This invention relates to compositions comprising
temozolomide and
thalidomide which can be used in the treatment or prevention of
cancer, in particular malignant
melanoma,
cancer of the
skin,
subcutaneous tissue,
lymph nodes, brain,
lung, liver, bone, intestine, colon, heart,
pancreas, adrenals,
kidney,
prostate, breast, colorectal, or a combination thereof. A particular composition comprises
temozolomide, or a pharmaceutically acceptable salt, solvate, or clathrate thereof, and
thalidomide, or a pharmaceutically acceptable salt, solvate, or clathrate thereof. The invention also relates to methods of treating or preventing
cancer, in particular malignant
melanoma, cancer of the
skin,
subcutaneous tissue,
lymph nodes, brain,
lung, liver, bone, intestine, colon, heart,
pancreas, adrenals,
kidney,
prostate, breast, colorectal, or a combination thereof, which comprise the administration of
temozolomide and
thalidomide and another anti-cancer
drug to a patient in need of such treatment or prevention. The invention further relates to methods of reducing or avoiding adverse side effects associated with the administration of
cancer chemotherapy or
radiation therapy which comprise the administration of temozolomide and thalidomide to a patient in need of such reduction or avoidance.