35 results about "XRCC1" patented technology

Evofosfamide (TH-302) or an analog thereof has a specific inhibitory effect on a cell having a specific gene mutation, in particular on a DNA repair-damaged cell. The cell or tissue has at least one or more gene mutations in BRCA1, BRCA2, FANCD1, FANCD2, ATM, ATR, CHEK1, CHEK2, CTP, BARD1, BRIP1, PALB2, RAD51D, RAD51C, RAD52, RAD54, RAD55, RAD57, FAM175, NBN, Rad50, MER11, p53, NBS1, XRS2, XRCC2,XRCC3, ERCC1, ERCC2, ERCC3, ERCC4, XRCC1, Ku80, MHS6, MGMT, PARP, and ERCC5. For this, a medical use of evofosfamide (TH-302) or an analog thereof in treating tumors or cancer in a cancer patient having the specific gene mutation(s) is provided.

The invention discloses an XRCC1 (X-Ray Repair Cross-Complementing Gene 1) gene mutation detection liquid-phase chip and specific primer. The XRCC1 gene mutation detection liquid-phase chip mainly comprises an ASPE primer, microspheres and an amplification primer, wherein the ASPE primer consists of a tag sequence at a 5'-end and a specific primer sequence for a gene mutation site at a 3'-end; the specific primer sequence is SEQ ID NO. 7 and SEQ ID NO. 8 for an A1196G site, SEQ ID NO. 9 and SEQ ID NO. 10 for a C580T site, and SEQ ID NO. 11 and SEQ ID NO. 12 for a G839A site; the microspheres are coated by an anti-tag sequence. The agreement rate of the detection result of the XRCC1 gene mutation detection liquid-phase chip and that of a sequencing method is as high as 100%. Independent or parallel detection on a wild type and a mutation type of multiple mutation sites can be achieved.

The invention relates to a primer group, reagent and / or kit and system for detecting lung cancer chemotherapy related genes, and application. The primer group contains primers for detecting gene mutation of ERCC1, MTHFR, GSTP1, XRCC1, DYNC2H1, ABCB1, CYP2C8*3, TP53, NQO1, CBR3, SOD2, CYP2C19, UGT1A1*6, TYMS, NT5C2 and CDA. The primer group, the reagent and / or the kit, the system and the application have the advantages of high accuracy, high specificity, high sensitivity, good precision and the like, and meanwhile, further have the advantages of sample saving, short detection period, easy operation, convenient analysis and the like.