31 results about "ALDH2" patented technology

Provided herein are methods, compositions and formulations to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by acetaldehyde accumulation, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity.

Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.

Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.

The invention relates to the technical field of medicines, and specially relates to two acetaldehyde dehydrogenase agonists, and a preparation method and application thereof. Specifically, the invention relates compounds shown as a formula I and a formula II, a preparation method of the compounds, and application of the above two compounds and pharmaceutically acceptable inorganic or organic salts to prepare ALDH2 agonists and to prepare medicines for treating alcohol poisoning and to prepare medicines for alleviating alcoholism. The formula I and the formula II are shown in the specification.

The invention relates to a primer composition for detecting a nitroglycerin drug related gene and a kit. The primer composition comprises a primer group ALDH2 (acetaldehyde dehydrogenase 2). The kit comprises the primer composition. Compared with the prior art, the primer composition and the kit have the advantages that the kit capable of rapidly, sensitively, simply and conveniently detecting gene polymorphism of a nitroglycerin drug treatment effect related gene (ALDH2) is obtained by adopting an ARMS (amplification refractory mutation system) technology and SYBR dye combined method; the kitcomprises a specific ARMS detection primer, an internal control primer and a PCR (polymerase chain reaction) solution, the detecting cost is reduced greatly through designing the ARMS primer and changing an Scorpions probe into an SYBR dye, thus, the kit is more applicable to the detection on polymorphism of the gene ALDH2 of a Chinese patient, has the advantages of high detection speed, high sensitivity, high specificity, simple method and accurate result and is applicable to popularization and application.

The present invention provides methods and compositions comprising ALDH2 in the treatment of a patient with toxicity resulting from ALDH2 deficiency. The physiological states that may be treated using the present invention include temporary ALDH2 deficiency, such as that seen by alcohol poisoning or an ischemic event.

The invention provides a gene detection reagent kit for evaluating alcohol tolerance. The gene detection reagent kit comprises six amplification primers for three genes including an internal reference gene GAPDH (glyceraldehyde phosphate dehydrogenase), a gene ADH1B (ethanol dehydrogenase 1B) and a gene ALDH2 (acetaldehyde dehydrogenase 2) and five Taq-man probe primers. One of the Taq-man probe primers is positioned at the internal reference gene GAPDH and is used for carrying out FAM fluorescence labeling; two other Taq-man probe primers are SNP (single nucleotide polymorphism) probes positioned at the gene ADH1B and are used for carrying out VIC and ROX (roxithromycin) labeling; the remaining two Taq-man probe primers are SNP probes positioned at the gene ALDH2 and are used for Cy5 and Quasar705 labeling, BHQ is used as a quenching group, and delta ct values can be computed. The gene detection reagent kit has the advantages that the alcohol tolerance of healthy persons can be evaluated by the gene detection reagent kit from the aspect of genes, and accordingly the healthy persons can know the strength and the weakness of alcohol tolerance, can drink alcohol scientifically and can carry on occasion such as party, gathering and banquet related to alcohol culture.