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153 results about "Microanalysis" patented technology
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Microanalysis is the chemical identification and quantitative analysis of very small amounts of chemical substances (generally less than 10 mg or 1 ml) or very small surfaces of material (generally less than 1 cm²). One of the pioneers in the microanalysis of chemical elements was the Austrian Nobel Prize winner Fritz Pregl.
Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
InactiveUS20050069913A1Promote sportsBioreactor/fermenter combinationsValve arrangementsMicrofluidicsData acquisition
This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The microsystem, platforms of the invention are also optionally provided having system informatics and data acquisition, analysis and storage and retrieval informatics encoded on the surface of the disk opposite to the surface containing the fluidic components. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.
Owner:TECAN TRADING AG TECAN GRP LTD
Bidirectional flow centrifugal microfluidic devices
This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention particularly provides microsystem platforms for achieving efficient mixing of one or a plurality of fluids on the surface of the platform when fluid flow is motivated by centripetal force produce by rotation.
Owner:TECAN TRADING AG
Hermetic sample holder and method for performing microanalysis under controlled atmosphere environment
ActiveUS8087309B2Reduce pressureParticle separator tubesPreparing sample for investigationEngineeringPressure difference
A hermetic sample holder for use in performing microanalysis of a sample under a controlled atmosphere environment. The sample holder comprises a sample holder body with a sample cavity to receive the sample and a cover movably mounted to the holder body between an open position to allow access to the cavity and a closed position to seal the cavity. The cover is secured in and released from the closed position at least in part by a pressure differential between the cavity and the ambient atmosphere. The cover may be biased toward the open position. The cover may be pivotally mounted about an axis that is perpendicular to a sealing surface of the cover and / or movable in a direction along the pivot axis. A valve may be provided to allow direct evacuation of the cavity to create a pressure differential. An adjustable clamp may be located in the cavity to secure the sample.
Owner:SION POWER CORP
Integrated, fluorescence-detecting microanalytical system
InactiveUS20050157301A1Improve portabilityBroaden range of potential applicationChemiluminescene/bioluminescencePhotometryPhotovoltaic detectorsPhotodetector
The present invention relates to a functionally integrated microanalytical system for performing fluorescence spectroscopy. A source of fluorescence-exciting radiation, typically a LED, is integrated onto a substrate along with a photodetector and, in some embodiments, an optical filter. A pixel-to-point laser lift-off process is used to effect this component integration. For those cases in which a filter is required, a thin film bandgap filter is typically used, such as CdS or CdSxSe1-x (0<x<1). A disposable microchannel containing the sample and its fluorescent tag is mounted onto the integrated assembly of LED, photodetector and (optionally) filter. This configuration of components allows the microchannel and sample to be readily removed and replaced, facilitating rapid analysis of multiple samples. Multiple LEDS, detectors and filters (if present) can also be integrated onto the same substrate, permitting multiple wavelength analysis of the sample to be performed concurrently.
Owner:RGT UNIV OF CALIFORNIA
Method and apparatus for sample formation and microanalysis in a vacuum chamber
ActiveUS20060011868A1Improve automationEconomic impactMaterial analysis using wave/particle radiationSemiconductor/solid-state device testing/measurementMicroanalysisVacuum chamber
Methods and apparatus are disclosed for forming a sample of an object, extracting the sample from the object, and subjecting this sample to microanalysis including surface analysis and electron transparency analysis in a vacuum chamber. In some embodiments, a method is provided for imaging an object cross section surface of an extracted sample. Optionally, the sample is iteratively thinned and imaged within the vacuum chamber. In some embodiments, the sample is situated on a sample support including an optional aperture. Optionally, the sample is situated on a surface of the sample support such that the object cross section surface is substantially parallel to the surface of the sample support. Once mounted on the sample support, the sample is either subjected to microanalysis in the vacuum chamber, or loaded onto a loading station. In some embodiments, the sample is imaged with an electron beam substantially normally incident to the object cross section surface.
