32results about How to "No need for secondary surgery" patented technology

The invention belongs to the technical field of medical biological materials, and in particular relates to a polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit and a preparation method thereof. The polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit is prepared as follows: dissolving polylactic acid and I type collagen in an organic solvent, evenly mixing, using electrospinning technique to prepare a nerve conduit inner layer membrane; dissolving the polylactic acid and beta-calcium phosphate in the organic solvent, evenly mixing, spraying the nerve conduit inner layer membrane with a spinning liquid by the electrospinning technique to form a nerve conduit outer layer membrane, and preparing a polylactic acid / beta-calcium phosphate / I type collagen composite electrospinning film into a tubular conduit, putting the tubular conduit in a vacuum drying oven to fully evaporate the organic solvent to obtain the polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit. The three material of the polylactic acid, the beta-calcium phosphate and the I type collagen are compounded by the electrospinning technique for complement of advantages, the polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit has excellent mechanical properties, cellular affinity and hydrophilicity, can simulate the structure of an extracellular matrix, and is bionic.

The invention relates to an artificial cochlea. The artificial cochlea comprises an external device and an implant, wherein the external device comprises a sound processing device and a power supply unit, the power supply unit is used for supplying power for the sound processing device, the sound processing device is used for processing acquired sound signals to form full frequency continuous sound signals which are sent to the implant, the continuous sound signals sent by the sound processing device are received by the implant, a spiral ganglion is further stimulated by utilizing electrical electrodes, and the continuous sound signals are transmitted to auditory nerves. The invention further relates to a sound processing method of the artificial cochlea. According to the artificial cochlea, after multi-channel sub-band processing on the sound signals, the sound signals are synthesized to form complete sine wave signals, the sine wave signals comprise all the sound information including tones, and patients are made to have real hearing feeling.

The invention discloses a preparation method of ion-exchange polyvinyl alcohol micro-spheres. The method comprises the steps that a water-soluble functional monomer is dissolved in water, and an initiator, a cross-linking agent and a polyvinyl alcohol aqueous solution with the mass fraction of 5%-15% are added for even mixing to obtain mixed liquid; an oil phase containing an emulsifying agent isprepared, stirred and heated to 40-80 DEG C, then the obtained mixed liquid is added into the oil phase, stirring is conducted for 10-60 minutes, then a catalyst is added for reaction for 3-6 hours, and after reaction is completed, an obtained product is washed to obtain the ion-exchange polyvinyl alcohol micro-spheres. According to the method, the technology is simple and convenient to operate, reaction heat is fully used, energy consumption is relatively low, synthesis time is short, the reaction temperature is reduced, and the production efficiency in industrialized production is improved;the prepared polyvinyl alcohol micro-spheres have good deformability and elasticity, are smooth in sphere surface, even in dispersion and high in drug loading capability and have good biocompatibilityand stability at the same time.

The invention discloses a novel allogeneic amnion composite material repair catheter and a preparation method, and relates to the field of nerve repair catheters. The preparation method comprises the following steps: firstly, after a puerpera cesarean placenta is obtained, conducting serum detection, adding a protective agent for protection after the placenta is qualified, conducting refrigeration, soaking and washing the placenta through a washing solution, then stripping the amnion, adding the protective agent to maintain the activity of the amnion; and secondly, selecting modified high polymer materials such as polylactic acid and amino polylactic acid which meet the requirements of controllable tensile strength, compressive strength, elasticity, tensile strength, molecular weight and degradation time, adhesion performance, safety and metabolic pathways, positively charging the modified high polymer materials. The amniotic membrane belt is rolled into a pipe shape and distributed inside and outside the high polymer materials; after being freeze-dried, the composite material can be firmly adhered to a polymer tubular material to prepare a novel allogenic amnion composite material nerve repair conduit taking a composite polymer material as a skeleton, so that the problem that the amnion material is softened when meeting water in vivo can be effectively solved.

