The invention discloses a traditional Chinese medicine combination for treating bone injury and fracture, which is characterized by comprising oral medicines and external-use medicines, wherein the oral medicines comprise the following active pharmaceutical ingredients: astragalus, angelica sinensis, barrenwort, herba cistanche, pseudo-ginseng, achyranthes root, safflower, cortex eucommiae, salvia miltiorrhiza, rhizomadrynariae, yam, fructus psoralea, sambucus williamsii hance, woodwardia japonica, prepared radix rehmanniae, lumbricus and white peony root; and the external-use medicines comprise various active pharmaceutical ingredients: myrrh, fructus evodiae, teasel, pseudo-ginseng, safflower, rhizoma ligustici wallichii, nux vomica, toad skin, centipede, notopterygium and herba lycopodti. The traditional Chinese medicine combination activates osteoblasts of endosteum and periosteum at the bone injury and fracture site to rapidly calcify, thereby having special efficacy to promote the generation a new bone. The traditional Chinese medicine combination is suitable for treating various bone injuries and fractures, has high cure rate, relieve severe pains of the bone injury and fracture of mass patients without using strong analgesics, can promote bone callus to rapidly form and has the effects of relieving flatulence and pains, eliminating blood stasis and promoting tissue regeneration and growth of the bone callus.