Owner:APPL MATERIALS ISRAEL LTD
Non-planar chemical preconcentrator
ActiveUS7118712B1Quick releaseComponent separationWithdrawing sample devicesAnalyteCompound (substance)
A non-planar chemical preconcentrator comprises a high-surface area, low mass, three-dimensional, flow-through sorption support structure that can be coated or packed with a sorptive material. The sorptive material can collect and concentrate a chemical analyte from a fluid stream and rapidly release it as a very narrow temporal plug for improved separations in a microanalytical system. The non-planar chemical preconcentrator retains most of the thermal and fabrication benefits of a planar preconcentrator, but has improved ruggedness and uptake, while reducing sorptive coating concerns and extending the range of collectible analytes.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC
Microfabricated cylindrical ion trap
InactiveUS6870158B1Stability-of-path spectrometersIsotope separationManufacturing cost reductionHigh pressure
A microscale cylindrical ion trap, having an inner radius of order one micron, can be fabricated using surface micromachining techniques and materials known to the integrated circuits manufacturing and microelectromechanical systems industries. Micromachining methods enable batch fabrication, reduced manufacturing costs, dimensional and positional precision, and monolithic integration of massive arrays of ion traps with microscale ion generation and detection devices. Massive arraying enables the microscale cylindrical ion trap to retain the resolution, sensitivity, and mass range advantages necessary for high chemical selectivity. The microscale CIT has a reduced ion mean free path, allowing operation at higher pressures with less expensive and less bulky vacuum pumping system, and with lower battery power than conventional- and miniature-sized ion traps. The reduced electrode voltage enables integration of the microscale cylindrical ion trap with on-chip integrated circuit-based rf operation and detection electronics (i.e., cell phone electronics). Therefore, the full performance advantages of microscale cylindrical ion traps can be realized in truly field portable, handheld microanalysis systems.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC
Hermetic sample holder and method for performing microanalysis under controlled atmosphere environment
ActiveUS20100294049A1Reduce pressureParticle separator tubesPreparing sample for investigationDifferential pressureEngineering
A hermetic sample holder for use in performing microanalysis of a sample under a controlled atmosphere environment. The sample holder comprises a sample holder body with a sample cavity to receive the sample and a cover movably mounted to the holder body between an open position to allow access to the cavity and a closed position to seal the cavity. The cover is secured in and released from the closed position at least in part by a pressure differential between the cavity and the ambient atmosphere. The cover may be biased toward the open position. The cover may be pivotally mounted about an axis that is perpendicular to a sealing surface of the cover and / or movable in a direction along the pivot axis. A valve may be provided to allow direct evacuation of the cavity to create a pressure differential. An adjustable clamp may be located in the cavity to secure the sample.
Owner:SION POWER CORP
Integrated, fluorescence-detecting microanalytical system
InactiveUS7221455B2Improve portabilityBroaden range of potential applicationChemiluminescene/bioluminescencePhotometryPhotovoltaic detectorsPhotodetector
Owner:RGT UNIV OF CALIFORNIA
Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids
InactiveUS7332326B1Bioreactor/fermenter combinationsBiological substance pretreatmentsPath lengthMicrofluidics
This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The microsystem platforms of the invention are provided having arrays of thermal control regions, wherein fluid applied to the platform can be placed at a temperature and maintained at that temperature for a time that is dependent on the path length of the channel in the region, the cross-section dimension of the channel, and the rotational speed of the platform. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.
Owner:TECAN TRADING AG
Mass-sensitive chemical preconcentrator
InactiveUS7168298B1Improve dynamic rangeHigh-precision detectionVibration measurement in solidsAnalysing fluids using sonic/ultrasonic/infrasonic wavesElectrical resistance and conductanceAnalyte
A microfabricated mass-sensitive chemical preconcentrator actively measures the mass of a sample on an acoustic microbalance during the collection process. The microbalance comprises a chemically sensitive interface for collecting the sample thereon and an acoustic-based physical transducer that provides an electrical output that is proportional to the mass of the collected sample. The acoustic microbalance preferably comprises a pivot plate resonator. A resistive heating element can be disposed on the chemically sensitive interface to rapidly heat and release the collected sample for further analysis. Therefore, the mass-sensitive chemical preconcentrator can optimize the sample collection time prior to release to enable the rapid and accurate analysis of analytes by a microanalytical system.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC
Microflow distribution device, manufacturing method and application thereof
The invention relates to a microflow distribution device, a manufacturing method and an application thereof, belonging to the field of minim testing device, or rather the field of microflow distribution. The microflow distribution device of the invention comprises a microflow distribution chip which is provided with at least one microflow layer; each microflow layer is provided with at least two paratactic microfluidic channels or a group of microfluidic channel trees formed in the way that a root microfluidic channel branches off for at least once; the microfluidic channel covers a cross-sectional area of at least 1 Mum <2>-1mm <2>; the entrance and exit are connected with the outside while all the other parts are arranged inside the microflow distribution chip. The microflow distribution device of the invention features low price and easy manufacturing, exact distribution of liquid samples at nano liter level and wide application prospect in multiple fields such as microfluid, microanalysis, drug screening, cell detecting and combined chemical reaction.
