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A method for treating diabetic neuropathy is disclosed consisting of administering pyridoxamine or a salt thereof.

The present invention is a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of denaturing due to a thermal change. The method comprises contacting the target molecule with one molecule of the multiplicity of different molecules in each of a multiplicity of containers, simultaneously heating the multiplicity of containers, measuring in each of the containers a physical change associated with the thermal denaturation of the target molecule resulting from the heating in each of the containers, generating a thermal denaturation curve for the target molecule as a function of temperature for each of the containers and determining a midpoint temperature (T.sub.m) therefrom, comparing the T.sub.m of each of the thermal denaturation curves with the T.sub.m of a thermal denaturation curve obtained for the target molecule in the absence of any of the molecules in the multiplicity of different molecules, and ranking the affinities of the multiplicity of different molecules according the change in T.sub.m of each of the thermal denaturation curves.

An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose / response profiles within a short timespan.

Essentially all of the processing parameters which control processing of a source audio signal to produce an encoded audio signal are stored in an audio processing profile. Multiple audio processing profiles are stored in a processing profile database such that specific combinations of processing parameters can be retrieved and used at a later time. Audio processing profiles are organized according to specific delivery bandwidths such that a sound engineer can quickly and efficiently encode audio signals for each of a number of distinct delivery media. Synchronized A / B switching during playback of various encoded audio signals allows the sound engineer to detect nuances in the sound characteristics of the various encoded audio signals.

An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose / response profiles within a short time span.

The invention discloses a Hadoop-based mass stream data storage and query method and a Hadoop-based mass stream data storage and query system. The method comprises the following steps of: constructing a segmented column cluster type storage structure; sequentially storing stream data as column cluster records, compressing the column cluster records from front to back to obtain compressed data pages, writing each compressed data page into a piece of column cluster data, and simultaneously additionally writing the page outline information of the compressed data pages into the tail ends of the column cluster data to obtain an integrated data segment; and in the process of executing query statements, constructing a scan table according to filtering restraints by utilizing the page outline information at the tail ends of data segments to quickly filter the data.

Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.

An inverted microwell (102) provides rapid and efficient microanalysis system (100) and method for screening of biological particles (128), particularly functional analysis of cells on a single cell basis. The use of an inverted open microwell system (102) permits identification of particles, cells, and biomolecules that may be combined to produce a desired functional effect also functional screening of secreted antibody therapeutic activity as well as the potential to recover cells and fluid, and optionally expand cells, such as antibody secreting cells, within the same microwell.

The invention discloses a technique method for producing high-concentration nitric phosphate, which comprises the following steps of: adding nitric acid into phosphorus ore for acidolysis, depositing and separating acid non-soluble substance, freezing and crystallizing calcium nitrate, filtering the calcium nitrate, neutralizing the mother liquid, vaporization, pelleting and drying. The invention is characterized in that: a step of thoroughly removing the calcium of the mother liquid is arranged between the steps of filtering the calcium nitrate, and neutralizing the mother liquid. The steps comprise the following steps of: I) thoroughly removing the calcium of the mother liquid and adding sulfuric acid or ammonium sulfate; the calcium ions and the sulfate ions in the mother liquid generate dihydrate calcium sulfate crystal; II) the grading processing of reaction slurry: employing a grading device to carry out grading processing to the reaction slurry; returning the reaction slurry provided with small grain calcium sulfate to the mother liquid for thoroughly removing the calcium, and feeding the reaction slurry provided with large grain calcium sulfate to the calcium sulfate for filtering; and III) filtering and washing the filtering reaction slurry of calcium sulfate by a filter, feeding the primary filtrate and the primary lavage fluid into the working procedure of neutralizing, and returning the secondary lavage fluid to the filter. The invention has the advantage of using middle-low quality phosphorite to prepare the high-concentration nitric phosphate.

There is provided a resonator sensor useful for detecting polymorphisms and mutations in DNA. The resonator sensor has a capture molecule immobilised on its surface, the capture molecule being either a probe DNA containing a reference sequence, or a mismatch binding molecule, and being capable of forming a probe DNA / target DNA / mismatch binding molecule complex on the surface of the resonator. A method for detecting mutations in a target DNA, including single nucleotide polymorphisms, is also provided.

