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Screening method of colorectal cancer treatment prognosis biomarkers

A biomarker, cancer treatment technology, applied in the direction of DNA/RNA fragments, special data processing applications, instruments, etc., can solve inconsistencies, affect the process of biomarker research and application of colorectal cancer treatment prognosis, and not achieve basic research to Clinical research translation and other issues to avoid outcome bias, reduce screening costs, and shorten screening time

Inactive Publication Date: 2013-09-25
浙江加州国际纳米技术研究院绍兴分院
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Problems solved by technology

[0004] Since the 1970s, clinical researchers began to carry out clinical research on various biomarkers related to colorectal cancer. studies may come to inconsistent or even contradictory conclusions
It takes a lot of manpower and time for clinicians to obtain information from these databases, which greatly affects the research and application of colorectal cancer treatment prognosis biomarkers
This reliance on individual medical practitioners to retrieve, collect, and evaluate existing evidence and apply it to practice and decision-making is not an effective way to translate basic research into clinical research

Method used

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  • Screening method of colorectal cancer treatment prognosis biomarkers
  • Screening method of colorectal cancer treatment prognosis biomarkers
  • Screening method of colorectal cancer treatment prognosis biomarkers

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Experimental program
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Embodiment 1

[0040] Embodiment 1, the screening method of rectal cancer treatment prognostic biomarkers, the following steps are performed in sequence:

[0041] 1. Develop a search strategy for primary screening biomarkers:

[0042] To screen biomarkers related to the treatment of colorectal cancer, the search terms are determined according to the PICOS principle. The search terms include: P: colorectal cancer patients; I: therapeutic drugs; C: no therapeutic drugs; O: survival value, adverse reactions; S: Unlimited; biomarkers. The databases used in the search include MEDLINE, EMBASE, Cochrane, TRIP, VIP (CPVIP), China Biomedical Journal Literature Database (CMDisc), Wanfang database and China National Knowledge Base (CNKI) for comprehensive search of literature. The retrieval time is 1980-2012.12.30.

[0043] Foreign language database retrieval formula: ("rectal" OR "rectum" OR "colon" OR "colonic" OR "colorectal" OR "crc" OR "mcrc" OR "colonic") AND ("cancer" OR "cancers" OR "tumor ...

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Abstract

The invention discloses a screening method of colorectal cancer treatment prognosis biomarkers. The screening method includes the following steps of: (1) making a primary search strategy for screening the biomarkers; (2) making a literature adopting and exclusion criterion; (3) analyzing data and primarily screening the biomarkers; (4) making evident grades; (5) making a high quality evident evaluation criterion; (6) performing grading retrieval and quality evaluation on biomarker clinic evident; (7) performing data analyzing and statistics on the biomarker clinic evident; (8) screening the prognosis biomarkers. The invention further provides the colorectal cancer treatment prognosis biomarkers obtained through screening according to the screening method, and the prognosis biomarkers include KRAS, TYMS, TYMS, EGFR, UGT1A1*28, DPYD, PIK3CA, ERCC1, PTEN, VEGFR, BRAF, GST P1, XRCC1, MTHFR, MSI and the like.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a screening method for colorectal cancer treatment prognosis biomarkers based on clinical evidence evaluation criteria. Background technique [0002] Colorectal cancer is a common malignant tumor of the digestive tract. Its incidence rate ranks third among malignant tumors in the world, and its case fatality rate ranks fourth. With the improvement of people's living standards, the incidence and mortality of colorectal cancer are still increasing year by year. It is understood that the incidence of colorectal cancer in my country has increased by about 4% year by year, far exceeding the international level of 2%. Although some progress has been made in the etiology research of colorectal cancer and the comprehensive treatment based on surgical resection, radiotherapy and chemotherapy, the effect is not satisfactory. The 5-year survival rate of surgical patients in the past 40 years is ...

Claims

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Application Information

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IPC IPC(8): G06F19/00G06F17/30C12N15/11
Inventor 张珊珊余科余文菁宓娅娜赵凌云
Owner 浙江加州国际纳米技术研究院绍兴分院
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