Owner:PEKING UNIV
Method and apparatus for sample formation and microanalysis in a vacuum chamber
ActiveUS7297965B2Minimizing damageElectron transparency of a cross section of the waferMaterial analysis using wave/particle radiationSemiconductor/solid-state device testing/measurementMicroanalysisVacuum chamber
Methods and apparatus are disclosed for forming a sample of an object, extracting the sample from the object, and subjecting this sample to microanalysis including surface analysis and electron transparency analysis in a vacuum chamber. In some embodiments, a method is provided for imaging an object cross section surface of an extracted sample. Optionally, the sample is iteratively thinned and imaged within the vacuum chamber. In some embodiments, the sample is situated on a sample support including an optional aperture. Optionally, the sample is situated on a surface of the sample support such that the object cross section surface is substantially parallel to the surface of the sample support. Once mounted on the sample support, the sample is either subjected to microanalysis in the vacuum chamber, or loaded onto a loading station. In some embodiments, the sample is imaged with an electron beam substantially normally incident to the object cross section surface.
Owner:APPL MATERIALS ISRAEL LTD
Method and apparatus for sample formation and microanalysis in a vacuum chamber
InactiveUS20060011867A1Minimizing damageElectron transparency of a cross section of the waferSemiconductor/solid-state device testing/measurementElectric discharge tubesMicroanalysisVacuum chamber
Methods and apparatus are disclosed for forming a sample of an object, extracting the sample from the object, and subjecting this sample to microanalysis including surface analysis and electron transparency analysis in a vacuum chamber. In some embodiments, a method is provided for imaging an object cross section surface of an extracted sample. Optionally, the sample is iteratively thinned and imaged within the vacuum chamber. In some embodiments, the sample is situated on a sample support including an optional aperture. Optionally, the sample is situated on a surface of the sample support such that the object cross section surface is substantially parallel to the surface of the sample support. Once mounted on the sample support, the sample is either subjected to microanalysis in the vacuum chamber, or loaded onto a loading station. In some embodiments, the sample is imaged with an electron beam substantially normally incident to the object cross section surface.
Owner:APPL MATERIALS ISRAEL LTD
Sample Preparation for Micro-Analysis
InactiveUS20080308727A1Easily subjectedPreventing and minimizing occurrenceSemiconductor/solid-state device testing/measurementSemiconductor/solid-state device manufacturingMicroanalysisFunctionally dependent
System and method for preparing a sample for micro-analysis, comprising: (a) sample precursor holding unit, for supporting and holding a sample precursor; (b) transporting and positioning unit, for transporting and positioning the sample precursor holding unit; (c) optical imaging unit, for optically imaging, recognizing, and identifying, target features on the sample precursor, and for monitoring the sample preparation; (d) picking and placing unit, for picking and placing the sample precursor and system components from initial positions to other functionally dependent positions; (e) micro-groove generating unit, for generating at least one micro-groove in a surface of the sample precursor, wherein the micro-groove generating unit includes components for controlling formation of each micro-groove in the surface; and (f) cryogenic sectioning unit, for cryogenically sectioning the sample precursor to a pre-determined configuration and size, for forming the prepared sample. Optionally, includes a micro-mask adhering unit, and a macro-mask adhering method.
Owner:CAMTEK LTD
Method for generating dolomite reservoir geochemical plate
ActiveCN102071929AAccurate and reliable explanationAccurate identificationBorehole/well accessoriesRare-earth elementAnalysis data
The invention provides a method for generating a dolomite reservoir geochemical plate. The method comprises the following steps: selecting a dolomite sample according to a core structure, and preparing the selected dolomite sample into sample pieces; carrying out electronic probe microanalysis, laser carbon oxygen isotope analysis, strontium isotope analysis and rare earth element analysis on thesample pieces to generate analysis data; determining the genetic type of the dolomite reservoir according to the sample pieces; and generating a geochemical plate according to the analysis data and the genetic type. By utilizing the dolomite reservoir geochemical plate in the invention, the genetic type of the dolomite reservoir can be accurately and rapidly identified; compared with the traditional method, the genesis of the reservoir is more accurate and reliable, and the reservoir formation mechanism and master control factors can be known deeply.