A minitype sleeve kirschner wire fixing device used for fixing a fracture of the metacarpal bone comprises a kirschner wire with puncture heads at the two ends, a minitype sleeve guider, a hollow cylindrical minitype sleeve with the zigzag front end, a first minitype sleeve core and a second minitype sleeve core. The minitype sleeve guider is composed of a handle and a hollow cylindrical guide sleeve with the zigzag front end, the handle is movably connected with the guide sleeve, the first minitype sleeve core and the second minitype sleeve core are kirschner wires with caps at the tail ends, and the minitype sleeve and the kirschner wire with the puncture heads are combined to form a minitype sleeve kirschner wire. The minitype sleeve kirschner wire fixing device used for fixing the fracture of the metacarpal bone aims to reduce damage to the interosseus during surgical method operation and popularize the coronal transverse fixing technology for the fracture of the metacarpal bone.

The invention discloses an articular cartilage restoration and regeneration stent and a preparation method thereof, belonging to the field of medical materials. The stent is made of decalcified spongiosa-cortical bone, and the decalcified spongiosa-cortical bone is provided with more than two holes penetrating through the decalcified spongiosa bone and the cortical bone. The holes are vertically arranged on the horizontal surface of the decalcified cortical bone and have diameter of 0.1-1mm. The width between hole centers is 0.5-5mm. The preparation method provided by the invention comprises the steps of: soaking the bone in a decalcified solution for decalcification; monitoring the decalcification process by using an atomic absorption spectrophotometer; carrying out X-ray and CT detection on a decalcified sample to prove that the bone is completely decalcified to obtain the decalcified spongiosa-cortical bone; drilling on the horizontal surface of the decalcified cortical bone by using laser in a diameter of 0.1-1mm; and cutting the decalcified cortical bone into a certain size, and freezing and storing. The articular cartilage restoration and regeneration stent is made of a natural collagen stent material without immunological rejection reaction, is easy to adsorb by cells, and has good biocompatibility and better mechanical strength.

The invention belongs to the technical field of medical biological materials, and in particular relates to a polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit and a preparation method thereof. The polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit is prepared as follows: dissolving polylactic acid and I type collagen in an organic solvent, evenly mixing, using electrospinning technique to prepare a nerve conduit inner layer membrane; dissolving the polylactic acid and beta-calcium phosphate in the organic solvent, evenly mixing, spraying the nerve conduit inner layer membrane with a spinning liquid by the electrospinning technique to form a nerve conduit outer layer membrane, and preparing a polylactic acid / beta-calcium phosphate / I type collagen composite electrospinning film into a tubular conduit, putting the tubular conduit in a vacuum drying oven to fully evaporate the organic solvent to obtain the polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit. The three material of the polylactic acid, the beta-calcium phosphate and the I type collagen are compounded by the electrospinning technique for complement of advantages, the polylactic acid / beta-calcium phosphate / I type collagen composite nerve conduit has excellent mechanical properties, cellular affinity and hydrophilicity, can simulate the structure of an extracellular matrix, and is bionic.

The invention relates to a combined joint movement apparatus comprising two carbon fiber poles, multiple connection block components and multiple wire clamping components. One connection block component is connected to the head of each carbon fiber pole, the two connection block components of the heads of the carbon fiber poles are connected with each other via a screw, more than one of the connection block components is arranged on a pole body of each carbon fiber poles, more than one of the wire clamping components is connected on each connection block component on the pole bodies, and Kirschner wires are arranged on each wire clamping component. Connection blocks of the heads of the carbon fiber poles are connected serially via screws, the first carbon fiber pole and the second carbon fiber pole are in the state of rotating freely and axially around the screws 5 or being locked, movement of joints is facilitated by dynamic and static combination, and poor blood circulation or muscle atrophy is prevented. The Kirschner wires pierce for fixation from the outside, minimally invasive treatment of fracture is realized, second operation is not required, the joints can be moved after operation, and the joint functions are unaffected after fracture healing.