The invention relates to an apparatus for simultaneously injecting fluids into a plurality of samples of porous media, comprising: a plurality of holders for the samples of porous media, each holder comprising a sleeve and first and second platens, the first platen having an inlet for an injection fluid and the second platen having an outlet for a produced fluid, and the samples of porous media being arranged, in use, in each of the holders such that the first platen and second platen of each holder contact a first and second end of the sample of porous medium respectively, the inlet of each first platen being in fluid communication with an injection line for injecting fluid into the sample of porous medium arranged in the holder, the outlet of each second platen being in fluid communication with a dedicated effluent line for removing fluid produced from the sample of porous medium arranged in the holder, on-line and / or off-line analytical means for analyzing the fluids injected into each of the samples of porous media, on-line and / or off-line means for analyzing the fluids removed from each of the samples of porous media. A method of simultaneously injecting injection fluid into the samples of porous media is also provided.

A thermally bonded filtration media that can be used in high temperature conditions in the absence of any loss of fiber through thermal effects or mechanical impact on the fiber components is disclosed. The filter media can be manufactured and used in a filter unit or structure, can be placed in a stream of removable fluid, and can remove a particulate load from the mobile stream at an increased temperature range. The combination of bi-component fiber, other filter media fiber, and other filtration additives provides an improved filtration media having unique properties in high temperature, high performance applications.

A switchable view angle control device includes an electrically switchable zenithal bistable liquid crystal display view angle control liquid crystal device (ZBD view angle control LCD) that is operable in a first state and a second state; a front polarizer located on a viewing side of the switchable ZBD view angle control LCD; and a polarized light source located on a non-viewing side of the switchable ZBD view angle control LCD that emits light that is polarized in a first direction. When the switchable ZBD view angle control LCD in the first state, the view angle control device operates in a narrow angle view mode in which the polarization of the light from the polarized light source is changed by the switchable ZBD view angle control LCD to be polarized in a second direction that is at least partially absorbed by the front polarizer, and on-axis light passes through the switchable ZBD view angle control LCD and the front polarizer. When the switchable ZBD view angle control LCD is in the second state, the view angle control device operates in a wide angle view mode in which the polarization state of the light from the polarized light source is not changed by the switchable ZBD view angle control LCD and passes through the front polarizer.

The invention relates to a device for assisting in the choice of a diversion airport for an aircraft piloted by a crew (200), said aircraft comprising a flight management system including location means (207) calculating the position of the aircraft, said device comprising a navigation database (202) and a performance database (203) of the aircraft, said device being characterized in that it comprises:a company database (201) comprising airports and characteristics of said airports,means (205) of calculating a list of airports, called candidate airports, from the airports in the company database, from the navigation database and from the selected characteristics by the crew,means (204) for calculating remaining flight time and fuel consumption predictions for each of the candidate airports from the position of the aircraft, from weather conditions and from the performance database,an interface giving the favoured airports for diversion according to pre-established criteria or determined in real time using the interface.

A protein obtainable from a non pathgenic microorgansim, said protein having mucosa binding promoting activity and a molecular weight of 20-40 kD is disclosed. Application of such a protein or a peptide derived therefrom in a method of screening non pathogenic microorganisms for a microorganism capable of specifically binding mucosa, said method comprising detection in a manner known per se of the presence of a particular protein on or in a microorganism or in a culture of microorganisms, said particular protein being the already defined protein. Kits suitable for such a screening method are also disclosed. Use of a component selected from the group of components comprising a protein or peptide as defined; an expression vector comprising nucleic acid encoding such protein or peptide; a recombinant microorganism or a part of said microorganism expressing such protein or peptide, said part expressing mucosa binding promoting activity; a non pathogenic microorganism capable of expressing such protein or peptide or a part of said microorganism, said part expressing mucosa binding promoting activity as pharmaceutically active component in a pharmaceutical composition for prophylaxis and / or treatment of disease or illness associated with a mucosa colonizing pathogenic microorganism. Use of such components as food additive and compositions comprising such components are described.

Several preferred embodiments of 1S1F 16T NVSRAM, 1S1F 20T NVSRAM, 1S2F 22T NVSRAM, 1S2F 14T NVSRAM cells are proposed, regardless of 1-poly, 2-poly, PMOS or NOS flash cell structures. Two separate sourcelines for the paired flash Strings are also proposed for easy adding ability for the NVSRAM circuit to detect the marginally erased Vt0 and marginally programmed Vt1 of the paired flash cell. By increasing an resistance added to common SRAM power line, the pull-down current through flash Strings to grounding source line can be made much larger than the pull-up current to improve SFwrite program operation. Simple method by increasing flash cell channel length to effectively enhance coupling area is applied to secure SRAM-to-Flash store operation under self-boost-program-inhibit scheme. 1S2F architecture also provide flexibility for alternate erasing and programming during both a recall and store operation.