Owner:PETROCHINA CO LTD
Microvolume Analysis System
ActiveUS20100277742A1Accurate measurementDeterioration of shapeWithdrawing sample devicesSurface/boundary effectGravitational forceAnalyser
An analyser comprising a source of electromagnetic radiation, a detector for said radiation and a drophead comprising a surface which is adapted to receive a drop of liquid to be tested, the drophead being positioned in use relative to the source and detector to illuminate a drop received thereon and to cause an interaction in the path of the electromagnetic radiation between the source and detector, characterised in that said surface of said drophead is dimensioned to constrain the drop to adopt a shape which is dominated more by surface tension forces than by gravitational forces.
Owner:MCMILLAN NORMAN +3
Microfluidics devices and methods of diluting samples and reagents
InactiveUS7476361B2Low cost of reagentsShorten reaction timeBioreactor/fermenter combinationsBiological substance pretreatmentsEngineeringMicroanalysis
This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. These assays may be performed for a variety of purposes, including but not limited to screening of drug candidate compounds, life sciences research, and clinical and molecular diagnostics. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.
Owner:TECAN TRADING AG
Use of vapor-deposited conformal coatings in microfluidic structures
InactiveUS20020050456A1Minimize contactReduce concentrationSludge treatmentFixed microstructural devicesParyleneMicrofluidics
This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention particularly provides microsystem platforms comprising microfluidics components wherein the interior surfaces of the components comprise a conformal coating of parylene.
Owner:TECAN TRADING AG
Amplified signal in binding assays
ActiveUS7635571B2Bioreactor/fermenter combinationsBiological substance pretreatmentsAnalytePhotosensitizer
Methods are disclosed for determining minute quantities of an analyte in a medium suspected of containing the analyte. One method comprises treating a medium suspected of containing an analyte under conditions such that the analyte, if present, causes a substrate having an oxidant cleavable linker and a photosensitizer to come into close proximity. The photosensitizer generates singlet oxygen which oxidatively cleaves the linker to form a product which can be detected in a sandwich detection assay such as LOCI. The amount of product detected is related to the amount of analyte in the medium. Compositions, kits, and compounds are also disclosed.
Owner:DADE BEHRING MARBURG GMBH
Micropyrolyzer for chemical analysis of liquid and solid samples
InactiveUS7078237B1Chemical analysis using combustionParticle separator tubesSemiconductor materialsField analysis
A micropyrolyzer has applications to pyrolysis, heated chemistry, and thermal desorption from liquid or solid samples. The micropyrolyzer can be fabricated from semiconductor materials and metals using standard integrated circuit technologies. The micropyrolyzer enables very small volume samples of less than 3 microliters and high sample heating rates of greater than 20° C. per millisecond. A portable analyzer for the field analysis of liquid and solid samples can be realized when the micropyrolyzer is combined with a chemical preconcentrator, chemical separator, and chemical detector. Such a portable analyzer can be used in a variety of government and industrial applications, such as non-proliferation monitoring, chemical and biological warfare detection, industrial process control, water and air quality monitoring, and industrial hygiene.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC
Capacitive chemical sensor
ActiveUS8736000B1Easy to operateImprove responseComponent separationSolid-state devicesDielectricAnalyte
A microfabricated capacitive chemical sensor can be used as an autonomous chemical sensor or as an analyte-sensitive chemical preconcentrator in a larger microanalytical system. The capacitive chemical sensor detects changes in sensing film dielectric properties, such as the dielectric constant, conductivity, or dimensionality. These changes result from the interaction of a target analyte with the sensing film. This capability provides a low-power, self-heating chemical sensor suitable for remote and unattended sensing applications. The capacitive chemical sensor also enables a smart, analyte-sensitive chemical preconcentrator. After sorption of the sample by the sensing film, the film can be rapidly heated to release the sample for further analysis. Therefore, the capacitive chemical sensor can optimize the sample collection time prior to release to enable the rapid and accurate analysis of analytes by a microanalytical system.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC
System and method for teaching writing using microanalysis of text
InactiveUS7013259B1Closely matchedData processing applicationsDigital data information retrievalTheoretic modelMicroanalysis
Owner:FUJIFILM BUSINESS INNOVATION CORP
Microfluidic devices and methods
InactiveUS20090028755A1Material nanotechnologySequential/parallel process reactionsEngineeringMicroanalysis
Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in a discharge aperture.
