on cartilage, that is, performing blunt stripping from a basibranchial gap at the rear of the skin of the nasal columella to the nasal columella base by using the blunt stripper. The self-repairing force and regeneration mechanism of a wounded human tissue are utilized under the assistance of the hyperplasia effect of collagen fibers and elastic fibers. The form of the nose and the middle part of the face are enabled tobe more beautiful due to the lifting effect of the nasal columella base.

The invention provides a self-assembled oligopeptide capable of inducing biological mineralization of a local anesthetic and a long-acting local anesthesia and analgesia medicinal preparation prepared from the self-assembled oligopeptide, and belongs to the field of pharmacy. According to the oligopeptide disclosed by the invention, the self-assembled nanostructure with negative charges on the surface is combined with local anesthetic molecules through the charge effect, and the local anesthetic is induced to be biomineralized under the condition that the alkaline pH regulator is used as an auxiliary agent, so that uniform micron-level injectable drug crystals are formed. The medicine crystal is used as a medicine preparation, has good biocompatibility, can effectively delay the release rate of the medicine and prolong the local anesthesia and analgesic effects, and has good application prospects in preparation of medicines with long-acting local anesthesia and long-acting analgesic effects.

The invention discloses a local anesthesia controllable spraying device for clinical anesthesia. The local anesthesia controllable spraying device comprises a spraying body, a jet flow medicine spraying pipe, a quantitative piston, a suction piston and a quantitative control assembly. A control cavity and a medicine storage cavity are horizontally arranged in the spray body at an interval, the control cavity and the medicine storage cavity are both columnar sealed cavities, and the tail end of the control cavity is communicated with the outside; the suction piston and the quantitative piston are installed in the control cavity and the medicine storage cavity in a matched mode respectively and can slide back and forth along the inner wall of the cavity in a sealed mode. The anesthetic spraying device is unique in structure and convenient to use, anesthetic can be quickly and uniformly sprayed to an affected part when the anesthetic spraying device is used, and the problems that an existing anesthetic spraying device is single in function, and the spraying dosage cannot be accurately controlled are effectively solved.

The invention provides a lipomyoma excision robot. The lipomyoma excision robot comprises a main body frame, a take-out part, an injection part, a cross-cutting part, an incision part and the like; the take-out part comprises a take-out part connecting rod, an electric cylinder base, a claw head, a needle seat and the like; the injection part comprises an injector, an injector holder, an injectionpart connecting rod and the like; the cross-cutting part comprises a cross-cutting part connecting rod, a telescopic electric cylinder seat, a lateral translation block, a cross-cutting cutter head and the like; the incision part comprises an incision cutter head, an incision cutter holder, an incision part connecting rod and the like; a main body of the robot is composed of the main body frame,a rotating rod, a sliding block moving frame and the like; the sliding block moving frame is provided with four mechanical arms of the take-out part, injection part, cross-cutting part and incision part; the injection part performs local anesthesia on the skin, the incision part cuts a part of the skin, a needle of the take-out part is inserted into a tumor body, and the claw head of the take-outpart and the cross-cutting part cut the periphery of the tumor body, so that the tumor body is separated, and the lipomyoma is removed.

The invention provides a microneedle array easily applied to an oral cavity and may exert an anesthetic effect according to an application site. Provided are an immediate-acting dental local anesthetic preparation including a microneedle array containing a local anesthetic, in which a needle part dissolves in a mucous membrane when being applied to an oral mucous membrane or gums, the microneedle array containing the local anesthetic, in which a height of a microneedle is 50 μm or more and 300 μm or less, a rip of the microneedle is a circle having a diameter of 1 μm or more and 50 μm or less or a plane having the same area, and a thickness of a substrate of the microneedle array is 5 μm or more and 100 μm or less, and a microneedle patch including the microneedle array and a support provided on a back surface of the microneedle array.