The invention relates to a nano-short fiber material for tissue repair, a preparation method and application thereof. The nano-short fiber material includes nano-short fibers with a diameter of 200-800 nm and a length of 10-200 μm, and at least one nano-short fiber has a porous structure on its surface. The nano-short fiber material provided by the present invention shortens the length of the nano-fiber and has better dispersion performance, and the nano-short fiber material is made of a biodegradable biomaterial with good biocompatibility and tissue repair performance, and does not need to be removed , no need for secondary surgery, especially suitable for tissue repair of small area or deep defect. In addition, the nano-short fiber material provided by the present invention can not only be prepared into powder, injection, etc., and can be used alone in combination with minimally invasive, laparoscopy, injection and other surgical methods, and can also be used in combination with other materials.

The invention discloses a high-strength degradable bone fracture binding band and a preparation method of the high-strength degradable bone fracture binding band and belongs to the technical field of medical instruments. The bone fracture binding band is formed by combined preparation of a high-strength orientation fiber band and a randomly arranged fiber film or a random orientation thin film. The degree of crystallinity is increased through a nucleating agent, and the orientation technology is adopted to obtain the high-strength orientation fiber band; the bone fracture binding band is prepared under the condition that the linear speed of a disc-shaped yarn take-up device is greater than or equal to 500 m / min by the adoption of the solution electrospinning technology; the mass percent of a spinning solution is that a degradable polymer accounts for 5-12%, the nucleating agent accounts for 0.5-2%, and a solvent accounts for 86-95%. The orientation fiber band is arranged in a single orientation or double orientations, the random fiber film is sprayed on the surface of the orientation fiber band, or the random orientation thin film is stacked on the orientation fiber band, and then the bone fracture binding band is prepared by means of ultrasonic welding. The tensile strength and tensile modulus of the prepared bone fracture binding band are improved substantially compared with those of a randomly arranged electrostatic spinning film, and the bone fracture binding band has good application prospect with respect to repair and fixation of clinical bone fractures.

The invention relates to an auxiliary calcaneus reduction fixing device for calcaneus fracture occlusion or minimal invasion reduction internal fixation. The auxiliary calcaneus reduction fixing device for calcaneus fracture occlusion or minimal invasion reduction internal fixation comprises a right outer side splint or a left outer side splint, a right inner side splint or a left inner side splint and a driving device used for fixing the right outer side splint and the right inner side splint or fixing the left outer side splint and the left inner side splint, wherein the driving device drives the right outer side splint and the right inner side splint or fixing the left outer side splint and the left inner side splint to move relatively. Compared with an existing operation method, the auxiliary calcaneus reduction fixing device does not need to carry out open reduction and internal fixation, thereby having the advantages of a small wound and accurate anatomical reduction. The right outer side splint 1 or the left outer side splint 2, and the right inner side splint 3 or the left inner side splint 4 correspond to the outer side wall or inner side wall of the right calcaneus in shape, and therefore the auxiliary calcaneus reduction fixing device has the advantages of being firm in fixation, few in complication, free of a second operation, small in pain of a patient and the like, and calcaneus fracture is made to be back to minimally invasive therapy.

The topical hemostatic composition comprises 0.5-50% w / v of N-acetylglucosamine and distilled water as a solvent. The topical hemostatic composition may also include one or more other sugars selected from sucrose, maltose, invert sugars, glucose, and fructose. The topical hemostatic composition may also include a salt of one or more selected from the group consisting of calcium chloride (CaCl2), sodium chloride (NaCl), ferric trichloride (FeCl3), alum [KAl (SO4) 2], and copperas (FeSO4). The local hemostatic composition can be applied to various traumatic hemorrhage including main artery hemorrhage, surgical hemorrhage or alimentary tract hemorrhage and the like, and also has a hemostatic curative effect in water.

The invention relates to a degradable nano-short fiber material for tissue repair. The nano-short fiber material is composed of nano-short fibers, wherein the diameter of the nano-short fibers is 200-800 nm, and the length of the nano-short fibers does not exceed 500 [mu] m; the length of at least 93% of the nano-short fibers in the nano-short fiber material is within 20-200 [mu] m, and the stacking density of the nano-short fiber material is 0.001-0.099 g / cm<3>. According to the nano-short fiber material, the length of the nano-fibers is shortened, the dispersing performance and repairing performance of the nano-fibers are improved, and the application range of the nano-short fiber material is expanded.