Owner:ZYOMYX
Microfabricated diffusion source
A microfabricated diffusion source to provide for a controlled diffusion rate of a vapor comprises a porous reservoir formed in a substrate that can be filled with a liquid, a headspace cavity for evaporation of the vapor therein, a diffusion channel to provide a controlled diffusion of the vapor, and an outlet to release the vapor into a gas stream. The microfabricated diffusion source can provide a calibration standard for a microanalytical system. The microanalytical system with an integral diffusion source can be fabricated with microelectromechanical systems technologies.
Owner:NAT TECH & ENG SOLUTIONS OF SANDIA LLC
Time-of-flight spectrometry and spectroscopy of surfaces
ActiveUS20110147578A1FocusTime-of-flight spectrometersMaterial analysis using wave/particle radiationParticle beamSpectroscopy
Described is an analytical method and apparatus for counting and measuring the flight time of secondary electrons, secondary ions and neutrals, scattered ions and / or neutrals and for correlating coincidences between these while maintaining a continuous un-pulsed, micro-focused, primary particle beam for impinging a surface for purposes of microprobe imaging and microanalysis.
Owner:IONWERKS
Method to determine 3-d elemental composition and structure of biological and organic materials via atom probe microscopy
InactiveUS20070184515A1Expand field of viewFaster analysis timeMaterial nanotechnologyFixed microstructural devicesElemental compositionAtom probe
Disclosed are methods to prepare a specimen for microanalysis, the specimens so prepared, and methods to analyze the specimens by atom probe microscopy. The specimens are prepared by embedding a specimen within an electrically conductive matrix to yield an embedded specimen; and then forming regions on the embedded specimen into shapes suitable for microanalysis by an atom probe.
Owner:IMAGO SCI INSTR
Method for electron beam-initiated coating for application of transmission electron microscopy
InactiveUS7180061B2Material analysis using wave/particle radiationPreparing sample for investigationElectron beam depositionMicroanalysis
A method for preparing a specimen for application of microanalysis thereto includes forming an initial conductive layer over a defined area of interest on a semiconductor substrate, the initial conductive layer formed through an electron beam deposition process. A volume of substrate material surrounding the area of interest is removed, thereby forming the specimen, including said area of interest and said initial conductive layer over the area of interest. The specimen is then removed from the bulk substrate material.
Owner:IBM CORP
Chiral porous metal phosphonates for heterogeneous asymmetric catalysis
InactiveUS6878838B2Ruthenium organic compoundsTin organic compoundsHybrid materialAsymmetric hydrogenation
Chiral porous zirconium phosphonates containing metal complex moieties are provided, synthesized via a molecular building block approach, and characterized by a variety of techniques including TGA, adsorption isotherms, XRD, SEM, IR, and microanalysis. These hybrid solids may be used for enantioselective heterogeneous asymmetric hydrogenation of aromatic ketones with remarkably high e.e. values of up to 99.2%. Similarly prepared chiral porous solids may be used for asymmetric hydrogenation of β-keto esters with e.e.'s of up to 95%. The solid catalysts can also be easily recycled and reused multiple times without the loss of activity and enantioselectivity. Ready tunability of such a molecular building block approach allows the optimization of these hybrid materials to provide practically useful heterogeneous asymmetric catalysts.
Owner:NORTH CAROLINA AT CHAPEL HILL UNIVERSTIY OF THE
Multi-factor detection system for ageing state of electromagnetic relay and ageing state estimation method
InactiveCN102636748AAssess aging statusCircuit interrupters testingElectrical resistance and conductanceEstimation methods
The invention discloses a multi-factor detection system for an ageing state of an electromagnetic relay and an ageing state estimation method. Through measuring a plurality of ageing sensitivity parameters such as contact resistance, coil resistance, attraction voltage, release voltage, coil temperature and coil enameled wire insulation level and carrying out contact surface microcosmic detection and microanalysis, and by comprehensively analyzing the ageing parts and ageing reasons of the electromagnetic relay, the ageing state of the electromagnetic relay is completely and accurately evaluated.
Owner:SUZHOU NUCLEAR POWER RES INST +1
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