The invention discloses nerve-soothing and qi-tonifying egg, ginger and shiitake mushroom stem floss which is prepared from the following raw materials in parts by weight: 50-65 parts of shiitake mushroom stems, 8-15 parts of egg liquor, 14-15.5 parts of ginger powder, 15-16 parts of bread crumbs, 4-5 parts of apple juice, 7-8 parts of cola, 1.8-2.3 parts of coconut shells, 2-2.6 parts of lucid ganoderma, 0.9-1.5 parts of Japanese eupatorium herb roots and a proper amount of cellulase, protease, 30-35% of liquid glucose, a1-2% citric acid solution, a 0.02-0.03% cysteine solution, refined salt, monosodium glutamate and pine needles. The shiitake mushroom stem floss disclosed by the invention is smoked, so that the fragrance is increased; the shiitake mushroom stem floss is fragrant and pure, long in aftertaste and good in taste quality; the nutrients of the shiitake mushroom stems are retained to the maximum extent, and formaldehyde in the shiitake mushroom stems is removed by virtue of the cysteine solution. By further adding the traditional Chinese medicinal materials such as coconut shells, lucid ganoderma, Japanese eupatorium herb roots and the like, the shiitake mushroom stem floss disclosed by the invention is endowed with the health-care functions of tonifying qi and soothing the nerves and relieving cough and asthma.