The invention relates to an artificial cochlea. The artificial cochlea comprises an external device and an implant, wherein the external device comprises a sound processing device and a power supply unit, the power supply unit is used for supplying power for the sound processing device, the sound processing device is used for processing acquired sound signals to form full frequency continuous sound signals which are sent to the implant, the continuous sound signals sent by the sound processing device are received by the implant, a spiral ganglion is further stimulated by utilizing electrical electrodes, and the continuous sound signals are transmitted to auditory nerves. The invention further relates to a sound processing method of the artificial cochlea. According to the artificial cochlea, after multi-channel sub-band processing on the sound signals, the sound signals are synthesized to form complete sine wave signals, the sine wave signals comprise all the sound information including tones, and patients are made to have real hearing feeling.

The invention discloses a scaffold material capable of blood sugar induced controlled-release of drugs and used for periodontal treatment and a preparation method thereof. The preparation method is characterized by comprising the following steps: dissolving collagen or gelatin or fibrin in a 0.5 to 5% dilute hydrochloric acid solution or 0.1 to 1% dilute acetic acid solution, or dissolving sodium alginate protein in double distilled water to form a solution with a concentration of 0.1 to 5 wt%; adjusting the pH value of the solution with alkali to 6.5 to 7.5; adding 10 to 20 parts of a natural degradable substance solution, 10 to 20 parts of quaternized chitosan, 1 to 5 parts of glucose oxidase and 5 to 15 parts of anti-inflammatory protein into a reaction vessel and carrying out stirring at a speed of 500 to 5000 rpm at a temperature below 4 DEG C for 10 to 30 min so as to obtain a uniform solution; adding 2 to 6 parts of sodium phosphate into the solution drop by drop; and adding obtained liquid into equipment with a cold eluting agent and into a plastic die with a constant temperature of 4 DEG C, disposing the liquid at a temperature of -20 DEG C for 2 to 4 h, refrigerating the liquid at a temperature of -80 DEG C for 24 to 48 h and carrying out freeze drying at a temperature of -100 DGE C so as to prepare the drug-loaded scaffold material. The scaffold material is stored in equipment with a temperature of 4 DEG C after disinfection by Co60 irradiation.

The present invention provides an airbag type rectum and anal canal drainage flusher with three cavities, which is a medical fluster. The fluster is main used for rectum and anal canal drainage, flushing, and prevents intestinal leakage, treats intestinal leakage after operation of low rectal carcinoma. The fluster has annular airbag, straight tube, outside plate, inflation tube, water inlet and water outlet. The annular airbag connects with upper side of straight tube, the down side of straight tube connects with outside plate, the straight tube has water outlet hole and inlet hole, the air outlet end of inflation tube connects with annular airbag by outside plate and straight tube, the water outlet end of water outlet connects water outlet hole of the straight tube by outside plate and straight tube inner cavity, the water inlet end of water outlet connects with water inlet hole by outside plate and straight tube inner cavity.

The invention discloses a stent used for the joint cartilage regeneration of the decalcification cortex bone of longitudinal drilling and a preparation method thereof, and the stent belongs to an animal decalcification cortex bone. Holes with the diameter of 0.1 to 1 mm are drilled perpendicularly on the horizontal surface of the decalcification cortex bone; the interval among the holes is 0.5 to5 mm, thereby forming three-dimensional porous stereo network structure; the porosity reaches 5 percent to 20 percent. The preparation method is as follows: a first step, the decalcification of the cortex bone: a cortex bone is taken out from the cattle or goat to remove the bone marrow and then soaked in decalcifying solution which is replaced everyday and the cortex bone is completely decalcified to enter into the next step; a second step, drilling: holes with the diameter of 0.1 to 1 mm are drilled on the horizontal surface of the decalcification cortex bone; the interval among the holes is supposed to be 0.5 to 5 mm, after the cortex bone is tailored into a designed dimension, then a stent used for the joint cartilage regeneration of the decalcification cortex bone of longitudinal drilling is gotten. The stent used for the joint cartilage regeneration of the decalcification cortex bone of longitudinal drilling has extensive material selection and quite good biocompatibility.