The invention relates to a quick multi-keyword semantic sorting search method for protecting data privacy in cloud computing. A domain weighted scoring concept is introduced in document scoring, and keywords in different domains such as a title, an abstract and the like are endowed with different weights to be distinguished; a retrieval keyword is subjected to semantic expansion, semantic similarity is calculated, a three-factor sorting method is designed by combining the semantic similarity, the domain weighted scoring and a correlation score, and a cloud server can perform accurate sorting on search results and return a sorting result to a search user; and for the defect of low query efficiency of a searchable encryption scheme, a vector block segmentation marking matching algorithm is designed, and a document vector created by a vector space model is subjected to block segmentation to generate a marking vector with a relatively small dimension number. According to the method, the query efficiency can be improved, the index creation time can be shortened, and semantic ciphertext keyword search is realized.

The present invention provides novel methods and compositions for the identification and selection of loci modulating transgene performance and expression in plant breeding. In addition, methods are provided for screening germplasm entries for the performance and expression of at least one transgene.

Compounds having quinone and quinone analogs useful for pharmaceutical preparations have now been found which inhibit cysteine proteases, in particular, caspases and 3C-cysteine proteases. The cysteine protease inhibitors of the present invention can be identified by their mode of action in disrupting the ability of cysteine proteases and, in particular, caspases to cleave a peptide chain. These compounds are useful in inhibiting cysteine protease or cysteine protease-like proteins and for treating infections diseases or physiopathological diseases or disorders attributed to the presence of excessive or insufficient levels of cysteine proteases.

The invention discloses a method for efficiently separating single antigen-specific B lymphocyte from spleen cells. High-throughput rapid screening of single antigen-specific B lymphocyte is realizedby negative screening adopting multiple lymphocyte surface marker antibodies, establishment of a rapid fluorescence marked antigen substance method and high-specificity screening by use of a fluorescence marked antigen substance, and the positive rate of the finally obtained antibody-specific B lymphocyte is increased from less than 5% in a traditional hybridoma method to 30%. Therefore, the scheme can shorten monoclonal antibody development time to a great extent and greatly increase the number and diversity of obtained monoclonal antibodies.

The invention discloses a remote sensing image rapid target detection method based on a deep Hash auxiliary network, and solves the problem that an existing target detection framework cannot carry outefficient detection on a background area which does not have a target and occupies a large area in a wide remote sensing image. The method comprises the following implementation steps: generating anexperimental training image block set and a test image block set; constructing a remote sensing image rapid target detection model based on a deep Hash auxiliary network; training a remote sensing image rapid target detection model based on a deep Hash auxiliary network; and using the trained deep Hash auxiliary network to obtain a test result of the test image block set, and counting the runningtime. According to the method, the Hash auxiliary branch network module is introduced, redundant calculation in target detection is greatly reduced by quickly filtering most non-target background areas in the wide remote sensing image, the detection time of the non-target background areas is greatly shortened, and the detection efficiency is greatly improved. The method is used for target detection of wide remote sensing images.

The invention provides a systemic solution aiming at the rapid clustered rendering of a multisource remote sensing data set, which is especially used for solving distributed organization and storage problems of data and union query problems of a plurality of data sets in mass remote sensing data and different kinds of data sets. The systemic solution comprises the following steps: firstly allocating a cluster environment suitable for a real-time mass remote sensing data rendering system, wherein the cluster environment is formed by a plurality of calculation and data integrating nodes and a central server; sending a tile rendering request of a client side to the central server through a network channel, carrying out the research, the sieving and the post-processing through the central server so as to obtain a visible data list within the tile scope, and determining the optimal node according to the storage position; reading the tiles corresponding to the data by the nodes, rendering the tiles to a canvas in an overlying mode one by one, and sending the results to the central server; and finally sending the results to the client side by the central server. The systemic solution provided by the invention is suitable for rendered grain on the two-dimensional or three-dimensional surfaces, and large scale application fields, such as visualization and the like in the production of the terrain tile production and the large-scale remote sensing data management.