The invention discloses a cable with a fluorine-modified polyacrylate sheath layer. The cable comprises a cable core and a sheath layer which coats the cable core. Raw materials of the sheath layer comprise, by weight, 32-35 parts of nitrile rubber 2707, 24-27 parts of fluorine-modified polyacrylate, 23-26 parts of ethylene propylene diene monomer, 13-16 parts of para-aramid fibers, 11-14 parts of furnace black, 17-20 parts of mica, 8-11 parts of sepiolite, 3-5 parts of a mono-alkoxy titanate coupling agent, 2.3-3.5 parts of sulphur, 1.5-1.8 parts of an accelerant TT, 2.2-2.5 parts of an accelerant DM, 1.1-1.4 parts of an anti-aging agent SP, 2.3-2.6 parts of an anti-aging agent RD, 0.7-1.1 parts of stearic acid, 7-11 parts of phenyl petroleum sulfonate and 1-3 parts of castor oil. The cable has good waterproofness and oil-proof performance, and has excellent weather fastness and corrosion resistance. The preparation process is simple and easy to operate, and reaction conditions are mild. The cable is convenient for industrial production.